Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.5821 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0155 | 0.3883 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0155 | 0.3883 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0155 | 0.3883 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0155 | 0.3883 | 0.3883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.625 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.3883 | 0.3883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0155 | 0.3883 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0155 | 0.3883 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0155 | 0.3883 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0155 | 0.3883 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0155 | 0.3883 | 0.3883 |
Brugia malayi | Carboxylesterase family protein | 0.0155 | 0.3883 | 0.3883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0155 | 0.3883 | 0.3883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.3883 | 0.3883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.625 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.