Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.4367 | 0.4367 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.017 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2017 | 0.3666 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.301 | 0.301 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2017 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.301 | 0.1849 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.301 | 0.301 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.017 | 0.0309 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2017 | 0.2017 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2017 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.4367 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2017 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0023 | 0.017 | 0.0309 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2017 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.4367 | 0.3431 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2017 | 0.462 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1425 | 0.2589 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4367 | 0.7935 |
Trypanosoma brucei | RNA helicase, putative | 0.0081 | 0.5503 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.4367 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4367 | 0.7935 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4367 | 0.7935 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4367 | 0.7935 |
Leishmania major | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0023 | 0.017 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.301 | 0.1849 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.5503 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2017 | 0.3666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4367 | 0.7935 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0023 | 0.017 | 0.0309 |
Giardia lamblia | Ribonuclease H | 0.0022 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.4367 | 0.4367 |
Toxoplasma gondii | ribonuclease HI protein | 0.0022 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1425 | 0.1425 |
Brugia malayi | RNA binding protein | 0.0069 | 0.4367 | 0.4367 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.4367 | 0.3431 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2017 | 0.462 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.4367 | 0.3431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.