Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0077 | 0 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0456 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0077 | 0 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0456 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0456 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0456 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0456 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0456 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0456 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.5345 | 0.5345 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.5345 | 0.5345 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0077 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0456 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0456 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0456 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.