Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa (strain LESB58) | PvdQ | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0076 | 0.3691 | 0.3624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1023 | 0.1023 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1023 | 0.1023 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1023 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1023 | 0.1023 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1023 | 0.1023 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0105 | 0.0105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Onchocerca volvulus | 0.0033 | 0.1023 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1023 | 0.1023 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3691 | 0.3624 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus granulosus | lamin | 0.0033 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0987 | 0.0987 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1023 | 0.0928 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1023 | 0.1023 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3691 | 0.3624 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1023 | 0.1023 |
Onchocerca volvulus | 0.0033 | 0.1023 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1023 | 0.1023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 3.789 uM | PUBCHEM_BIOASSAY: Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488968] | ChEMBL. | No reference |
AC50 (functional) | = 262.001 uM | PUBCHEM_BIOASSAY: Mammalian cell toxicity screen in HeLa cells 48h Measured in Cell-Based System Using Plate Reader - 2091-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488968] | ChEMBL. | No reference |
Potency (binding) | 2.8184 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.