Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0521 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0181 | 0.2454 | 0.2454 |
Mycobacterium ulcerans | proteasome PrcB | 0.0521 | 1 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0181 | 0.2454 | 0.2454 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0521 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0521 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0521 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0181 | 0.2454 | 0.2454 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0521 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0181 | 0.2454 | 0.15 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0521 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0521 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0521 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0521 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0122 | 0.1123 | 0.1123 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0521 | 1 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0521 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.2971 | 0.2971 |
Brugia malayi | proteasome subunit beta type 2 | 0.0122 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0122 | 0.1123 | 0.1123 |
Echinococcus granulosus | proteasome prosome macropain | 0.0521 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0181 | 0.2454 | 0.15 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0181 | 0.2454 | 0.15 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0181 | 0.2454 | 0.15 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0521 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0181 | 0.2454 | 0.2454 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0181 | 0.2454 | 0.2454 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0122 | 0.1123 | 0.1123 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2971 | 0.2971 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0122 | 0.1123 | 0.1123 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0181 | 0.2454 | 0.15 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0122 | 0.1123 | 0.1123 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0181 | 0.2454 | 0.15 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0521 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0521 | 1 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0521 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0181 | 0.2454 | 0.15 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0181 | 0.2454 | 0.15 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2971 | 0.2971 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0181 | 0.2454 | 0.15 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0181 | 0.2454 | 0.15 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2971 | 0.2971 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5174 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.