Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0344 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4589 | 0.4589 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.4589 | 0.4589 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0344 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.1254 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.4589 | 0.4589 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0344 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0344 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.0141 | 0.0141 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.1254 | 0.1254 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.4589 | 0.4589 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.1254 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.1254 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0344 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0251 | 0.6914 | 0.6914 |
Onchocerca volvulus | Peroxidasin homolog | 0.0344 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0175 | 0.4416 | 0.4416 |
Schistosoma mansoni | lipoxygenase | 0.0251 | 0.6914 | 0.6914 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.1254 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0344 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0344 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0344 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0344 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4589 | 0.4589 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0344 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0251 | 0.6914 | 0.6914 |
Brugia malayi | Animal haem peroxidase family protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.1254 | 0.1254 |
Brugia malayi | Peroxidasin | 0.0344 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.1254 | 0.1254 |
Onchocerca volvulus | Peroxidasin homolog | 0.0344 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.1254 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.1254 | 0.1254 |
Onchocerca volvulus | Peroxidase homolog | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0344 | 1 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.0344 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.4589 | 0.4589 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0344 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.