TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.729 | Formula: C32H42N8
H donors: 4 H acceptors: 3 LogP: 6.08 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: C=CCNc1nc(NCCN2CCC(CC2)NCC2c3ccccc3CCc3c2cccc3)nc(n1)NCC=C
InChi: 1S/C32H42N8/c1-3-17-33-30-37-31(34-18-4-2)39-32(38-30)35-19-22-40-20-15-26(16-21-40)36-23-29-27-11-7-5-9-24(27)13-14-25-10-6-8-12-28(25)29/h3-12,26,29,36H,1-2,13-23H2,(H3,33,34,35,37,38,39)
InChiKey: BTCHIXWVGRGIJS-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.006	0.0059
Echinococcus multilocularis	chromobox protein 1	0.0011	0.0051	0.005
Echinococcus multilocularis	carboxylesterase 5A	0.1248	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.006	0.0059
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0015	0.008	0.0769
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.006	0.0059
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.006	0.0059
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.006	0.0059
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.006	0.0059
Trypanosoma brucei	adenosine transporter, putative	0.0015	0.008	0.0089
Echinococcus granulosus	histone deacetylase 3	0.001	0.0042	0.0041
Brugia malayi	Animal haem peroxidase family protein	0.0522	0.4157	0.4157
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0028	0.0185	0.0184
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0051	0.0291
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.006	0.0059
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Brugia malayi	G-protein coupled receptor	0.0012	0.006	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Onchocerca volvulus		0.0105	0.0808	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trypanosoma brucei	unspecified product	0.0015	0.008	0.0089
Loa Loa (eye worm)	jmjC domain-containing protein	0.0006	0.0006	0.0006
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0033	0.0228	0.0228
Echinococcus multilocularis	somatostatin receptor	0.0012	0.006	0.0059
Leishmania major	histone deacetylase, putative	0.001	0.0042	0.0365
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.006	0.006
Loa Loa (eye worm)	notch protein	0.0105	0.0808	0.0808
Echinococcus granulosus	protein jagged 2	0.0105	0.0808	0.0807
Echinococcus multilocularis	neurogenic locus notch protein	0.0105	0.0808	0.0807
Brugia malayi	G-protein coupled receptor	0.0012	0.006	0.0059
Plasmodium vivax	histone deacetylase 1, putative	0.001	0.0042	0.4223
Onchocerca volvulus		0.0012	0.006	0.0145
Brugia malayi	jmjC domain containing protein	0.0015	0.0084	0.0083
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus granulosus	carbonic anhydrase II	0.0124	0.0954	0.0954
Brugia malayi	latrophilin 2 splice variant baaae	0.0005	0.0003	0.0003
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0012	0.006	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0025	0.0025
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0037	0.0257	0.0256
Onchocerca volvulus		0.0012	0.006	0.0145
Brugia malayi	Blistered cuticle protein 3	0.0522	0.4157	0.4157
Trichomonas vaginalis	set domain proteins, putative	0.0037	0.0259	0.155
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Trypanosoma brucei	adenosine transporter 2, putative	0.0015	0.008	0.0089
Onchocerca volvulus		0.0522	0.4157	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.006	0.0059
Schistosoma mansoni	hypothetical protein	0.0226	0.1774	0.1773
Schistosoma mansoni	neuropeptide receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus		0.0012	0.006	0.0145
Brugia malayi	Animal haem peroxidase family protein	0.0522	0.4157	0.4157
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.006	0.0059
Onchocerca volvulus		0.0012	0.006	0.0145
Trypanosoma brucei	purine nucleoside transporter	0.0015	0.008	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0015	0.0084	0.0083
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.006	0.0059
Onchocerca volvulus		0.0012	0.006	0.0145
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0006	0.0007	0.5
Mycobacterium tuberculosis	Probable reductase	0.0038	0.027	0.1616
Entamoeba histolytica	nucleoside transporter, putative	0.0015	0.008	1
Brugia malayi	RE15519p	0.0012	0.006	0.0059
Echinococcus granulosus	histone deacetylase 1	0.001	0.0042	0.0041
Onchocerca volvulus		0.0105	0.0808	0.1943
Echinococcus granulosus	lipoxygenase domain containing protein	0.0007	0.0016	0.0015
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.006	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Trypanosoma cruzi	nucleobase transporter, putative	0.0015	0.008	0.0769
Echinococcus multilocularis	histone deacetylase 3	0.001	0.0042	0.0041
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Schistosoma mansoni	histamine h1 receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0011	0.0046	0.0045
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.006	0.0059
Loa Loa (eye worm)	Notch2	0.0105	0.0808	0.0808
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0028	0.0185	0.0184
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0016	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Mycobacterium ulcerans	carboxylesterase, LipT	0.0211	0.1657	1
Brugia malayi	hypothetical protein	0.0015	0.008	0.0079
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0011	0.0046	0.0045
Loa Loa (eye worm)	hypothetical protein	0.1248	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0011	0.0046	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0042	0.0042
Echinococcus multilocularis	survival motor neuron protein 1	0.0037	0.0258	0.0258
Leishmania major	inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040	0.0015	0.008	0.0769
Onchocerca volvulus		0.0012	0.006	0.0145
Schistosoma mansoni	hypothetical protein	0.0008	0.0021	0.002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Trypanosoma brucei	trypanothione reductase	0.0017	0.0096	0.0109
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	heterochromatin protein 1	0.0011	0.0051	0.0051
Onchocerca volvulus		0.0023	0.0146	0.035
Onchocerca volvulus		0.0211	0.1657	0.3985
Schistosoma mansoni	histone deacetylase	0.001	0.0042	0.0041
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.006	0.0059
Toxoplasma gondii	transporter, cation channel family protein	0.001	0.0039	0.0044
Echinococcus granulosus	survival motor neuron protein 1	0.0037	0.0258	0.0258
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0006	0.0006	0.0005
Echinococcus multilocularis	serotonin receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.006	0.0059
Trichomonas vaginalis	chromobox protein, putative	0.0007	0.0015	0.0075
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Echinococcus granulosus	neurogenic locus notch protein 4	0.0105	0.0808	0.0807
Plasmodium vivax	thioredoxin reductase, putative	0.0017	0.0096	1
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Schistosoma mansoni	carbonic anhydrase-related	0.0074	0.0553	0.0552
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0028	0.0185	0.0184
Schistosoma mansoni	hypothetical protein	0.0007	0.0016	0.0015
Schistosoma mansoni	amine GPCR	0.0012	0.006	0.0059
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Schistosoma mansoni	chromobox protein	0.0011	0.0051	0.005
Brugia malayi	neuropeptide F receptor	0.0012	0.006	0.0059
Brugia malayi	Calcium binding EGF domain containing protein	0.0105	0.0808	0.0807
Schistosoma mansoni	opsin-like receptor	0.0012	0.006	0.0059
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0015	0.008	0.0089
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0015	0.008	0.0079
Echinococcus multilocularis	sex peptide receptor	0.0012	0.006	0.0059
Brugia malayi	Dopamine receptor protein 2	0.0012	0.006	0.0059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.006	0.0059
Echinococcus granulosus	notch	0.0105	0.0808	0.0807
Brugia malayi	Animal haem peroxidase family protein	0.0522	0.4157	0.4157
Brugia malayi	hypothetical protein	0.0037	0.0258	0.0258
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0007	0.0019	0.0098
Schistosoma mansoni	opsin-like receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0008	0.0023	0.0023
Trypanosoma brucei	adenosine transporter 2, putative	0.0015	0.008	0.0089
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.006	0.0059
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0124	0.0954	0.0954
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.006	0.0059
Echinococcus granulosus	slit 2 protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0005	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0006	0.0007	0.003
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0015	0.008	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0011	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0553	0.0553
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.001	0.0039	0.033
Echinococcus granulosus	protein jagged 1	0.0105	0.0808	0.0807
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0074	0.0553	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0076	0.0445
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Loa Loa (eye worm)	hypothetical protein	0.001	0.0039	0.0039
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Brugia malayi	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.006	0.0059
Schistosoma mansoni	cell polarity protein	0.0105	0.0808	0.0807
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0033	0.0228	0.0228
Trypanosoma cruzi	histone deacetylase 1, putative	0.001	0.0042	0.0365
Echinococcus granulosus	RUN	0.0007	0.0016	0.0015
Schistosoma mansoni	acetylcholinesterase	0.0211	0.1657	0.1656
Echinococcus multilocularis	carbonic anhydrase II	0.0124	0.0954	0.0954
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0008	0.0021	0.002
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	calcium channel	0.0028	0.0185	0.0185
Echinococcus granulosus	voltage dependent calcium channel	0.0028	0.0185	0.0184
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	histone deacetylase 1	0.001	0.0042	0.0042
Brugia malayi	Thioredoxin reductase	0.0017	0.0096	0.0095
Onchocerca volvulus	Peroxidase homolog	0.0522	0.4157	1
Echinococcus granulosus	protein jagged 1	0.0105	0.0808	0.0807
Echinococcus granulosus	g protein coupled receptor	0.0012	0.006	0.0059
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Loa Loa (eye worm)	blistered cuticle protein 3	0.0522	0.4157	0.4157
Echinococcus multilocularis	protein jagged 2	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Loa Loa (eye worm)	carbonic anhydrase 3	0.0124	0.0954	0.0954
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0043	0.0304	0.1824
Loa Loa (eye worm)	carboxylesterase	0.0211	0.1657	0.1657
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0092	0.0543
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0028	0.0185	0.0184
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0011	0.005	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus granulosus	BC026374 protein S09 family	0.0211	0.1657	0.1656
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Onchocerca volvulus		0.0105	0.0808	0.1943
Trypanosoma brucei	adenosine transporter 2, putative	0.0015	0.008	0.0089
Schistosoma mansoni	slit	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Onchocerca volvulus	Neurogenic locus notch homolog	0.0105	0.0808	0.1944
Echinococcus granulosus	neural cadherin	0.0105	0.0808	0.0807
Echinococcus granulosus	jun protein	0.0029	0.0196	0.0195
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0005	0.0001	0.0000000039155
Echinococcus multilocularis	voltage dependent calcium channel	0.0028	0.0185	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus	Peroxidasin homolog	0.0522	0.4157	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0006	0.0007	0.003
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0211	0.1657	0.1656
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0211	0.1657	0.1656
Echinococcus multilocularis	carbonic anhydrase	0.0074	0.0553	0.0552
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0006	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0038	0.027	0.1616
Echinococcus granulosus	carbonic anhydrase	0.0074	0.0553	0.0552
Plasmodium falciparum	glutathione reductase	0.0017	0.0096	0.17
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.008
Onchocerca volvulus		0.0008	0.0021	0.0051
Trichomonas vaginalis	chromobox protein, putative	0.0007	0.0015	0.0075
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.006	0.0059
Onchocerca volvulus		0.0211	0.1657	0.3985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus multilocularis	acetylcholinesterase	0.1248	1	1
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Echinococcus multilocularis	protein jagged 1	0.0105	0.0808	0.0807
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0087	0.0087
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0007	0.0019	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0258	0.0258
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0013	0.0069	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Schistosoma mansoni	jumonji domain containing protein	0.0012	0.0059	0.0058
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0007	0.0019	0.0018
Brugia malayi	Nucleoside transporter family protein	0.0015	0.008	0.0079
Schistosoma mansoni	myosin xvIII	0.0012	0.006	0.0059
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0105	0.0808	0.0807
Schistosoma mansoni	rab6-interacting	0.0007	0.0016	0.0015
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0124	0.0954	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.006	0.006
Toxoplasma gondii	NADPH-glutathione reductase	0.0006	0.0007	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.006	0.0059
Echinococcus granulosus	geminin	0.0226	0.1774	0.1773
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0076	0.0445
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0076	0.0445
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	geminin	0.0226	0.1774	0.1773
Schistosoma mansoni	carbonic anhydrase-related	0.0074	0.0553	0.0552
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0006	0.0007	0.009
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trypanosoma brucei	adenosine transporter 2, putative	0.0015	0.008	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Mycobacterium tuberculosis	Probable oxidoreductase	0.0043	0.0304	0.1824
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0005	0.0001	0.0000000039155
Toxoplasma gondii	hypothetical protein	0.0009	0.0029	0.0033
Loa Loa (eye worm)	thioredoxin reductase	0.0017	0.0096	0.0096
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0015	0.008	0.0089
Schistosoma mansoni	amine GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	serotonin receptor	0.0012	0.006	0.0059
Brugia malayi	notch-like transmembrane receptor	0.0105	0.0808	0.0807
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0012	0.006	0.0145
Schistosoma mansoni	septate junction protein	0.0105	0.0808	0.0807
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0006	0.0007	0.0007
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0033	0.0228	0.1365
Echinococcus multilocularis	jun protein	0.0029	0.0196	0.0195
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Chlamydia trachomatis	dipeptidase	0.0075	0.0563	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0007	0.0016	0.0015
Schistosoma mansoni	hypothetical protein	0.0005	0.0003	0.0003
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Trypanosoma brucei	unspecified product	0.0015	0.008	0.0089
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0074	0.0553	0.0552
Loa Loa (eye worm)	animal heme peroxidase	0.0522	0.4157	0.4157
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.006	0.0059
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.006	0.0059
Loa Loa (eye worm)	animal heme peroxidase	0.0522	0.4157	0.4157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0038	0.0038
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.006	0.0059
Brugia malayi	glutathione reductase	0.0017	0.0096	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Schistosoma mansoni	jun-related protein	0.0024	0.0152	0.0151
Brugia malayi	AKH receptor	0.0012	0.006	0.0059
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.006	0.0059
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0124	0.0954	0.0954
Toxoplasma gondii	nucleoside transporter protein	0.1021	0.8169	1
Toxoplasma gondii	nucleoside transporter protein	0.0015	0.008	0.0095
Echinococcus multilocularis	notch	0.0105	0.0808	0.0807
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.006	0.006
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Onchocerca volvulus	Netrin receptor homolog	0.0005	0.0001	0.0002
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0017	0.0096	0.0566
Leishmania major	carbonic anhydrase-like protein	0.0124	0.0954	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0553	0.0552
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0011	0.0046	0.0045
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0026	0.0167	0.0166
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.006	0.0059
Echinococcus multilocularis	fibropellin Ia	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Toxoplasma gondii	EGF family domain-containing protein	0.0105	0.0808	0.0986
Brugia malayi	Dopamine receptor protein 1	0.0012	0.006	0.0059
Echinococcus multilocularis	lysine specific demethylase 5A	0.0006	0.0006	0.0005
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.006	0.0059
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0007	0.0019	0.0098
Schistosoma mansoni	equilibrative nucleoside transporter	0.0015	0.008	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0553	0.0553
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.006	0.0059
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0006	0.0007	0.0007
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0029	0.0196	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0087	0.0087
Brugia malayi	Dopamine receptor	0.0012	0.006	0.0059
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Echinococcus granulosus	chromobox protein 1	0.0011	0.0051	0.005
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0011	0.0046	0.0046
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.006	0.0059
Leishmania major	histone deacetylase, putative	0.001	0.0042	0.0365
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.006	0.0059
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0006	0.0007	0.0531
Schistosoma mansoni	laminin gamma-3 chain	0.0105	0.0808	0.0807
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0074	0.0553	0.0552
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0006	0.0007	0.0531
Brugia malayi	hypothetical protein	0.0007	0.0016	0.0015
Brugia malayi	Doublecortin family protein	0.0007	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Echinococcus granulosus	carbonic anhydrase	0.0074	0.0553	0.0552
Schistosoma mansoni	amine GPCR	0.0012	0.006	0.0059
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0015	0.008	0.0193
Schistosoma mansoni	microtubule-associated protein tau	0.0108	0.083	0.0829
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.006	0.0059
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0015	0.008	0.0769
Plasmodium falciparum	carbonic anhydrase	0.0074	0.0553	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.0059
Onchocerca volvulus	Peroxidase homolog	0.0522	0.4157	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Onchocerca volvulus	Peroxidasin homolog	0.0522	0.4157	1
Brugia malayi	Cadherin domain containing protein	0.0105	0.0808	0.0807
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.006	0.0059
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0124	0.0954	0.0954
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Brugia malayi	sulfakinin receptor protein	0.0012	0.006	0.0059
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0006	0.0007	0.0006
Schistosoma mansoni	rab6-interacting	0.0007	0.0016	0.0015
Onchocerca volvulus	Slit protein homolog	0.0105	0.0808	0.1943
Brugia malayi	GnHR receptor homolog	0.0012	0.006	0.0059
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0006	0.0007	0.003
Trichomonas vaginalis	glutathione reductase, putative	0.0006	0.0007	0.003
Brugia malayi	Animal haem peroxidase family protein	0.0522	0.4157	0.4157
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0016	0.0092	0.0896
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.006	0.006
Brugia malayi	Calcium binding EGF domain containing protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0029	0.019	0.019
Onchocerca volvulus		0.0211	0.1657	0.3985
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0031	0.021	0.021
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0011	0.0046	0.0045
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.006	0.006
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0007	0.0019	0.0098
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Echinococcus multilocularis	acetylcholinesterase	0.1248	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0105	0.0808	0.0807
Schistosoma mansoni	biogenic amine receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	peroxidasin	0.0522	0.4157	0.4157
Echinococcus granulosus	neurogenic locus protein delta	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Plasmodium vivax	glutathione reductase, putative	0.0017	0.0096	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.006	0.0059
Brugia malayi	Uncoordinated protein 44	0.0005	0.0001	0.0000000039155
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0015	0.008	0.0089
Schistosoma mansoni	carbonic anhydrase-related	0.0074	0.0553	0.0552
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0051	0.0291
Trypanosoma brucei	histone deacetylase 1	0.001	0.0042	0.0042
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0015	0.008	0.0769
Schistosoma mansoni	hypothetical protein	0.0226	0.1774	0.1773
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0019	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.001	0.0042	0.0239
Echinococcus granulosus	neuropeptide receptor	0.0012	0.006	0.0059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.006	0.0059
Brugia malayi	neuropeptide F receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0028	0.0185	0.0184
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.006	0.0059
Brugia malayi	Melatonin receptor type 1A	0.0012	0.006	0.0059
Schistosoma mansoni	voltage-gated cation channel	0.0028	0.0185	0.0184
Trypanosoma brucei	nucleoside transporter 1, putative	0.0015	0.008	0.0089
Brugia malayi	hypothetical protein	0.0015	0.008	0.0079
Echinococcus multilocularis	carbonic anhydrase	0.0074	0.0553	0.0552
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0007	0.0016	0.0015
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0074	0.0553	0.0552
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Leishmania major	trypanothione reductase	0.0017	0.0096	0.0936
Trichomonas vaginalis	spcc417.12 protein, putative	0.0211	0.1657	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0033	0.0228	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.0001
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.1657	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0033	0.0228	0.1365
Entamoeba histolytica	nucleoside transporter, putative	0.0015	0.008	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	polycystin 1-related	0.0007	0.0016	0.0015
Loa Loa (eye worm)	carboxylesterase	0.0211	0.1657	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Brugia malayi	putative neuropeptide receptor	0.0012	0.006	0.0059
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0033	0.0228	0.0228
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0007	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0086	0.0086
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Brugia malayi	G protein-coupled receptor	0.0012	0.006	0.0059
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Schistosoma mansoni	neuropeptide receptor	0.0012	0.006	0.0059
Leishmania major	nucleobase transporter	0.0015	0.008	0.0769
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0028	0.0185	0.0184
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Onchocerca volvulus		0.0012	0.006	0.0145
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.006	0.0059
Brugia malayi	Carboxylesterase family protein	0.0211	0.1657	0.1656
Echinococcus multilocularis	neurogenic locus protein delta	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Brugia malayi	Calcium binding EGF domain containing protein	0.0105	0.0808	0.0807
Schistosoma mansoni	neuropeptide receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.006	0.0059
Brugia malayi	Carboxylesterase family protein	0.0211	0.1657	0.1656
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0019	0.0115	0.0115
Echinococcus multilocularis	serotonin receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0553	0.0553
Trypanosoma cruzi	histone deacetylase 1, putative	0.001	0.0042	0.0365
Brugia malayi	Cadherin domain containing protein	0.0105	0.0808	0.0807
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.006	0.0059
Onchocerca volvulus		0.0522	0.4157	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0105	0.0808	0.0807
Brugia malayi	Muscle positioning protein 4	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0185	0.0185
Brugia malayi	bZIP transcription factor family protein	0.0029	0.0196	0.0195
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.006	0.0059
Schistosoma mansoni	lipoxygenase	0.0007	0.0016	0.0015
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.1248	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0006	0.0007	0.009
Brugia malayi	GCC2 and GCC3 family protein	0.0105	0.0808	0.0807
Toxoplasma gondii	nucleoside transporter protein	0.0015	0.008	0.0095
Onchocerca volvulus		0.0211	0.1657	0.3985
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	voltage dependent calcium channel	0.0028	0.0185	0.0184
Trypanosoma brucei	adenosine transporter 2	0.0015	0.008	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus		0.0522	0.4157	1
Schistosoma mansoni	amine GPCR	0.0138	0.1067	0.1067
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.006	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Schistosoma mansoni	biogenic amine receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	slit 2 protein	0.0105	0.0808	0.0807
Echinococcus granulosus	carbonic anhydrase	0.0074	0.0553	0.0552
Echinococcus granulosus	fmrfamide receptor	0.0012	0.006	0.0059
Brugia malayi	Pre-SET motif family protein	0.0033	0.0223	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	neurogenic locus notch protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0016	0.0092	0.0896
Echinococcus granulosus	allatostatin A receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	animal heme peroxidase	0.0522	0.4157	0.4157
Echinococcus multilocularis	jumonji domain containing protein	0.0007	0.0013	0.0012
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.006	0.0059
Brugia malayi	ORL1-like opioid receptor	0.0012	0.006	0.0059
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.006	0.0059
Brugia malayi	chromobox protein homolog 3	0.0006	0.0011	0.001
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0015	0.008	0.0089
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0001	0.0000000039155
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.1657	0.1656
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.006	0.0059
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Brugia malayi	larval opioid receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	protein jagged 1	0.0105	0.0808	0.0807
Echinococcus multilocularis	microtubule associated protein 2	0.0108	0.083	0.0829
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.006	0.0059
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.006	0.0059
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.001	0.0042	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0074	0.0553	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.006	0.0059
Trypanosoma brucei	purine nucleoside transporter	0.0015	0.008	0.0089
Onchocerca volvulus	Chorion peroxidase homolog	0.0522	0.4157	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0033	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	somatostatin receptor	0.0012	0.006	0.0059
Trypanosoma brucei	adenosine transporter 2	0.0015	0.008	0.0089
Trypanosoma brucei	nucleoside transporter 1, putative	0.0015	0.008	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0124	0.0954	0.0954
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.006	0.0059
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0007	0.0013	0.0012
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.006	0.0059
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0043	0.0304	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0011	0.0011
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus multilocularis	neurogenic locus protein delta	0.0105	0.0808	0.0807
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0007	0.0019	0.0018
Schistosoma mansoni	amine GPCR	0.0012	0.006	0.0059
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0124	0.0954	0.0954
Echinococcus granulosus	peroxidasin	0.0522	0.4157	0.4157
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.006	0.0059
Plasmodium vivax	multidomain scavenger receptor, putative	0.0007	0.0016	0.1425
Schistosoma mansoni	lipoxygenase	0.0019	0.0115	0.0115
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.006	0.0059
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.006	0.0059
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0016	0.0092	0.0104
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0038	0.027	0.8856
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Echinococcus granulosus	acetylcholinesterase	0.1248	1	1
Schistosoma mansoni	protein kinase	0.0015	0.008	0.0079
Echinococcus granulosus	g protein coupled receptor	0.0012	0.006	0.0059
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0038	0.027	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0096	0.17
Schistosoma mansoni	histone deacetylase	0.001	0.0042	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Toxoplasma gondii	histone deacetylase HDAC3	0.001	0.0042	0.0048
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0026	0.0167	0.0166
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Brugia malayi	hypothetical protein	0.0023	0.0146	0.0145
Mycobacterium tuberculosis	Probable dehydrogenase	0.0038	0.027	0.1616
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0011	0.0046	0.0045
Trypanosoma brucei	adenosine transporter, putative	0.1021	0.8169	1
Echinococcus multilocularis	histone deacetylase 1	0.001	0.0042	0.0041
Giardia lamblia	High cysteine protein	0.0105	0.0808	1
Echinococcus granulosus	neuroligin	0.0211	0.1657	0.1656
Brugia malayi	Carboxylesterase family protein	0.1248	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0019	0.0019
Onchocerca volvulus		0.0007	0.0016	0.0038
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Schistosoma mansoni	survival motor neuron protein	0.0008	0.0021	0.002
Schistosoma mansoni	peroxidasin	0.0522	0.4157	0.4157
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Onchocerca volvulus	Putative cubilin	0.0105	0.0808	0.1943
Loa Loa (eye worm)	voltage-dependent calcium channel	0.001	0.0039	0.0039
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0211	0.1657	1
Plasmodium falciparum	glutathione reductase	0.0006	0.0007	0.009
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	Polycystic kidney disease protein	0.0007	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	acetylcholinesterase 1	0.1248	1	1
Onchocerca volvulus		0.0105	0.0808	0.1943
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.006	0.0059
Echinococcus granulosus	hypothetical protein	0.0012	0.006	0.0059
Brugia malayi	histone deacetylase 3 (HD3)	0.001	0.0042	0.0041
Schistosoma mansoni	gliotactin	0.0211	0.1657	0.1656
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0008	0.0023	0.0022
Schistosoma mansoni	biogenic amine receptor	0.0012	0.006	0.0059
Onchocerca volvulus		0.0007	0.0016	0.0038
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.006	0.0059
Brugia malayi	Heterochromatin protein 1	0.0011	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.0001
Schistosoma mansoni	chromobox protein	0.0011	0.0051	0.005
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0029	0.0196	0.0195
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0211	0.1657	0.1656
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0211	0.1657	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0211	0.1657	0.1656
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0011	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0003
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.006	0.0059
Schistosoma mansoni	carbonic anhydrase	0.0074	0.0553	0.0552
Echinococcus granulosus	equilibrative nucleoside transporter	0.0015	0.008	0.0079
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.006	0.0059
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.006	0.0059
Leishmania major	nucleoside transporter 1, putative	0.0015	0.008	0.0769
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0211	0.1657	0.1656
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.006	0.006
Plasmodium falciparum	LCCL domain-containing protein	0.0007	0.0016	0.0242
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	carboxylesterase 5A	0.1248	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0028	0.0185	0.0184
Onchocerca volvulus		0.0012	0.006	0.0145
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0015	0.008	0.0079
Echinococcus multilocularis	RUN	0.0007	0.0016	0.0015
Schistosoma mansoni	opsin-like receptor	0.0012	0.006	0.0059
Echinococcus granulosus	acetylcholinesterase	0.1248	1	1
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Echinococcus granulosus	lysine specific demethylase 5A	0.0006	0.0006	0.0005
Echinococcus multilocularis	neuroligin	0.0211	0.1657	0.1656
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0015	0.008	0.0769
Echinococcus granulosus	Polycystic kidney disease protein	0.0007	0.0016	0.0015
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0008	0.0023	0.0022
Trypanosoma brucei	adenosine transporter 2, putative	0.0015	0.008	0.0089
Plasmodium falciparum	histone deacetylase 1	0.001	0.0042	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0024	0.0152	0.0151
Schistosoma mansoni	ankyrin 23/unc44	0.0005	0.0001	0.0000000039155
Brugia malayi	histone deacetylase 1 (HD1)	0.001	0.0042	0.0041
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0028	0.0185	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Brugia malayi	EGF-like domain containing protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus granulosus	microtubule associated protein 2	0.0108	0.083	0.0829
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0011	0.005	0.0453
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0028	0.0185	0.0184
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.006	0.0059
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.006	0.0059
Onchocerca volvulus		0.0211	0.1657	0.3985
Brugia malayi	Histone deacetylase 1	0.001	0.0042	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Brugia malayi	Serotonin receptor	0.0012	0.006	0.0059
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0563	0.3388
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0124	0.0954	1
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.006	0.0059
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.006	0.0059
Echinococcus multilocularis	carbonic anhydrase	0.0074	0.0553	0.0552
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.006	0.0059
Brugia malayi	Peroxidasin	0.0522	0.4157	0.4157
Brugia malayi	Delta serrate ligand family protein	0.0105	0.0808	0.0807
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0105	0.0808	0.0807
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.006	0.006
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.1657	0.1656
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0028	0.0185	0.0184
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.006	0.006
Onchocerca volvulus		0.0012	0.006	0.0145
Schistosoma mansoni	loxhd1	0.0007	0.0016	0.0015
Loa Loa (eye worm)	carboxylesterase	0.1248	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0211	0.1657	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Giardia lamblia	Hypothetical protein	0.0015	0.008	0.0909
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.006	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.008
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.006	0.0059
Toxoplasma gondii	hypothetical protein	0.0014	0.0076	0.009
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.006	0.0059
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0006	0.0006	0.0005
Onchocerca volvulus	Dual oxidase homolog	0.0522	0.4157	1
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0015	0.008	0.0193
Echinococcus granulosus	neuropeptide receptor	0.0012	0.006	0.0059
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Echinococcus granulosus	para nitrobenzyl esterase	0.0211	0.1657	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Entamoeba histolytica	nucleoside transporter, putative	0.0015	0.008	1
Brugia malayi	hypothetical protein	0.0211	0.1657	0.1656
Plasmodium falciparum	thioredoxin reductase	0.0006	0.0007	0.009
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0006	0.0007	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.006	0.0059
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.006	0.0059
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0015	0.008	0.0089
Loa Loa (eye worm)	doublecortin family protein	0.0007	0.0016	0.0016
Toxoplasma gondii	hypothetical protein	0.0074	0.0553	0.0674
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0006	0.0011	0.0026
Echinococcus granulosus	chromobox protein 1	0.0011	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Leishmania major	nucleobase transporter	0.0015	0.008	0.0769
Echinococcus granulosus	orexin receptor type 2	0.0012	0.006	0.0059
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0017	0.0097	0.0096
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0007	0.0019	0.0018
Trichomonas vaginalis	mercuric reductase, putative	0.0006	0.0007	0.003
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	Death domain containing protein	0.0005	0.0001	0.0000000039155
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.001	0.0042	0.0239
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0016	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Trypanosoma cruzi	nucleobase transporter, putative	0.0015	0.008	0.0769
Giardia lamblia	Histone deacetylase	0.001	0.0042	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Brugia malayi	Carboxylesterase family protein	0.0211	0.1657	0.1656
Echinococcus granulosus	thioredoxin glutathione reductase	0.0017	0.0097	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.008
Schistosoma mansoni	peroxidasin	0.0522	0.4157	0.4157
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.006	0.0059
Echinococcus multilocularis	neurogenic locus notch protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0105	0.0808	0.1943
Echinococcus granulosus	jumonji domain containing protein	0.0007	0.0013	0.0012
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0007	0.0019	0.0018
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0096	0.0936
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0016	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Echinococcus multilocularis	chromobox protein 1	0.0011	0.0051	0.005
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.006	0.0059
Schistosoma mansoni	BC026374 protein (S09 family)	0.0211	0.1657	0.1656
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.006	0.006
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0038	0.027	0.1616
Trypanosoma cruzi	nucleobase transporter, putative	0.0015	0.008	0.0769
Brugia malayi	hypothetical protein	0.0007	0.0016	0.0015
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.006	0.0059
Echinococcus granulosus	delta-like protein 1	0.0105	0.0808	0.0807
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0006	0.0007	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Schistosoma mansoni	adenoreceptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1657	0.1657
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Echinococcus granulosus	voltage dependent calcium channel	0.001	0.0039	0.0038
Schistosoma mansoni	notch	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0016	0.0016
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Brugia malayi	Serotonin receptor	0.0012	0.006	0.0059
Onchocerca volvulus		0.0007	0.0013	0.0031
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0074	0.0553	0.0552
Echinococcus granulosus	sex peptide receptor	0.0012	0.006	0.0059
Onchocerca volvulus		0.0105	0.0808	0.1943
Loa Loa (eye worm)	animal heme peroxidase	0.0522	0.4157	0.4157
Toxoplasma gondii	thioredoxin reductase	0.0017	0.0096	0.0115
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Onchocerca volvulus		0.0012	0.006	0.0145
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0015	0.008	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0011	0.0046	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Echinococcus granulosus	protein jagged 2	0.0105	0.0808	0.0807
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0015	0.008	0.0089
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0007	0.0015	0.0035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0011	0.0046	0.0045
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0016	0.0092	0.0896
Loa Loa (eye worm)	histone deacetylase 3	0.001	0.0042	0.0042
Loa Loa (eye worm)	glutathione reductase	0.0017	0.0096	0.0096
Trichomonas vaginalis	histone deacetylase, putative	0.001	0.0042	0.0239
Leishmania major	nucleoside transporter 1, putative	0.0015	0.008	0.0769
Onchocerca volvulus		0.0037	0.0259	0.0624
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0211	0.1657	1
Echinococcus granulosus	g protein coupled receptor	0.0012	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0002	0.0002
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.006	0.0059
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0043	0.0304	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0016	0.0092	0.0104
Treponema pallidum	NADH oxidase	0.0006	0.0007	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.006	0.0059
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.006	0.0059
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0015	0.008	0.0769
Onchocerca volvulus		0.0012	0.006	0.0145
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0033	0.0228	0.1365
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0011	0.005	0.0289
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0033	0.0223	0.0223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.006	0.0059
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.001	0.0039	0.0038
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.006	0.0059
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.006	0.0059
Schistosoma mansoni	hypothetical protein	0.0105	0.0808	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1248	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0808	0.0808
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0016	0.0092	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Onchocerca volvulus		0.0012	0.006	0.0145
Brugia malayi	jmjC domain containing protein	0.0006	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.006
Trypanosoma brucei	carbonic anhydrase-like protein	0.0124	0.0954	0.116
Schistosoma mansoni	neuropeptide receptor	0.0012	0.006	0.0059
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0015	0.0084	0.0083
Echinococcus multilocularis	neural cadherin	0.0105	0.0808	0.0807
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.006	0.0059
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0038	0.027	0.1616
Brugia malayi	Carboxylesterase family protein	0.0211	0.1657	0.1656
Brugia malayi	hypothetical protein	0.0012	0.006	0.0059
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0015	0.008	0.047
Loa Loa (eye worm)	hypothetical protein	0.0522	0.4157	0.4157
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.006	0.0059
Brugia malayi	Animal haem peroxidase family protein	0.0522	0.4157	0.4157
Echinococcus granulosus	fibropellin Ia	0.0105	0.0808	0.0807
Toxoplasma gondii	histone deacetylase HDAC2	0.001	0.0042	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
Fold reversion (functional)	< 25	In vitro activity in DC-3F/AD cell line Ratio of IC50(adriamycin alone) / IC50(adriamycin + modulator) at a concentration of 10 microM	ChEMBL.	1352353
Fold reversion (functional)	< 25	In vitro activity in KB-A1 cell line activity expressed as fold reversion (Ratio of IC50(adriamycin alone) / IC50(adriamycin + modulator) at a concentration of 5 microM	ChEMBL.	1352353
Fold reversion (functional)	= 120	In vitro activity in DC-3F/AD cell line(Ratio of IC50(adriamycin alone) / IC50(adriamycin + modulator) at a concentration of 5 microM	ChEMBL.	1352353
Increase (functional)	= 12.4	Increase in adriamycin uptake in modulator-treated cells relative to untreated cells at a concentration of 10 microM	ChEMBL.	1352353
Increase (functional)	= 13.7	Increase in adriamycin uptake in modulator-treated cells relative to untreated cells at a concentration of 5 microM	ChEMBL.	1352353
Increase (functional)	= 20.9	Increase in adriamycin uptake in modulator-treated cells relative to untreated KB-A1 cells at a concentration of 5 microM	ChEMBL.	1352353
Viability (functional)	= 41 %	Percent of cell viability remaining after incubating the cells with the modulator alone a concentration of 5 microM	ChEMBL.	1352353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 135495