Detailed information for compound 1354266

Basic information

Technical information
  • TDR Targets ID: 1354266
  • Name: 5-(2-propoxyethyl)-1,3,4-thiadiazol-2-amine
  • MW: 187.263 | Formula: C7H13N3OS
  • H donors: 1 H acceptors: 2 LogP: 1.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOCCc1nnc(s1)N
  • InChi: 1S/C7H13N3OS/c1-2-4-11-5-3-6-9-10-7(8)12-6/h2-5H2,1H3,(H2,8,10)
  • InChiKey: NYONJKZIQKEVTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(2-propoxyethyl)-1,3,4-thiadiazol-2-yl]amine
  • 5-(2-Propoxy-ethyl)-[1,3,4]thiadiazol-2-ylamine
  • MLS000529494
  • SMR000121969
  • ST5257300
  • BAS 01891975
  • ZINC04299035

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acetyltransferase 0.0155 0.761 0.9341
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.3632 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 0.7513
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0949 0.1133
Brugia malayi Sex muscle abnormal protein 5 0.0164 0.8136 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0164 0.8136 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.0949 0.0982
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0071 0.295 0.2831
Loa Loa (eye worm) hypothetical protein 0.0095 0.4263 0.5141
Onchocerca volvulus 0.0101 0.4632 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.4501 0.4423
Onchocerca volvulus 0.0101 0.4632 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0029 0.0611 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.2591 0.2485
Echinococcus multilocularis aldehyde reductase 0.0072 0.2993 0.2874
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0039 0.1143 0.0993
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.4291 0.9263
Loa Loa (eye worm) hypothetical protein 0.0095 0.4263 0.5141
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0039 0.1143 0.1015
Trichomonas vaginalis aldo/keto reductase, putative 0.0101 0.4632 1
Brugia malayi SH2 domain containing protein 0.0021 0.0166 0.0167
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Brugia malayi jmjC domain containing protein 0.0065 0.2591 0.3159
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis aldo keto reductase 0.0101 0.4632 0.4542
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Giardia lamblia Aldose reductase 0.0101 0.4632 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0612 0.0002
Echinococcus granulosus c src tyrosine kinase 0.0039 0.1143 0.0993
Entamoeba histolytica aldose reductase, putative 0.0101 0.4632 1
Plasmodium vivax aldehyde reductase, putative 0.0029 0.0611 0.0111
Entamoeba histolytica aldose reductase, putative 0.0101 0.4632 1
Loa Loa (eye worm) oxidoreductase 0.0101 0.4632 0.5604
Echinococcus granulosus tyrosine protein kinase Src64B 0.0071 0.295 0.2831
Echinococcus granulosus tyrosine protein kinase Lyn 0.0072 0.2977 0.2859
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0071 0.295 0.2831
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0071 0.295 0.2831
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0166 0.0167
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0949 0.1133
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0071 0.295 0.2831
Schistosoma mansoni tyrosine kinase 0.0021 0.0166 0.0025
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0973 0.082
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1512 0.1368
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Echinococcus multilocularis c src tyrosine kinase 0.0039 0.1143 0.0993
Schistosoma mansoni tyrosine kinase 0.0071 0.295 0.2849
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0101 0.4632 0.5678
Echinococcus granulosus tyrosine protein kinase Src42A 0.0071 0.295 0.2831
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.761 0.7576
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 0.5
Loa Loa (eye worm) oxidoreductase 0.0101 0.4632 0.5604
Loa Loa (eye worm) oxidoreductase 0.0101 0.4632 0.5604
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0035 0.0949 0.0819
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0095 0.4291 0.5176
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.4501 0.4408
Loa Loa (eye worm) hypothetical protein 0.0101 0.4632 0.5604
Trypanosoma cruzi aldo/keto reductase, putative 0.0101 0.4632 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.3632 0.3525
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0101 0.4632 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0029 0.0611 0.0111
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0101 0.4632 0.5678
Schistosoma mansoni pol-related 0.0101 0.4632 0.4555
Schistosoma mansoni aldo-keto reductase 0.0101 0.4632 0.4555
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.178 0.1641
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.4291 0.4209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus granulosus dual specificity 0.0095 0.4291 0.4194
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0029 0.0611 0.0452
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.2591 0.2485
Mycobacterium leprae Possible oxidoreductase 0.0029 0.0611 0.0084
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0071 0.295 0.2831
Trypanosoma brucei aldo-keto reductase, putative 0.0101 0.4632 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.2027 0.352
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.2027 0.3574
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Loa Loa (eye worm) hypothetical protein 0.0029 0.0612 0.0559
Echinococcus granulosus voltage gated potassium channel subunit 0.0029 0.0611 0.0452
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 1
Echinococcus multilocularis dual specificity 0.0095 0.4291 0.4194
Brugia malayi Protein kinase domain containing protein 0.0021 0.0166 0.0167
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.0611 0.1319
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0101 0.4632 0.5678
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.2709 0.2585
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.1974 0.1838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.4501 0.4423
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.0611 0.1319
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1512 0.224
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.0166 0.0359
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.2709 0.5216
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.2709 0.5216
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.2709 0.2604
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0612 0.0002
Echinococcus granulosus hypothetical protein 0.0101 0.4632 0.4542
Brugia malayi SH2 domain containing protein 0.0021 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0021 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0095 0.4291 0.5256
Schistosoma mansoni jumonji domain containing protein 0.0065 0.2591 0.2485
Onchocerca volvulus 0.0101 0.4632 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0164 0.8136 0.8104
Loa Loa (eye worm) TK protein kinase 0.0054 0.1974 0.2268
Plasmodium falciparum aldehyde reductase, putative 0.0029 0.0611 0.0111
Schistosoma mansoni tyrosine kinase 0.0039 0.1143 0.1015
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.761 0.9352
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0071 0.295 0.2831
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.2709 0.5256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.4501 0.4408
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.3632 0.7534
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1512 0.3059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.4501 0.5516
Schistosoma mansoni aldo-keto reductase 0.0101 0.4632 0.4555
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0071 0.295 0.2831
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.2709 0.5216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.2709 0.5216
Brugia malayi protein-tyrosine kinase 0.0054 0.1974 0.2397
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.2027 0.1892
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.3632 0.3541
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.3632 0.7534
Onchocerca volvulus 0.0101 0.4632 1
Schistosoma mansoni tyrosine kinase 0.0071 0.295 0.2849
Loa Loa (eye worm) hypothetical protein 0.0035 0.0949 0.0982
Schistosoma mansoni hypothetical protein 0.0198 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0973 0.082
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0101 0.4632 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0166 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.4501 0.4423
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.4291 0.9151
Echinococcus multilocularis voltage gated potassium channel subunit 0.0029 0.0611 0.0452
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1512 0.2305
Echinococcus granulosus aldehyde reductase 0.0072 0.2993 0.2874
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0612 0.0086
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0029 0.0611 0.0716
Plasmodium falciparum aldo-keto reductase, putative 0.0029 0.0611 0.0111
Brugia malayi SRC-1 0.0071 0.295 0.3602
Loa Loa (eye worm) TK protein kinase 0.0036 0.0973 0.1012
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 0.7513
Echinococcus granulosus tyrosine kinase 0.0054 0.1974 0.1838
Entamoeba histolytica hypothetical protein 0.0095 0.4291 0.9263
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.178 0.1641
Brugia malayi hypothetical protein 0.0029 0.0612 0.0717
Schistosoma mansoni tyrosine kinase 0.0021 0.0166 0.0025
Echinococcus multilocularis NCK adaptor protein 0.0035 0.0949 0.0796
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0101 0.4632 0.5678
Echinococcus granulosus aldo keto reductase 0.0101 0.4632 0.4542
Schistosoma mansoni growth factor receptor-bound protein 0.0164 0.8136 0.8109
Echinococcus granulosus aldo keto reductase 0.0101 0.4632 0.4542
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 0.5
Brugia malayi jmjC domain containing protein 0.0065 0.2591 0.3159
Onchocerca volvulus 0.0029 0.0611 0.0996
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.2709 0.5216
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0612 0.0113
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.2591 0.2466
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.4291 0.9151
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0612 0.0002
Loa Loa (eye worm) oxidoreductase 0.0101 0.4632 0.5604
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0101 0.4632 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.295 0.2831
Echinococcus granulosus aldo keto reductase 0.0101 0.4632 0.4542
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0612 0.0113
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.1974 0.1838
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0039 0.1143 0.0993
Trichomonas vaginalis aldo/keto reductase, putative 0.0101 0.4632 1
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.2591 0.2466
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Trypanosoma brucei prostaglandin f synthase 0.0101 0.4632 1
Loa Loa (eye worm) SRC-1 0.0071 0.295 0.3493
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0612 0.0113
Brugia malayi Tyrosine-protein kinase abl-1 0.0039 0.1143 0.1372
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0029 0.0611 0.0084
Entamoeba histolytica aldose reductase, putative 0.0101 0.4632 1
Schistosoma mansoni growth factor receptor-bound protein 0.0164 0.8136 0.8109
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0101 0.4632 1
Toxoplasma gondii aldose reductase, putative 0.0101 0.4632 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1512 0.224
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.4501 0.544
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.2591 0.2466
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.2709 0.2604
Mycobacterium ulcerans oxidoreductase 0.0101 0.4632 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.2027 0.352
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0029 0.0611 0.0558
Echinococcus multilocularis tyrosine protein kinase Abl 0.0039 0.1143 0.0993
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.1974 0.1838
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.2027 0.1892
Brugia malayi Probable ClpP-like protease 0.0084 0.3632 0.4444
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.3632 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Entamoeba histolytica protein kinase, putative 0.0095 0.4291 0.9263
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Leishmania major hypothetical protein, conserved 0.0029 0.0612 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1512 0.2305
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.1974 0.1838
Loa Loa (eye worm) oxidoreductase 0.0101 0.4632 0.5604
Echinococcus multilocularis geminin 0.0198 1 1
Echinococcus multilocularis aldo keto reductase 0.0101 0.4632 0.4542
Echinococcus granulosus growth factor receptor bound protein 2 0.0164 0.8136 0.8104
Leishmania major aldo-keto reductase-like protein 0.0101 0.4632 1
Brugia malayi NADH-dependent xylose reductase 0.0029 0.0611 0.0716
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.7368 0.7324
Toxoplasma gondii aldo-keto reductase 0.0029 0.0611 0.0084
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.2591 0.3043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.2591 0.2466
Schistosoma mansoni nck2/grb4 0.0035 0.0949 0.0819
Entamoeba histolytica protein kinase, putative 0.0095 0.4291 0.9263
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0095 0.4291 0.9151
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.1974 0.1838
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.4632 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0166 0.0167
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.2993 0.5956
Giardia lamblia Aldose reductase 0.0101 0.4632 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.4501 0.4408
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0101 0.4632 0.4542
Brugia malayi hypothetical protein 0.0021 0.0166 0.0167
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.3632 0.7534
Loa Loa (eye worm) hypothetical protein 0.0084 0.3632 0.4349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.4501 0.4408
Onchocerca volvulus 0.0101 0.4632 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.2709 0.2585
Leishmania major prostaglandin f synthase, putative 0.0101 0.4632 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.13 0.2807
Schistosoma mansoni adapter molecule crk 0.0035 0.0949 0.0819
Trypanosoma cruzi aldo-keto reductase 0.0101 0.4632 1
Echinococcus granulosus NCK adaptor protein 0.0035 0.0949 0.0796
Echinococcus multilocularis aldo keto reductase 0.0101 0.4632 0.4542
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Schistosoma mansoni potassium channel beta 0.0029 0.0611 0.0476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Schistosoma mansoni hypothetical protein 0.0198 1 1
Schistosoma mansoni tyrosine kinase 0.0039 0.1143 0.1015
Onchocerca volvulus 0.0101 0.4632 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.4291 0.9151
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0101 0.4632 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0071 0.295 0.2831
Echinococcus multilocularis aldo keto reductase 0.0101 0.4632 0.4542
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.3632 0.3525
Entamoeba histolytica protein kinase, putative 0.0036 0.0973 0.2099
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0101 0.4632 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0101 0.4632 0.4542
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.761 0.757
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.13 0.2366
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0101 0.4632 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0101 0.4632 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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