Detailed information for compound 1354576

Basic information

Technical information
  • TDR Targets ID: 1354576
  • Name: [2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxoeth yl] 2-[(4-acetamidophenyl)sulfonyl-methylamin o]acetate
  • MW: 424.428 | Formula: C17H20N4O7S
  • H donors: 2 H acceptors: 6 LogP: 0.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)COC(=O)CN(S(=O)(=O)c1ccc(cc1)NC(=O)C)C
  • InChi: 1S/C17H20N4O7S/c1-11-8-15(20-28-11)19-16(23)10-27-17(24)9-21(3)29(25,26)14-6-4-13(5-7-14)18-12(2)22/h4-8H,9-10H2,1-3H3,(H,18,22)(H,19,20,23)
  • InChiKey: UHNKQPJJOZBPCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(5-methylisoxazol-3-yl)amino]-2-oxo-ethyl] 2-[(4-acetamidophenyl)sulfonyl-methyl-amino]acetate
  • 2-[(4-acetamidophenyl)sulfonyl-methylamino]acetic acid [2-[(5-methyl-3-isoxazolyl)amino]-2-oxoethyl] ester
  • 2-[(4-acetamidophenyl)sulfonyl-methyl-amino]acetic acid [2-keto-2-[(5-methylisoxazol-3-yl)amino]ethyl] ester
  • [2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxo-ethyl] 2-[(4-acetamidophenyl)sulfonyl-methyl-amino]ethanoate
  • T5355742

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Leishmania major DNA polymerase eta, putative 0.0034 0.0071 0.0079
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0132 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.0517 0.0707
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.02 0.0178
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0358 0.0483
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0031 0.0044 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0088 0.0517 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0132 0.0165
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.0517 0.0707
Brugia malayi ecdysone receptor 0.0042 0.0132 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0132 0.0132
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0022
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0132 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.0517 0.0707
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0132 0.0165
Echinococcus granulosus amiloride sensitive cation channel 0.0031 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0517 0.0517
Brugia malayi hypothetical protein 0.0047 0.0173 0.0223
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0887 0.7123 0.7117
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Echinococcus granulosus tar DNA binding protein 0.0069 0.0358 0.0336
Schistosoma mansoni FMRFamide-gated Na+ channel 0.0031 0.0044 0.0044
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0023 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0358 0.0483
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0517 0.0707
Echinococcus granulosus amiloride sensitive cation channel 4 A 0.0031 0.0044 0.0022
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0132 0.011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0887 0.7123 0.7402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0517 0.0707
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.0517 0.0516
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0191 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.0517 0.0707
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0023 0.0011
Echinococcus multilocularis Na+ channel, amiloride sensitive 0.0031 0.0044 0.0023
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0031 0.0044 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.0517 0.0516
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.0517 0.0707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0132 0.0114
Brugia malayi RNA binding protein 0.0069 0.0358 0.0483
Echinococcus multilocularis sodium channel nonvoltage gated 1 alpha 0.0031 0.0044 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0132 0.011
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0358 0.0483
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0132 0.011
Echinococcus multilocularis geminin 0.0351 0.2691 0.2782
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Echinococcus granulosus sodium channel nonvoltage gated 1 alpha 0.0031 0.0044 0.0022
Onchocerca volvulus 0.0042 0.0132 0.1859
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Schistosoma mansoni zinc finger protein 0.0042 0.0132 0.0132
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0887 0.7123 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.0517 0.0517
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0023 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0517 0.0496
Schistosoma mansoni coup transcription factor 0.0088 0.0517 0.0517
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.1236 1 1
Echinococcus multilocularis amiloride sensitive cation channel 4 A 0.0031 0.0044 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0248
Echinococcus granulosus amiloride sensitive sodium channel 0.0031 0.0044 0.0022
Loa Loa (eye worm) amiloride-sensitive sodium channel family protein 0.0031 0.0044 0.0041
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0132 0.0165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Schistosoma mansoni nuclear receptor 0.0042 0.0132 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.02 0.02
Brugia malayi hypothetical protein 0.0047 0.0173 0.0223
Echinococcus multilocularis amiloride sensitive cation channel acid sensing ion channel pituitary 0.0031 0.0044 0.0023
Brugia malayi Amiloride-sensitive sodium channel family protein 0.0031 0.0044 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.0517 0.0517
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0112 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.02 0.0178
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0173 0.0151
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0173 0.0157
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.0517 0.0707
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0132 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Echinococcus multilocularis dna polymerase eta 0.0049 0.0191 0.0176
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0132 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.0517 0.0517
Echinococcus granulosus dna polymerase eta 0.0049 0.0191 0.0169
Schistosoma mansoni nuclear receptor 0.0042 0.0132 0.0132
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.0517 0.0516
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0132 0.011
Plasmodium falciparum flap endonuclease 1 0.0028 0.0023 1
Echinococcus granulosus protein vprbp 0.0031 0.0044 0.0022
Brugia malayi nuclear receptor NHR-67 0.0042 0.0132 0.0165
Brugia malayi conserved hypotetical protein 0.0042 0.0132 0.0165
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.0517 0.0707
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0173 0.0223
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0132 0.1859
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0887 0.7123 1
Brugia malayi TAR-binding protein 0.0069 0.0358 0.0483
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0132 0.0132
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0132 0.0165
Brugia malayi nuclear receptor RXR 0.0042 0.0132 0.0165
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0132 0.0165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.0517 0.0516
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0223
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0223
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0223
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.0517 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.0517 0.0707
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0517 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0517 0.0707
Brugia malayi nuclear receptor RXR 0.0047 0.0173 0.0223
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.0517 0.0517
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.0517 0.0517
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.02 0.02
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0023 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0132 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0191 0.0248
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0358 0.035
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0358 0.0358
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0132 0.0165
Schistosoma mansoni hypothetical protein 0.0039 0.0112 0.0112
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0887 0.7123 1
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0022
Brugia malayi steroid hormone receptor 0.0088 0.0517 0.0707
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Echinococcus granulosus transcription factor Dp 1 0.0514 0.4034 0.402
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.0126
Brugia malayi hypothetical protein 0.0039 0.0112 0.0136
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.0517 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0132 0.0114
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0887 0.7123 1
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.0517 0.0516
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0088 0.0517 0.0517
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.0517 0.0496
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0132 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.0517 0.0496
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0173 0.0223
Brugia malayi nuclear receptor NHR-88 0.0088 0.0517 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.0517 0.0707
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0191 0.0248
Loa Loa (eye worm) degenerin unc-8 0.0031 0.0044 0.0041
Brugia malayi hypothetical protein 0.0042 0.0132 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.02 0.0185
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0173 0.0223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.02 0.026
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.0126
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0132 0.0114
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0132 0.011
Loa Loa (eye worm) amiloride-sensitive sodium channel 0.0031 0.0044 0.0041
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0887 0.7123 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Brugia malayi tailless protein 0.0042 0.0132 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.0517 0.0707
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0887 0.7123 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Brugia malayi Degenerin-like protein C41C4.5 in chromosome II, putative 0.0031 0.0044 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.0517 0.0707
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0358 0.0358
Echinococcus granulosus amiloride sensitive cation channel 4 A 0.0031 0.0044 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.0517 0.0707
Brugia malayi ecdysteroid receptor 0.0088 0.0517 0.0707
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.0517 0.0516
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Echinococcus multilocularis transcription factor Dp 1 0.0514 0.4034 0.4182
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0071 0.0079
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0223
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.0517 0.0517
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.02 0.0185
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Schistosoma mansoni acid sensing ion channel 4 pituitary 0.0031 0.0044 0.0044
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Brugia malayi Degenerin-like protein ZK770.1 in chromosome I, putative 0.0031 0.0044 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0517 0.0516
Onchocerca volvulus 0.0088 0.0517 1
Echinococcus granulosus Na channel amiloride sensitive 0.0031 0.0044 0.0022
Echinococcus granulosus geminin 0.0351 0.2691 0.2674
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Echinococcus multilocularis amiloride sensitive cation channel 4 A 0.0031 0.0044 0.0023
Brugia malayi hypothetical protein 0.0042 0.0132 0.0165
Brugia malayi nuclear receptor NHR-88 0.0042 0.0132 0.0165
Echinococcus multilocularis Na+ channel, amiloride sensitive 0.0031 0.0044 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0358 0.0358
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1189 0.9615 1
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.0517 0.0496
Brugia malayi Degenerin unc-8 0.0031 0.0044 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0223
Leishmania major DNA polymerase eta, putative 0.0049 0.0191 0.0248
Brugia malayi Degenerin mec-4 0.0031 0.0044 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.0517 0.0707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0173 0.0173
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0023 0.5
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0031 0.0044 0.0044
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0132 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.0517 0.0496
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Echinococcus multilocularis protein vprbp 0.0031 0.0044 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0517 0.0496
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0132 0.0132
Loa Loa (eye worm) amiloride-sensitive sodium channel family protein 0.0031 0.0044 0.0041
Loa Loa (eye worm) DR-78 0.0042 0.0132 0.0165
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.0126
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Schistosoma mansoni DNA polymerase eta 0.0049 0.0191 0.0191
Brugia malayi Amiloride-sensitive sodium channel family protein 0.0031 0.0044 0.0041
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0031 0.0044 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0358 0.0358
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0358 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Brugia malayi nuclear hormone receptor 0.0088 0.0517 0.0707
Echinococcus granulosus FTZ F1 alpha 0.0088 0.0517 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.02 0.02
Brugia malayi nuclear hormone receptor 0.0042 0.0132 0.0165
Schistosoma mansoni hypothetical protein 0.0351 0.2691 0.2691
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0173 0.0173
Brugia malayi Flap endonuclease-1 0.0028 0.0023 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.0517 0.0496
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0088 0.0517 0.0707
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0887 0.7123 0.7123
Onchocerca volvulus 0.0042 0.0132 0.1859
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0071 1
Schistosoma mansoni hypothetical protein 0.0351 0.2691 0.2691
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0887 0.7123 1
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0031 0.0044 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.0517 0.0707
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0112 0.009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0112 0.0093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0132 0.1859
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0023 0.1335
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0023 0.0011
Echinococcus granulosus Na channel amiloride sensitive 0.0031 0.0044 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.0517 0.0707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0517 0.0516
Brugia malayi amiloride-sensitive sodium channel alpha-subunit, putative 0.0031 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0132 0.0165
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.02 0.026
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0088 0.0517 0.0517

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 141.2538 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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