Detailed information for compound 1354564

Basic information

Technical information
  • TDR Targets ID: 1354564
  • Name: 2-(1-cyclopentylimidazol-2-yl)sulfanyl-N-phen ylacetamide
  • MW: 301.407 | Formula: C16H19N3OS
  • H donors: 1 H acceptors: 2 LogP: 2.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CSc1nccn1C1CCCC1
  • InChi: 1S/C16H19N3OS/c20-15(18-13-6-2-1-3-7-13)12-21-16-17-10-11-19(16)14-8-4-5-9-14/h1-3,6-7,10-11,14H,4-5,8-9,12H2,(H,18,20)
  • InChiKey: ISRKOGUYKPQEKE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(1-cyclopentylimidazol-2-yl)sulfanyl-N-phenyl-acetamide
  • 2-[(1-cyclopentyl-2-imidazolyl)thio]-N-phenylacetamide
  • 2-[(1-cyclopentylimidazol-2-yl)thio]-N-phenyl-acetamide
  • 2-(1-cyclopentylimidazol-2-yl)sulfanyl-N-phenyl-ethanamide
  • NCGC00141794-01
  • G877-0002

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0275 0.2419
Onchocerca volvulus 0.002 0.0578 0.5082
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0343 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0275 0.3182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0347 0.0347
Echinococcus multilocularis basement membrane specific heparan sulfate 0.001 0.0093 0.0125
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0578 0.0782
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 0.3452
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Echinococcus granulosus Immunoglobulin 0.001 0.0093 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2551 0.2551
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0578 0.0782
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0275 0.0372
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0578 0.0782
Loa Loa (eye worm) hypothetical protein 0.0033 0.1138 0.1138
Plasmodium vivax vivapain-2 0.002 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0347 0.0347
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2551 0.3452
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0578 0.0782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Echinococcus granulosus cathepsin l1 0.002 0.0578 0.0782
Onchocerca volvulus 0.002 0.0578 0.5082
Echinococcus multilocularis lamin dm0 0.0033 0.1138 0.1539
Echinococcus granulosus cysteine protease 0.001 0.0134 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 0.3452
Loa Loa (eye worm) hypothetical protein 0.0015 0.0343 0.0343
Echinococcus granulosus twitchin 0.0012 0.0203 0.0274
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0134 0.0181
Onchocerca volvulus 0.002 0.0578 0.5082
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0578 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0578 0.0782
Brugia malayi RNA binding protein 0.0064 0.2551 0.2551
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0093 0.0093
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0013 0.0233 0.0315
Loa Loa (eye worm) cysteine protease 0.002 0.0578 0.0578
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0134 0.0134
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0578 0.0782
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3154 1
Brugia malayi TAR-binding protein 0.0064 0.2551 0.2551
Leishmania major cathepsin L-like protease 0.0077 0.3154 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.001 0.0093 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 0.3452
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0275 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Leishmania major cathepsin L-like protease 0.0077 0.3154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Onchocerca volvulus 0.0033 0.1138 1
Brugia malayi intermediate filament protein 0.0033 0.1138 0.1138
Schistosoma mansoni cell adhesion molecule 0.0013 0.0233 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Echinococcus granulosus defective proboscis extension response 0.001 0.0093 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Echinococcus multilocularis musashi 0.0033 0.1138 0.1539
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0134 0.0181
Echinococcus granulosus neuroglian 0.0012 0.0203 0.0274
Echinococcus multilocularis Immunoglobulin 0.001 0.0093 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Echinococcus multilocularis geminin 0.0171 0.7392 1
Echinococcus multilocularis roundabout 2 0.0015 0.0343 0.0464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Plasmodium vivax vivapain-2 0.002 0.0578 1
Onchocerca volvulus 0.002 0.0578 0.5082
Loa Loa (eye worm) hypothetical protein 0.002 0.0578 0.0578
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0453 0.0453
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1138 0.1138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.2551 0.3452
Echinococcus multilocularis cathepsin L 0.001 0.0134 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Schistosoma mansoni hypothetical protein 0.0171 0.7392 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.2551 0.2551
Echinococcus multilocularis cysteine protease 0.002 0.0578 0.0782
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 0.3452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0016 0.0374 0.0374
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0578 0.0782
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0374 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0374 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Schistosoma mansoni lamin 0.0033 0.1138 0.1539
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3154 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 0.3452
Schistosoma mansoni nephrin 0.0012 0.0203 0.0274
Onchocerca volvulus Cathepsin L homolog 0.002 0.0578 0.5082
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0013 0.0233 0.0233
Echinococcus granulosus cathepsin l1 0.0014 0.0275 0.0372
Echinococcus multilocularis Immunoglobulin 0.001 0.0093 0.0125
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1138 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0578 1
Onchocerca volvulus 0.002 0.0578 0.5082
Echinococcus multilocularis lamin 0.0033 0.1138 0.1539
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0578 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.1138 0.1539
Echinococcus granulosus geminin 0.0171 0.7392 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.3154 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0578 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2551 0.2551
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Schistosoma mansoni lamin 0.0033 0.1138 0.1539
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0578 1
Onchocerca volvulus 0.0033 0.1138 1
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0134 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Onchocerca volvulus 0.002 0.0578 0.5082
Brugia malayi Cathepsin L-like precursor 0.0014 0.0275 0.0275
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0275 0.3182
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0578 0.0578
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0578 0.0578
Onchocerca volvulus Cathepsin L homolog 0.002 0.0578 0.5082
Echinococcus granulosus cathepsin L 0.001 0.0134 0.0181
Brugia malayi Cathepsin L-like precursor 0.002 0.0578 0.0578
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0578 0.1472
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Loa Loa (eye worm) fibroinase 0.002 0.0578 0.0578
Brugia malayi hypothetical protein 0.001 0.0093 0.0093
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0578 0.0782
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.001 0.0093 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0275 0.0275
Onchocerca volvulus Cathepsin F homolog 0.002 0.0578 0.5082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0275 0.0275
Echinococcus granulosus lamin dm0 0.0033 0.1138 0.1539
Brugia malayi cathepsin L-like precursor 0.0014 0.0275 0.0275
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0578 0.0578
Onchocerca volvulus 0.002 0.0578 0.5082
Schistosoma mansoni vesicular amine transporter 0.001 0.0093 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Leishmania major cathepsin L-like protease 0.0077 0.3154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1111 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0275 0.3182
Echinococcus granulosus lamin 0.0033 0.1138 0.1539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0171 0.7392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Echinococcus granulosus roundabout 2 0.0015 0.0343 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Echinococcus multilocularis neuroglian 0.0012 0.0203 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Echinococcus multilocularis cysteine protease 0.002 0.0578 0.0782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3154 1
Toxoplasma gondii cathepsin CPL 0.002 0.0578 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3154 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0578 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.2407 0.7525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0578 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2551 0.2551
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2851 0.8997
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0134 0.0181
Loa Loa (eye worm) ctsf protein 0.002 0.0578 0.0578
Echinococcus granulosus intermediate filament protein 0.0033 0.1138 0.1539
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1138 0.1138
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0233 0.0233

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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