Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0123 | 0.0123 |
Trypanosoma brucei | RNA helicase, putative | 0.0099 | 0.6215 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0123 | 0.0123 |
Giardia lamblia | Ribonuclease H | 0.0026 | 0.0677 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.1159 | 0.17 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0677 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0123 | 0.0123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3769 | 0.5984 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3769 | 0.5984 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3769 | 0.3769 |
Schistosoma mansoni | lamin | 0.0033 | 0.1159 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1113 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1817 | 0.1817 |
Toxoplasma gondii | ribonuclease HI protein | 0.0026 | 0.0677 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0026 | 0.0677 | 0.152 |
Echinococcus granulosus | ribonuclease H1 | 0.0026 | 0.0677 | 0.152 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3276 | 0.3276 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3276 | 0.3276 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3769 | 0.3769 |
Echinococcus granulosus | lamin | 0.0033 | 0.1159 | 0.2841 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1159 | 0.1159 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3769 | 0.3769 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.8285 | 0.8285 |
Onchocerca volvulus | 0.0033 | 0.1159 | 0.0517 | |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1159 | 0.2841 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3769 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3769 | 0.3769 |
Schistosoma mansoni | phosphoglucomutase | 0.0026 | 0.0677 | 0.091 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0848 | 0.0309 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0848 | 0.0309 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.8285 | 0.8285 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0026 | 0.0677 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0848 | 0.0309 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0677 | 0.0677 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3769 | 0.5984 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.8285 | 0.8285 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3769 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3769 | 0.5984 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1817 | 0.1817 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3276 | 0.3276 |
Leishmania major | ribonuclease H1, putative | 0.0026 | 0.0677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3276 | 0.3276 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0677 | 0.0677 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3769 | 0.5984 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1159 | 0.2841 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0026 | 0.0677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.1159 | 0.0517 | |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1159 | 0.1159 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0848 | 0.0309 |
Schistosoma mansoni | phosphoglucomutase | 0.0026 | 0.0677 | 0.091 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3769 | 0.3769 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1159 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1159 | 0.1159 |
Schistosoma mansoni | phosphoglucomutase | 0.0026 | 0.0677 | 0.091 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0026 | 0.0677 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.0848 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.6215 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1159 | 0.1159 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1159 | 0.2841 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3769 | 0.3769 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1159 | 0.2841 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0026 | 0.0677 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1817 | 0.278 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1159 | 0.2841 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0123 | 0.0123 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1159 | 0.1159 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0026 | 0.0677 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.