Detailed information for compound 1352552

Basic information

Technical information
  • TDR Targets ID: 1352552
  • Name: N-(tert-butylcarbamoyl)-2-piperidin-1-ylaceta mide
  • MW: 241.33 | Formula: C12H23N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(=O)NC(C)(C)C)CN1CCCCC1
  • InChi: 1S/C12H23N3O2/c1-12(2,3)14-11(17)13-10(16)9-15-7-5-4-6-8-15/h4-9H2,1-3H3,(H2,13,14,16,17)
  • InChiKey: SNINDDLEGPUENO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(tert-butylcarbamoyl)-2-(1-piperidyl)acetamide
  • N-[(tert-butylamino)-oxomethyl]-2-(1-piperidyl)acetamide
  • N-(tert-butylcarbamoyl)-2-piperidino-acetamide
  • N-(tert-butylcarbamoyl)-2-piperidin-1-yl-ethanamide
  • MLS001033019
  • SMR000363568
  • T0518-7041

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0036 0.0072 0.0068
Schistosoma mansoni endoplasmin 0.0569 0.2796 0.2792
Brugia malayi Transient-receptor-potential like protein 0.004 0.0092 0.0167
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Treponema pallidum catabolite gene activator (Crp) 0.0036 0.0072 0.0327
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0056 0.0173 0.0169
Onchocerca volvulus 0.0279 0.1317 0.2485
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0116 0.0481 0.1719
Entamoeba histolytica heat shock protein 90, putative 0.0569 0.2796 1
Schistosoma mansoni cpg binding protein 0.0097 0.0387 0.0383
Trypanosoma cruzi cAMP binding protein, putative 0.0036 0.0072 0.0242
Leishmania major mitochondrial DNA topoisomerase II 0.0116 0.0481 0.1706
Brugia malayi Cation transporter family protein 0.0711 0.3523 0.6695
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Trypanosoma cruzi heat shock protein 85, putative 0.0569 0.2796 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Loa Loa (eye worm) TATA binding protein associated factor 0.004 0.0093 0.0088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0102 0.041 0.0406
Leishmania major cyclic nucleotide-binding protein-like protein 0.0036 0.0072 0.0242
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Entamoeba histolytica hypothetical protein 0.0041 0.01 0.0344
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.0412 0.1994 0.199
Onchocerca volvulus 0.1051 0.526 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0058 0.0102
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0075 0.0071
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0299 0.1418 0.1414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.0687 0.0683
Mycobacterium ulcerans two component sensor kinase MprB 0.0116 0.0481 0.2142
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0116 0.0481 0.1706
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0116 0.0481 0.1706
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0151 0.0146
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0011 0.0007
Brugia malayi Melatonin receptor type 1A 0.0279 0.1317 0.2497
Brugia malayi CXXC zinc finger family protein 0.0092 0.036 0.0676
Schistosoma mansoni amine GPCR 0.0279 0.1317 0.1313
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0056 0.0173 0.0169
Brugia malayi hypothetical protein 0.0299 0.1418 0.269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.01 0.0096
Mycobacterium ulcerans hypothetical protein 0.0036 0.0072 0.0278
Onchocerca volvulus 0.0279 0.1317 0.2485
Mycobacterium leprae Possible transporter protein 0.0025 0.0016 0.0074
Onchocerca volvulus 0.0073 0.0263 0.0477
Toxoplasma gondii LsmAD domain-containing protein 0.0039 0.0086 0.0308
Schistosoma mansoni hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0612 0.3018 0.3015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0091 0.018
Schistosoma mansoni hypothetical protein 0.0156 0.0684 0.0679
Echinococcus multilocularis SAM and MBT domain containing protein 0.0024 0.0013 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0228 0.0989
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0036 0.0072 0.0068
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0025 0.0016 0.0042
Mycobacterium ulcerans hypothetical protein 0.0036 0.0072 0.0278
Brugia malayi Cation transporter family protein 0.0711 0.3523 0.6695
Trypanosoma cruzi heat shock protein 90, putative 0.0336 0.1604 0.5733
Schistosoma mansoni glutaminase 0.0221 0.1018 0.1014
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0139 0.06 0.1332
Plasmodium vivax DNA topoisomerase II, putative 0.0116 0.0481 0.1719
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0151 0.0278
Schistosoma mansoni alpha-glucosidase 0.0088 0.0338 0.0333
Mycobacterium ulcerans aminopeptidase N PepN 0.004 0.0093 0.0373
Brugia malayi Dopamine receptor 0.0279 0.1317 0.2497
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0036 0.0072 0.0242
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0274 0.1287 0.1283
Echinococcus granulosus glycine receptor subunit beta 0.0711 0.3523 0.352
Schistosoma mansoni biogenic amine receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0006 0.0001
Brugia malayi Tachykinin-like peptides receptor 99D 0.0279 0.1317 0.2497
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0711 0.3523 0.352
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0086 0.0308
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0412 0.1994 0.3785
Echinococcus granulosus short transient receptor potential channel 6 0.0057 0.0179 0.0175
Plasmodium falciparum heat shock protein 90, putative 0.0233 0.108 0.3862
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0088 0.0084
Chlamydia trachomatis DNA gyrase subunit B 0.0116 0.0481 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0595 0.2929 0.2926
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0279 0.1317 0.1313
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0035 0.0066 0.0236
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0299 0.1418 0.269
Trypanosoma brucei Flagellar Member 6 0.0036 0.0072 0.0242
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0274 0.1287 0.1283
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0104 0.0418 0.0414
Schistosoma mansoni adenoreceptor 0.0279 0.1317 0.1313
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.0716 0.1354
Loa Loa (eye worm) hypothetical protein 0.0077 0.0281 0.0277
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0072 0.0327
Echinococcus granulosus 7TM GPCR rhodopsin 0.0279 0.1317 0.1313
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Mycobacterium tuberculosis Conserved protein 0.0139 0.06 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Echinococcus multilocularis hyperpolarization activated cyclic 0.0056 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.1978 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Schistosoma mansoni hypothetical protein 0.0111 0.0454 0.045
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Loa Loa (eye worm) MBCTL1 0.0028 0.003 0.0026
Trypanosoma brucei heat shock protein 84, putative 0.0233 0.108 0.3853
Loa Loa (eye worm) endoplasmin 0.0569 0.2796 0.2792
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0711 0.3523 0.352
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Onchocerca volvulus 0.0279 0.1317 0.2485
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0058 0.0213
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Echinococcus multilocularis muscleblind protein 0.0094 0.0367 0.0363
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0279 0.1317 0.2497
Loa Loa (eye worm) G-protein coupled receptor 0.0279 0.1317 0.1313
Brugia malayi Peptidase family M1 containing protein 0.004 0.0093 0.0168
Echinococcus granulosus aminopeptidase N 0.004 0.0093 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0091 0.0309
Onchocerca volvulus 0.0412 0.1994 0.3775
Toxoplasma gondii ABC1 family protein 0.0139 0.06 0.2146
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.0609 0.0605
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0711 0.3523 0.352
Mycobacterium tuberculosis Probable hydrolase 0.0139 0.06 0.1332
Giardia lamblia Grp94/Hsp90 0.0453 0.2204 0.7831
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0279 0.1317 0.2497
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0072 0.0138
Plasmodium vivax DNA gyrase subunit B, putative 0.0116 0.0481 0.1719
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0412 0.1994 0.199
Trypanosoma cruzi DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Mycobacterium ulcerans glutaminase 0.0221 0.1018 0.4594
Echinococcus multilocularis conserved hypothetical protein 0.1071 0.5365 0.5363
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0071 0.0254 0.025
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.004 0.0093 0.0332
Schistosoma mansoni acetyl-CoA carboxylase 0.0074 0.0267 0.0263
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0208
Brugia malayi MH2 domain containing protein 0.0141 0.0609 0.115
Echinococcus multilocularis hyperpolarization activated cyclic 0.0056 0.0173 0.0169
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) heat shock protein 90 0.0569 0.2796 0.2792
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0011 0.0024
Echinococcus multilocularis sex peptide receptor 0.0279 0.1317 0.1313
Entamoeba histolytica heat shock protein 90, putative 0.0569 0.2796 1
Treponema pallidum cyclic nucleotide binding protein 0.0036 0.0072 0.0327
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0453 0.2204 0.4959
Brugia malayi G protein-coupled receptor F59B2.13 0.0279 0.1317 0.2497
Onchocerca volvulus 0.004 0.0093 0.0153
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0008
Schistosoma mansoni hypothetical protein 0.0041 0.01 0.0096
Echinococcus granulosus glycine receptor subunit beta 0.0711 0.3523 0.352
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0116 0.0481 0.2142
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Schistosoma mansoni microtubule-associated protein tau 0.0376 0.1808 0.1805
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0711 0.3523 0.352
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0208
Echinococcus granulosus hypothetical protein 0.1351 0.6793 0.6792
Trichomonas vaginalis heat shock protein, putative 0.0453 0.2204 0.7879
Giardia lamblia Heat shock protein HSP 90-alpha 0.0453 0.2204 0.7831
Loa Loa (eye worm) hypothetical protein 0.1051 0.526 0.5258
Brugia malayi Glycosyl hydrolases family 31 protein 0.0102 0.041 0.0772
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0056 0.0173 0.0169
Brugia malayi Cation transporter family protein 0.1051 0.526 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.004 0.0093 0.0317
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus transient receptor potential ion channel A 0.0057 0.018 0.0176
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0102 0.041 0.0406
Loa Loa (eye worm) LGC-31 protein 0.0711 0.3523 0.352
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0034 0.003
Echinococcus multilocularis g protein coupled receptor 0.0279 0.1317 0.1313
Trypanosoma brucei heat shock protein 90, putative 0.0569 0.2796 1
Schistosoma mansoni voltage-gated potassium channel 0.0299 0.1415 0.1411
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0279 0.1317 0.1313
Trypanosoma brucei acetyl-CoA carboxylase 0.0074 0.0267 0.0942
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0039 0.0088 0.0301
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0036 0.0074 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.06 0.2133
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.0716 0.1354
Schistosoma mansoni nAChR subunit 0.0299 0.1418 0.1414
Schistosoma mansoni biogenic amine (5HT) receptor 0.1978 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0412 0.1994 0.3785
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0116 0.0481 0.1062
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0116 0.0481 0.0892
Schistosoma mansoni opsin-like receptor 0.0279 0.1317 0.1313
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0279 0.1317 0.1313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0151 0.0146
Onchocerca volvulus 0.004 0.0093 0.0153
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.004 0.0093 0.0317
Leishmania major DNA topoisomerase ii 0.0116 0.0481 0.1706
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Brugia malayi neuropeptide F receptor 0.0279 0.1317 0.2497
Schistosoma mansoni biogenic amine (5HT) receptor 0.0595 0.2929 0.2926
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0116 0.0481 0.1062
Echinococcus multilocularis glycine receptor subunit beta 0.0711 0.3523 0.352
Echinococcus granulosus tm gpcr rhodopsin 0.0279 0.1317 0.1313
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0711 0.3523 0.352
Brugia malayi Probable DNA topoisomerase II 0.0116 0.0481 0.0906
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Brugia malayi cytochrome P450 0.0024 0.0011 0.0013
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0036 0.0072 0.0138
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0036 0.0072 0.0242
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis neuropeptides capa receptor 0.0279 0.1317 0.1313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0036 0.0072 0.0068
Echinococcus multilocularis expressed conserved protein 0.0036 0.0074 0.0069
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0116 0.0481 0.2181
Trichomonas vaginalis glutaminase, putative 0.0221 0.1018 0.3632
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0279 0.1317 0.1313
Schistosoma mansoni hypothetical protein 0.0715 0.3544 0.3541
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0453 0.2204 0.7879
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0028 0.0033 0.0099
Brugia malayi Hsp90 protein 0.0233 0.108 0.2046
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0453 0.2204 1
Loa Loa (eye worm) glutaminase 0.0221 0.1018 0.1014
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0011 0.0024
Loa Loa (eye worm) GABA receptor subunit 0.0412 0.1994 0.199
Echinococcus granulosus neuropeptides capa receptor 0.0279 0.1317 0.1313
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0056 0.0173 0.0169
Trichomonas vaginalis esterase, putative 0.0139 0.06 0.2133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0156 0.0687 0.0683
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0093 0.0317
Brugia malayi hypothetical protein 0.0041 0.01 0.0183
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0116 0.0481 0.1062
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis aminopeptidase N 0.004 0.0093 0.0088
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0036 0.0072 0.0242
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0028 0.0033 0.0049
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0612 0.3018 0.3015
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0033 0.0054
Schistosoma mansoni gabp alpha 0.0039 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0116 0.0481 0.0477
Loa Loa (eye worm) hypothetical protein 0.0116 0.0481 0.0477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis GA binding protein alpha chain 0.0039 0.009 0.0086
Brugia malayi G-protein coupled receptor 0.0279 0.1317 0.2497
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0025 0.0016 0.0023
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0116 0.0481 0.1062
Trypanosoma brucei DNA topoisomerase ii 0.0116 0.0481 0.1706
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0072 0.0242
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.1051 0.526 0.5258
Echinococcus granulosus fmrfamide receptor 0.0279 0.1317 0.1313
Brugia malayi RE15519p 0.0279 0.1317 0.2497
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0711 0.3523 0.352
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0025 0.0016 0.0042
Entamoeba histolytica hypothetical protein 0.0412 0.1994 0.7126
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0011 0.0024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0036 0.0072 0.0068
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0116 0.0481 0.1062
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0116 0.0481 0.1062
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0299 0.1418 0.1414
Trichomonas vaginalis adenylate cyclase type, putative 0.0025 0.0016 0.0042
Plasmodium vivax endoplasmin, putative 0.0569 0.2796 1
Trypanosoma cruzi aminopeptidase, putative 0.004 0.0093 0.0317
Schistosoma mansoni ets-related 0.012 0.05 0.0496
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0028 0.0033 0.0102
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0082
Onchocerca volvulus 0.0279 0.1317 0.2485
Schistosoma mansoni hypothetical protein 0.0279 0.1317 0.1313
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0279 0.1317 0.2497
Loa Loa (eye worm) ACC-1 protein 0.0711 0.3523 0.352
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0025 0.0016 0.0042
Echinococcus granulosus orexin receptor type 2 0.0279 0.1317 0.1313
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0116 0.0481 0.0477
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0072 0.0242
Brugia malayi beta-lactamase family protein 0.0139 0.06 0.1133
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Onchocerca volvulus Neuropeptide F receptor homolog 0.0279 0.1317 0.2485
Mycobacterium tuberculosis Conserved protein 0.0036 0.0072 0.0138
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0279 0.1317 0.1313
Toxoplasma gondii pyruvate carboxylase 0.0028 0.0033 0.0118
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0058 0.0054
Loa Loa (eye worm) fli-1 protein 0.012 0.05 0.0496
Echinococcus granulosus 7tm_1 domain containing protein 0.0279 0.1317 0.1313
Echinococcus granulosus cGMP dependent protein kinase 1 0.0036 0.0074 0.0069
Schistosoma mansoni myosin xvIII 0.0279 0.1317 0.1313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0299 0.1418 0.269
Onchocerca volvulus 0.0139 0.06 0.1119
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Schistosoma mansoni amine GPCR 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0228 0.0224
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Schistosoma mansoni transient receptor potential channel 0.0057 0.0179 0.0175
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0711 0.3523 0.6695
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus multilocularis mitogen activated protein kinase 3 0.0035 0.0066 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0091 0.0086
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0299 0.1418 0.1414
Loa Loa (eye worm) hypothetical protein 0.0051 0.0151 0.0146
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0081 0.0301 0.0297
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Echinococcus multilocularis polycomb protein SCMH1 0.0024 0.0013 0.0008
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0081 0.0301 0.0564
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Mycobacterium ulcerans DNA gyrase subunit B 0.0116 0.0481 0.2142
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0116 0.0481 0.0892
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.0716 0.0712
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Brugia malayi beta-lactamase 0.0139 0.06 0.1133
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.004 0.0093 0.0317
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0035 0.0066 0.0221
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Leishmania major carboxylase, putative 0.0028 0.0033 0.0102
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0028 0.003 0.0026
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.004 0.0093 0.0317
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0088 0.0084
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0711 0.3523 0.352
Onchocerca volvulus 0.0279 0.1317 0.2485
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0436 0.2117 0.2114
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.0066 0.0221
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0711 0.3523 0.6695
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0139 0.06 0.0596
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0054 0.0163 0.0582
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0091 0.0309
Trichomonas vaginalis heat shock protein, putative 0.0453 0.2204 0.7879
Trichomonas vaginalis heat shock protein, putative 0.0453 0.2204 0.7879
Mycobacterium tuberculosis Probable two component sensor kinase 0.0116 0.0481 0.1062
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus granulosus heat shock protein 0.0569 0.2796 0.2792
Echinococcus multilocularis somatostatin receptor 0.0279 0.1317 0.1313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.0687 0.0683
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Schistosoma mansoni amine GPCR 0.0279 0.1317 0.1313
Brugia malayi MAP kinase sur-1 0.0035 0.0066 0.0117
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0711 0.3523 0.352
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0036 0.0072 0.0068
Trypanosoma cruzi cAMP response protein 1, putative 0.0036 0.0072 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.0066 0.0221
Schistosoma mansoni hypothetical protein 0.0051 0.0151 0.0146
Trypanosoma brucei heat shock protein 90, putative 0.0569 0.2796 1
Schistosoma mansoni voltage-gated potassium channel 0.0056 0.0173 0.0169
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0711 0.3523 0.352
Schistosoma mansoni aminopeptidase A (M01 family) 0.004 0.0093 0.0088
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0151 0.0278
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0233 0.108 0.1076
Mycobacterium leprae conserved hypothetical protein 0.0139 0.06 0.2722
Mycobacterium leprae Probable lipase LipE 0.0139 0.06 0.2722
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0036 0.0072 0.0068
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0116 0.0481 0.2142
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0116 0.0481 0.1062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Conserved protein 0.0139 0.06 0.1332
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Brugia malayi kinase, mitochondrial precursor 0.0116 0.0481 0.0906
Trypanosoma brucei Aminopeptidase M1, putative 0.004 0.0093 0.0317
Schistosoma mansoni hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus tm gpcr rhodopsin 0.0279 0.1317 0.1313
Brugia malayi hypothetical protein 0.0299 0.1418 0.269
Schistosoma mansoni neuropeptide receptor 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0036 0.0072 0.0138
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.01 0.0096
Schistosoma mansoni neuropeptide receptor 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0116 0.0481 0.1062
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0072 0.0258
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Plasmodium falciparum M1-family alanyl aminopeptidase 0.004 0.0093 0.0332
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0116 0.0481 0.1719
Schistosoma mansoni alpha-1 adrenergic receptor 0.0279 0.1317 0.1313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Echinococcus granulosus mitogen activated protein kinase 0.0035 0.0066 0.0062
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0036 0.0072 0.0068
Toxoplasma gondii DNA topoisomerase 2, putative 0.0116 0.0481 0.1719
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.1051 0.526 0.5258
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Onchocerca volvulus 0.0299 0.1418 0.2678
Schistosoma mansoni heat shock protein 0.0569 0.2796 0.2792
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0752 0.3731 0.3728
Onchocerca volvulus 0.0279 0.1317 0.2485
Echinococcus granulosus dro:myosuppressin receptor 0.0279 0.1317 0.1313
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0036 0.0072 0.0068
Echinococcus granulosus transient receptor potential gamma protein 0.0077 0.0281 0.0277
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0058 0.0054
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.01 0.0456
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0116 0.0481 0.1706
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0156 0.0687 0.1299
Trypanosoma cruzi heat shock protein 90, putative 0.0569 0.2796 1
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis adenylate cyclase type, putative 0.0025 0.0016 0.0042
Treponema pallidum catabolite gene activator 0.0036 0.0072 0.0327
Leishmania major hypothetical protein, conserved 0.0036 0.0072 0.0242
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0058 0.0192
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Plasmodium vivax ataxin-2 like protein, putative 0.0039 0.0086 0.0308
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0056 0.0173 0.0169
Echinococcus multilocularis neuropeptide s receptor 0.0279 0.1317 0.1313
Plasmodium vivax heat shock protein 90, putative 0.0233 0.108 0.3862
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0093 0.0317
Trichomonas vaginalis DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus neuropeptides capa receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Schistosoma mansoni amine GPCR 0.0279 0.1317 0.1313
Mycobacterium leprae putative cytochrome p450 0.0024 0.0011 0.005
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0116 0.0481 0.1706
Echinococcus multilocularis short transient receptor potential channel 6 0.0057 0.0179 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0609 0.0605
Echinococcus granulosus peptide allatostatin:somatostatin 0.0279 0.1317 0.1313
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0228 0.0989
Trypanosoma cruzi Heat shock protein 83, putative 0.0569 0.2796 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.4169
Leishmania major acetyl-CoA carboxylase, putative 0.0074 0.0267 0.0942
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0228 0.0989
Onchocerca volvulus 0.0279 0.1317 0.2485
Plasmodium vivax heat shock protein 86, putative 0.0569 0.2796 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Schistosoma mansoni hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0091 0.0086
Mycobacterium leprae Probable two-component sensor kinase 0.0116 0.0481 0.2181
Mycobacterium ulcerans hypothetical protein 0.0036 0.0072 0.0278
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0299 0.1418 0.1414
Brugia malayi hypothetical protein 0.0299 0.1418 0.269
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0036 0.0072 0.0068
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0028 0.0033 0.0102
Schistosoma mansoni neurotransmitter gated ion channel 0.0299 0.1418 0.1414
Echinococcus granulosus sex peptide receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Leishmania major protein kinase, putative 0.0036 0.0074 0.0248
Leishmania major hypothetical protein, conserved 0.0036 0.0072 0.0242
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0541 0.2655 0.2652
Brugia malayi mbt repeat family protein 0.0024 0.0013 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis allatostatin A receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0034 0.003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0116 0.0481 0.2181
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0139 0.06 0.2133
Leishmania major protein kinase, putative 0.0036 0.0074 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0091 0.0411
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis geminin 0.0715 0.3544 0.3541
Echinococcus multilocularis voltage gated potassium channel 0.0081 0.0301 0.0297
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Brugia malayi ORL1-like opioid receptor 0.0279 0.1317 0.2497
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0279 0.1317 0.2497
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Echinococcus multilocularis nAChR subunit 0.0711 0.3523 0.352
Brugia malayi hypothetical protein 0.0299 0.1418 0.269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Onchocerca volvulus 0.0092 0.036 0.0662
Schistosoma mansoni hypothetical protein 0.0036 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Schistosoma mansoni sex comb on midleg homolog 0.0024 0.0013 0.0008
Treponema pallidum cyclic nucleotide binding protein 0.0036 0.0072 0.0327
Loa Loa (eye worm) neuropeptide F receptor 0.0279 0.1317 0.1313
Mycobacterium ulcerans hypothetical protein 0.0139 0.06 0.2685
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0091 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0086 0.0293
Echinococcus granulosus voltage gated potassium channel 0.0081 0.0301 0.0297
Mycobacterium ulcerans hypothetical protein 0.0036 0.0072 0.0278
Trichomonas vaginalis heat shock protein, putative 0.0349 0.1672 0.5974
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0036 0.0072 0.0068
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0279 0.1317 0.1313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Trichomonas vaginalis penicillin-binding protein, putative 0.0139 0.06 0.2133
Trichomonas vaginalis penicillin-binding protein, putative 0.0139 0.06 0.2133
Echinococcus multilocularis endoplasmin 0.0453 0.2204 0.22
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0104 0.0418 0.0414
Loa Loa (eye worm) hypothetical protein 0.0034 0.0061 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0016 0.0042
Brugia malayi hypothetical protein 0.0346 0.1655 0.3141
Loa Loa (eye worm) hypothetical protein 0.0073 0.0263 0.0259
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0036 0.0072 0.0068
Brugia malayi Serotonin receptor 0.0994 0.4968 0.9444
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0824
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0151 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Schistosoma mansoni peptidase Clp (S14 family) 0.0063 0.0212 0.0208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0006 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0088 0.0352
Plasmodium falciparum DNA topoisomerase 2 0.0116 0.0481 0.1719
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0116 0.0481 0.2181
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0889 0.4432 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0156 0.0687 0.0683
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Echinococcus multilocularis cpg binding protein 0.0097 0.0387 0.0383
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0035 0.0066 0.0221
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.0481 0.0477
Echinococcus granulosus glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Entamoeba histolytica hypothetical protein 0.0041 0.01 0.0344
Mycobacterium ulcerans two component regulator - sensor kinase 0.0116 0.0481 0.2142
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0274 0.1287 0.2441
Brugia malayi G protein-coupled receptor 0.0279 0.1317 0.2497
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0056 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.0094 0.0367 0.0363
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0028 0.0033 0.0028
Echinococcus multilocularis fmrfamide receptor 0.0279 0.1317 0.1313
Onchocerca volvulus 0.0279 0.1317 0.2485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0092 0.0088
Echinococcus multilocularis dnaJ subfamily B 0.1313 0.66 0.6599
Onchocerca volvulus 0.0036 0.0072 0.0113
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0116 0.0481 0.2142
Echinococcus granulosus mitogen activated protein kinase 3 0.0035 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0711 0.3523 0.352
Echinococcus multilocularis muscleblind protein 1 0.0094 0.0367 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.0066 0.0221
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0299 0.1418 0.1414
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0116 0.0481 0.2142
Brugia malayi beta-lactamase family protein 0.0139 0.06 0.1133
Trypanosoma cruzi Aminopeptidase M1, putative 0.004 0.0093 0.0317
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.004 0.0093 0.0332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0279 0.1317 0.1313
Schistosoma mansoni cpg binding protein 0.0097 0.0387 0.0383
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0711 0.3523 0.352
Trichomonas vaginalis sensor histidine kinase, putative 0.0116 0.0481 0.1706
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0238 0.1104 0.11
Onchocerca volvulus 0.0279 0.1317 0.2485
Echinococcus granulosus heat shock protein 90 0.0569 0.2796 0.2792
Mycobacterium tuberculosis Conserved protein 0.0139 0.06 0.1332
Echinococcus granulosus short transient receptor potential channel 6 0.0057 0.0179 0.0175
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0116 0.0481 0.1706
Mycobacterium leprae Probable two component sensor kinase MprB 0.0116 0.0481 0.2181
Mycobacterium tuberculosis Probable esterase LipL 0.0139 0.06 0.1332
Trypanosoma brucei aminopeptidase, putative 0.004 0.0093 0.0317
Trypanosoma cruzi heat shock protein 85, putative 0.0569 0.2796 1
Trypanosoma cruzi Flagellar Member 6 0.0036 0.0072 0.0242
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0279 0.1317 0.1313
Echinococcus granulosus neuropeptide receptor 0.0279 0.1317 0.1313
Schistosoma mansoni heat shock protein 0.0233 0.108 0.1076
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0752 0.3731 0.3728
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0279 0.1317 0.1313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis g-protein coupled receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis transient receptor potential gamma protein 0.0077 0.0281 0.0277
Loa Loa (eye worm) acetylcholine receptor protein 0.0299 0.1418 0.1414
Schistosoma mansoni neuropeptide F-like receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0711 0.3523 0.352
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0711 0.3523 0.6695
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0279 0.1317 0.1313
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0454 0.0856
Trichomonas vaginalis heat shock protein, putative 0.0569 0.2796 1
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0056 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus multilocularis G protein coupled receptor 139 0.0279 0.1317 0.1313
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.041 0.0406
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Brugia malayi hypothetical protein 0.004 0.0093 0.0168
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0116 0.0481 0.1062
Echinococcus granulosus histone acetyltransferase MYST2 0.0028 0.003 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0116 0.0481 0.0477
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0279 0.1317 0.1313
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0091 0.0363
Brugia malayi neuropeptide F receptor 0.0279 0.1317 0.2497
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0116 0.0481 0.1062
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0279 0.1317 0.1313
Brugia malayi excitatory GABA receptor EXP-1A 0.0711 0.3523 0.6695
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Onchocerca volvulus 0.0139 0.06 0.1119
Loa Loa (eye worm) beta-lactamase 0.0139 0.06 0.0596
Onchocerca volvulus 0.0279 0.1317 0.2485
Leishmania major cytochrome p450-like protein 0.0033 0.0058 0.0192
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0711 0.3523 0.352
Schistosoma mansoni nAChR subunit 0.0299 0.1418 0.1414
Onchocerca volvulus 0.0139 0.06 0.1119
Entamoeba histolytica aminopeptidase, putative 0.004 0.0093 0.0317
Schistosoma mansoni ap endonuclease 0.004 0.0091 0.0086
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0036 0.0072 0.0242
Onchocerca volvulus 0.1051 0.526 1
Mycobacterium ulcerans aminopeptidase N PepN 0.004 0.0093 0.0373
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.004 0.0093 0.0088
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0139 0.06 0.1332
Leishmania major hypothetical protein, conserved 0.0116 0.0481 0.1706
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0088 0.0352
Leishmania major regulatory subunit of protein kinase a-like protein 0.0036 0.0072 0.0242
Echinococcus granulosus SAM and MBT domain containing protein 0.0024 0.0013 0.0008
Schistosoma mansoni opsin-like receptor 0.0279 0.1317 0.1313
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0233 0.108 0.2034
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.1051 0.526 0.5258
Plasmodium falciparum heat shock protein 90, putative 0.0233 0.108 0.3862
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0156 0.0687 0.0683
Schistosoma mansoni histamine h1 receptor 0.0279 0.1317 0.1313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0116 0.0481 0.2142
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0036 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0094 0.0367 0.0363
Entamoeba histolytica DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Schistosoma mansoni neuropeptide f receptor 76f 0.0279 0.1317 0.1313
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0036 0.0072 0.0258
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0711 0.3523 0.6695
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0025 0.0016 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0279 0.1317 0.1313
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0279 0.1317 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Brugia malayi putative neuropeptide receptor NPR1 0.0279 0.1317 0.2497
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0116 0.0481 0.0477
Echinococcus multilocularis neuropeptide receptor 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Probable lipase LipD 0.0139 0.06 0.1332
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0066 0.0062
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0279 0.1317 0.1313
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Echinococcus granulosus polycomb protein SCMH1 0.0024 0.0013 0.0008
Brugia malayi Probable ClpP-like protease 0.0063 0.0212 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0091 0.0309
Trypanosoma cruzi heat shock protein 85, putative 0.0453 0.2204 0.7879
Brugia malayi TATA binding protein associated factor 0.004 0.0093 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0139 0.06 0.2146
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0711 0.3523 0.352
Trichomonas vaginalis adenylate cyclase type III, putative 0.0025 0.0016 0.0042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0091 0.0324
Echinococcus multilocularis fmrfamide receptor 0.0279 0.1317 0.1313
Brugia malayi Carboxyl transferase domain containing protein 0.0071 0.0254 0.0475
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0279 0.1317 0.1313
Schistosoma mansoni voltage-gated potassium channel 0.0299 0.1415 0.1411
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0058 0.0054
Onchocerca volvulus 0.0711 0.3523 0.6689
Brugia malayi Endoplasmin precursor 0.0569 0.2796 0.5311
Echinococcus multilocularis heat shock protein 90 0.0453 0.2204 0.22
Onchocerca volvulus 0.0279 0.1317 0.2485
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0072 0.0258
Echinococcus multilocularis dro:myosuppressin receptor 0.0279 0.1317 0.1313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0116 0.0481 0.2142
Trypanosoma brucei cAMP response protein 1, putative 0.0036 0.0072 0.0242
Onchocerca volvulus 0.0279 0.1317 0.2485
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Trypanosoma brucei protein kinase, putative 0.0035 0.0066 0.0221
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0025 0.0016 0.0042
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.4169
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0058 0.0192
Trichomonas vaginalis receptor histidine kinase, putative 0.0116 0.0481 0.1706
Echinococcus granulosus leukotriene A 4 hydrolase 0.0752 0.3731 0.3728
Brugia malayi mbt repeat family protein 0.0024 0.0013 0.0016
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0056 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.0056 0.0173 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.06 0.2133
Leishmania major heat shock protein, putative 0.0233 0.108 0.3853
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0116 0.0481 0.0477
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0116 0.0481 0.2181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0915
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0056 0.0173 0.0169
Echinococcus granulosus neuropeptide receptor A26 0.0279 0.1317 0.1313
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.036 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0156 0.0687 0.0683
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.01 0.0202
Echinococcus multilocularis GPCR, family 2 0.0051 0.0151 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0279 0.1317 0.1313
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0116 0.0481 0.0906
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Onchocerca volvulus 0.1051 0.526 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0054 0.0163 0.0582
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0116 0.0481 0.0906
Echinococcus multilocularis histone acetyltransferase MYST2 0.0028 0.003 0.0026
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0056 0.0173 0.0606
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0711 0.3523 0.6695
Echinococcus granulosus serotonin receptor 0.0279 0.1317 0.1313
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0711 0.3523 0.352
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Echinococcus granulosus nAChR subunit 0.0412 0.1994 0.199
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0279 0.1317 0.1313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Echinococcus granulosus cGMP dependent protein kinase 0.0036 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus alpha 1A adrenergic receptor 0.0279 0.1317 0.1313
Toxoplasma gondii heat shock protein 75, putative 0.0233 0.108 0.3862
Echinococcus granulosus neuropeptide s receptor 0.0279 0.1317 0.1313
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0028 0.0033 0.0149
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0279 0.1317 0.1313
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0116 0.0481 0.2063
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0068
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0036 0.0072 0.0138
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0036 0.0072 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0063 0.0212 0.0961
Brugia malayi Ets-domain containing protein 0.0039 0.009 0.0163
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0274 0.1287 0.1283
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0011 0.0007
Trichomonas vaginalis receptor histidine kinase, putative 0.0116 0.0481 0.1706
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0116 0.0481 0.2142
Onchocerca volvulus 0.0711 0.3523 0.6689
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Plasmodium falciparum heat shock protein 90 0.0569 0.2796 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.041 0.0406
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0028 0.003 0.0049
Schistosoma mansoni 60S ribosomal protein L21 0.0045 0.0118 0.0113
Schistosoma mansoni sex comb on midleg homolog 0.0024 0.0013 0.0008
Schistosoma mansoni ap endonuclease 0.004 0.0091 0.0086
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0116 0.0481 0.0892
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0279 0.1317 0.1313
Plasmodium falciparum cGMP-dependent protein kinase 0.0036 0.0074 0.0263
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0036 0.0074 0.0069
Echinococcus granulosus allatostatin A receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0026
Echinococcus granulosus nAChR subunit 0.0711 0.3523 0.352
Echinococcus granulosus g protein coupled receptor 0.0279 0.1317 0.1313
Mycobacterium ulcerans pyruvate carboxylase 0.0028 0.0033 0.0099
Brugia malayi Ets-domain containing protein 0.0039 0.009 0.0163
Schistosoma mansoni biogenic amine receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.1978 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0228 0.0224
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0279 0.1317 0.1313
Leishmania major hypothetical protein, conserved 0.0039 0.0086 0.0293
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Echinococcus multilocularis beta LACTamase domain containing family member 0.0139 0.06 0.0596
Echinococcus granulosus G protein coupled receptor 139 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0036 0.0072 0.0138
Echinococcus granulosus neuropeptide Y receptor 0.0279 0.1317 0.1313
Toxoplasma gondii Hsp90 domain-containing protein 0.0233 0.108 0.3862
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0074 0.0069
Schistosoma mansoni cytochrome P450 0.0024 0.0011 0.0007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0056 0.0173 0.0169
Onchocerca volvulus 0.0299 0.1418 0.2678
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0711 0.3523 0.352
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0091 0.0309
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.01 0.0096
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0091 0.0309
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0196 0.0888 0.0884
Echinococcus granulosus muscleblind protein 0.0094 0.0367 0.0363
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0036 0.0072 0.0068
Trypanosoma cruzi DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Mycobacterium tuberculosis Conserved protein 0.0116 0.0481 0.1062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0228 0.0801
Trypanosoma brucei developmentally regulated phosphoprotein 0.0116 0.0481 0.1706
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0036 0.0072 0.0258
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Brugia malayi hypothetical protein 0.0073 0.0263 0.0492
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0228 0.0224
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0074 0.0267 0.0263
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0012
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0116 0.0481 0.1706
Loa Loa (eye worm) hypothetical protein 0.0752 0.3731 0.3728
Echinococcus multilocularis neuropeptide FF receptor 2 0.0279 0.1317 0.1313
Echinococcus multilocularis 0.0024 0.0011 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Onchocerca volvulus 0.0711 0.3523 0.6689
Schistosoma mansoni acetylcholine receptor-related 0.0299 0.1418 0.1414
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0279 0.1317 0.2497
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0453 0.2204 0.22
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0301 0.0297
Schistosoma mansoni neurotransmitter gated ion channel 0.0299 0.1418 0.1414
Brugia malayi Cyclic-nucleotide gated cation channel 0.0056 0.0173 0.0322
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0116 0.0481 0.1062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis short transient receptor potential channel 6 0.0057 0.0179 0.0175
Echinococcus multilocularis g protein coupled receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0228 0.0815
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0279 0.1317 0.1313
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0028 0.0033 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0139 0.06 0.0596
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0711 0.3523 0.352
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0028 0.0033 0.0029
Echinococcus multilocularis heat shock protein 90 0.0569 0.2796 0.2792
Schistosoma mansoni alpha-glucosidase 0.0088 0.0338 0.0333
Onchocerca volvulus Putative nachr subunit 0.0711 0.3523 0.6689
Echinococcus granulosus neuropeptide FF receptor 2 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Toxoplasma gondii aminopeptidase n, putative 0.004 0.0093 0.0332
Plasmodium falciparum endoplasmin, putative 0.0349 0.1672 0.598
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Schistosoma mansoni endoplasmin 0.0569 0.2796 0.2792
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0039 0.009 0.0086
Schistosoma mansoni neuropeptide receptor 0.0279 0.1317 0.1313
Brugia malayi hypothetical protein 0.0025 0.0016 0.0022
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Loa Loa (eye worm) hypothetical protein 0.0063 0.0212 0.0208
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0711 0.3523 0.6695
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.004 0.0093 0.0317
Onchocerca volvulus 0.0412 0.1994 0.3775
Leishmania major hypothetical protein, conserved 0.0139 0.06 0.2133
Mycobacterium ulcerans transmembrane transport protein 0.0036 0.0072 0.0278
Echinococcus multilocularis transient receptor potential ion channel A 0.0057 0.018 0.0176
Toxoplasma gondii exonuclease III APE 0.004 0.0091 0.0324
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0116 0.0481 0.1719
Schistosoma mansoni hypothetical protein 0.0715 0.3544 0.3541
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0039 0.0088 0.016
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0091 0.009
Loa Loa (eye worm) TYRA-2 protein 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Schistosoma mansoni hypothetical protein 0.0051 0.0151 0.0146
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0039 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0279 0.1317 0.1313
Echinococcus granulosus single minded 2 0.0025 0.0016 0.0012
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Brugia malayi heat shock protein 90 0.0569 0.2796 0.5311
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0116 0.0481 0.1706
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0072 0.0258
Schistosoma mansoni pyruvate carboxylase 0.0028 0.0033 0.0028
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Schistosoma mansoni hypothetical protein 0.1313 0.66 0.6599
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.0212 0.0758
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0025 0.0016 0.0042
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0412 0.1994 0.3785
Loa Loa (eye worm) ACC-1 protein 0.0711 0.3523 0.352
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Leishmania major cytochrome p450-like protein 0.0024 0.0011 0.0024
Onchocerca volvulus 0.0279 0.1317 0.2485
Echinococcus multilocularis microtubule associated protein 2 0.0376 0.1808 0.1805
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0301 0.0297
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis neuropeptide receptor A26 0.0279 0.1317 0.1313
Brugia malayi Dopamine receptor protein 2 0.0279 0.1317 0.2497
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0711 0.3523 0.352
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.004 0.0093 0.0317
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0072 0.0242
Echinococcus granulosus glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.004 0.0093 0.0088
Leishmania major protein kinase A regulatory subunit, putative 0.0036 0.0072 0.0242
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0091 0.0266
Loa Loa (eye worm) glutaminase 2 0.0221 0.1018 0.1014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0072 0.0138
Schistosoma mansoni transient receptor potential channel 0.0057 0.0179 0.0175
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0025 0.0018 0.0048
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0036 0.0072 0.0113
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0279 0.1317 0.1313
Trypanosoma brucei Heat shock protein 83, putative 0.0569 0.2796 1
Mycobacterium ulcerans beta-lactamase 0.0139 0.06 0.2685
Trichomonas vaginalis hypothetical protein 0.0025 0.0016 0.0042
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0088
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0035 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus granulosus tachykinin peptides receptor 99D 0.0279 0.1317 0.1313
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0023 0.0004 0.0016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0028 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0093 0.0317
Chlamydia trachomatis DNA gyrase subunit B 0.0116 0.0481 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0116 0.0481 0.1706
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0711 0.3523 0.352
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0028 0.0033 0.0102
Echinococcus granulosus g-protein coupled receptor 0.0279 0.1317 0.1313
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0139 0.06 0.2685
Brugia malayi G-protein coupled receptor 0.0279 0.1317 0.2497
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0036 0.0072 0.0129
Trichomonas vaginalis heat shock protein, putative 0.0233 0.108 0.3853
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0116 0.0481 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0139 0.06 0.1332
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0035 0.0066 0.0221
Onchocerca volvulus 0.0059 0.019 0.0338
Echinococcus granulosus beta LACTamase domain containing family member 0.0139 0.06 0.0596
Echinococcus multilocularis orexin receptor type 2 0.0279 0.1317 0.1313
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0011 0.005
Mycobacterium tuberculosis Possible two component sensor kinase 0.0116 0.0481 0.1062
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus granulosus somatostatin receptor 0.0279 0.1317 0.1313
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0118 0.0113
Echinococcus multilocularis nAChR subunit 0.0412 0.1994 0.199
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0036 0.0072 0.0022
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Loa Loa (eye worm) hypothetical protein 0.0162 0.0716 0.0712
Echinococcus multilocularis serotonin receptor 0.1978 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0711 0.3523 0.6695
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0116 0.0481 0.1719
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0056 0.0173 0.0169
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.0212 0.0758
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0056 0.0173 0.0606
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0036 0.0072 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Schistosoma mansoni amine GPCR 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Loa Loa (eye worm) heat shock protein 75 0.0233 0.108 0.1076
Toxoplasma gondii aminopeptidase N, putative 0.004 0.0093 0.0332
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0116 0.0481 0.1706
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0116 0.0481 0.2063
Toxoplasma gondii heat shock protein 90, putative 0.0569 0.2796 1
Schistosoma mansoni opsin-like receptor 0.0279 0.1317 0.1313
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.0781 0.2795
Brugia malayi follicle stimulating hormone receptor 0.0436 0.2117 0.4021
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0752 0.3731 0.3728
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.01 0.0096
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0228 0.0224
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0228 0.049
Loa Loa (eye worm) mbt repeat family protein 0.0024 0.0013 0.0008
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0299 0.1418 0.269
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0139 0.06 0.0596
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0299 0.1418 0.269
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Toxoplasma gondii cytochrome p450 superfamily protein 0.0024 0.0011 0.004
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0299 0.1418 0.1414
Brugia malayi Muscleblind-like protein 0.0094 0.0367 0.069
Echinococcus granulosus cGMP dependent protein kinase 1 0.0036 0.0074 0.0069
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.004 0.0093 0.0317
Brugia malayi Egg laying defective protein 4 0.0036 0.0074 0.0132
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0034 0.003
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0036 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Brugia malayi Cytochrome P450 family protein 0.0024 0.0011 0.0013
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0036 0.0072 0.0242
Echinococcus granulosus GPCR family 2 0.0051 0.0151 0.0146
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0035 0.0066 0.0221
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0758
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0139 0.06 0.1133
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0091 0.0324
Brugia malayi sulfakinin receptor protein 0.0279 0.1317 0.2497
Leishmania major developmentally regulated phosphoprotein-like protein 0.0116 0.0481 0.1706
Entamoeba histolytica hypothetical protein 0.0041 0.01 0.0344
Brugia malayi hypothetical protein 0.0299 0.1418 0.269
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0006 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0139 0.06 0.0596
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0081 0.0301 0.0297
Brugia malayi GnHR receptor homolog 0.0279 0.1317 0.2497
Trichomonas vaginalis adenylate cyclase type III, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) cytochrome P450 0.0024 0.0011 0.0007
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0116 0.0481 0.1706
Leishmania major hypothetical protein, conserved 0.0036 0.0072 0.0242
Trypanosoma cruzi protein kinase A regulatory subunit 0.0036 0.0072 0.0242
Echinococcus granulosus patatin phospholipase domain containing protein 0.0036 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0711 0.3523 0.352
Echinococcus multilocularis G-protein coupled receptor, putative 0.0279 0.1317 0.1313
Mycobacterium ulcerans regulatory protein 0.0036 0.0072 0.0278
Mycobacterium tuberculosis Probable lipase LipE 0.0139 0.06 0.1332
Mycobacterium ulcerans lipase LipD 0.0139 0.06 0.2685
Trypanosoma cruzi acetyl-CoA carboxylase 0.0046 0.0123 0.0425
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0915
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0016 0.0042
Schistosoma mansoni biogenic amine receptor 0.0279 0.1317 0.1313
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0299 0.1418 0.269
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0279 0.1317 0.1313
Brugia malayi AKH receptor 0.0279 0.1317 0.2497
Entamoeba histolytica hypothetical protein 0.0041 0.01 0.0344
Schistosoma mansoni transient receptor potential channel 4 0.0077 0.0281 0.0277
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0299 0.1418 0.269
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0056 0.0173 0.0169
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0035 0.0066 0.0221
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Trypanosoma brucei protein kinase A regulatory subunit 0.0036 0.0072 0.0242
Echinococcus granulosus endoplasmin 0.0453 0.2204 0.22
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0279 0.1317 0.1313
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0412 0.1994 0.199
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.06 0.2133
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0056 0.0173 0.0169
Brugia malayi hypothetical protein 0.004 0.0093 0.0168
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0151 0.0146
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0028 0.0033 0.0028
Echinococcus granulosus microtubule associated protein 2 0.0376 0.1808 0.1805
Trichomonas vaginalis adenylate cyclase type, putative 0.0025 0.0016 0.0042
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Trichomonas vaginalis CMGC family protein kinase 0.0035 0.0066 0.0221
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Echinococcus granulosus neuropeptide receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis neuropeptide receptor 0.0279 0.1317 0.1313
Brugia malayi hypothetical protein 0.0039 0.0086 0.0155
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0091 0.0309
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0036 0.0072 0.0068
Onchocerca volvulus 0.0279 0.1317 0.2485
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0036 0.0072 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0072 0.0242
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.004 0.0093 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0074 0.0069
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0093 0.0317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0006 0.0001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0279 0.1317 0.1313
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0036 0.0072 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0086 0.0308
Loa Loa (eye worm) AGC/PKG protein kinase 0.0036 0.0074 0.0069
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0711 0.3523 0.352
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0039 0.0086 0.0293
Brugia malayi Serotonin receptor 0.0279 0.1317 0.2497
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0453 0.2204 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0036 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Schistosoma mansoni growth hormone secretagogue receptor 0.0279 0.1317 0.1313
Echinococcus multilocularis g protein coupled receptor 0.0279 0.1317 0.1313
Schistosoma mansoni heat shock protein 0.0569 0.2796 0.2792
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0116 0.0481 0.2063
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0233 0.108 0.1076
Echinococcus granulosus dnaJ subfamily B 0.1313 0.66 0.6599
Schistosoma mansoni hypothetical protein 0.0051 0.0151 0.0146
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0036 0.0072 0.0242
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0711 0.3523 0.6695
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.01 0.0096
Brugia malayi hypothetical protein 0.0279 0.1317 0.2497
Leishmania major hypothetical protein, unknown function 0.0036 0.0072 0.0242
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0091 0.0309
Toxoplasma gondii aminopeptidase N protein 0.004 0.0093 0.0332
Trichomonas vaginalis endoplasmin, putative 0.0349 0.1672 0.5974
Echinococcus granulosus hyperpolarization activated cyclic 0.0056 0.0173 0.0169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0711 0.3523 0.6695
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Mycobacterium ulcerans transcriptional regulatory protein 0.0036 0.0072 0.0278
Loa Loa (eye worm) hypothetical protein 0.0111 0.0454 0.045
Brugia malayi Cytochrome P450 family protein 0.0033 0.0058 0.0102
Mycobacterium ulcerans putative regultory protein 0.0116 0.0481 0.2142
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) peptidase family M1 containing protein 0.004 0.0093 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0086 0.0293
Loa Loa (eye worm) hypothetical protein 0.0496 0.2425 0.2422
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Treponema pallidum heat shock protein 90 0.0453 0.2204 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0595 0.2929 0.2926
Brugia malayi Dopamine receptor protein 1 0.0279 0.1317 0.2497
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0036 0.0072 0.0068
Schistosoma mansoni neuropeptide receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0711 0.3523 0.352
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0279 0.1317 0.1313
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0711 0.3523 0.6695
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.004 0.0093 0.0332
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0091 0.0164
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.0212 0.0758
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0036 0.0072 0.0068
Toxoplasma gondii heat shock protein HSP90 0.0569 0.2796 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0036 0.0072 0.0068
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0028 0.0033 0.0049
Brugia malayi putative neuropeptide receptor 0.0279 0.1317 0.2497
Leishmania major cytochrome p450-like protein 0.0024 0.0011 0.0024
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0074 0.0267 0.0956
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0279 0.1317 0.1313
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0024 0.0013 0.0008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0711 0.3523 0.352
Echinococcus multilocularis glycine receptor subunit beta 0.0711 0.3523 0.352
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0412 0.1994 0.3785
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0056 0.0173 0.0169
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Schistosoma mansoni neuropeptide F-like receptor 0.0279 0.1317 0.1313
Trypanosoma brucei Aminopeptidase M1, putative 0.004 0.0093 0.0317
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0028 0.003 0.0026
Echinococcus granulosus geminin 0.0715 0.3544 0.3541
Brugia malayi Fli-1 protein 0.012 0.05 0.0944
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0035 0.0066 0.0221
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0016 0.0042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.0093 0.0088
Plasmodium falciparum DNA gyrase subunit B 0.0116 0.0481 0.1719
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0036 0.0072 0.0242
Loa Loa (eye worm) TOPoisomerase family member 0.0116 0.0481 0.0477
Echinococcus granulosus g protein coupled receptor 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0156 0.0687 0.0683
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0074 0.0267 0.0263
Schistosoma mansoni hypothetical protein 0.0051 0.0151 0.0146
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0279 0.1317 0.1313
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0711 0.3523 0.352
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0036 0.0072 0.1137
Loa Loa (eye worm) hypothetical protein 0.0412 0.1994 0.199
Echinococcus granulosus cpg binding protein 0.0097 0.0387 0.0383
Trypanosoma cruzi aminopeptidase, putative 0.004 0.0093 0.0317
Mycobacterium ulcerans heat shock protein 90 0.0453 0.2204 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0279 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.06 0.2133
Onchocerca volvulus 0.0036 0.0072 0.0113
Brugia malayi glutaminase DH11.1 0.0221 0.1018 0.1929
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0036 0.0072 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Trypanosoma brucei cAMP binding protein, putative 0.0036 0.0072 0.0242
Schistosoma mansoni transient receptor potential channel 0.0077 0.0281 0.0277
Giardia lamblia Pms1-like protein 0.0116 0.0481 0.1519
Brugia malayi larval opioid receptor 0.0279 0.1317 0.2497
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0279 0.1317 0.2485
Plasmodium vivax heat shock protein, putative 0.0233 0.108 0.3862
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0569 0.2796 1
Loa Loa (eye worm) G-protein coupled receptor 0.0279 0.1317 0.1313
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0035 0.0066 0.0221
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0058 0.0192
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0212 0.0961
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0299 0.1418 0.1414
Echinococcus granulosus GA binding protein alpha chain 0.0039 0.009 0.0086
Brugia malayi Cytochrome P450 family protein 0.0024 0.0011 0.0013
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0074 0.0267 0.0956
Brugia malayi N-terminal motif family protein 0.0036 0.0072 0.0129
Echinococcus granulosus heat shock protein 90 0.0453 0.2204 0.22
Trypanosoma cruzi cAMP response protein 1 0.0036 0.0072 0.0242
Brugia malayi Peptidase family M1 containing protein 0.004 0.0093 0.0168
Echinococcus multilocularis neuropeptide Y receptor 0.0279 0.1317 0.1313
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0016 0.0042
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0116 0.0481 0.2142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0279 0.1317 0.1313
Trichomonas vaginalis D-aminoacylase, putative 0.0139 0.06 0.2133
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0036 0.0072 0.0129
Onchocerca volvulus 0.004 0.0093 0.0153
Onchocerca volvulus 0.0299 0.1418 0.2678
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0254 0.1186 0.4233
Trypanosoma brucei heat shock protein, putative 0.0569 0.2796 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0028 0.0033 0.0102
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0233 0.108 0.3853
Echinococcus granulosus g protein coupled receptor 0.0279 0.1317 0.1313
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.004 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.004 0.0092 0.0088
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0036 0.0072 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.0139 0.06 0.2685
Loa Loa (eye worm) hypothetical protein 0.0081 0.0301 0.0297
Trypanosoma cruzi heat shock protein 90, putative 0.0453 0.2204 0.7879
Echinococcus granulosus hyperpolarization activated cyclic 0.0056 0.0173 0.0169
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0279 0.1317 0.1313
Schistosoma mansoni acetylcholine receptor subunit beta 0.0299 0.1418 0.1414
Brugia malayi Peptidase family M1 containing protein 0.004 0.0093 0.0168
Loa Loa (eye worm) aminopeptidase N 0.004 0.0093 0.0088
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0088 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0016 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.01 0.0202
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.0687 0.0683
Onchocerca volvulus 0.0279 0.1317 0.2485
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0151 0.0146
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0028 0.0033 0.0029
Onchocerca volvulus 0.0279 0.1317 0.2485
Schistosoma mansoni pyruvate dehydrogenase 0.0116 0.0481 0.0477
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0092 0.0088
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0028 0.0033 0.0102
Loa Loa (eye worm) hypothetical protein 0.0279 0.1317 0.1313
Leishmania major heat shock protein 83-1 0.0569 0.2796 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0711 0.3523 0.6695
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0299 0.1418 0.1414
Loa Loa (eye worm) neuropeptide F receptor 0.0279 0.1317 0.1313
Echinococcus granulosus neuropeptide Y receptor 0.0279 0.1317 0.1313
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0481 0.1719
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0116 0.0481 0.0477
Onchocerca volvulus 0.0279 0.1317 0.2485
Trypanosoma cruzi heat shock protein 85, putative 0.0569 0.2796 1
Echinococcus multilocularis heat shock protein 0.0569 0.2796 0.2792
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.004 0.0093 0.0317
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0016 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0254 0.1186 0.4233
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0036 0.0072 0.0068
Schistosoma mansoni DNA topoisomerase II 0.0116 0.0481 0.0477
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0074
Schistosoma mansoni nAChR subunit 0.0711 0.3523 0.352
Schistosoma mansoni cpg binding protein 0.0092 0.036 0.0356
Trypanosoma cruzi heat shock protein, putative 0.0233 0.108 0.3853
Echinococcus granulosus rhodopsin orphan GPCR 0.0279 0.1317 0.1313
Echinococcus multilocularis serotonin receptor 0.1978 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0035 0.0066 0.0062
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0116 0.0481 0.1706
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0036 0.0072 0.0258
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0016 0.0042
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0036 0.0072 0.0258
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0028 0.0033 0.0099

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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