Detailed information for compound 1352347

Basic information

Technical information
  • TDR Targets ID: 1352347
  • Name: N-(3-carbamoylthiophen-2-yl)-4-oxochromene-2- carboxamide
  • MW: 314.316 | Formula: C15H10N2O4S
  • H donors: 2 H acceptors: 3 LogP: 2.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(=O)c2c(o1)cccc2)Nc1sccc1C(=O)N
  • InChi: 1S/C15H10N2O4S/c16-13(19)9-5-6-22-15(9)17-14(20)12-7-10(18)8-3-1-2-4-11(8)21-12/h1-7H,(H2,16,19)(H,17,20)
  • InChiKey: CAPHGJRHWJXXBC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(3-carbamoyl-2-thienyl)-4-oxo-chromene-2-carboxamide
  • N-(3-carbamoyl-2-thienyl)-4-oxo-2-chromenecarboxamide
  • N-(3-carbamoyl-2-thienyl)-4-keto-chromene-2-carboxamide
  • N-(3-aminocarbonylthiophen-2-yl)-4-oxo-chromene-2-carboxamide
  • IFLab1_005525
  • IDI1_010928
  • ZINC04275743
  • MLS000724704
  • SMR000237557

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis CREB binding protein 0.0041 0.0127 0.0304
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0621 0.2628 0.2628
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0022 0.0044 0.6125
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0044 0.0549
Leishmania major trypanothione reductase 0.0064 0.0225 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0044 0.9475
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0169 0.143
Toxoplasma gondii thioredoxin reductase 0.0064 0.0225 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.02 0.1352
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0062 0.0216 0.1456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0169 0.1427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0169 0.1427
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.2017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.0549
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0064 0.0064
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0044 0.1971
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0064 0.156
Trypanosoma brucei unspecified product 0.0014 0.0007 0.0329
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0047 0.0178
Brugia malayi MH2 domain containing protein 0.0122 0.0475 0.4023
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0044 0.0549
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.2328 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0728 0.6157
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0047 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0146 0.1237
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.0549
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0044 0.0168
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.00000014495 0.00000014495
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 1
Brugia malayi Flap endonuclease-1 0.0027 0.0064 0.0538
Loa Loa (eye worm) hypothetical protein 0.009 0.0337 0.2856
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0169 0.0988
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0021 0.0041 0.1809
Echinococcus granulosus CREB binding protein 0.0157 0.0626 0.3659
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.00000014495 0.00000097914
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0047 0.2081
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0044 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.2017
Brugia malayi Muscleblind-like protein 0.018 0.0728 0.6157
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0197 0.9556
Echinococcus multilocularis dna polymerase eta 0.0046 0.0146 0.035
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0056 0.019 0.1108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.1088
Onchocerca volvulus 0.0013 0.0005 0.0224
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0109 0.0919
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.0107
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0034 0.0228
Schistosoma mansoni DNA polymerase eta 0.0046 0.0146 0.0988
Loa Loa (eye worm) MBCTL1 0.0066 0.0232 0.1962
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.0949 0.2271
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0197 0.1154
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.2017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Schistosoma mansoni ap endonuclease 0.0023 0.0047 0.0316
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0107
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0034 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0169 0.0405
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 1
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.026 0.1073 0.1073
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0234 0.0561
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.1088
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0034 0.4677
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0047 0.0273
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0234 0.1371
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0047 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Schistosoma mansoni ap endonuclease 0.0023 0.0047 0.0316
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0044 0.1972
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0044 0.0549
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0197 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.015 0.088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0072 0.2017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.015 0.036
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0109 0.4837
Trypanosoma brucei unspecified product 0.002 0.0034 0.1506
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0064 0.0242
Echinococcus granulosus flap endonuclease 1 0.0027 0.0064 0.0372
Echinococcus multilocularis transcription factor eb 0.011 0.0425 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0329
Schistosoma mansoni hypothetical protein 0.0058 0.02 0.1352
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0197 0.1333
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0064 0.0538
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0044 0.1972
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0044 0.6125
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0109 0.0635
Echinococcus granulosus CREB binding protein 0.0041 0.0127 0.0743
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0197 0.1333
Schistosoma mansoni eyes absent homolog 0.009 0.0337 0.2279
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trypanosoma brucei trypanothione reductase 0.0064 0.0225 1
Echinococcus granulosus replication factor c subunit 1 0.0012 0.00000014495 0.00000084743
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0347
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0462 0.391
Loa Loa (eye worm) hypothetical protein 0.0051 0.0169 0.1427
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0612
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.036
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0207 0.1395
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0047 0.2081
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0041 0.1827
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0034 0.1506
Plasmodium falciparum thioredoxin reductase 0.0022 0.0044 0.1971
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Echinococcus multilocularis ubiquitin 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0612
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0072 0.0674
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0682 0.3989
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Giardia lamblia NADPH oxidoreductase, putative 0.0621 0.2628 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0044 0.1972
Schistosoma mansoni flap endonuclease-1 0.0024 0.0053 0.0355
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0047 0.0436
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0347
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0044 0.1972
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.047 0.3174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.015 0.1016
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0109 0.0109
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0197 0.167
Brugia malayi hypothetical protein 0.009 0.0337 0.2856
Echinococcus granulosus expressed conserved protein 0.0112 0.0431 0.2519
Echinococcus granulosus ubiquitin 0.0013 0.0005 0.0027
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0062 0.0216 0.0516
Echinococcus granulosus histone acetyltransferase KAT2B 0.0021 0.0041 0.0237
Loa Loa (eye worm) hypothetical protein 0.011 0.0423 0.3576
Brugia malayi Thioredoxin reductase 0.0064 0.0225 0.19
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0107
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0064 0.283
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0043
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0072 0.0674
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0044 0.1972
Loa Loa (eye worm) hypothetical protein 0.0286 0.1182 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0109 0.0919
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0034 0.1506
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.1748
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0621 0.2628 0.2628
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0064 0.0225 1
Schistosoma mansoni CREB-binding protein 2 0.0253 0.1043 0.7044
Loa Loa (eye worm) acetyltransferase 0.0062 0.0216 0.1825
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0044 0.1971
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Schistosoma mansoni patched 1 0.0051 0.0169 0.1141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.015 0.1273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Entamoeba histolytica acetyltransferase, GNAT family 0.0015 0.0015 0.0144
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0034 0.1506
Onchocerca volvulus 0.006 0.0207 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0034 0.0129
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0087 0.3896
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0034 0.0286
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0047 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0064 0.283
Echinococcus multilocularis CREB binding protein 0.0041 0.0127 0.0304
Echinococcus multilocularis CREB binding protein 0.0174 0.0701 0.1678
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0169 0.1427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.015 0.1016
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0044 0.0549
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0044 0.6125
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0047 0.2081
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0019 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0347
Onchocerca volvulus 0.0058 0.0197 0.9556
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.02 0.1694
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0072 0.2017
Leishmania major DNA polymerase eta, putative 0.0046 0.0146 0.5892
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0232 0.0555
Echinococcus multilocularis CREB binding protein 0.0041 0.0127 0.0304
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Trichomonas vaginalis ubiquitin, putative 0.0013 0.0005 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0034 0.0034
Brugia malayi CHE-14 protein 0.0051 0.0169 0.143
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0475 0.4023
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 1
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0146 0.1237
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0044 0.1971
Loa Loa (eye worm) hypothetical protein 0.009 0.0337 0.2856
Schistosoma mansoni hypothetical protein 0.0355 0.148 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0047 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1182 0.2829
Giardia lamblia NADPH oxidoreductase, putative 0.0621 0.2628 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.0155
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0109 0.026
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0232 0.1355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.015 0.1016
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Plasmodium falciparum thioredoxin reductase 0.0064 0.0225 1
Leishmania major small ubiquitin protein, putative 0.0037 0.0109 0.3922
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Loa Loa (eye worm) hypothetical protein 0.018 0.0728 0.6157
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Entamoeba histolytica modulator of drug activity B homolog, putative 0.026 0.1073 1
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0109 0.0734
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0347
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0169 0.0988
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0072 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0047 0.6464
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0109 0.4837
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0197 0.1333
Entamoeba histolytica ubiquitin like protein 0.0037 0.0109 0.1013
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.026 0.1073 1
Giardia lamblia Sentrin 0.0037 0.0109 0.0413
Plasmodium falciparum glutathione reductase 0.0022 0.0044 0.1971
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0462 0.4307
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0019 0.016
Plasmodium falciparum flap endonuclease 1 0.0027 0.0064 0.283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0114
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0047 0.0677
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0047 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1182 0.6908
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0034 0.0081
Loa Loa (eye worm) thioredoxin reductase 0.0064 0.0225 0.19
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4177 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0034 0.1506
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0462 0.1106
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0034 0.1506
Trypanosoma brucei unspecified product 0.0014 0.0007 0.0329
Echinococcus multilocularis expressed conserved protein 0.0112 0.0431 0.1032
Echinococcus multilocularis muscleblind protein 0.018 0.0728 0.1742
Loa Loa (eye worm) CBP-B 0.0176 0.071 0.6012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0044 0.1972
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0034 0.0198
Toxoplasma gondii exonuclease III APE 0.0023 0.0047 0.2081
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.0225 0.0538
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0044 0.9475
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0197 0.1154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.015 0.088
Loa Loa (eye worm) hypothetical protein 0.0118 0.046 0.3889
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.0225 0.1313
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0109 0.4837
Brugia malayi acetyltransferase, GNAT family protein 0.0062 0.0216 0.1825
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.00000014495 0.00000014495
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0041 0.5677
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0232 0.1962
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.1088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0047 0.0112
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0047 0.0395
Giardia lamblia NADPH oxidoreductase, putative 0.0621 0.2628 1
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0253 0.1043 0.7044
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0034 0.0034
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0197 0.0473
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0044 0.1972
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0044 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0034 0.1506
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.00000014495 0.00000014495
Trichomonas vaginalis bromodomain-containing protein, putative 0.0021 0.0041 0.0041
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0064 0.0593
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0041 0.1827
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0114
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0044 0.0259
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0044 0.0549
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0047 0.2081
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0072 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0034 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Entamoeba histolytica hypothetical protein 0.026 0.1073 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Brugia malayi mbt repeat family protein 0.0058 0.0197 0.167
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0099 0.0838
Loa Loa (eye worm) hypothetical protein 0.0051 0.0169 0.143
Loa Loa (eye worm) hypothetical protein 0.0119 0.0462 0.391
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.026 0.1073 0.1073
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0044 0.1972
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0682 0.1634
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0072 1
Echinococcus granulosus tumor protein p63 0.0408 0.1711 1
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0109 0.4837
Plasmodium falciparum glutathione reductase 0.0064 0.0225 1
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.0155
Echinococcus granulosus CREB binding protein 0.0041 0.0127 0.0743
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.015 0.1273
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0034 0.0315
Mycobacterium ulcerans hypothetical protein 0.0029 0.0072 1
Plasmodium vivax glutathione reductase, putative 0.0064 0.0225 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.02 0.0479
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.00000014495 0.0000013514
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0044 0.1972
Loa Loa (eye worm) hypothetical protein 0.0066 0.0232 0.1962
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.011 0.0423 0.3576
Plasmodium vivax thioredoxin reductase, putative 0.0064 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0612
Loa Loa (eye worm) glutathione reductase 0.0064 0.0225 0.19
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0347
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0034 0.4677
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0087 0.3896
Plasmodium falciparum histone acetyltransferase GCN5 0.0015 0.0015 0.0689
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0044 0.0549
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0146 0.651
Echinococcus granulosus transcription factor eb 0.011 0.0425 0.2484
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0044 0.1972
Onchocerca volvulus 0.0058 0.02 0.9691
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0064 0.0152
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0612
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0044 0.1971
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0621 0.2628 0.2628
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0047 0.0047
Brugia malayi mbt repeat family protein 0.0058 0.0197 0.167
Giardia lamblia Histone acetyltransferase GCN5 0.0015 0.0015 0.0059
Leishmania major DNA polymerase eta, putative 0.0032 0.0087 0.2814
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0114
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0034 0.0286
Echinococcus granulosus CREB binding protein 0.0253 0.1043 0.6097
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0232 0.1566
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0035 0.0099 0.0669
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0041 0.0379
Treponema pallidum NADH oxidase 0.0022 0.0044 0.9475
Brugia malayi hypothetical protein 0.0286 0.1182 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0047 0.2081
Echinococcus multilocularis tumor protein p63 0.0408 0.1711 0.4095
Brugia malayi hypothetical protein 0.0013 0.0005 0.0039
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.0425 0.3596
Echinococcus granulosus muscleblind protein 0.018 0.0728 0.4253
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.00000014495 0.00000034704
Echinococcus multilocularis dna polymerase kappa 0.002 0.0034 0.0081
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.0949 0.5546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0072 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0021 0.0041 0.1809
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0072 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0034 0.1506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.015 0.036
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.1088
Echinococcus multilocularis protein patched 0.0051 0.0169 0.0405
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0109 0.4837
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Echinococcus granulosus dna polymerase eta 0.0046 0.0146 0.0855
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0041 0.9268
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0072 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0072 0.0674
Onchocerca volvulus 0.0029 0.0072 0.35
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.00000014495 0.0000064548
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0021 0.0041 0.1809
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0064 0.283
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0034 0.1506
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0109 0.4837
Trichomonas vaginalis conserved hypothetical protein 0.036 0.1504 0.1504
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0475 0.4023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0044 0.0299
Loa Loa (eye worm) hypothetical protein 0.0062 0.0219 0.1849
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0146 0.651
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0044 1
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Brugia malayi TAZ zinc finger family protein 0.0253 0.1043 0.8825
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0123
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0225 1
Brugia malayi glutathione reductase 0.0064 0.0225 0.19
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0044 0.0106
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Trichomonas vaginalis modulator of drug activity B, putative 0.026 0.1073 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0621 0.2628 0.2628
Echinococcus multilocularis muscleblind protein 1 0.018 0.0728 0.1742
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0462 0.2701
Loa Loa (eye worm) hypothetical protein 0.0058 0.0197 0.167
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0044 0.6125
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0064 0.283

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 11.7 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 66.6 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.7375 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 1.4125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6855 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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