Detailed information for compound 1355979

Basic information

Technical information
  • TDR Targets ID: 1355979
  • Name: 2-[4-(2-chlorophenyl)-4-methyl-2,5-dioxoimida zolidin-1-yl]-N-(1,5-dimethyl-3-oxo-2-phenylp yrazol-4-yl)acetamide
  • MW: 467.905 | Formula: C23H22ClN5O4
  • H donors: 2 H acceptors: 4 LogP: 2.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)NC(C1=O)(C)c1ccccc1Cl)Nc1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C23H22ClN5O4/c1-14-19(20(31)29(27(14)3)15-9-5-4-6-10-15)25-18(30)13-28-21(32)23(2,26-22(28)33)16-11-7-8-12-17(16)24/h4-12H,13H2,1-3H3,(H,25,30)(H,26,33)
  • InChiKey: LEGVOOIPLYSLHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(2-chlorophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)acetamide
  • 2-[4-(2-chlorophenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)acetamide
  • 2-[4-(2-chlorophenyl)-2,5-diketo-4-methyl-imidazolidin-1-yl]-N-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)acetamide
  • 2-[4-(2-chlorophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)ethanamide
  • SMR000255258
  • T0512-9037
  • MLS000389084

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.3491 0.3599
Onchocerca volvulus 0.0069 0.3491 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Schistosoma mansoni adenoreceptor 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0069 0.3491 0.3491
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0645 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis g protein coupled receptor 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide f receptor 76f 0.0069 0.3491 0.3491
Schistosoma mansoni amine GPCR 0.0069 0.3491 0.3491
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0645 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.3491 0.3491
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0069 0.3491 0.3491
Echinococcus granulosus somatostatin receptor 0.0069 0.3491 0.3599
Echinococcus multilocularis sex peptide receptor 0.0069 0.3491 0.3491
Echinococcus granulosus serotonin receptor 0.0069 0.3491 0.3599
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9699 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Onchocerca volvulus Neuropeptide F receptor homolog 0.0069 0.3491 0.4187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.3491 0.3599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.8587 0.8587
Brugia malayi putative neuropeptide receptor 0.0069 0.3491 0.3491
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide FF receptor 2 0.0069 0.3491 0.3491
Brugia malayi larval opioid receptor 0.0069 0.3491 0.3491
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus alpha 1A adrenergic receptor 0.0069 0.3491 0.3599
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0069 0.3491 0.3599
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2412 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2412 1
Schistosoma mansoni neuropeptide receptor 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Onchocerca volvulus Huntingtin homolog 0.0148 0.8337 1
Onchocerca volvulus 0.0069 0.3491 0.4187
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus dro:myosuppressin receptor 0.0069 0.3491 0.3599
Echinococcus granulosus g protein coupled receptor 0.0069 0.3491 0.3599
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0069 0.3491 0.3491
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Brugia malayi neuropeptide F receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9337 0.9337
Echinococcus granulosus neuropeptide receptor A26 0.0069 0.3491 0.3599
Echinococcus granulosus g-protein coupled receptor 0.0069 0.3491 0.3599
Echinococcus granulosus peptide allatostatin:somatostatin 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.3491 0.3599
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 1 1
Schistosoma mansoni amine GPCR 0.0069 0.3491 0.3491
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0069 0.3491 0.3491
Brugia malayi GnHR receptor homolog 0.0069 0.3491 0.3491
Schistosoma mansoni ap endonuclease 0.0023 0.0645 0.0645
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Echinococcus multilocularis g protein coupled receptor 0.0069 0.3491 0.3491
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0645 0.5
Onchocerca volvulus 0.0069 0.3491 0.4187
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0645 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.3491 0.3599
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0069 0.3491 0.3599
Brugia malayi G-protein coupled receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis fmrfamide receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0645 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis G-protein coupled receptor, putative 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine receptor 0.0069 0.3491 0.3491
Schistosoma mansoni opsin-like receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni myosin xvIII 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.3491 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi neuropeptide F receptor 0.0069 0.3491 0.3491
Brugia malayi Melatonin receptor type 1A 0.0069 0.3491 0.3491
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Schistosoma mansoni histamine h1 receptor 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) acetyltransferase 0.0175 1 1
Echinococcus multilocularis serotonin receptor 0.0069 0.3491 0.3491
Schistosoma mansoni alpha-1 adrenergic receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Schistosoma mansoni hypothetical protein 0.0069 0.3491 0.3491
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0645 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0069 0.3491 0.3491
Schistosoma mansoni amine GPCR 0.0069 0.3491 0.3491
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis serotonin receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide receptor A26 0.0069 0.3491 0.3491
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2412 0.2487
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2412 1
Onchocerca volvulus 0.0069 0.3491 0.4187
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus granulosus g protein coupled receptor 0.0069 0.3491 0.3599
Echinococcus granulosus allatostatin A receptor 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide receptor 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0645 0.5
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis g-protein coupled receptor 0.0069 0.3491 0.3491
Echinococcus granulosus G protein coupled receptor 139 0.0069 0.3491 0.3599
Brugia malayi Dopamine receptor protein 1 0.0069 0.3491 0.3491
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.9337 0.9337
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus neuropeptide receptor 0.0069 0.3491 0.3599
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0069 0.3491 0.3491
Echinococcus multilocularis g protein coupled receptor 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0148 0.8337 0.8337
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0148 0.8337 0.8337
Brugia malayi putative neuropeptide receptor NPR1 0.0069 0.3491 0.3491
Loa Loa (eye worm) melatonin receptor type 1A 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi Serotonin receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus neuropeptide s receptor 0.0069 0.3491 0.3599
Echinococcus granulosus hypothetical protein 0.0069 0.3491 0.3599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0645 0.0645
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis fmrfamide receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0069 0.3491 0.3491
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.2148 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis dro:myosuppressin receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus granulosus fmrfamide receptor 0.0069 0.3491 0.3599
Echinococcus multilocularis G protein coupled receptor 139 0.0069 0.3491 0.3491
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0069 0.3491 0.3491
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0645 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0069 0.3491 0.3491
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0645 0.0665
Brugia malayi RE15519p 0.0069 0.3491 0.3491
Brugia malayi Dopamine receptor 0.0069 0.3491 0.3491
Schistosoma mansoni growth hormone secretagogue receptor 0.0069 0.3491 0.3491
Schistosoma mansoni opsin-like receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0069 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0152 0.8587 0.8587
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.8587 0.8854
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2412 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.3491 0.3491
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Echinococcus granulosus sex peptide receptor 0.0069 0.3491 0.3599
Echinococcus granulosus 7TM GPCR rhodopsin 0.0069 0.3491 0.3599
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Onchocerca volvulus Huntingtin homolog 0.0148 0.8337 1
Brugia malayi G protein-coupled receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0069 0.3491 0.3491
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0069 0.3491 0.4187
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.3491 0.3491
Schistosoma mansoni ap endonuclease 0.0023 0.0645 0.0645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.3491 0.3491
Brugia malayi sulfakinin receptor protein 0.0069 0.3491 0.3491
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2412 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.3491 0.3491
Echinococcus granulosus 7tm_1 domain containing protein 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.3491 0.3599
Onchocerca volvulus 0.0069 0.3491 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.3491 0.3599
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi Tachykinin-like peptides receptor 99D 0.0069 0.3491 0.3491
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi Dopamine receptor protein 2 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Loa Loa (eye worm) TYRA-2 protein 0.0069 0.3491 0.3491
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.3491 0.3599
Echinococcus multilocularis allatostatin A receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.3491 0.3491
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.3491 0.3491
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0069 0.3491 0.3491
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0069 0.3491 0.3599
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0069 0.3491 0.3491
Schistosoma mansoni amine GPCR 0.0069 0.3491 0.3491
Brugia malayi AKH receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus g protein coupled receptor 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide s receptor 0.0069 0.3491 0.3491
Echinococcus granulosus orexin receptor type 2 0.0069 0.3491 0.3599
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0069 0.3491 0.3491
Echinococcus multilocularis somatostatin receptor 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine receptor 0.0069 0.3491 0.3491
Brugia malayi follicle stimulating hormone receptor 0.0069 0.3491 0.3491
Echinococcus granulosus neuropeptide receptor 0.0069 0.3491 0.3599
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0645 0.0645
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus granulosus neuropeptide FF receptor 2 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.3491 0.3491
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.3491 0.3599
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0069 0.3491 0.3599
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.2148 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0069 0.3491 0.3491
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.2148 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0069 0.3491 0.3491
Echinococcus multilocularis neuropeptide receptor 0.0069 0.3491 0.3491
Schistosoma mansoni amine GPCR 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Echinococcus granulosus tachykinin peptides receptor 99D 0.0069 0.3491 0.3599
Brugia malayi hypothetical protein 0.0069 0.3491 0.3491
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0069 0.3491 0.3491
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9337 0.9337
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0069 0.3491 0.3491
Brugia malayi Serotonin receptor 0.0069 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0148 0.8337 0.8337
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.3491 0.3491
Brugia malayi G-protein coupled receptor 0.0069 0.3491 0.3491
Brugia malayi ORL1-like opioid receptor 0.0069 0.3491 0.3491
Schistosoma mansoni opsin-like receptor 0.0069 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0069 0.3491 0.3491
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0069 0.3491 0.3491
Schistosoma mansoni neuropeptide receptor 0.0069 0.3491 0.3491
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.3491 0.3599
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.3491 0.3599
Echinococcus multilocularis orexin receptor type 2 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.3491 0.3491
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.3491 0.3491
Onchocerca volvulus 0.0069 0.3491 0.4187
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.3491 0.3599
Brugia malayi G protein-coupled receptor F59B2.13 0.0069 0.3491 0.3491
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.3491 0.3491

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0045 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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