Detailed information for compound 135484

Basic information

Technical information
  • TDR Targets ID: 135484
  • Name: 8-(6,8-diaminopurin-9-yl)-3-hydroxy-3-oxo-2,4 ,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan- 9-ol
  • MW: 344.221 | Formula: C10H13N6O6P
  • H donors: 4 H acceptors: 6 LogP: -2.9 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1C2OP(=O)(O)OCC2OC1n1c(N)nc2c1ncnc2N
  • InChi: 1S/C10H13N6O6P/c11-7-4-8(14-2-13-7)16(10(12)15-4)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H2,12,15)(H,18,19)(H2,11,13,14)
  • InChiKey: XKAQQTTUGGGUIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(6,8-diamino-9-purinyl)-3-hydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • 8-[6,8-bis(azanyl)purin-9-yl]-3-hydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • 8-(6,8-diaminopurin-9-yl)-3-hydroxy-3-keto-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • 56973-14-9
  • NSC288118

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0033 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4674 0.4672
Schistosoma mansoni hypothetical protein 0.0176 0.2034 0.4353
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0033 0.0071
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0359 0.2147
Schistosoma mansoni cpg binding protein 0.0029 0.0282 0.0604
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0258 0.3008 0.4582
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Echinococcus multilocularis cyclin B 0.0018 0.014 0.0137
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0359 0.0356
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.088 0.8573
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0024 0.0039
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0116 0.0211
Trypanosoma cruzi cyclin 6, putative 0.0018 0.014 0.1336
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.014 0.0257
Schistosoma mansoni inositol monophosphatase 0.0075 0.0831 0.1779
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Trypanosoma brucei glyoxalase II 0.0016 0.0116 0.0658
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.1095
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Mycobacterium leprae Beta-lactamase-like protein 0.0016 0.0116 0.014
Trichomonas vaginalis helicase, putative 0.0006 0.0006 0.002
Trichomonas vaginalis cyclin D, putative 0.0018 0.014 0.1336
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0222 0.1431
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1026 0.1022
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0008 0.0025 0.0061
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0025 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0116 0.0676
Toxoplasma gondii hypothetical protein 0.0013 0.0089 0.0381
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0067 0.0737 0.1382
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.004
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Brugia malayi hypothetical protein 0.0016 0.0116 0.0211
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1315 0.2472
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0116 0.1095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8099
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trypanosoma brucei poly(adp-ribose) polymerase 0.0079 0.088 0.6183
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0024 0.0052
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0116 0.0676
Leishmania major hypothetical protein, conserved 0.0019 0.0156 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0359 0.3478
Loa Loa (eye worm) hypothetical protein 0.0067 0.0737 0.1382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1026 0.2194
Loa Loa (eye worm) hypothetical protein 0.0018 0.014 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0113 0.0206
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0116 0.0112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Entamoeba histolytica zinc finger protein, putative 0.0011 0.0058 0.0331
Echinococcus granulosus tankyrase 0.0011 0.0058 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0156 0.1489
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0057 0.0611 0.1146
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2024 0.5887
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.002
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0601
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.088 0.8573
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0116 0.0676
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0025 0.0053
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Echinococcus granulosus cyclin B 0.0018 0.014 0.0257
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0553 0.6536 1
Echinococcus granulosus poly adp ribose polymerase 2 0.0079 0.088 0.1652
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0113 0.0206
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1025 0.1022
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0831 0.4741
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0116 0.014
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0258 0.3008 0.4582
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0909
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Schistosoma mansoni tsg101-related 0.0056 0.0602 0.1287
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8059
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0737 0.1094
Loa Loa (eye worm) hypothetical protein 0.0048 0.0508 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Toxoplasma gondii hypothetical protein 0.0009 0.0033 0.0051
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0831 0.8099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0009
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1025 0.1022
Schistosoma mansoni cpg binding protein 0.0028 0.0263 0.0563
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0113 0.0206
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0079 0.088 0.1882
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4674 0.8806
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0033 0.0056
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0033 0.0071
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0116 0.0909
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Trypanosoma cruzi cyclin, putative 0.0018 0.014 0.1336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0508 0.0952
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0831 0.0828
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.5833
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0116 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Leishmania major hypothetical protein, conserved 0.0024 0.0222 0.1977
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus granulosus inositol monophosphatase 0.0008 0.0025 0.004
Echinococcus multilocularis cpg binding protein 0.0029 0.0282 0.0279
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0553 0.6536 1
Onchocerca volvulus 0.0028 0.0263 0.0757
Brugia malayi hypothetical protein 0.0016 0.0119 0.0217
Loa Loa (eye worm) Smad1 0.0008 0.0024 0.0039
Onchocerca volvulus Tankyrase homolog 0.0011 0.0058 0.0159
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0831 0.1561
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0359 0.3341
Schistosoma mansoni dep domain containing protein 0.0009 0.0033 0.0071
Schistosoma mansoni hypothetical protein 0.0397 0.4674 1
Brugia malayi N-terminal motif family protein 0.0175 0.2024 0.3809
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0025 0.0205
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0359 0.067
Schistosoma mansoni hypothetical protein 0.0008 0.0025 0.0053
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.045 0.5307 1
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.1028 0.1025
Onchocerca volvulus 0.0293 0.3435 1
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0188 0.1805
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0072 0.079 0.169
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.3478
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0033 0.0056
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0116 0.0909
Brugia malayi RNA binding protein 0.0071 0.0778 0.146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0637 0.1362
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0024 0.0021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.003
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0124 0.1408 0.2124
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Trypanosoma brucei mitotic cyclin 6 0.0018 0.014 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0222 0.2142
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Schistosoma mansoni cyclin B3 0.0018 0.014 0.03
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0016 0.0116 0.0326
Entamoeba histolytica cyclin family protein 0.0018 0.014 0.0825
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0553 0.6536 1
Brugia malayi hypothetical protein 0.0067 0.0737 0.1382
Onchocerca volvulus 0.0016 0.0116 0.0326
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0018 0.014 0.1154
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0601
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0222 0.2142
Echinococcus granulosus cyclin B3 1 0.0018 0.014 0.0257
Schistosoma mansoni hypothetical protein 0.0011 0.0061 0.0131
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0145 0.1659 0.1656
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0039
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0116 0.0658
Trichomonas vaginalis cyclin A, putative 0.0018 0.014 0.1336
Brugia malayi CXXC zinc finger family protein 0.0028 0.0263 0.0489
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0025 0.0205
Trypanosoma brucei beta lactamase 0.0124 0.1408 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0737 0.1094
Schistosoma mansoni dishevelled 0.0009 0.0033 0.0071
Loa Loa (eye worm) RNA binding protein 0.0071 0.0778 0.146
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0909
Loa Loa (eye worm) hypothetical protein 0.0079 0.088 0.1652
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0472 0.4587
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0145 0.1659 1
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0116 0.0535
Giardia lamblia Kinase, PLK 0.0092 0.1026 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0067 0.0737 0.0733
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0033 0.0056
Trichomonas vaginalis cyclin D, putative 0.0018 0.014 0.1336
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0359 0.3478
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0831 0.1239
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0211
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0222 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Loa Loa (eye worm) tnks protein 0.0011 0.0058 0.0103
Giardia lamblia Hypothetical protein 0.0018 0.014 0.1154
Brugia malayi Muscleblind-like protein 0.045 0.5307 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0033 0.003
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0116 0.1095
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0359 0.0768
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1026 0.1927
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.2418
Trypanosoma cruzi CYC2-like cyclin, putative 0.0018 0.014 0.1336
Brugia malayi hypothetical protein 0.0293 0.3435 0.647
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0778 0.146
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0033 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0024 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0113 0.0206
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0033 0.0056
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Trichomonas vaginalis cyclin B3, putative 0.0018 0.014 0.1336
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Brugia malayi Inositol-1 0.0075 0.0831 0.1561
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1026 1
Brugia malayi ethe1-prov protein 0.0016 0.0116 0.0211
Echinococcus granulosus smad 0.0008 0.0024 0.0039
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0211
Leishmania major hypothetical protein, conserved 0.0016 0.0116 0.0909
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0025 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.079 0.1482
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Echinococcus multilocularis Smad4 0.0008 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0156 0.0287
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0359 0.0356
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0831 0.5001
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Brugia malayi hypothetical protein 0.0072 0.079 0.1482
Brugia malayi WGR domain containing protein 0.0079 0.088 0.1652
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0113 0.011
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1025 0.1927
Schistosoma mansoni inositol monophosphatase 0.0075 0.0831 0.1779
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.014 0.0137
Leishmania major cyclin 0.0018 0.014 0.1154
Loa Loa (eye worm) inositol-1 0.0075 0.0831 0.1561
Mycobacterium ulcerans glyoxalase II, GloB 0.0016 0.0116 0.014
Entamoeba histolytica cyclin, putative 0.0018 0.014 0.0825
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0061 0.0109
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0116 0.0112
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0676
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0116 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0508 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Schistosoma mansoni cyclin B 0.0018 0.014 0.03
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0033 0.0056
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0116 0.0211
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.014 0.0257
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.3478
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0156 0.0949
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1025 0.1927
Echinococcus multilocularis muscleblind protein 0.045 0.5307 0.5305
Echinococcus multilocularis smad 0.0008 0.0024 0.0021
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0024 0.0039
Schistosoma mansoni kinase 0.0047 0.0487 0.1042
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1026 0.2978
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0116 0.0112
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1026 1
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0116 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.1095
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0033 0.003
Leishmania major DNA repair protein, putative 0.0019 0.0156 0.1311
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.015 0.1726 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0909
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0018 0.014 0.1154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0359 0.067
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0325 0.0607
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Mycobacterium leprae POSSIBLE HYDROLASE 0.0016 0.0116 0.014
Mycobacterium ulcerans lipoprotein LpqF 0.0124 0.1408 0.2124
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0188 0.1182
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0359 0.0768
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0069 0.0752 0.1608
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1026 0.1927
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0561 0.3153
Echinococcus multilocularis cyclin B3 1 0.0018 0.014 0.0137
Brugia malayi TAR-binding protein 0.0071 0.0778 0.146
Chlamydia trachomatis ribonuclease Z 0.0016 0.0116 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0116 0.0247
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Entamoeba histolytica cyclin family protein 0.0018 0.014 0.0825
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0116 0.0676
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0033 0.0056
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0467 0.0874
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0461 0.0862
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0025 0.0205
Loa Loa (eye worm) hypothetical protein 0.0175 0.2024 0.3809
Echinococcus granulosus GPCR family 2 0.0015 0.0113 0.0206
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0535
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Treponema pallidum ribonuclease Z 0.0016 0.0116 0.5
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0359 0.067
Mycobacterium tuberculosis Beta lactamase like protein 0.0016 0.0116 0.014
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0461 0.0457
Brugia malayi Tnks protein 0.0011 0.0058 0.0103
Loa Loa (eye worm) hypothetical protein 0.0293 0.3435 0.647
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0116 0.0909
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0033 0.0056
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0039
Echinococcus granulosus tar DNA binding protein 0.0071 0.0778 0.146
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.011 0.1246 0.2342
Onchocerca volvulus Putative hydrolase PNKD 0.0016 0.0116 0.0326
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0025 0.0205
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1025 0.1927
Trypanosoma cruzi cyclin, putative 0.0018 0.014 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0065 0.0601
Giardia lamblia Cyclin A 0.0018 0.014 0.1154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0461 0.0457
Echinococcus granulosus Smad4 0.0008 0.0024 0.0039
Entamoeba histolytica hypothetical protein 0.0022 0.0199 0.1178
Mycobacterium ulcerans beta lactamase-like protein 0.0016 0.0116 0.014
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0461 0.0862
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0778 0.146
Echinococcus multilocularis ETHE1 protein 0.0016 0.0116 0.0112
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Echinococcus multilocularis tankyrase 0.0011 0.0058 0.0055
Schistosoma mansoni cyclins 0.0018 0.014 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0004 0.0008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0013 0.0018
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0025 0.004
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.014 0.1336
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0831 0.8099
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.079 0.169
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0112
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1026 0.1927
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1026 0.6175
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.1095
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0013 0.0009
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0039
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.0658
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0116 0.0211
Echinococcus multilocularis muscleblind protein 1 0.045 0.5307 0.5305
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.079 0.0786
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.1095
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0359 0.067
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0359 0.067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.0413
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0016 0.0116 0.014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0831 0.8099
Onchocerca volvulus 0.0016 0.0116 0.0326
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0116 0.1095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0508 0.0952
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0124 0.1408 0.2124
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1315 0.2472
Onchocerca volvulus 0.0018 0.014 0.0398
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0778 0.0775
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0145 0.1659 0.3549
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0116 0.0247
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0116 0.014
Schistosoma mansoni tsg101-related 0.0056 0.0602 0.1287
Schistosoma mansoni tsg101-related 0.0046 0.0479 0.1024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0033 0.0327 0.0323
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0222 0.1163
Leishmania major hypothetical protein, conserved 0.0022 0.0188 0.1633
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0676
Brugia malayi hypothetical protein 0.0024 0.0222 0.0413
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0079 0.088 0.0876
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0479 0.2871
Brugia malayi hypothetical protein 0.0009 0.0033 0.0056
Schistosoma mansoni dishevelled 0.0009 0.0033 0.0071
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0156 0.1489
Brugia malayi WGR domain containing protein 0.0145 0.1659 0.3121
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Entamoeba histolytica cyclin, putative 0.0018 0.014 0.0825
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0461 0.0862
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0156 0.0949
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0065 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Brugia malayi hypothetical protein 0.0009 0.0033 0.0056
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0033 0.003
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.0658
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0778 0.146
Echinococcus granulosus ETHE1 protein 0.0016 0.0116 0.0211
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0359 0.3341
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0024 0.0039
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Schistosoma mansoni hypothetical protein 0.0176 0.2034 0.4353
Onchocerca volvulus DNA ligase 3 homolog 0.0019 0.0156 0.0444
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0025 0.0021
Echinococcus granulosus WGR domain containing protein 0.0045 0.0467 0.0874
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Echinococcus multilocularis cyclin b3 0.0018 0.014 0.0137
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0033 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0033 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0472 0.4587
Echinococcus granulosus geminin 0.0176 0.2034 0.3829
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0113 0.0206
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0033 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0025 0.004
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0033 0.0086
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0116 0.1095
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Echinococcus granulosus cpg binding protein 0.0029 0.0282 0.0525
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0033 0.0071
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0116 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0025 0.0127
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0116 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Schistosoma mansoni hypothetical protein 0.0033 0.0325 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0116 0.014
Trypanosoma brucei polo-like protein kinase 0.0092 0.1026 0.7238
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0025 0.0205
Plasmodium falciparum cyclin 0.0018 0.014 0.2296
Echinococcus granulosus muscleblind protein 0.045 0.5307 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0061 0.0058
Schistosoma mansoni Smad4 0.0008 0.0024 0.0052
Echinococcus multilocularis geminin 0.0176 0.2034 0.2032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0025 0.0127
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0039
Brugia malayi Smad1 0.0008 0.0024 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0222 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0359 0.3478
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0325 0.0607
Schistosoma mansoni tankyrase 0.0011 0.0058 0.0125
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0359 0.0356
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0025 0.0205
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0263 0.0489
Schistosoma mansoni cpg binding protein 0.0029 0.0282 0.0604
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0032 0.0053
Trichomonas vaginalis hypothetical protein 0.0033 0.0323 0.3125
Schistosoma mansoni smad 0.0008 0.0024 0.0052
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Brugia malayi MH2 domain containing protein 0.0116 0.1315 0.2472
Loa Loa (eye worm) hypothetical protein 0.0018 0.014 0.0257
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1026 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0461 0.0862
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0113 0.011
Echinococcus granulosus cyclin b3 0.0018 0.014 0.0257
Onchocerca volvulus 0.0009 0.0033 0.0086
Schistosoma mansoni hypothetical protein 0.0008 0.0025 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0024 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0116 0.0211
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.045 0.5307 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0113 0.011
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Trichomonas vaginalis A-type flavoprotein 0.0016 0.0116 0.1095
Schistosoma mansoni hypothetical protein 0.0092 0.1028 0.2201
Brugia malayi DIX domain containing protein 0.0009 0.0033 0.0056
Echinococcus granulosus poly ADP ribose polymerase 1 0.0145 0.1659 0.3121
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.002

Activities

Activity type Activity value Assay description Source Reference
Hydrolysis (functional) = 0.8 Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney ChEMBL. 6245211
I50 (binding) = 33 uM Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM ChEMBL. 6245211
I50 (binding) = 83 uM Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM ChEMBL. 6245211
Ka' (binding) = 1.5 Activate a partially purified type II cAMP-dependent protein kinase from bovine brain ChEMBL. 6245211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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