Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.659 | 0.6519 |
Onchocerca volvulus | 0.0265 | 0.7731 | 0.7731 | |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.3191 | 0.3191 |
Onchocerca volvulus | 0.0329 | 1 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.4805 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0053 | 0.0204 | 0.0695 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.7731 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.2929 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0516 | 0.0516 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0.0204 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0053 | 0.0204 | 0.0443 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.4805 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0051 | 0.0142 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3191 | 0.3049 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0516 | 0.1148 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.4805 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0053 | 0.0204 | 0.0695 |
Giardia lamblia | Ribonuclease H | 0.0047 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0051 | 0.0142 | 0.0296 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.4805 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0051 | 0.0142 | 0.0296 |
Brugia malayi | hypothetical protein | 0.0137 | 0.3191 | 0.3191 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.3067 | 0.2923 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.659 | 0.659 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0047 | 0 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0053 | 0.0204 | 0.0204 |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.3191 | 0.3191 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.2929 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.2929 | 0.2782 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0051 | 0.0142 | 0.0296 |
Trypanosoma brucei | RNA helicase, putative | 0.0177 | 0.46 | 0.9573 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.4805 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0516 | 0.1074 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.2929 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2929 | 0.6367 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3191 | 0.3049 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0051 | 0.0142 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.2929 | 1 |
Onchocerca volvulus | 0.013 | 0.2929 | 0.2929 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0516 | 0.0668 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.3067 | 0.3067 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.4805 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0053 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.3067 | 0.2923 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.2929 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.2929 | 0.2929 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.46 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5.4 uM | Tested for caspase activation activity in human breast cancer ZR75-1 cells | ChEMBL. | 12773051 |
EC50 (functional) | = 5.4 uM | Tested for caspase activation activity in human breast cancer ZR75-1 cells | ChEMBL. | 12773051 |
EC50 (functional) | > 10 uM | Tested for caspase activation activity in human breast cancer T47D cells | ChEMBL. | 12773051 |
EC50 (functional) | > 10 uM | Tested for caspase activation activity in colorectal DLD-1 cell line | ChEMBL. | 12773051 |
EC50 (functional) | > 10 uM | Tested for caspase activation activity in human breast cancer T47D cells | ChEMBL. | 12773051 |
EC50 (functional) | > 10 uM | Tested for caspase activation activity in colorectal DLD-1 cell line | ChEMBL. | 12773051 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12773051 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.