Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.5104 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0583 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3073 | 0.6021 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.5104 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3073 | 0.5507 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5104 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3073 | 0.1263 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5104 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.5104 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3073 | 0.5507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3073 | 0.1263 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3073 | 0.1263 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.5104 | 0.3825 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3073 | 0.5507 |
Brugia malayi | hypothetical protein | 0.003 | 0.0583 | 0.1143 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.5104 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.5104 | 0.2932 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.5104 | 0.2932 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.5104 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3073 | 0.1263 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.5104 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3073 | 0.6021 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5104 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3073 | 0.6021 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.5104 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3073 | 0.1263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1853 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.1582 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.4662 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.