Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingomyelin phosphodiesterase 1, acid lysosomal | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | TFIIF-stimulated CTD phosphatase, putative | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | 260 aa | 263 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3358 | 0.3358 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0045 | 0.3569 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3732 | 0.5069 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.3569 | 0.4848 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0.3732 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3358 | 0.3358 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3358 | 0.4562 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.3732 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3358 | 0.4562 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.2025 | 0.2751 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0.3732 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0.3732 | 0.3732 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.3732 | 0.5069 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.3732 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0047 | 0.3732 | 0.5069 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0.3732 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | unspecified product | 0.0032 | 0.2025 | 0.2751 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 0.7361 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0077 | 0.7361 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3358 | 0.4562 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 0.7361 | 1 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3358 | 0.4562 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.2025 | 0.2751 |
Leishmania major | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3358 | 0.3358 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0.3732 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.2025 | 0.2751 |
Plasmodium falciparum | NLI interacting factor-like phosphatase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0047 | 0.3732 | 0.5069 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.3732 | 0.5069 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0047 | 0.3732 | 0.3732 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3732 | 0.5069 |
Echinococcus granulosus | dna polymerase kappa | 0.0047 | 0.3732 | 0.5069 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.3569 | 0.4848 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3358 | 0.4562 |
Trypanosoma brucei | unspecified product | 0.0032 | 0.2025 | 0.2751 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.3732 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3732 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3358 | 0.3358 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.7361 | 0.7361 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 0.7361 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 0.7361 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 0.7361 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 0.7361 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2337, AID2466, AID2475, AID2485, AID2503, AID2793, AID2798, AID2799] | ChEMBL. | No reference |
EC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] | ChEMBL. | No reference |
IC50 (functional) | = 2.007 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] | ChEMBL. | No reference |
IC50 (functional) | = 14.442 uM | PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD2 cell inhibition assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID2260, AID2334, AID2335, AID2475, AID2503, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] | ChEMBL. | No reference |
Potency (functional) | 0.0891 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 33.5875 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.