TDR Targets

Basic information

Technical information

TDR Targets ID: 1354157
Name: N-[4-methoxy-3-(thiophene-2-carbonylamino)phe nyl]furan-2-carboxamide
MW: 342.369 | Formula: C17H14N2O4S
H donors: 2 H acceptors: 2 LogP: 2.98 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)c1cccs1)NC(=O)c1ccco1
InChi: 1S/C17H14N2O4S/c1-22-13-7-6-11(18-16(20)14-4-2-8-23-14)10-12(13)19-17(21)15-5-3-9-24-15/h2-10H,1H3,(H,18,20)(H,19,21)
InChiKey: YGKNSKCRWKGTDR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[4-methoxy-3-[[oxo-(2-thienyl)methyl]amino]phenyl]-2-furancarboxamide
N-[4-methoxy-3-(thiophene-2-carbonylamino)phenyl]-2-furamide
N-[4-methoxy-3-(thiophen-2-ylcarbonylamino)phenyl]furan-2-carboxamide
BAS 08207716
MLS000064881
ZINC00557706
SMR000077852
ST062797
N-{4-methoxy-3-[(2-thienylcarbonyl)amino]phenyl}-2-furamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.078	0.1509
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.3819	0.3786
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2587	0.3581
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0774	0.1498
Brugia malayi	steroid hormone receptor	0.0297	0.5166	0.7149
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0265	0.0513
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0297	0.5166	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0053	0.0624
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0053	0.0064
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0834	0.9896
Onchocerca volvulus		0.0465	0.8266	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Schistosoma mansoni	hypothetical protein	0.0165	0.2734	0.5293
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0479	0.0663
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0265	0.0513
Brugia malayi	beta-lactamase family protein	0.0035	0.0345	0.0477
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0345	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0166	0.023
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Schistosoma mansoni	lamin	0.0052	0.0666	0.1289
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0053	0.0624
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0297	0.5166	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0345	0.0668
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.078	0.1509
Mycobacterium ulcerans	hypothetical protein	0.0102	0.1589	0.1544
Echinococcus granulosus	GPCR family 2	0.0031	0.0265	0.0513
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Schistosoma mansoni	retinoic acid receptor RXR	0.0297	0.5166	1
Schistosoma mansoni	intermediate filament proteins	0.0052	0.0666	0.1289
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1894	0.2291
Schistosoma mansoni	hypothetical protein	0.0031	0.0265	0.0513
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.079	0.153
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0345	0.3701
Brugia malayi	Steroid receptor seven-up type 2	0.0297	0.5166	0.7149
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0102	0.1589	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0834	0.9903
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0297	0.5166	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0344	0.0667
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0157	0.2587	0.5009
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0571	0.1105
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0297	0.5166	0.7149
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0053	0.0102
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0834	1
Brugia malayi	ecdysone receptor	0.014	0.2278	0.3153
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0053	0.0624
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0345	0.0294
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.3132	0.6063
Brugia malayi	nuclear receptor RXR	0.0157	0.2587	0.3581
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0012	0.0022
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0075	0.1091	0.2112
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0834	0.9903
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0692	0.1339
Schistosoma mansoni	nuclear hormone receptor	0.0297	0.5166	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0297	0.5166	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0408	0.7226	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0025	0.0166	0.0322
Leishmania major	hypothetical protein, conserved	0.0035	0.0345	0.4093
Brugia malayi	Melibiase family protein	0.0066	0.0923	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Brugia malayi	nuclear hormone receptor family member odr-7	0.014	0.2278	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1894	0.2621
Echinococcus granulosus	lamin	0.0052	0.0666	0.1289
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0265	0.0513
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.014	0.2278	0.4411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0265	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2587	0.3581
Toxoplasma gondii	melibiase subfamily protein	0.01	0.1534	0.9655
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0149	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0066	0.092	0.1274
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1894	0.2291
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0157	0.2587	0.3581
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0053	0.0624
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0692	0.1339
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	1
Brugia malayi	hypothetical protein	0.0119	0.1894	0.2621
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0692	0.0957
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0345	0.0417
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0834	0.1009
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0297	0.5166	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0345	0.0477
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.079	0.153
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.014	0.2278	0.2756
Schistosoma mansoni	thyroid hormone receptor	0.0297	0.5166	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.0923	0.1787
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.4963	0.9607
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0345	0.0294
Leishmania major	cathepsin L-like protease	0.0062	0.0842	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0053	0.0624
Brugia malayi	nuclear hormone receptor	0.014	0.2278	0.3153
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0025	0.0166	0.0322
Onchocerca volvulus	Protein ultraspiracle homolog	0.0297	0.5166	0.6249
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0066	0.0923	0.1117
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0053	0.0624
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.1534	0.297
Echinococcus multilocularis	ecdysone induced protein 78C	0.0297	0.5166	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.0614
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0834	0.1615
Onchocerca volvulus		0.0058	0.0774	0.0936
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1534	0.297
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0297	0.5166	0.7149
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0218	0.0301
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.078	0.1509
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1534	0.297
Schistosoma mansoni	nuclear hormone receptor	0.014	0.2278	0.4411
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0297	0.5166	0.7149
Mycobacterium ulcerans	hypothetical protein	0.0102	0.1589	0.1544
Echinococcus multilocularis	nuclear receptor nhr 48	0.014	0.2278	0.4411
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0834	0.9903
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.1589	0.1544
Brugia malayi	mbt repeat family protein	0.0047	0.0571	0.079
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0648	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Schistosoma mansoni	coup transcription factor	0.0297	0.5166	1
Brugia malayi	PHD-finger family protein	0.0025	0.0155	0.0214
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0297	0.5166	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.014	0.2278	0.4411
Schistosoma mansoni	nuclear receptor nhr-48	0.014	0.2278	0.4411
Brugia malayi	nuclear receptor NHR-88	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0053	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0149	0.0206
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0598	0.7098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0297	0.5166	0.7149
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1354	0.2622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0855	0.1656
Brugia malayi	intermediate filament protein	0.0052	0.0666	0.0922
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0345	0.0417
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0555
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1485	0.2056
Loa Loa (eye worm)	nuclear receptor NHR-67	0.014	0.2278	0.3153
Echinococcus multilocularis	lamin	0.0052	0.0666	0.1289
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Echinococcus granulosus	lamin dm0	0.0052	0.0666	0.1289
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0834	0.9903
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0345	0.0294
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0834	0.1615
Schistosoma mansoni	nuclear receptor	0.014	0.2278	0.4411
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0075	0.1091	0.2112
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0559	1	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0834	0.1615
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0053	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0265	0.0367
Brugia malayi	Nuclear hormone receptor-like 1	0.0297	0.5166	0.7149
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0834	0.525
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0345	0.0668
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0297	0.5166	0.7149
Brugia malayi	hypothetical protein	0.014	0.2278	0.3153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0053	0.0102
Schistosoma mansoni	hypothetical protein	0.002	0.0077	0.0149
Brugia malayi	orphan nuclear receptor NR2E1	0.014	0.2278	0.3153
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1354	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0297	0.5166	0.7149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0297	0.5166	0.7149
Brugia malayi	ecdysteroid receptor	0.0297	0.5166	0.7149
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0345	0.0294
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1485	0.2056
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0112	0.0216
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0356	0.069
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0297	0.5166	1
Brugia malayi	Pre-SET motif family protein	0.0408	0.7226	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1354	0.2622
Schistosoma mansoni	RAR-like nuclear receptor	0.0297	0.5166	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1091	0.151
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2587	0.3581
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.014	0.2278	0.4411
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0157	0.2587	0.5009
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0345	0.0294
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0012	0.0022
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0	0.5
Onchocerca volvulus		0.0052	0.0666	0.0806
Brugia malayi	nuclear receptor NHR-88	0.014	0.2278	0.3153
Brugia malayi	hypothetical protein	0.014	0.2278	0.3153
Plasmodium vivax	SET domain protein, putative	0.0059	0.078	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Echinococcus granulosus	Nuclear hormone receptor HR96	0.014	0.2278	0.4411
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0834	0.1009
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.014	0.2278	0.4411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0053	0.0102
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.4963	0.9607
Onchocerca volvulus		0.0035	0.0345	0.0417
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0692	0.0957
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0692	0.1339
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.014	0.2278	0.4411
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0297	0.5166	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.4963	0.6868
Loa Loa (eye worm)	MBCTL1	0.0054	0.0692	0.0957
Brugia malayi	hypothetical protein	0.0286	0.4963	0.6868
Brugia malayi	beta-lactamase family protein	0.0035	0.0345	0.0477
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0571	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Echinococcus granulosus	thyroid hormone receptor alpha	0.014	0.2278	0.4411
Schistosoma mansoni	zinc finger protein	0.014	0.2278	0.4411
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1485	0.2056
Echinococcus granulosus	intermediate filament protein	0.0052	0.0666	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1894	0.2621
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.1534	0.297
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0112	0.0216
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.1534	0.297
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0053	0.0073
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0157	0.2587	0.5009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0297	0.5166	1
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0102	0.1589	0.1544
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0345	0.4423
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1838	0.2543
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0345	0.0294
Treponema pallidum	licC protein (licC)	0.0102	0.1589	0.5
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0559	1	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Brugia malayi	Nuclear hormone receptor-like 1	0.0157	0.2587	0.3581
Schistosoma mansoni	thyroid hormone receptor	0.0297	0.5166	1
Onchocerca volvulus	Bile acid receptor homolog	0.0297	0.5166	0.6249
Brugia malayi	MAP kinase sur-1	0.0062	0.0834	0.1154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0297	0.5166	0.7149
Trichomonas vaginalis	esterase, putative	0.0035	0.0345	0.0417
Toxoplasma gondii	ABC1 family protein	0.0035	0.0345	0.217
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0842	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0265	0.0513
Echinococcus multilocularis	zinc finger protein	0.0019	0.0058	0.0111
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0743	0.8824
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0692	0.1339
Echinococcus granulosus	FTZ F1 alpha	0.0297	0.5166	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0297	0.5166	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2587	0.3581
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0297	0.5166	1
Brugia malayi	conserved hypotetical protein	0.014	0.2278	0.3153
Brugia malayi	nuclear hormone receptor family member nhr-6	0.014	0.2278	0.3153
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0345	0.0294
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0075	0.1091	0.2112
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0356	0.069
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0571	0.1105
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1534	0.297
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0053	0.0064
Brugia malayi	Intermediate filament tail domain containing protein	0.0052	0.0666	0.0922
Loa Loa (eye worm)	nuclear hormone receptor	0.014	0.2278	0.3153
Schistosoma mansoni	lamin	0.0052	0.0666	0.1289
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1354	0.2622
Loa Loa (eye worm)	DR-78	0.014	0.2278	0.3153
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.0923	0.1787
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0265	0.0367
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0157	0.2587	0.5009
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0345	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2587	0.3581
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0834	0.1009
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.014	0.2278	0.4411
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0834	0.9903
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0012	0.0022
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0023	0.0031
Loa Loa (eye worm)	intermediate filament protein	0.0052	0.0666	0.0922
Echinococcus granulosus	geminin	0.0165	0.2734	0.5293
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0344	0.0667
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0053	0.0102
Echinococcus granulosus	nuclear receptor nhr 48	0.014	0.2278	0.4411
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0297	0.5166	1
Echinococcus multilocularis	lamin dm0	0.0052	0.0666	0.1289
Echinococcus multilocularis	FTZ F1 alpha	0.0297	0.5166	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0297	0.5166	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0053	0.0073
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.1589	0.1544
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0345	0.4093
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0077	0.0106
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0345	0.0477
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0053	0.1525
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0012	0.0022
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0842	1
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0559	1	1
Onchocerca volvulus		0.0297	0.5166	0.6249
Schistosoma mansoni	hypothetical protein	0.0165	0.2734	0.5293
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0923	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0073
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0297	0.5166	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0265	0.0367
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0297	0.5166	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1485	0.2056
Brugia malayi	Bromodomain containing protein	0.0074	0.1069	0.148
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0834	0.1009
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0345	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0297	0.5166	0.7149
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0571	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Schistosoma mansoni	hypothetical protein	0.0287	0.4994	0.9668
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0345	0.0668
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0265	0.0513
Brugia malayi	hypothetical protein	0.0035	0.0344	0.0477
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0297	0.5166	0.7149
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0112	0.0216
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.078	0.4907
Brugia malayi	nuclear receptor RXR	0.014	0.2278	0.3153
Echinococcus granulosus	zinc finger protein	0.0019	0.0058	0.0111
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0692	0.1339
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0345	0.0294
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0053	0.0102
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.092	0.1274
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0571	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Onchocerca volvulus		0.0052	0.0666	0.0806
Schistosoma mansoni	nuclear receptor	0.014	0.2278	0.4411
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.014	0.2278	0.4411
Echinococcus granulosus	histone lysine methyltransferase setb	0.0075	0.1091	0.2112
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0297	0.5166	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.0053	0.0624
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.014	0.2278	0.3153
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Onchocerca volvulus		0.0035	0.0345	0.0417
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0053	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0571	0.079
Onchocerca volvulus		0.0047	0.0571	0.0691
Onchocerca volvulus		0.0035	0.0345	0.0417
Brugia malayi	Bromodomain containing protein	0.0038	0.0399	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5166	0.7149
Echinococcus multilocularis	geminin	0.0165	0.2734	0.5293
Brugia malayi	hypothetical protein	0.0157	0.2587	0.3581
Leishmania major	cathepsin L-like protease	0.0062	0.0842	1
Echinococcus multilocularis	musashi	0.0052	0.0666	0.1289
Brugia malayi	mbt repeat family protein	0.0047	0.0571	0.079
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0345	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0345	0.0294
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0345	0.0417
Schistosoma mansoni	hypothetical protein	0.0031	0.0265	0.0513
Trypanosoma brucei	protein kinase, putative	0.0062	0.0834	0.9896
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1354	0.2622
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.014	0.2278	0.4411
Brugia malayi	Nuclear hormone receptor E75	0.014	0.2278	0.3153
Onchocerca volvulus		0.014	0.2278	0.2756
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0265	0.0513
Leishmania major	cathepsin L-like protease	0.0062	0.0842	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.014	0.2278	0.4411
Schistosoma mansoni	hypothetical protein	0.0066	0.092	0.1782
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0297	0.5166	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0344	0.0667
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.014	0.2278	0.3153
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1534	0.297
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0297	0.5166	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.074	0.1432
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0345	0.0294
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0297	0.5166	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0834	0.1154
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.014	0.2278	0.2756
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0053	0.0102
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0345	0.0294
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0265	0.0367
Onchocerca volvulus		0.014	0.2278	0.2756
Loa Loa (eye worm)	hypothetical protein	0.014	0.2278	0.3153
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0571	0.1105
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0834	0.1615
Brugia malayi	beta-lactamase	0.0035	0.0345	0.0477
Schistosoma mansoni	hypothetical protein	0.0035	0.0344	0.0667
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0297	0.5166	0.7149
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0297	0.5166	0.7149
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1354	0.2622
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0842	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0157	0.2587	0.3581
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0345	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0345	0.0417
Brugia malayi	nuclear receptor NHR-67	0.014	0.2278	0.3153
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0571	0.079
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0345	0.0477
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.3132	0.6063
Echinococcus granulosus	dna polymerase eta	0.0019	0.0053	0.0102
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0842	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0834	0.9903
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0297	0.5166	1
Brugia malayi	Pre-SET motif family protein	0.0059	0.078	0.1079
Entamoeba histolytica	hypothetical protein	0.0035	0.0344	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1838	0.2543
Schistosoma mansoni	hypothetical protein	0.0058	0.0774	0.1498
Onchocerca volvulus		0.0059	0.078	0.0943
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.1354	0.1874
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0345	0.4093
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.1354	0.1874
Brugia malayi	nuclear hormone receptor	0.0297	0.5166	0.7149
Trichomonas vaginalis	set domain proteins, putative	0.0465	0.8266	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0297	0.5166	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1354	0.2622
Schistosoma mansoni	nuclear hormone receptor	0.014	0.2278	0.4411
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0297	0.5166	0.7149
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.007	0.0991	0.1372
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0571	0.1105
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0345	0.0417
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0218	0.0301
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0834	0.1615
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0297	0.5166	0.6249
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0774	0.1071
Brugia malayi	tailless protein	0.014	0.2278	0.3153
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.014	0.2278	0.4411
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0053	0.0624
Loa Loa (eye worm)	steroid hormone receptor	0.0297	0.5166	0.7149
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0666	0.0922
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0297	0.5166	0.7149
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1838	0.2543
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0052	0.0666	0.0922
Brugia malayi	hypothetical protein	0.0157	0.2587	0.3581
Schistosoma mansoni	zinc finger protein	0.0019	0.0058	0.0111
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0345	0.0668
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0297	0.5166	1
Brugia malayi	Nuclear hormone receptor E75	0.014	0.2278	0.3153
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0571	0.0691
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0842	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0297	0.5166	0.7149

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1446363

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1354157