Detailed information for compound 1355358

Basic information

Technical information
  • TDR Targets ID: 1355358
  • Name: 3-(2-hydroxy-1-phenylethyl)-2-sulfanylideneim idazolidin-4-one
  • MW: 236.29 | Formula: C11H12N2O2S
  • H donors: 2 H acceptors: 2 LogP: 0.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(N1C(=S)NCC1=O)c1ccccc1
  • InChi: 1S/C11H12N2O2S/c14-7-9(8-4-2-1-3-5-8)13-10(15)6-12-11(13)16/h1-5,9,14H,6-7H2,(H,12,16)
  • InChiKey: FURQFDBXKBROJI-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(2-hydroxy-1-phenyl-ethyl)-2-thioxo-imidazolidin-4-one
  • 3-(2-hydroxy-1-phenylethyl)-2-thioxo-4-imidazolidinone
  • 3-(2-hydroxy-1-phenyl-ethyl)-2-sulfanylidene-imidazolidin-4-one
  • Oprea1_104998
  • 5N-905

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0024
Schistosoma mansoni coup transcription factor 0.0012 0.0017 0.0028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0032 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0166
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0298 1
Schistosoma mansoni cpg binding protein 0.0038 0.0224 0.159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0726 0.0957
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0017 0.0028
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0087 0.0562
Brugia malayi nuclear hormone receptor 0.0012 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0033 0.0185 0.1294
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.0816 0.0139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0275 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.037 0.2697
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0165 0.0597
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0045 0.022
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0017 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0355 0.1284
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0925
Plasmodium falciparum glutathione reductase 0.0044 0.0275 0.9093
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0017 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0017 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0017 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0017 0.0028
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0127 0.0611
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0726 0.0957
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0306 0.1582
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0104 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0104 0.0487
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0306 0.1578
Loa Loa (eye worm) hypothetical protein 0.0046 0.0291 0.15
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.1337 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0207 0.1461
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.028 0.1998
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.091 0.7159 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0726 0.0957
Schistosoma mansoni hypothetical protein 0.0164 0.1224 0.9148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0017 0.0028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0045 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.002
Plasmodium falciparum thioredoxin reductase 0.0044 0.0275 0.9093
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0232
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0818
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0275 1
Brugia malayi Pre-SET motif family protein 0.0244 0.1866 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0213
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0355 0.1663
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0045 0.1512
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.019 0.0955
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.2764 0.3168
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.091 0.7159 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.2764 0.2731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0104 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0165 0.474
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0104 0.2543
Echinococcus multilocularis GPCR, family 2 0.0015 0.0044 0.0213
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0045 0.0163
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0045 0.0239
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0275 0.7426
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0185 0.0928
Schistosoma mansoni zinc finger protein 0.003 0.016 0.1109
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0104 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0104 0.0082
Toxoplasma gondii exonuclease III APE 0.0023 0.0104 0.0375
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0104 0.1888
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0045 0.0211
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0355 0.2691
Echinococcus granulosus cpg binding protein 0.0038 0.0224 0.1651
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0155 0.1101
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.028 0.2095
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0017 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0017 0.0009
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0298 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0306 0.1582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0104 0.2543
Loa Loa (eye worm) glutathione reductase 0.0044 0.0275 0.1413
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0087 0.0536
Schistosoma mansoni ap endonuclease 0.0023 0.0104 0.0681
Schistosoma mansoni cpg binding protein 0.0034 0.019 0.1337
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0207 0.0748
Loa Loa (eye worm) hypothetical protein 0.0058 0.0382 0.1988
Brugia malayi CXXC zinc finger family protein 0.0034 0.019 0.0959
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0232
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0496 0.1796
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0165 0.5213
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0033 0.0111
Toxoplasma gondii thioredoxin reductase 0.0044 0.0275 0.0995
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0045 0.0231
Trypanosoma cruzi ISWI complex protein 0.0018 0.007 0.1079
Echinococcus multilocularis zinc finger protein 0.003 0.016 0.1092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Schistosoma mansoni zinc finger protein 0.0018 0.007 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.002
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.2764 1
Trichomonas vaginalis set domain proteins, putative 0.0278 0.2133 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Echinococcus granulosus zinc finger protein 0.003 0.016 0.1146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0726 0.0957
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0545 0.4204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0165 0.3871
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0355 0.1284
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0024
Schistosoma mansoni cpg binding protein 0.0038 0.0224 0.159
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0044 0.017
Schistosoma mansoni hypothetical protein 0.0018 0.007 0.0427
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0165 0.5213
Brugia malayi Thioredoxin reductase 0.0044 0.0275 0.1416
Schistosoma mansoni hypothetical protein 0.0025 0.0121 0.0813
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.002
Loa Loa (eye worm) acetyltransferase 0.0178 0.1337 0.7144
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0017 0.0024
Schistosoma mansoni bromodomain containing protein 0.0083 0.058 0.4279
Brugia malayi Bromodomain containing protein 0.0097 0.0692 0.3667
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0017 0.0028
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0165 0.5213
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0087 0.0554
Brugia malayi hypothetical protein 0.002 0.0079 0.0359
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0044 0.0166
Brugia malayi steroid hormone receptor 0.0012 0.0017 0.0024
Echinococcus multilocularis cpg binding protein 0.0038 0.0224 0.1574
Leishmania major hypothetical protein, conserved 0.0018 0.007 0.1079
Loa Loa (eye worm) hypothetical protein 0.0085 0.0602 0.3176
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0275 0.1413
Echinococcus granulosus geminin 0.0164 0.1224 0.9595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0121 0.0581
Brugia malayi PHD-finger family protein 0.0036 0.0211 0.1073
Onchocerca volvulus 0.0034 0.019 0.0819
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0009
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0357 0.2764 0.2731
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0224
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0355 1
Echinococcus multilocularis geminin 0.0164 0.1224 0.9146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0009
Brugia malayi glutathione reductase 0.0044 0.0275 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0165 0.474
Plasmodium vivax glutathione reductase, putative 0.0044 0.0275 0.7426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0045 0.0211
Brugia malayi nuclear receptor NHR-88 0.0012 0.0017 0.0024
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.1337 0.7145
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0017 0.0028
Schistosoma mansoni hypothetical protein 0.0164 0.1224 0.9148
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.037 0.2683
Echinococcus granulosus GPCR family 2 0.0015 0.0044 0.0224
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0045 0.0163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.0816 0.1083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0213
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0032 0.0124
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0207 0.1444
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0191 0.1387
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0545 0.4008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0207 0.1461
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0104 0.2543
Brugia malayi Bromodomain containing protein 0.0051 0.0325 0.1684
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0017 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0104 0.2543
Brugia malayi hypothetical protein 0.003 0.0165 0.0822
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.1337 1
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0232
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0017 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0298 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.002
Trypanosoma brucei ISWI complex protein 0.0018 0.007 0.1079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0044 0.017
Brugia malayi Pre-SET motif family protein 0.0036 0.0207 0.1047
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0104 0.049
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0017 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0017 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0306 0.1578
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0155 0.105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0268 0.2001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.05 0.3678
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0155 0.1067
Loa Loa (eye worm) hypothetical protein 0.0053 0.0348 0.1807
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1275 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0207 0.5218
Onchocerca volvulus 0.0036 0.0207 0.0896
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0017 0.0028
Onchocerca volvulus 0.0278 0.2133 1
Schistosoma mansoni hypothetical protein 0.0014 0.0032 0.0137
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0104 0.3475
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0104 0.0663
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.037 0.2815
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0268 0.1907
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0726 0.0957
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0017 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.0816 0.1083
Mycobacterium tuberculosis Probable reductase 0.0101 0.0726 0.0957
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0104 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0017 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0104 0.0485
Leishmania major trypanothione reductase 0.0044 0.0275 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0087 0.0554
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.037 0.2697
Schistosoma mansoni ap endonuclease 0.0023 0.0104 0.0681
Trypanosoma brucei trypanothione reductase 0.0044 0.0275 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0355 0.1663
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0017 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.0816 0.1083
Brugia malayi ecdysteroid receptor 0.0012 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0024
Trypanosoma cruzi ISWI complex protein 0.0018 0.007 0.1079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0104 0.2312
Loa Loa (eye worm) hypothetical protein 0.0056 0.037 0.1927
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.1866 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0104 0.0696
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0017 0.0024
Leishmania major hypothetical protein, conserved 0.003 0.0165 0.5213

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 1.6834 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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