Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | runt-related transcription factor 1 | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | core-binding factor, beta subunit | No references | |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_133916 | All targets in OG5_133916 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133916 | All targets in OG5_133916 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133916 | All targets in OG5_133916 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133916 | All targets in OG5_133916 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.0282 | 0.0282 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0163 | 0.0282 | 0.2136 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3586 | 0.9828 | 0.9828 |
Mycobacterium leprae | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0062 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1557 | 0.4169 | 0.4169 |
Mycobacterium leprae | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0566 | 0.1405 | 0.241 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0062 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0535 | 0.132 | 1 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 0.566 | 0.566 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.132 | 0.132 |
Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.0015 | 0.0015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2153 | 0.5831 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3586 | 0.9828 | 0.9828 |
Onchocerca volvulus | 0.0535 | 0.132 | 0.132 | |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2153 | 0.5831 | 1 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0062 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2153 | 0.5831 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.0282 | 0.0282 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3586 | 0.9828 | 0.9828 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3648 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.132 | 0.132 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0062 | 0 | 0.5 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0062 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3648 | 1 | 1 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0062 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3648 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0062 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | lozenge | 0.0067 | 0.0015 | 0.0015 |
Treponema pallidum | phosphoglyceromutase | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 0.0282 | 0.0282 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0566 | 0.1405 | 1 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2153 | 0.5831 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2153 | 0.5831 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1557 | 0.4169 | 0.4169 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | runx1 | 0.0067 | 0.0015 | 0.0015 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1557 | 0.4169 | 0.4169 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.0219 | 0.0219 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3648 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 0.0282 | 0.0282 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3586 | 0.9828 | 0.9828 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0.0091 | 0.0091 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1557 | 0.4169 | 0.4169 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3648 | 1 | 1 |
Onchocerca volvulus | 0.3648 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.3648 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3648 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3586 | 0.9828 | 0.9828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.