Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3285 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0164 | 0.0499 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0164 | 0.0499 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3285 | 0.3273 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0164 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3285 | 1 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0164 | 0.0499 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0164 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0164 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 1 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3285 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3285 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0164 | 0.0447 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3285 | 0.3273 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Onchocerca volvulus | 0.0009 | 0.0164 | 0.0146 | |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3285 | 0.3273 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0006 | 0.0018 | 0.0054 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3285 | 0.3273 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3285 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0447 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3285 | 0.3273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3285 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0447 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0499 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3285 | 0.3273 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0164 | 0.0146 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3285 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor | 0.0006 | 0.0018 | 0.0054 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -27 % | Antihypertensive activity determined as percent fall in blood pressure after 2 hr in spontaneously hypertensive rats administered with 10 mg/kg (po) | ChEMBL. | 3941410 |
Activity (functional) | = -7 % | Antihypertensive activity determined as percent fall in blood pressure after 4 hours in spontaneously hypertensive rats administered with 10mg/kg, (po) | ChEMBL. | 3941410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.