TDR Targets

Basic information

Technical information

TDR Targets ID: 1356975
Name: 9-chloro-N-[(3-chlorophenyl)methyl]-5,6,7,8-t etrahydroacridine-3-carboxamide
MW: 385.286 | Formula: C21H18Cl2N2O
H donors: 1 H acceptors: 2 LogP: 5.45 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)CNC(=O)c1ccc2c(c1)nc1c(c2Cl)CCCC1
InChi: 1S/C21H18Cl2N2O/c22-15-5-3-4-13(10-15)12-24-21(26)14-8-9-17-19(11-14)25-18-7-2-1-6-16(18)20(17)23/h3-5,8-11H,1-2,6-7,12H2,(H,24,26)
InChiKey: GVCKNVOHQFZWML-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

9-chloro-N-(3-chlorobenzyl)-5,6,7,8-tetrahydroacridine-3-carboxamide
C598-0585
NCGC00110614-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0295	0.806	0.8769
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0045	0.0649	0.0499
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0045	0.0649	0.0706
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0755	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0333	0.919	0.9162
Onchocerca volvulus		0.0056	0.0985	0.1215
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.2203	0.2175
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0222	0.0241
Schistosoma mansoni	patched 1	0.0042	0.0555	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0039	0.048	0.0141
Entamoeba histolytica	hypothetical protein	0.0045	0.0649	0.033
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.3442	0.3746
Brugia malayi	TAR-binding protein	0.0076	0.1587	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Loa Loa (eye worm)	carboxylesterase	0.0056	0.0985	0.0664
Schistosoma mansoni	acetylcholinesterase	0.0056	0.0985	0.1071
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1587	0.1526
Schistosoma mansoni	hypothetical protein	0.0169	0.4329	0.4711
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0056	0.0985	0.1071
Brugia malayi	Carboxylesterase family protein	0.0056	0.0985	0.092
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.036	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.3442	0.3746
Echinococcus granulosus	carboxylesterase 5A	0.0333	0.919	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Echinococcus granulosus	geminin	0.0169	0.4329	0.4711
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0045	0.0649	0.033
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0739	0.0804
Brugia malayi	Pre-SET motif family protein	0.0213	0.5628	0.5596
Schistosoma mansoni	BC026374 protein (S09 family)	0.0056	0.0985	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0056	0.0985	0.1071
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0045	0.0649	0.033
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0629	0.0561
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1587	0.1726
Echinococcus multilocularis	expressed conserved protein	0.0091	0.2028	0.2207
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0344	0.0274
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0056	0.0985	0.1071
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0629	0.04
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0755	0.0821
Onchocerca volvulus		0.0056	0.0985	0.1215
Echinococcus granulosus	neuroligin	0.0056	0.0985	0.1071
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0755	0.0821
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0045	0.0649	0.0114
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0045	0.0649	0.0114
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0954	0.1038
Echinococcus granulosus	dna polymerase eta	0.0044	0.0629	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1587	0.1726
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0239	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0649	0.0114
Schistosoma mansoni	hypothetical protein	0.004	0.0511	0.0556
Giardia lamblia	Synaptic glycoprotein SC2	0.0045	0.0649	0.5
Brugia malayi	RNA binding protein	0.0076	0.1587	0.1526
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.2203	0.2397
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0755	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0552	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0333	0.919	0.9162
Onchocerca volvulus		0.0056	0.0985	0.1215
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0045	0.0649	0.0114
Loa Loa (eye worm)	acetylcholinesterase 1	0.0333	0.919	0.9162
Brugia malayi	Carboxylesterase family protein	0.0056	0.0985	0.092
Schistosoma mansoni	gliotactin	0.0056	0.0985	0.1071
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1587	0.1726
Echinococcus multilocularis	acetylcholinesterase	0.0333	0.919	1
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0319	0.8794	0.8785
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1587	0.1287
Leishmania major	C-8 sterol isomerase-like protein	0.036	1	1
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0045	0.0649	0.0499
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0045	0.0649	0.0706
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.2203	0.2397
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0188	0.0205
Echinococcus multilocularis	neuroligin	0.0056	0.0985	0.1071
Echinococcus granulosus	para nitrobenzyl esterase	0.0056	0.0985	0.1071
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0819	0.0753
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0319	0.8794	1
Plasmodium falciparum	polyprenol reductase, putative	0.0045	0.0649	0.5
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0755	0.0849
Schistosoma mansoni	hypothetical protein	0.0035	0.0344	0.0374
Echinococcus granulosus	acetylcholinesterase	0.0333	0.919	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.1127	0.1226
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1587	0.1287
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0191	0.4984	0.5423
Echinococcus multilocularis	carboxylesterase 5A	0.0333	0.919	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0056	0.0985	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0555	0.0219
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0045	0.0649	0.0021
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0319	0.8794	1
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0319	0.8794	0.8764
Echinococcus granulosus	expressed conserved protein	0.0091	0.2028	0.2207
Plasmodium vivax	polyprenol reductase, putative	0.0045	0.0649	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0819	0.0753
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.2248	0.2446
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0954	0.1038
Brugia malayi	Synaptic glycoprotein SC2	0.0045	0.0649	0.0582
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0954	0.1038
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0629	0.0685
Schistosoma mansoni	hypothetical protein	0.0036	0.0371	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0755	0.0425
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0739	0.0804
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0739	0.0804
Loa Loa (eye worm)	carboxylesterase	0.0056	0.0985	0.0664
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1587	0.1287
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1587	0.1726
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0056	0.0985	0.1071
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.1127	0.1226
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0555	0.0604
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0319	0.8794	0.8764
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0555	0.0219
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0056	0.0985	0.1071
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0954	0.1038
Leishmania major	DNA polymerase eta, putative	0.0044	0.0629	0.04
Onchocerca volvulus		0.0242	0.65	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0739	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0819	0.0493
Schistosoma mansoni	hypothetical protein	0.004	0.0511	0.0556
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.2203	0.2147
Echinococcus multilocularis	para nitrobenzyl esterase	0.0056	0.0985	0.1071
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0954	0.1038
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0755	0.0821
Onchocerca volvulus		0.0048	0.0755	0.0849
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0222	0.0241
Loa Loa (eye worm)	hypothetical protein	0.036	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0834	0.0508
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0191	0.4984	0.5423
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0319	0.8794	1
Brugia malayi	CHE-14 protein	0.0042	0.0555	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0184	0.4777	0.4591
Mycobacterium ulcerans	short chain dehydrogenase	0.0272	0.7402	0.8217
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0045	0.0649	0.5
Brugia malayi	mbt repeat family protein	0.0048	0.0755	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0954	0.0632
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0819	0.0493
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0319	0.8794	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0371	0.0404
Onchocerca volvulus		0.0056	0.0985	0.1215
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0954	0.0888
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0056	0.0985	0.1071
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0045	0.0649	1
Brugia malayi	Bromodomain containing protein	0.0039	0.0478	0.0409
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0406	0.0442
Echinococcus granulosus	synaptic glycoprotein sc2	0.0045	0.0649	0.0706
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0045	0.0649	0.042
Mycobacterium tuberculosis	Probable oxidoreductase	0.0272	0.7402	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0371	0.0404
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0319	0.8794	0.8713
Loa Loa (eye worm)	hypothetical protein	0.0319	0.8794	0.8751
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0045	0.0649	0.0114
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0333	0.919	1
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0319	0.8794	0.8764
Brugia malayi	hypothetical protein	0.0056	0.0985	0.092
Brugia malayi	hypothetical protein	0.0036	0.0371	0.0302
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0045	0.0649	0.0706
Onchocerca volvulus		0.0056	0.0985	0.1215
Schistosoma mansoni	hypothetical protein	0.004	0.0511	0.0556
Brugia malayi	Carboxylesterase family protein	0.0333	0.919	0.9185
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0649	0.0114
Brugia malayi	Pre-SET motif family protein	0.0031	0.0222	0.0151
Brugia malayi	Bromodomain containing protein	0.0077	0.1591	0.153
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2203	0.1926
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0045	0.0649	0.0706
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0406	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Echinococcus multilocularis	acetylcholinesterase	0.0333	0.919	1
Echinococcus granulosus	BC026374 protein S09 family	0.0056	0.0985	0.1071
Echinococcus multilocularis	geminin	0.0169	0.4329	0.4711
Schistosoma mansoni	hypothetical protein	0.004	0.0511	0.0556
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0555	0.0604
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0629	0.0685
Loa Loa (eye worm)	carboxylesterase	0.0333	0.919	0.9162
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0555	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0649	0.0316
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1587	0.1726
Brugia malayi	Carboxylesterase family protein	0.0056	0.0985	0.092
Brugia malayi	Carboxylesterase family protein	0.0056	0.0985	0.092
Trypanosoma brucei	C-8 sterol isomerase, putative	0.036	1	1
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0755	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0629	0.0296
Schistosoma mansoni	bromodomain containing protein	0.0065	0.1235	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0044	0.061	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1461	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0649	0.0316
Echinococcus multilocularis	protein patched	0.0042	0.0555	0.0604
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0222	0.0241
Loa Loa (eye worm)	MBCTL1	0.0055	0.0954	0.0632
Onchocerca volvulus		0.0045	0.0649	0.0681
Brugia malayi	Carboxylesterase family protein	0.0333	0.919	0.9185
Trichomonas vaginalis	set domain proteins, putative	0.0242	0.65	0.7216
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0371	0.0404
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0739	0.0804
Schistosoma mansoni	hypothetical protein	0.0169	0.4329	0.4711
Echinococcus granulosus	acetylcholinesterase	0.0333	0.919	1
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0319	0.8794	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.5628	0.5472
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0985	0.0664
Trichomonas vaginalis	spcc417.12 protein, putative	0.0056	0.0985	0.0521
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0056	0.0985	0.0521
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1587	0.1726
Echinococcus multilocularis	protein dispatched 1	0.0048	0.073	0.0795
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1587	0.1726
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0755	0.0821
Brugia malayi	mbt repeat family protein	0.0048	0.0755	0.0688
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0045	0.0649	0.0706
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0755	0.0821
Mycobacterium ulcerans	hypothetical protein	0.0319	0.8794	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1477211

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1356975