TDR Targets

Basic information

Technical information

TDR Targets ID: 1354712
Name: 2-(1,3-benzoxazol-2-ylsulfanyl)-N-[2-morpholi n-4-yl-5-(trifluoromethyl)phenyl]acetamide
MW: 437.435 | Formula: C20H18F3N3O3S
H donors: 1 H acceptors: 2 LogP: 4.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(ccc1N1CCOCC1)C(F)(F)F)CSc1nc2c(o1)cccc2
InChi: 1S/C20H18F3N3O3S/c21-20(22,23)13-5-6-16(26-7-9-28-10-8-26)15(11-13)24-18(27)12-30-19-25-14-3-1-2-4-17(14)29-19/h1-6,11H,7-10,12H2,(H,24,27)
InChiKey: DUHKTACXDINFCC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(1,3-benzoxazol-2-ylsulfanyl)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide
2-(1,3-benzoxazol-2-ylthio)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide
2-(1,3-benzoxazol-2-ylsulfanyl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]ethanamide
T0505-7664
MLS000569341
SMR000155017
ZINC03216989

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0046	0.0351	0.0351
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0097	0.2126	0.2126
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0046	0.0351	0.0351
Brugia malayi	Proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0097	0.2126	0.2126
Brugia malayi	proteasome subunit alpha type 1	0.0046	0.0351	0.0351
Mycobacterium ulcerans	proteasome PrcB	0.0324	1	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0097	0.2126	0.184
Leishmania major	proteasome beta 5 subunit, putative	0.0324	1	1
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0046	0.0351	0.0351
Brugia malayi	proteasome subunit beta type 2	0.0097	0.2126	0.2126
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0324	1	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0046	0.0351	0.5
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.015	0.3968	0.3968
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0046	0.0351	0.0351
Schistosoma mansoni	hypothetical protein	0.0041	0.0177	0.0177
Echinococcus granulosus	proteasome subunit beta t family	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome subunit alpha type 6	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome subunit alpha type 2	0.0046	0.0351	0.0351
Loa Loa (eye worm)	PAS-3 protein	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0046	0.0351	0.0351
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0666	0.0666
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0046	0.0351	0.0351
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0046	0.0351	0.0351
Brugia malayi	Proteasome subunit alpha type 7-1	0.0046	0.0351	0.0351
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.015	0.3968	0.3748
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0046	0.0351	0.0351
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0097	0.2126	0.184
Toxoplasma gondii	heat shock protein hslv, putative	0.0046	0.0351	0.0351
Brugia malayi	proteasome subunit alpha type 3	0.0046	0.0351	0.0351
Leishmania major	proteasome beta 2 subunit, putative	0.0097	0.2126	0.184
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0839	0.0839
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0324	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.7476	0.7476
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0839	0.0839
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0046	0.0351	0.0351
Trypanosoma cruzi	20S proteasome subunit	0.0097	0.2126	0.184
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0046	0.0351	0.0351
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0324	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0666	0.0666
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0046	0.0351	0.0351
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0324	1	1
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0046	0.0351	0.0351
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0046	0.0351	0.0351
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0666	0.0666
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0097	0.2126	0.2126
Echinococcus granulosus	Proteasome subunit alpha beta	0.0046	0.0351	0.0351
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0046	0.0351	0.0351
Brugia malayi	proteasome subunit beta type 3	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome prosome macropain	0.0324	1	1
Trypanosoma brucei	proteasome beta 6 subunit	0.015	0.3968	0.3748
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.015	0.3968	0.3968
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0046	0.0351	0.0351
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0097	0.2126	0.184
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0097	0.2126	0.184
Brugia malayi	proteasome subunit alpha type 4	0.0046	0.0351	0.0351
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0324	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0177	0.0177
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0046	0.0351	0.0351
Brugia malayi	Proteasome subunit alpha type 1	0.0046	0.0351	0.0351
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.015	0.3968	0.3748
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0046	0.0351	0.0351
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0324	1	1
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0046	0.0351	0.0351
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0666	0.0666
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0097	0.2126	0.2126
Brugia malayi	Proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Echinococcus multilocularis	proteasome subunit beta type 6	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.015	0.3968	0.3968
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0046	0.0351	0.0351
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0046	0.0351	0.0351
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.015	0.3968	0.3748
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0046	0.0351	0.0351
Toxoplasma gondii	proteasome beta subunit	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0046	0.0351	0.0351
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0046	0.0351	0.0351
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0666	0.0666
Brugia malayi	proteasome subunit alpha type 2	0.0046	0.0351	0.0351
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0666	0.0666
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0046	0.0351	0.0351
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome subunit beta type 6	0.0046	0.0351	0.0351
Brugia malayi	Pre-SET motif family protein	0.0251	0.7476	0.7476
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0097	0.2126	0.2126
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0046	0.0351	0.0351
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.015	0.3968	0.3748
Toxoplasma gondii	proteasome subunit	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0046	0.0351	0.0351
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0097	0.2126	0.184
Toxoplasma gondii	peptidase, T1 family protein	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0046	0.0351	0.0351
Echinococcus granulosus	proteasome subunit beta type 7	0.0046	0.0351	0.0351
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.8682	0.8634
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0097	0.2126	0.2126
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0046	0.0351	0.0351
Plasmodium falciparum	proteasome subunit beta type-5	0.0324	1	1
Onchocerca volvulus	Notchless protein homolog	0.0046	0.0351	0.0404
Brugia malayi	20S proteasome alpha5 subunit	0.0046	0.0351	0.0351
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0324	1	1
Plasmodium vivax	proteasome subunit beta type-1, putative	0.015	0.3968	0.3968
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.015	0.3968	0.3748
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.015	0.3968	0.3968
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0046	0.0351	0.0351
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0324	1	1
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0046	0.0351	0.0351
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0839	0.0839
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0097	0.2126	0.184
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0046	0.0351	0.0351
Toxoplasma gondii	proteasome subunit beta type, putative	0.0324	1	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0046	0.0351	0.0351
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Giardia lamblia	Proteasome subunit beta type 1	0.015	0.3968	0.3748
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0046	0.0351	0.0351
Brugia malayi	proteasome subunit alpha type 6	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0097	0.2126	0.2126
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0324	1	1
Loa Loa (eye worm)	proteasome subunit beta type 1	0.015	0.3968	0.3968
Brugia malayi	proteasome subunit beta type 1	0.015	0.3968	0.3968
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0324	1	1
Onchocerca volvulus		0.0286	0.8682	1
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0046	0.0351	0.0351
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.015	0.3968	0.3748
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0046	0.0351	0.0351
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0046	0.0351	0.0351
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0046	0.0351	0.0351
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0046	0.0351	0.0351
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0666	0.0666
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0046	0.0351	0.0351
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0666	0.0666
Brugia malayi	Proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0324	1	1
Giardia lamblia	Proteasome subunit beta type 2	0.0097	0.2126	0.184
Echinococcus multilocularis	proteasome subunit beta type 7	0.0046	0.0351	0.0351
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0177	0.0177
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0324	1	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0046	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.006	0.0839	0.0839
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0046	0.0351	0.0351
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0046	0.0351	0.0351

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1413 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	1000 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1458345

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1354712