Detailed information for compound 1355312

Basic information

Technical information
  • TDR Targets ID: 1355312
  • Name: 2-[(3-chlorophenyl)methylsulfanyl]-5-(3-pyrro l-1-ylthiophen-2-yl)-1,3,4-oxadiazole
  • MW: 373.88 | Formula: C17H12ClN3OS2
  • H donors: 0 H acceptors: 2 LogP: 4.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CSc1nnc(o1)c1sccc1n1cccc1
  • InChi: 1S/C17H12ClN3OS2/c18-13-5-3-4-12(10-13)11-24-17-20-19-16(22-17)15-14(6-9-23-15)21-7-1-2-8-21/h1-10H,11H2
  • InChiKey: AYRSAAWZKZRUTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3-chlorophenyl)methylsulfanyl]-5-(3-pyrrol-1-yl-2-thienyl)-1,3,4-oxadiazole
  • 2-[(3-chlorophenyl)methylthio]-5-[3-(1-pyrrolyl)-2-thienyl]-1,3,4-oxadiazole
  • 2-[(3-chlorobenzyl)thio]-5-(3-pyrrol-1-yl-2-thienyl)-1,3,4-oxadiazole
  • 7P-431S
  • 3-chlorobenzyl 5-[3-(1H-pyrrol-1-yl)-2-thienyl]-1,3,4-oxadiazol-2-yl sulfide
  • MLS000327113
  • SMR000179667
  • ZINC01398823
  • Bionet1_003945
  • CDS1_001401
  • DivK1c_002441

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Yersinia pestis DNA topoisomerase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma japonicum DNA topoisomerase 3-alpha, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis DNA topoisomerase III Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania braziliensis DNA topoisomerase 1A Get druggable targets OG5_126736 All targets in OG5_126736
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia DNA topoisomerase III Get druggable targets OG5_126736 All targets in OG5_126736
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA topoisomerase 1A Get druggable targets OG5_126736 All targets in OG5_126736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA topoisomerase IA, putative Get druggable targets OG5_126736 All targets in OG5_126736
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi DNA topoisomerase 3, putative Get druggable targets OG5_126736 All targets in OG5_126736
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum DNA topoisomerase III alpha, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans likely DNA topoisomerase III similar to S. cerevisiae TOP3 (YLR234W) involved in recombination repair events Get druggable targets OG5_126736 All targets in OG5_126736
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum DNA topoisomerase 3, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma mansoni prokaryotic DNA topoisomerase Get druggable targets OG5_126736 All targets in OG5_126736
Loa Loa (eye worm) DNA topoisomerase III Get druggable targets OG5_126736 All targets in OG5_126736
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA topoisomerase 3 alpha Get druggable targets OG5_126736 All targets in OG5_126736
Echinococcus multilocularis rho GTPase activating protein 20 Get druggable targets OG5_126736 All targets in OG5_126736
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi DNA topoisomerase III Get druggable targets OG5_126736 All targets in OG5_126736
Chlamydia trachomatis DNA topoisomerase I Get druggable targets OG5_126736 All targets in OG5_126736
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major DNA topoisomerase 1A Get druggable targets OG5_126736 All targets in OG5_126736
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum DNA topoisomerase I (topA) Get druggable targets OG5_126736 All targets in OG5_126736
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03165 DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania donovani DNA topoisomerase 1A Get druggable targets OG5_126736 All targets in OG5_126736
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense DNA topoisomerase IA, putative Get druggable targets OG5_126736 All targets in OG5_126736
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative Get druggable targets OG5_126736 All targets in OG5_126736
Trypanosoma cruzi DNA topoisomerase IA, putative Get druggable targets OG5_126736 All targets in OG5_126736
Trypanosoma cruzi DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Babesia bovis DNA topoisomerase family protein Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii DNA topoisomerase iii Get druggable targets OG5_126736 All targets in OG5_126736
Trypanosoma cruzi DNA topoisomerase IA, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania major DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Trypanosoma brucei DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Theileria parva DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans likely DNA topoisomerase III similar to S. cerevisiae TOP3 (YLR234W) involved in recombination repair events Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei DNA topoisomerase 3, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax DNA topoisomerase 3, putative Get druggable targets OG5_126736 All targets in OG5_126736
Schistosoma japonicum DNA topoisomerase 3-alpha, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania infantum DNA topoisomerase III, putative Get druggable targets OG5_126736 All targets in OG5_126736
Mycobacterium ulcerans DNA topoisomerase I Get druggable targets OG5_126736 All targets in OG5_126736
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii DNA topoisomerase family protein Get druggable targets OG5_126736 All targets in OG5_126736
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-c Get druggable targets OG5_126736 All targets in OG5_126736
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA Get druggable targets OG5_126736 All targets in OG5_126736
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense DNA topoisomerase IA, putative Get druggable targets OG5_126736 All targets in OG5_126736
Leishmania mexicana DNA topoisomerase 1A Get druggable targets OG5_126736 All targets in OG5_126736
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0024 0.0107 0.0446
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0048 0.0595 0.0524
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0451 0.0451
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0024 0.0107 0.0032
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0509 1 1
Leishmania major oxidoreductase-like protein 0.0058 0.0792 0.0723
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.0979
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0067 0.0979 0.0979
Schistosoma mansoni cytochrome B5 0.0058 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0395 0.7669 0.7669
Plasmodium falciparum nitric oxide synthase, putative 0.0509 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0024 0.0107 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0451 0.0451
Trypanosoma brucei NADH-dependent fumarate reductase 0.0058 0.0792 0.0723
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0067 0.0979 0.0979
Leishmania major cytochrome p450-like protein 0.0035 0.0323 0.025
Trichomonas vaginalis sulfite reductase, putative 0.0509 1 1
Schistosoma mansoni ap endonuclease 0.0023 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0451
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0058 0.0792 0.0792
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0396 0.0323
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0024 0.0107 0.0446
Leishmania major NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Schistosoma mansoni sodium/chloride dependent transporter 0.0067 0.0979 0.0979
Loa Loa (eye worm) cytochrome P450 0.0024 0.0107 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0024 0.0107 0.0446
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0058 0.0792 0.0792
Leishmania major nitrate reductase, putative 0.0058 0.0792 0.0723
Echinococcus granulosus serotonin transporter 0.0395 0.7669 0.7669
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Leishmania major reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0323 0.025
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Leishmania major cytochrome P450 reductase, putative 0.0451 0.8819 0.881
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0107 0.0032
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0025 0.0124 0.0124
Leishmania major DNA topoisomerase 1A 0.0048 0.0595 0.0524
Entamoeba histolytica type A flavoprotein, putative 0.0195 0.3585 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0024 0.0107 0.0446
Chlamydia trachomatis DNA topoisomerase I 0.0097 0.1595 0.1534
Echinococcus multilocularis cytochrome b5 reductase 4 0.0058 0.0792 0.0792
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0107 0.0032
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Brugia malayi Cytochrome P450 family protein 0.0035 0.0323 0.0323
Onchocerca volvulus 0.0395 0.7669 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0024 0.0107 0.0032
Plasmodium falciparum transporter, putative 0.0067 0.0979 0.0911
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.084 0.084
Echinococcus multilocularis 0.0024 0.0107 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.084 0.084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.0979
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0979 0.0911
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0024 0.0107 0.0446
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0195 0.3585 0.3537
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Schistosoma mansoni hypothetical protein 0.0024 0.0107 0.0107
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0395 0.7669 0.7669
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Loa Loa (eye worm) norepinephrine transporter 0.0395 0.7669 0.7669
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0048 0.0595 0.0524
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0058 0.0792 0.0723
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0195 0.3585 0.3537
Leishmania major NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0509 1 1
Leishmania major cytochrome-b5 reductase, putative 0.0058 0.0792 0.0723
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0058 0.0792 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0075 0.0075
Schistosoma mansoni sodium-dependent amino acid transporter 0.0067 0.0979 0.0979
Trypanosoma brucei NADH-dependent fumarate reductase 0.0058 0.0792 0.0723
Trypanosoma brucei oxidoreductase-protein, putative 0.0058 0.0792 0.0723
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0024 0.0107 0.0446
Leishmania major NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Plasmodium falciparum ferredoxin--NADP reductase 0.0058 0.0792 0.0723
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0058 0.0792 0.082
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0097 0.1595 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0509 1 1
Trypanosoma brucei DNA topoisomerase III, putative 0.0048 0.0595 0.0524
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0058 0.0792 0.0792
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0195 0.3585 0.3537
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0509 1 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0024 0.0107 0.0032
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0024 0.0107 0.0032
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Leishmania major DNA topoisomerase III, putative 0.0097 0.1595 0.1532
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0058 0.0792 0.1529
Leishmania major NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0509 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0395 0.7669 0.7669
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0058 0.0792 0.0723
Giardia lamblia Hypothetical protein 0.0451 0.8819 1
Echinococcus multilocularis rho GTPase activating protein 20 0.0048 0.0595 0.0595
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0025 0.0124 0.0124
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0058 0.0792 0.0723
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0024 0.0107 0.0446
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.0979
Plasmodium falciparum amino acid transporter, putative 0.0067 0.0979 0.0911
Brugia malayi hypothetical protein 0.0067 0.0979 0.0979
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0024 0.0107 0.0032
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0195 0.3585 0.3537
Leishmania major cytochrome p450-like protein 0.0024 0.0107 0.0032
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Trypanosoma brucei nitrate reductase, putative 0.0058 0.0792 0.0723
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0024 0.0107 0.0446
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0323 0.025
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0058 0.0792 0.0792
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0323 0.0323
Mycobacterium tuberculosis Possible oxygenase 0.0058 0.0792 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0058 0.0792 0.0792
Plasmodium vivax amine transporter, putative 0.0067 0.0979 0.0911
Echinococcus granulosus sodium and chloride dependent glycine 0.0067 0.0979 0.0979
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0075 0.0075
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0024 0.0107 0.0032
Trypanosoma brucei DNA topoisomerase IA, putative 0.0048 0.0595 0.0524
Loa Loa (eye worm) solute carrier family 6 member 4 0.0395 0.7669 0.7669
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0395 0.7669 0.7669
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0509 1 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0048 0.0595 0.0524
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.1927
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0024 0.0107 0.0032
Brugia malayi Cytochrome P450 family protein 0.0047 0.0577 0.0577
Trypanosoma brucei DNA topoisomerase III, putative 0.0025 0.0124 0.0049
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.1927
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0195 0.3585 0.3537
Brugia malayi FAD binding domain containing protein 0.0314 0.6026 0.6026
Echinococcus granulosus sodium and chloride dependent glycine 0.0067 0.0979 0.0979
Trypanosoma cruzi DNA topoisomerase III, putative 0.0025 0.0124 0.0049
Entamoeba histolytica DNA topoisomerase III, putative 0.0025 0.0124 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0024 0.0107 0.0446
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0024 0.0107 0.0032
Toxoplasma gondii flavodoxin domain-containing protein 0.0253 0.4766 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0395 0.7669 0.7669
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0067 0.0979 0.0357
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0314 0.6026 0.6026
Onchocerca volvulus 0.0067 0.0979 0.1134
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0025 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0739 0.0739
Loa Loa (eye worm) DNA topoisomerase III 0.0048 0.0595 0.0595
Entamoeba histolytica type A flavoprotein, putative 0.0195 0.3585 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0451 0.8819 0.881
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0024 0.0107 0.0446
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0509 1 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0097 0.1595 0.1595
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0195 0.3585 0.3537
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0739 0.0739
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Schistosoma mansoni sodium/chloride dependent transporter 0.0067 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.034
Mycobacterium ulcerans oxygenase 0.0058 0.0792 0.0723
Toxoplasma gondii flavodoxin domain-containing protein 0.0253 0.4766 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0024 0.0107 0.0446
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0739 0.0739
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0509 1 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0509 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0024 0.0107 0.0446
Entamoeba histolytica type A flavoprotein, putative 0.0195 0.3585 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0024 0.0107 0.0446
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.0979
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0058 0.0792 0.0723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0739 0.0739
Toxoplasma gondii hypothetical protein 0.0067 0.0979 0.1927
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0509 1 1
Leishmania major cytochrome-b5 reductase, putative 0.0058 0.0792 0.0723
Mycobacterium ulcerans monooxygenase 0.0058 0.0792 0.0723
Mycobacterium ulcerans oxidoreductase 0.0058 0.0792 0.0723
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0451 0.0451
Brugia malayi cytochrome P450 0.0024 0.0107 0.0107
Leishmania major cytochrome p450-like protein 0.0024 0.0107 0.0032
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0024 0.0107 0.0032
Entamoeba histolytica DNA topoisomerase III, putative 0.0048 0.0595 0.1481
Treponema pallidum sodium- and chloride- dependent transporter 0.0395 0.7669 1
Leishmania major NADH-dependent fumarate reductase-like protein 0.0058 0.0792 0.0723
Trypanosoma cruzi reductase, putative 0.0058 0.0792 0.0723
Giardia lamblia DNA topoisomerase III 0.0048 0.0595 0.0595
Loa Loa (eye worm) serotonin transporter b 0.0395 0.7669 0.7669
Onchocerca volvulus 0.0067 0.0979 0.1134
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0107 0.0032
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0067 0.0979 0.0979
Mycobacterium ulcerans DNA topoisomerase I 0.0048 0.0595 0.0524
Schistosoma mansoni diflavin oxidoreductase 0.0253 0.4766 0.4766
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0067 0.0979 0.0979
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0024 0.0107 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0577 0.0577
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0024 0.0107 0.0446
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0067 0.0979 0.0979
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0024 0.0107 0.0032
Treponema pallidum DNA topoisomerase I (topA) 0.0097 0.1595 0.2002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0739 0.0739
Entamoeba histolytica type A flavoprotein, putative 0.0195 0.3585 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0451 0.0451
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0792 1
Mycobacterium tuberculosis Probable monooxygenase 0.0058 0.0792 1
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0058 0.0792 0.0723
Mycobacterium ulcerans electron transfer protein FdxB 0.0058 0.0792 0.0723
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Brugia malayi Cytochrome P450 family protein 0.0024 0.0107 0.0107
Trypanosoma cruzi DNA topoisomerase III, putative 0.0048 0.0595 0.0524
Loa Loa (eye worm) hypothetical protein 0.006 0.084 0.084
Onchocerca volvulus 0.0058 0.0792 0.0886
Entamoeba histolytica type A flavoprotein, putative 0.0195 0.3585 1
Giardia lamblia DNA topoisomerase III 0.0025 0.0124 0.0056
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0024 0.0107 0.0032
Plasmodium falciparum DNA topoisomerase 3, putative 0.0048 0.0595 0.0524
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Loa Loa (eye worm) hypothetical protein 0.0509 1 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0058 0.0792 1
Echinococcus multilocularis methionine synthase reductase 0.0314 0.6026 0.6026
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0509 1 1
Trypanosoma cruzi p450 reductase, putative 0.0509 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0041 0.0451 0.0451
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0024 0.0107 0.0032
Trypanosoma cruzi nitrate reductase, putative 0.0058 0.0792 0.0723
Leishmania major hypothetical protein, conserved 0.0195 0.3585 0.3537
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0195 0.3585 0.3537
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.0979
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0024 0.0107 0.0446
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0024 0.0107 0.0032
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0509 1 1
Chlamydia trachomatis sulfite reductase 0.0314 0.6026 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0323 0.0323
Brugia malayi flavodoxin family protein 0.0195 0.3585 0.3585
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0048 0.0595 1
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0058 0.0792 0.0723
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0024 0.0107 0.0032
Mycobacterium tuberculosis DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-c 0.0023 0.0082 0.0105
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0528 0.0528
Plasmodium vivax flavodoxin domain containing protein 0.0451 0.8819 0.881
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0058 0.0792 0.0723
Schistosoma mansoni sodium/chloride dependent transporter 0.0395 0.7669 0.7669
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0058 0.0792 0.1529
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi p450 reductase, putative 0.0058 0.0792 0.0723
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0025 0.0124 0.0124
Brugia malayi DNA topoisomerase III beta-1 0.0025 0.0124 0.0124
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0323 0.025
Schistosoma mansoni cytochrome P450 0.0024 0.0107 0.0107
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0979 0.0979
Echinococcus multilocularis sodium and chloride dependent glycine 0.0067 0.0979 0.0979
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0323 0.025
Echinococcus granulosus cytochrome b5 reductase 4 0.0058 0.0792 0.0792
Toxoplasma gondii hypothetical protein 0.0067 0.0979 0.1927
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0048 0.0595 0.0595
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0024 0.0107 0.0032
Echinococcus multilocularis sodium and chloride dependent glycine 0.0067 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Toxoplasma gondii SWI2/SNF2-containing protein 0.0049 0.0612 0.1144
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0195 0.3585 0.3537
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0058 0.0792 0.0723
Treponema pallidum flavodoxin 0.0195 0.3585 0.4622
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.084 0.084
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0024 0.0107 0.0446
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0067 0.0979 0.1927
Echinococcus granulosus methionine synthase reductase 0.0314 0.6026 0.6026
Brugia malayi FAD binding domain containing protein 0.0509 1 1
Leishmania major DNA topoisomerase III, putative 0.0025 0.0124 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0024 0.0107 0.0446
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0396 0.0323
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0048 0.0595 0.0524
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0074 0.1124 0.2237
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Loa Loa (eye worm) FAD binding domain-containing protein 0.0314 0.6026 0.6026
Plasmodium vivax hypothetical protein, conserved 0.0195 0.3585 0.3537
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0048 0.0595 0.0524
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0024 0.0107 0.0446
Brugia malayi diaphorase 0.0058 0.0792 0.0792
Loa Loa (eye worm) diaphorase 0.0058 0.0792 0.0792
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0107 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0024 0.0107 0.0446
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0024 0.0107 0.0032
Schistosoma mansoni cytochrome P450 reductase 0.0509 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0979 0.0979
Schistosoma mansoni ap endonuclease 0.0023 0.0075 0.0075
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0058 0.0792 0.0723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0739 0.0739
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0024 0.0107 0.0032
Brugia malayi DNA topoisomerase III 0.0048 0.0595 0.0595
Brugia malayi Cytochrome P450 family protein 0.0035 0.0323 0.0323
Trypanosoma cruzi oxidoreductase-protein, putative 0.0058 0.0792 0.0723
Toxoplasma gondii cytochrome p450 superfamily protein 0.0024 0.0107 0.0068
Trypanosoma cruzi DNA topoisomerase III, putative 0.0048 0.0595 0.0524
Giardia lamblia Nitric oxide synthase, inducible 0.0451 0.8819 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0107 0.0032
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0024 0.0107 0.0032
Echinococcus multilocularis serotonin transporter 0.0395 0.7669 0.7669
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0075 0.0075
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0195 0.3585 0.3537
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0058 0.0792 0.0792
Loa Loa (eye worm) FAD binding domain-containing protein 0.0509 1 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0024 0.0107 0.0446
Onchocerca volvulus 0.0067 0.0979 0.1134
Leishmania major p450 reductase, putative 0.0509 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0979 0.0979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0739 0.0739
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0979 0.0979
Toxoplasma gondii DNA topoisomerase family protein 0.0048 0.0595 0.1108
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0509 1 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0195 0.3585 0.3537
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0107 0.0107
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0067 0.0979 0.0979
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0451 0.0451
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0509 1 1
Loa Loa (eye worm) flavodoxin family protein 0.0195 0.3585 0.3585
Schistosoma mansoni NADPH flavin oxidoreductase 0.0256 0.4845 0.4845
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0739 0.0739
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0058 0.0792 0.0945
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0058 0.0792 0.0723

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.398107171 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.584893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (binding) = 5.15 uM PUBCHEM_BIOASSAY: Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540310] ChEMBL. No reference
AC50 (functional) = 8.912509381 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.01 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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