Detailed information for compound 1353689

Basic information

Technical information
  • TDR Targets ID: 1353689
  • Name: 2-butyl-N-[3-(dimethylsulfamoyl)-4-methylphen yl]-1,3-dioxoisoindole-5-carboxamide
  • MW: 443.516 | Formula: C22H25N3O5S
  • H donors: 1 H acceptors: 5 LogP: 2.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1C(=O)c2c(C1=O)cc(cc2)C(=O)Nc1ccc(c(c1)S(=O)(=O)N(C)C)C
  • InChi: 1S/C22H25N3O5S/c1-5-6-11-25-21(27)17-10-8-15(12-18(17)22(25)28)20(26)23-16-9-7-14(2)19(13-16)31(29,30)24(3)4/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,26)
  • InChiKey: JQECRWINANQWRS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-butyl-N-[3-(dimethylsulfamoyl)-4-methyl-phenyl]-1,3-dioxo-isoindoline-5-carboxamide
  • 2-butyl-N-[3-(dimethylsulfamoyl)-4-methylphenyl]-1,3-dioxo-5-isoindolinecarboxamide
  • 2-butyl-N-[3-(dimethylsulfamoyl)-4-methyl-phenyl]-1,3-diketo-isoindoline-5-carboxamide
  • 2-butyl-N-[3-(dimethylsulfamoyl)-4-methyl-phenyl]-1,3-dioxo-isoindole-5-carboxamide
  • SMR000247719
  • T5728809
  • MLS000394125

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin receptor 0.003 0.1293 0.1133
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0217 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0217 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.1293 0.1099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.1293 0.1133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Echinococcus granulosus allatostatin A receptor 0.003 0.1293 0.1133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Echinococcus multilocularis neuropeptide s receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni hypothetical protein 0.0038 0.1773 0.159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.1773 0.1598
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.2733 0.2578
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1767 0.6175
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.2319 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.1293 0.1099
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.4429 0.4311
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.1293 0.1099
Echinococcus multilocularis serotonin receptor 0.003 0.1293 0.1099
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0884 0.069
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi ecdysteroid receptor 0.0012 0.0217 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.1293 0.1099
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0884 0.1836
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0038 0.1773 0.159
Schistosoma mansoni neuropeptide receptor 0.003 0.1293 0.1099
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.1293 0.1099
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9705 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Echinococcus multilocularis g protein coupled receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi RE15519p 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni histamine h1 receptor 0.003 0.1293 0.1099
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.2319 1
Schistosoma mansoni amine GPCR 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.0054 0.2733 0.2733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.1773 0.164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.1773 0.159
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.1293 0.1099
Brugia malayi Dopamine receptor 0.003 0.1293 0.1107
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.2733 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.1293 0.1107
Echinococcus granulosus neuropeptide receptor 0.003 0.1293 0.1133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.389 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.1293 0.1099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Echinococcus multilocularis g protein coupled receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0208 0.0208
Onchocerca volvulus 0.003 0.1293 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.1293 0.1293
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0217 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.1293 0.1107
Schistosoma mansoni hypothetical protein 0.0038 0.1773 0.159
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.1293 0.1099
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.1293 0.1099
Schistosoma mansoni neuropeptide receptor 0.003 0.1293 0.1099
Echinococcus granulosus neuropeptide receptor A26 0.003 0.1293 0.1133
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0884 0.0884
Schistosoma mansoni biogenic amine receptor 0.003 0.1293 0.1099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis orexin receptor type 2 0.003 0.1293 0.1099
Echinococcus granulosus orexin receptor type 2 0.003 0.1293 0.1133
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0884 0.2678
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.1293 0.1099
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.1293 0.1099
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2577 0.3814
Brugia malayi G protein-coupled receptor 0.003 0.1293 0.1107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.1293 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0217 0.0009
Loa Loa (eye worm) hypothetical protein 0.012 0.6718 0.6718
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Schistosoma mansoni amine GPCR 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni adenoreceptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi putative neuropeptide receptor 0.003 0.1293 0.1107
Leishmania major DNA polymerase kappa, putative 0.0023 0.0884 0.1836
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.1293 0.1133
Brugia malayi Latrophilin receptor protein 2 0.0038 0.1773 0.1598
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.1293 0.1293
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni neuropeptide receptor 0.003 0.1293 0.1099
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.1293 0.1099
Schistosoma mansoni hypothetical protein 0.0082 0.4429 0.4305
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Brugia malayi steroid hormone receptor 0.0012 0.0217 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.045 0.0956
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.389 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.1293 0.1099
Echinococcus multilocularis g protein coupled receptor 0.003 0.1293 0.1099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.1293 0.1133
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0884 0.2678
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.1293 0.1107
Echinococcus granulosus dna polymerase kappa 0.0023 0.0884 0.0703
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0208 0.0208
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0217 0.0009
Schistosoma mansoni DNA polymerase eta 0.0054 0.2733 0.2571
Echinococcus granulosus sex peptide receptor 0.003 0.1293 0.1133
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.1293 0.1099
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.1293 0.1099
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.1293 0.1099
Schistosoma mansoni myosin xvIII 0.003 0.1293 0.1099
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.1293 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0217 0.0009
Schistosoma mansoni biogenic amine receptor 0.003 0.1293 0.1099
Schistosoma mansoni opsin-like receptor 0.003 0.1293 0.1099
Schistosoma mansoni hypothetical protein 0.003 0.1293 0.1099
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.389 1
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.1293 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0217 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.2733 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.1293 0.1293
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.389 0.387
Loa Loa (eye worm) hypothetical protein 0.0082 0.4429 0.4429
Trypanosoma brucei unspecified product 0.0023 0.0884 0.2678
Schistosoma mansoni amine GPCR 0.003 0.1293 0.1099
Echinococcus multilocularis serotonin receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0884 0.2678
Schistosoma mansoni neuropeptide receptor 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0884 0.0682
Echinococcus granulosus g protein coupled receptor 0.003 0.1293 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0217 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.1293 0.1133
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1293 0.1099
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0217 0.0009
Onchocerca volvulus 0.003 0.1293 1
Schistosoma mansoni amine GPCR 0.003 0.1293 0.1099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.1773 0.1773
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.1293 0.1133
Schistosoma mansoni hypothetical protein 0.003 0.1293 0.1099
Schistosoma mansoni opsin-like receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0208 0.0208
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.389 0.3754
Echinococcus multilocularis allatostatin A receptor 0.003 0.1293 0.1099
Schistosoma mansoni biogenic amine receptor 0.003 0.1293 0.1099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Leishmania major DNA polymerase eta, putative 0.0054 0.2733 0.6857
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.1293 0.1293
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1293 0.1133
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.1293 0.1293
Echinococcus multilocularis neuropeptide receptor 0.003 0.1293 0.1099
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.1293 0.1133
Echinococcus granulosus g protein coupled receptor 0.003 0.1293 0.1133
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.1293 0.1293
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.1293 0.1133
Echinococcus granulosus neuropeptides capa receptor 0.003 0.1293 0.1133
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.1293 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1293 0.1133
Loa Loa (eye worm) TYRA-2 protein 0.003 0.1293 0.1293
Brugia malayi Serotonin receptor 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus granulosus g protein coupled receptor 0.003 0.1293 0.1133
Loa Loa (eye worm) hypothetical protein 0.0038 0.1773 0.1773
Brugia malayi G-protein coupled receptor 0.003 0.1293 0.1107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0217 0.0009
Onchocerca volvulus 0.003 0.1293 1
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.1293 0.1099
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.6718 0.6648
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0217 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.045 0.0956
Echinococcus multilocularis dna polymerase eta 0.0054 0.2733 0.2571
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.1293 0.1293
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2577 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.1293 0.1099
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2577 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Brugia malayi G-protein coupled receptor 0.003 0.1293 0.1107
Echinococcus granulosus G protein coupled receptor 139 0.003 0.1293 0.1133
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.6718 0.6648
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.1293 0.1107
Echinococcus granulosus g-protein coupled receptor 0.003 0.1293 0.1133
Leishmania major DNA polymerase eta, putative 0.0038 0.1767 0.4234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0217 0.0217
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.1293 0.1293
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Schistosoma mansoni hypothetical protein 0.003 0.1293 0.1099
Echinococcus granulosus neuropeptide receptor 0.003 0.1293 0.1133
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0884 0.1836
Brugia malayi nuclear hormone receptor 0.0012 0.0217 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1293 0.1099
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2577 0.2487
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.389 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.1773 0.159
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.1293 0.1133
Echinococcus granulosus neuropeptide Y receptor 0.003 0.1293 0.1133
Echinococcus multilocularis somatostatin receptor 0.003 0.1293 0.1099
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.1293 0.1133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.1773 0.164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Brugia malayi Serotonin receptor 0.003 0.1293 0.1107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.6718 0.6718
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.045 0.0956
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.1293 0.1099
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Brugia malayi Dopamine receptor protein 2 0.003 0.1293 0.1107
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Brugia malayi sulfakinin receptor protein 0.003 0.1293 0.1107
Brugia malayi GnHR receptor homolog 0.003 0.1293 0.1107
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.1293 0.1133
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.1293 0.1133
Echinococcus multilocularis g-protein coupled receptor 0.003 0.1293 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0217 0.0009
Schistosoma mansoni opsin-like receptor 0.003 0.1293 0.1099
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0217 0.0009
Onchocerca volvulus 0.003 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1293 0.1099
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2577 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.1293 0.1099
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0217 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0217 0.0009
Brugia malayi neuropeptide F receptor 0.003 0.1293 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.1293 0.1099
Brugia malayi ORL1-like opioid receptor 0.003 0.1293 0.1107
Trypanosoma brucei unspecified product 0.0016 0.045 0.0956
Brugia malayi nuclear receptor NHR-88 0.0012 0.0217 0.0009
Brugia malayi neuropeptide F receptor 0.003 0.1293 0.1107
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.389 0.3754
Echinococcus multilocularis GPCR, family 2 0.0038 0.1773 0.159
Trypanosoma brucei unspecified product 0.0016 0.045 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0217 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0217 0.0009
Onchocerca volvulus 0.003 0.1293 1
Echinococcus granulosus hypothetical protein 0.003 0.1293 0.1133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2577 0.3814
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni hypothetical protein 0.0038 0.1773 0.159
Brugia malayi Dopamine receptor protein 1 0.003 0.1293 0.1107
Echinococcus granulosus neuropeptide Y receptor 0.003 0.1293 0.1133
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0217 0.0009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0884 0.0682
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.1293 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.389 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.1293 0.1099
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.1293 0.1099
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.1293 0.1133
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.1293 0.1133
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Brugia malayi Melatonin receptor type 1A 0.003 0.1293 0.1107
Brugia malayi AKH receptor 0.003 0.1293 0.1107
Onchocerca volvulus 0.003 0.1293 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.1293 0.1099
Echinococcus granulosus neuropeptides capa receptor 0.003 0.1293 0.1133
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.389 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.1293 1
Echinococcus multilocularis sex peptide receptor 0.003 0.1293 0.1099
Echinococcus multilocularis neuropeptide receptor 0.003 0.1293 0.1099
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0217 0.0217
Onchocerca volvulus 0.003 0.1293 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0884 0.0703
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.1293 0.1099
Echinococcus granulosus GPCR family 2 0.0038 0.1773 0.164
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.1293 0.1099
Onchocerca volvulus 0.003 0.1293 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.1293 0.1099
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0884 0.0682
Echinococcus granulosus dna polymerase eta 0.0054 0.2733 0.2651
Echinococcus granulosus neuropeptide s receptor 0.003 0.1293 0.1133
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.2319 0.5
Echinococcus granulosus fmrfamide receptor 0.003 0.1293 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.1293 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0217 0.0009
Schistosoma mansoni amine GPCR 0.003 0.1293 0.1099
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.1293 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.1293 0.1099
Echinococcus multilocularis fmrfamide receptor 0.003 0.1293 0.1099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.1293 0.1099
Echinococcus granulosus somatostatin receptor 0.003 0.1293 0.1133
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.1293 0.1107
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.1293 0.1099
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.389 0.3754
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0884 0.1836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0217 0.0217
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.1293 0.1099
Brugia malayi larval opioid receptor 0.003 0.1293 0.1107
Onchocerca volvulus 0.003 0.1293 1
Brugia malayi hypothetical protein 0.003 0.1293 0.1107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.1293 0.1133
Loa Loa (eye worm) acetyltransferase 0.0175 1 1
Brugia malayi follicle stimulating hormone receptor 0.003 0.1293 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0884 0.2678
Echinococcus multilocularis fmrfamide receptor 0.003 0.1293 0.1099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.1293 0.1099
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0884 0.0682
Loa Loa (eye worm) hypothetical protein 0.003 0.1293 0.1293
Schistosoma mansoni hypothetical protein 0.003 0.1293 0.1099

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Parental Cell Line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 169.4406 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in HTRF Activity in a Luteinizing Hormone Receptor Cell Line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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