Detailed information for compound 1354847

Basic information

Technical information
  • TDR Targets ID: 1354847
  • Name: (1,3-dioxoisoindol-2-yl) 4-fluoro-3-methylben zenesulfonate
  • MW: 335.307 | Formula: C15H10FNO5S
  • H donors: 0 H acceptors: 4 LogP: 2.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1C)S(=O)(=O)ON1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C15H10FNO5S/c1-9-8-10(6-7-13(9)16)23(20,21)22-17-14(18)11-4-2-3-5-12(11)15(17)19/h2-8H,1H3
  • InChiKey: JLBSSWRLMYEVNP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (1,3-dioxoisoindolin-2-yl) 4-fluoro-3-methyl-benzenesulfonate
  • 4-fluoro-3-methylbenzenesulfonic acid (1,3-dioxo-2-isoindolinyl) ester
  • 4-fluoro-3-methyl-benzenesulfonic acid (1,3-diketoisoindolin-2-yl) ester
  • (1,3-dioxoisoindol-2-yl) 4-fluoro-3-methyl-benzenesulfonate
  • ZINC02685096

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0359 0.0215
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2834 0.2833
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0045 0.0065
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0045 0.0044
Schistosoma mansoni importin beta-1 0.0035 0.063 0.0629
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0375 0.0373
Leishmania major importin beta-1 subunit, putative 0.0028 0.0447 0.0295
Echinococcus multilocularis geminin 0.0205 0.5353 0.5352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0652 0.113
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0664 0.0663
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6182 0.8913
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0447 0.3337
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0664 0.0663
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2834 0.2833
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2002 0.2001
Onchocerca volvulus 0.01 0.2454 0.3221
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.039 0.0584
Schistosoma mansoni hypothetical protein 0.0372 1 1
Onchocerca volvulus 0.0028 0.0443 0.058
Brugia malayi chromobox protein homolog 3 0.0047 0.0974 0.1462
Toxoplasma gondii thioredoxin reductase 0.0103 0.252 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2002 0.2584
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0508 0.0544
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0652 0.113
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0447 0.0647
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0257 0.0857
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6182 0.8947
Onchocerca volvulus 0.0052 0.1117 0.1465
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0652 0.113
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0447 0.1625
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0652 0.0802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.039 0.0584
Treponema pallidum NADH oxidase 0.0036 0.0652 1
Schistosoma mansoni chromobox protein 0.0014 0.0045 0.0044
Loa Loa (eye worm) helicase 0.0014 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0047 0.0974 0.0972
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0652 0.0802
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.1169 0.1533
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2537 0.2536
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.2454 0.2453
Mycobacterium ulcerans polyketide synthase 0.003 0.0498 0.4065
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0652 0.113
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1232 0.1568
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0375 0.1332
Brugia malayi glutathione reductase 0.0103 0.252 0.3788
Echinococcus granulosus chromobox protein 1 0.0084 0.2002 0.2001
Echinococcus granulosus chromobox protein 2 0.0014 0.0045 0.0044
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0359 0.2064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0042 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.6652 0.6651
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.252 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0911 0.1319
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.691 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.063 0.2365
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.063 0.1039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0447 0.0531
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0498 0.0423
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0652 0.0651
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0508 0.1873
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0045 0.0044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6182 0.8947
Onchocerca volvulus 0.0286 0.7617 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2537 0.2536
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0447 0.0347
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6182 0.8947
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0591 0.0721
Entamoeba histolytica hypothetical protein 0.0028 0.0447 0.1442
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0375 0.0561
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.01 0.2454 0.2453
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0652 0.113
Brugia malayi Pre-SET motif family protein 0.0036 0.0664 0.0997
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6182 0.8947
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.055 0.0796
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0045 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0664 0.0663
Plasmodium falciparum glutathione reductase 0.0103 0.252 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0628 0.0626
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0084 0.016
Brugia malayi Heterochromatin protein 1 0.0084 0.2002 0.3008
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0447 0.3337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0664 0.0663
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0335 0.0179
Plasmodium vivax importin-beta 2, putative 0.0035 0.063 0.2365
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0974 0.1277
Schistosoma mansoni chromobox protein 0.0014 0.0045 0.0044
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0375 0.1332
Loa Loa (eye worm) glutathione reductase 0.0103 0.252 0.2519
Onchocerca volvulus 0.0014 0.0045 0.0057
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.055 0.0796
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0045 0.0065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0498 0.0423
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0508 0.0544
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0375 0.0373
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.063 0.1039
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2834 0.372
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0498 0.0721
Brugia malayi hypothetical protein 0.0014 0.0045 0.0065
Plasmodium vivax glutathione reductase, putative 0.0103 0.252 1
Mycobacterium ulcerans thioesterase 0.0025 0.0359 0.2064
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0652 0.113
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0652 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0346 0.05
Giardia lamblia Kinase, PLK 0.0114 0.2834 1
Schistosoma mansoni chromobox protein 0.0084 0.2002 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0974 0.1226
Plasmodium falciparum glutathione reductase 0.0036 0.0652 0.2454
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0335 0.172
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0359 0.0519
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0447 0.1625
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0652 0.2454
Plasmodium falciparum importin beta, putative 0.0035 0.063 0.2365
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0137 0.0199
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0652 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0447 0.0295
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.2454 0.2453
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.055 0.0796
Echinococcus multilocularis Chromo domain 0.0014 0.0045 0.0044
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2834 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0375 0.1332
Leishmania major trypanothione reductase 0.0103 0.252 0.8724
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0045 0.0044
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0652 0.0944
Brugia malayi Thioredoxin reductase 0.0103 0.252 0.3788
Entamoeba histolytica hypothetical protein 0.0028 0.0447 0.1442
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1073 0.1407
Echinococcus granulosus Chromo domain 0.0014 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.063 0.0629
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.2454 0.2453
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0443 0.0641
Brugia malayi hypothetical protein 0.003 0.0508 0.0763
Schistosoma mansoni kinase 0.0058 0.1274 0.1273
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.691 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.252 0.8724
Schistosoma mansoni hypothetical protein 0.0205 0.5353 0.5352
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.691 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0447 0.0531
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.252 0.3647
Brugia malayi Importin beta-1 subunit 0.0035 0.063 0.0946
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.055 0.481
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0652 0.2454
Brugia malayi hypothetical protein 0.002 0.0208 0.0311
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0652 0.113
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6182 0.8947
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0508 0.1873
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0652 0.6282
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0447 0.0295
Mycobacterium ulcerans polyketide synthase 0.0032 0.055 0.481
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0911 0.1041
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0045 0.0065
Loa Loa (eye worm) fatty acid synthase 0.003 0.0487 0.0486
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0652 0.113
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1232 0.1568
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.055 0.0501
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0045 0.0044
Brugia malayi RNA, U transporter 1 0.0099 0.2416 0.3631
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0498 0.4065
Schistosoma mansoni hypothetical protein 0.0014 0.0042 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Loa Loa (eye worm) hypothetical protein 0.0036 0.0664 0.0663
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.0689
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2834 0.426
Trichomonas vaginalis ran, putative 0.0026 0.0375 0.0435
Echinococcus granulosus importin subunit beta 1 0.0035 0.063 0.0629
Onchocerca volvulus 0.005 0.1047 0.1374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0443 0.0664
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0042 0.004
Onchocerca volvulus 0.0014 0.0045 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.1047 0.1046
Onchocerca volvulus 0.0037 0.069 0.0904
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0045 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.252 0.2519
Echinococcus granulosus chromobox protein 1 0.0084 0.2002 0.2001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0447 0.0295
Trichomonas vaginalis set domain proteins, putative 0.0286 0.7617 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0335 0.172
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0974 0.1226
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0652 0.2454
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Brugia malayi Protein cec-1. 0.0014 0.0045 0.0065
Plasmodium falciparum thioredoxin reductase 0.0103 0.252 1
Echinococcus granulosus Chromobox protein 3 0.0014 0.0045 0.0044
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2834 0.2833
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0652 0.0979
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2834 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0375 0.0373
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0652 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0262 0.038
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1073 0.1358
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0045 0.0044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0664 0.2503
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0045 0.0044
Brugia malayi CHD4 protein 0.0014 0.0045 0.0065
Loa Loa (eye worm) hypothetical protein 0.0051 0.1066 0.1065
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.2454 0.3688
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1073 0.1358
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0664 0.0663
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0498 0.0747
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0508 0.0544
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.055 0.0501
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0498 0.0721
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0911 1
Schistosoma mansoni chromobox protein 0.0084 0.2002 0.2001
Loa Loa (eye worm) hypothetical protein 0.003 0.0508 0.0507
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.055 0.0501
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0498 0.4065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0652 0.6282
Schistosoma mansoni ran 0.0026 0.0375 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0591 0.0721
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2834 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.055 0.481
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0447 0.1625
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.1247 0.1872
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2834 1
Brugia malayi Pre-SET motif family protein 0.0251 0.6652 1
Mycobacterium tuberculosis Probable reductase 0.0234 0.6182 0.8947
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0508 0.1873
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.691 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.2002 0.2001
Schistosoma mansoni ran 0.0026 0.0375 0.0373
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0652 0.2454
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0472 0.0684
Trypanosoma brucei trypanothione reductase 0.0103 0.252 0.8724
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0443 0.0442
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0652 0.113
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0652 0.2454
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0911 0.1319
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.055 0.204
Echinococcus multilocularis importin subunit beta 1 0.0035 0.063 0.0629
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0045 0.0044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0652 0.0651
Plasmodium falciparum thioredoxin reductase 0.0036 0.0652 0.2454
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0652 0.2454
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2834 0.3684
Schistosoma mansoni hypothetical protein 0.0205 0.5353 0.5352
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0472 0.0684
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0204 0.0644
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0447 0.0531
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0046 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Leishmania major hypothetical protein, conserved 0.003 0.0508 0.0544
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0652 0.113
Plasmodium vivax SET domain protein, putative 0.0036 0.0664 0.2503
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0129
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0447 0.1625
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0664 0.0663
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0044
Echinococcus multilocularis snurportin 1 0.0372 1 1
Echinococcus granulosus geminin 0.0205 0.5353 0.5352
Brugia malayi SET domain containing protein 0.0015 0.0082 0.0121
Entamoeba histolytica Ran family GTPase 0.0026 0.0375 0.1182
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0045 0.0065
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0498 0.0721
Trypanosoma brucei polo-like protein kinase 0.0114 0.2834 1
Echinococcus multilocularis chromobox protein 2 0.0014 0.0045 0.0044
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0508 0.1873
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0652 0.6282
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2834 0.2833
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0498 0.4065
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0652 0.113
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0045 0.0044
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0498 0.4065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0652 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2002 0.2584
Echinococcus multilocularis chromobox protein 1 0.0084 0.2002 0.2001

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 112.219 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
IC50 (functional) 2.07 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 2.43 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.7016 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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