Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0091 | 0.0091 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0849 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0849 | 0.0849 |
Echinococcus granulosus | neuroligin | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | gliotactin | 0.0102 | 0.0849 | 0.0849 |
Echinococcus multilocularis | acetylcholinesterase | 0.0601 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.4219 | 0.4219 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.4219 | 0.4219 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | acetylcholinesterase | 0.0102 | 0.0849 | 0.0849 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0849 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0055 | 0.0055 |
Echinococcus multilocularis | neuroligin | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0055 | 0.0055 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0091 | 0.0091 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0102 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0102 | 0.0849 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0102 | 0.0849 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Echinococcus granulosus | carboxylesterase 5A | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Echinococcus granulosus | acetylcholinesterase | 0.0601 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0.0849 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0055 | 0.0055 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0849 | 0.0849 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0102 | 0.0849 | 0.0849 |
Brugia malayi | hypothetical protein | 0.0286 | 0.4219 | 0.4219 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0.0849 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0102 | 0.0849 | 0.0849 |
Brugia malayi | Carboxylesterase family protein | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0601 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0.0849 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0601 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0849 | 0.0849 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.4219 | 0.4219 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0091 | 0.0091 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0.0849 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0102 | 0.0849 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0601 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0.0849 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0601 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0.0849 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0849 | 0.0849 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0849 | 0.0849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1122 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.