Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.008 | 0.1372 | 0.1076 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.008 | 0.1372 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.008 | 0.1372 | 0.5 |
Onchocerca volvulus | 0.008 | 0.1372 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.008 | 0.1372 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.008 | 0.1372 | 0.1076 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0.1372 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.008 | 0.1372 | 0.5 |
Schistosoma mansoni | gliotactin | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0.1372 | 0.1372 |
Echinococcus granulosus | acetylcholinesterase | 0.0473 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0332 | 0.0332 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.008 | 0.1372 | 0.5 |
Onchocerca volvulus | 0.008 | 0.1372 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0332 | 0.0332 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0332 | 0.0332 |
Brugia malayi | Carboxylesterase family protein | 0.0473 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Loa Loa (eye worm) | carboxylesterase | 0.008 | 0.1372 | 0.1372 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0.1372 | 0.1372 |
Onchocerca volvulus | 0.008 | 0.1372 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0.1372 | 0.1372 |
Echinococcus granulosus | neuroligin | 0.008 | 0.1372 | 0.1076 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0332 | 0.0332 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.008 | 0.1372 | 0.1076 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | carboxylesterase | 0.008 | 0.1372 | 0.1372 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0473 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0473 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.008 | 0.1372 | 0.1076 |
Echinococcus granulosus | acetylcholinesterase | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0319 | 0.0319 |
Echinococcus granulosus | BC026374 protein S09 family | 0.008 | 0.1372 | 0.1076 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.008 | 0.1372 | 0.1076 |
Schistosoma mansoni | acetylcholinesterase | 0.008 | 0.1372 | 0.1076 |
Echinococcus granulosus | carboxylesterase 5A | 0.0473 | 1 | 1 |
Onchocerca volvulus | 0.008 | 0.1372 | 1 | |
Echinococcus multilocularis | neuroligin | 0.008 | 0.1372 | 0.1076 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.008 | 0.1372 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0332 | 0.0332 |
Onchocerca volvulus | 0.008 | 0.1372 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.008 | 0.1372 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1372 | 0.1372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0794 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.