TDR Targets

Basic information

Technical information

TDR Targets ID: 1357223
Name: 6-ethoxy-N-(4-nitrophenyl)-N'-prop-2-enyl-1,3 ,5-triazine-2,4-diamine
MW: 316.315 | Formula: C14H16N6O3
H donors: 2 H acceptors: 5 LogP: 3.31 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: C=CCNc1nc(Nc2ccc(cc2)[N+](=O)[O-])nc(n1)OCC
InChi: 1S/C14H16N6O3/c1-3-9-15-12-17-13(19-14(18-12)23-4-2)16-10-5-7-11(8-6-10)20(21)22/h3,5-8H,1,4,9H2,2H3,(H2,15,16,17,18,19)
InChiKey: VOYXYUJYDYOQBG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N'-allyl-6-ethoxy-N-(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
[4-(allylamino)-6-ethoxy-s-triazin-2-yl]-(4-nitrophenyl)amine
ChemDiv1_016915
Oprea1_263712
MLS000584847
N-allyl-6-ethoxy-N'-(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
SMR000207232

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-ets avian erythroblastosis virus E26 oncogene homolog	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	snurportin 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K09435 transcriptional regulator ERG, putative	Get druggable targets OG5_131947	All targets in OG5_131947
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ets-related	Get druggable targets OG5_131947	All targets in OG5_131947
Brugia malayi	Fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0265	0.0801
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0073	0.0211
Leishmania major	hypothetical protein, conserved	0.0027	0.0161	0.0454
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0013	0.0053	0.0092
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0161	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1656	0.4999
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0224
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0219
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0031	0.0084
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0033	0.0098
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0055	0.0364	0.0361
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0033	0.0098
Onchocerca volvulus		0.0047	0.0306	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0027	0.0161	0.0454
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Echinococcus multilocularis	transportin 1	0.0007	0.0008	0.0014
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0031	0.0067
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.001	0.0007
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0465	0.3368	1
Brugia malayi	Probable ClpP-like protease	0.0077	0.0521	0.1566
Loa Loa (eye worm)	TK protein kinase	0.0033	0.0205	0.0611
Giardia lamblia	Hypothetical protein	0.0017	0.0084	0.4068
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0031	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0073	0.0211
Chlamydia trachomatis	acyltransferase family protein	0.0027	0.0161	0.2657
Brugia malayi	Ets-domain containing protein	0.0087	0.0601	0.1808
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0084	0.0074
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0073	0.0219
Echinococcus multilocularis	abhydrolase domain containing protein 13	0.0017	0.0084	0.0145
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0095	0.0085
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0073	0.1345
Schistosoma mansoni	hypothetical protein	0.0014	0.0063	0.0191
Echinococcus multilocularis	ets variant gene 4	0.0013	0.0053	0.0092
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0033	0.0979
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0216	0.1545	0.2674
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0306	0.0924
Schistosoma mansoni	elf1	0.0013	0.0053	0.016
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Mycobacterium tuberculosis	Probable lipase/esterase LipG	0.0017	0.0084	0.0081
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0008	0.002	0.0053
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0063	0.0191
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0027	0.0161	0.0158
Brugia malayi	Protein C20orf22	0.0027	0.0161	0.0478
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0027	0.0161	0.0454
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0015	0.0073	0.0219
Brugia malayi	jmjC domain containing protein	0.0015	0.0073	0.0211
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.001	0.0007
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0153	0.0447
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0033	0.0056
Mycobacterium ulcerans	oxidoreductase	0.0017	0.0084	0.0074
Brugia malayi	jmjC domain containing protein	0.0058	0.0382	0.1146
Loa Loa (eye worm)	oxidoreductase	0.0007	0.001	0.0021
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0328	0.0325
Mycobacterium ulcerans	amidase	0.0055	0.0364	0.0355
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0055	0.0364	0.063
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0382	0.1154
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0033	0.0979
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0167	0.0472
Echinococcus granulosus	tyrosine kinase	0.0038	0.0235	0.0711
Schistosoma mansoni	adapter molecule crk	0.0008	0.002	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0182
Echinococcus multilocularis	translational activator gcn1	0.0007	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0033	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Echinococcus granulosus	translational activator gcn1	0.0007	0.0008	0.0025
Mycobacterium ulcerans	peptide amidase, GatA	0.0055	0.0364	0.0355
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0027	0.0161	0.0454
Plasmodium vivax	lysophospholipase, putative	0.0027	0.0161	0.047
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0161	0.0478
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0265	0.0459
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0219
Toxoplasma gondii	hypothetical protein	0.0017	0.0084	0.1559
Mycobacterium tuberculosis	Possible hydrolase	0.0017	0.0084	0.0081
Schistosoma mansoni	tyrosine kinase	0.0042	0.0265	0.0801
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.013	0.0385
Brugia malayi	nuclear hormone receptor	0.001	0.0033	0.009
Plasmodium vivax	PST-A protein	0.0027	0.0161	0.047
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0008	0.002	0.0061
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.0265	0.0801
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0055	0.0364	0.11
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0084	0.0074
Mycobacterium ulcerans	amidase	0.0055	0.0364	0.0355
Onchocerca volvulus		0.0007	0.001	0.0234
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.1656	0.5003
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0027	0.0161	0.0454
Mycobacterium leprae	Possible hydrolase	0.0017	0.0084	0.0212
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0027	0.0161	0.045
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0027	0.0161	0.045
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0263	0.0795
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0073	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0031	0.0067
Schistosoma mansoni	hypothetical protein	0.0013	0.0053	0.016
Loa Loa (eye worm)	kap beta 3 protein	0.0007	0.0008	0.0016
Mycobacterium tuberculosis	Probable haloalkane dehalogenase	0.0017	0.0084	0.0081
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0033	0.0098
Echinococcus multilocularis	importin 5	0.0007	0.0008	0.0014
Entamoeba histolytica	hypothetical protein	0.0028	0.0167	0.0472
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0153	0.0447
Onchocerca volvulus		0.001	0.0031	0.0917
Loa Loa (eye worm)	SRC-1	0.0042	0.0265	0.0793
Schistosoma mansoni	hypothetical protein	0.004	0.0252	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0255
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0265	0.0459
Schistosoma mansoni	ets	0.0013	0.0053	0.016
Giardia lamblia	Hypothetical protein	0.0017	0.0084	0.4068
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0095	0.0092
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0031	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0033	0.009
Schistosoma mansoni	topbp1	0.001	0.0031	0.0093
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0013	0.0053	0.0092
Mycobacterium tuberculosis	Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap)	0.0017	0.0084	0.0081
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0073	0.0211
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0306	0.053
Brugia malayi	DKFZp564C0469 protein	0.001	0.0031	0.0084
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.1656	0.2867
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0482	0.3491	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0031	0.0067
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0095	0.0258
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.001	0.0007
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0027	0.0161	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0666	0.2006
Schistosoma mansoni	fatty-acid amide hydrolase	0.0055	0.0364	0.11
Mycobacterium tuberculosis	Possible lysophospholipase	0.0482	0.3491	0.3489
Schistosoma mansoni	patched 1	0.0041	0.0263	0.0795
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0265	0.0801
Chlamydia trachomatis	hydrolase	0.0027	0.0161	0.2657
Leishmania major	hypothetical protein, conserved	0.0017	0.0084	0.0224
Schistosoma mansoni	tyrosine kinase	0.0009	0.0029	0.0087
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0008	0.002	0.0035
Mycobacterium ulcerans	amidase	0.0055	0.0364	0.0355
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.001	0.0021
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0148	0.8995
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	0.0511
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0382	0.1154
Leishmania major	hypothetical protein, conserved	0.0027	0.0161	0.0454
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Echinococcus multilocularis	snurportin 1	0.0372	0.2684	0.4647
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0033	0.0098
Loa Loa (eye worm)	ets-domain-containing protein	0.0013	0.0053	0.0152
Entamoeba histolytica	Ran family GTPase	0.0026	0.0148	0.0415
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0219
Mycobacterium tuberculosis	Probable lignin peroxidase LipJ	0.0017	0.0084	0.0081
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0033	0.0098
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	1
Echinococcus granulosus	ewsr:fli fusion protein type	0.0013	0.0053	0.016
Mycobacterium tuberculosis	Possible haloalkane dehalogenase	0.0017	0.0084	0.0081
Mycobacterium tuberculosis	Possible lipase LipV	0.0017	0.0084	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0263	0.0758
Trypanosoma cruzi	amidase, putative	0.0055	0.0364	0.1055
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0042	0.0265	0.0801
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0055	0.0364	0.0361
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0063	0.0191
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0215	0.4099
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.001	0.0137
Plasmodium vivax	PST-A protein	0.0465	0.3368	1
Toxoplasma gondii	phospholipase	0.0027	0.0161	0.3051
Plasmodium falciparum	epoxide hydrolase 2	0.0027	0.0161	0.047
Toxoplasma gondii	hypothetical protein	0.0026	0.0153	0.2903
Echinococcus multilocularis	maspardin	0.0017	0.0084	0.0145
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Brugia malayi	CHE-14 protein	0.0041	0.0263	0.0787
Echinococcus granulosus	importin 5	0.0007	0.0008	0.0025
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0055	0.0364	0.0355
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.013	0.012
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0331	0.0993
Mycobacterium ulcerans	thioesterase	0.0017	0.0084	0.0074
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0382	0.1154
Brugia malayi	SRC-1	0.0042	0.0265	0.0793
Toxoplasma gondii	hypothetical protein	0.0027	0.0161	0.3051
Echinococcus multilocularis	protein C ets 2	0.0013	0.0053	0.0092
Schistosoma mansoni	DNA ligase IV	0.001	0.0031	0.0093
Plasmodium falciparum	exported lipase 2	0.0027	0.0161	0.047
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0033	0.009
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0027	0.0161	0.3051
Mycobacterium leprae	Possible membrane protein	0.0017	0.0084	0.0212
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0161	0.047
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0465	0.3368	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0073	0.0211
Plasmodium falciparum	lysophospholipase, putative	0.0465	0.3368	1
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0073	0.0219
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0033	0.0056
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0033	0.0205	0.0355
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0263	0.0787
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0033	0.0056
Echinococcus granulosus	snurportin 1	0.0372	0.2684	0.8108
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0095	0.1311
Brugia malayi	protein-tyrosine kinase	0.0038	0.0235	0.0703
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0095	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0161	0.0478
Schistosoma mansoni	hypothetical protein	0.004	0.0252	0.0762
Brugia malayi	Sex muscle abnormal protein 5	0.0008	0.002	0.0053
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0013	0.0053	0.0092
Schistosoma mansoni	ap endonuclease	0.0018	0.0095	0.0287
Onchocerca volvulus		0.0007	0.001	0.0234
Entamoeba histolytica	hypothetical protein	0.001	0.0031	0.0067
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0007
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0465	0.3368	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0095	0.0278
Entamoeba histolytica	hypothetical protein	0.0027	0.0161	0.0454
Loa Loa (eye worm)	CCG1-interacting factor B	0.0017	0.0084	0.0244
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0031	0.0067
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.013	0.0385
Onchocerca volvulus		0.0017	0.0084	0.2665
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0224
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0095	0.0164
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0084	0.0219
Schistosoma mansoni	coup transcription factor	0.001	0.0033	0.0098
Toxoplasma gondii	hypothetical protein	0.0027	0.0161	0.3051
Echinococcus granulosus	death domain containing protein	0.0014	0.0063	0.0191
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0306	0.0916
Brugia malayi	Ets-domain containing protein	0.0013	0.0053	0.0152
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0148	0.0438
Mycobacterium ulcerans	lysophospholipase	0.0465	0.3368	0.3361
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0161	0.0151
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Brugia malayi	putative amidase	0.0055	0.0364	0.1092
Onchocerca volvulus	Valacyclovir hydrolase homolog	0.0017	0.0084	0.2665
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0055	0.0364	0.6802
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0033	0.0098
Loa Loa (eye worm)	amidase	0.0055	0.0364	0.1092
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0084	0.0219
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0055	0.0364	0.1059
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.0265	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0255
Leishmania major	hypothetical protein, conserved	0.0055	0.0364	0.1059
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0055	0.0364	0.1074
Giardia lamblia	Hypothetical protein	0.0017	0.0084	0.4068
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0033	0.009
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0073	0.0219
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0038	0.0235	0.0407
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0215	0.0642
Echinococcus granulosus	NCK adaptor protein	0.0008	0.002	0.0061
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0027	0.0161	0.0454
Mycobacterium tuberculosis	Probable epoxide hydrolase EphB (epoxide hydratase)	0.0017	0.0084	0.0081
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0215	0.0616
Plasmodium vivax	unspecified product	0.0027	0.0161	0.047
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0031	0.0059
Brugia malayi	hypothetical protein	0.001	0.0031	0.0084
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.001	0.0007
Echinococcus granulosus	abhydrolase domain containing 3	0.0027	0.0161	0.0486
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Toxoplasma gondii	chain a, pp2a-specific methylesterase apo form (pme), putative	0.0017	0.0084	0.1559
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0027	0.0161	0.0454
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0031	0.0083
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.013	0.012
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0148	0.0411
Brugia malayi	jmjC domain containing protein	0.0015	0.0073	0.0211
Plasmodium vivax	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0255
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0064	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0385
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0224
Echinococcus multilocularis	protein patched	0.0041	0.0263	0.0455
Brugia malayi	protein phosphatase methylesterase 1	0.0017	0.0084	0.0244
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0521	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0148	0.2798
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0623	0.1079
Schistosoma mansoni	fatty-acid amide hydrolase	0.0457	0.331	1
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0027	0.0161	0.0486
Plasmodium vivax	PST-A protein	0.0027	0.0161	0.047
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0027	0.0161	0.0279
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0095	0.4934
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0013	0.0053	0.0152
Entamoeba histolytica	;Alias	0.0027	0.0161	0.0454
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0095	0.0258
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.0265	0.0801
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0055	0.0364	0.6802
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0382	0.0661
Brugia malayi	ecdysteroid receptor	0.001	0.0033	0.009
Mycobacterium ulcerans	amidase	0.0055	0.0364	0.0355
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.5776	1
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	0.154
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0521	0.1468
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0017	0.0084	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0152
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0031	0.0067
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0055	0.0364	0.11
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0148	0.0411
Brugia malayi	jmjC domain containing protein	0.0058	0.0382	0.1146
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0027	0.0161	0.045
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.001	0.0005
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0013	0.0053	0.016
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.001	0.0005
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.0265	0.0459
Plasmodium falciparum	esterase, putative	0.0027	0.0161	0.047
Leishmania major	hypothetical protein, conserved	0.0015	0.0073	0.0191
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0521	0.0902
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0095	0.0258
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0666	0.2013
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.0601	0.1815
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0969	0.2928
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.013	0.0363
Mycobacterium tuberculosis	Unknown protein	0.0017	0.0084	0.0081
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0457	0.331	0.5731
Mycobacterium ulcerans	hypothetical protein	0.0023	0.013	0.012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0033	0.009
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0027	0.0161	1
Trypanosoma cruzi	serine peptidase, putative	0.0027	0.0161	0.045
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0033	0.0098
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0055	0.0364	0.0361
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Mycobacterium tuberculosis	Probable epoxide hydrolase EphC (epoxide hydratase)	0.0017	0.0084	0.0081
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0167	0.0472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0063	0.0182
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0027	0.0161	0.0454
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0073	0.0219
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0033	0.009
Brugia malayi	Importin beta-1 subunit	0.0035	0.0215	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0161	0.0478
Toxoplasma gondii	hypothetical protein	0.0027	0.0161	0.3051
Brugia malayi	Tyrosine-protein kinase abl-1	0.0009	0.0029	0.0079
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0063	0.0191
Brugia malayi	Amidase family protein	0.0055	0.0364	0.1092
Echinococcus granulosus	ETS transcription factor Elf 2	0.0013	0.0053	0.016
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0063	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0033	0.009
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0084	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0008	0.002	0.0053
Toxoplasma gondii	HEAT repeat-containing protein	0.0007	0.0008	0.0105
Plasmodium falciparum	prodrug activation and resistance esterase	0.0027	0.0161	0.047
Mycobacterium tuberculosis	Probable oxidoreductase	0.0017	0.0084	0.0081
Leishmania major	hypothetical protein, conserved	0.0017	0.0084	0.0224
Brugia malayi	amidase	0.0457	0.331	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0161	0.0478
Schistosoma mansoni	ran	0.0026	0.0148	0.0447
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0009	0.0029	0.005
Echinococcus granulosus	tyrosine protein kinase Blk	0.0038	0.0235	0.0711
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0017	0.0084	0.0224
Echinococcus granulosus	transportin 1	0.0007	0.0008	0.0025
Entamoeba histolytica	hypothetical protein	0.0027	0.0161	0.0454
Brugia malayi	steroid hormone receptor	0.001	0.0033	0.009
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0215	0.0616
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0033	0.0098
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0521	0.154
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0161	0.047
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0215	0.0373
Brugia malayi	nuclear receptor NHR-88	0.001	0.0033	0.009
Mycobacterium tuberculosis	Conserved protein	0.0017	0.0084	0.0081
Plasmodium falciparum	importin beta, putative	0.0035	0.0215	0.0631
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0031	0.0053
Brugia malayi	Death domain containing protein	0.0014	0.0063	0.0182
Mycobacterium tuberculosis	Possible hydrolase	0.0017	0.0084	0.0081
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0148	0.0415
Schistosoma mansoni	tyrosine kinase	0.0009	0.0029	0.0087
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.0265	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0161	0.0478
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0457	0.331	1
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0031	0.0084
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0095	0.0278
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0055	0.0364	0.0361
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0328	0.0567
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0095	0.0258
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0033	0.0056
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0055	0.0364	0.0361
Mycobacterium leprae	PROBABLE LIPASE/ESTERASE LIPG	0.0017	0.0084	0.0212
Echinococcus granulosus	expressed conserved protein	0.0091	0.0623	0.1883
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0033	0.009
Giardia lamblia	ENC6 protein	0.0017	0.0084	0.4068
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.0265	0.0801
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0027	0.0161	0.0454
Mycobacterium ulcerans	hydrolase	0.0017	0.0084	0.0074
Plasmodium vivax	PST-A protein	0.0027	0.0161	0.047
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0095	0.0287
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0013	0.0053	0.0152
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0033	0.0098
Schistosoma mansoni	growth factor receptor-bound protein	0.0008	0.002	0.0061
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0038	0.0235	0.0711
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.002	0.0053
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0328	0.0913
Schistosoma mansoni	ran	0.0026	0.0148	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0263	0.0787
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0073	0.0219
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0084	0.0081
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.013	0.012
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0521	1
Brugia malayi	hypothetical protein	0.0231	0.1656	0.4999
Plasmodium falciparum	exported lipase 1	0.0027	0.0161	0.047
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.013	0.0127
Plasmodium vivax	transportin, putative	0.0007	0.0008	0.0016
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0148	0.0431
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0465	0.3368	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0008	0.002	0.0053
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0027	0.0161	0.045
Schistosoma mansoni	hypothetical protein	0.0372	0.2684	0.8108
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0027	0.0161	0.045
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0064	0.0185
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.001	0.0017
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0328	0.0325
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.001	0.0021
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0073	0.0207
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0027	0.0161	0.0454
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0666	0.1958
Loa Loa (eye worm)	protein phosphatase methylesterase 1	0.0017	0.0084	0.0244
Brugia malayi	RNA, U transporter 1	0.0099	0.0686	0.2064
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.013	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0031	0.0067
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0265	0.0801
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0007
Mycobacterium ulcerans	epoxide hydrolase EphC	0.0017	0.0084	0.0074
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0148	0.0431
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0033	0.0098
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0033	0.0098
Trypanosoma brucei	Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0224
Brugia malayi	transcription factor E74 isoform	0.0013	0.0053	0.0152
Echinococcus multilocularis	abhydrolase domain containing protein 8	0.0017	0.0084	0.0145
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0027	0.0161	0.0454
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0033	0.0098
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0073	0.0219
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.0265	0.0801
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0382	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0457	0.331	1
Plasmodium falciparum	esterase, putative	0.0027	0.0161	0.047
Schistosoma mansoni	gabp alpha	0.0087	0.0601	0.1815
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0013	0.0053	0.0092
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.001	0.0137
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0677	0.2046
Onchocerca volvulus		0.0007	0.001	0.0234
Mycobacterium tuberculosis	Conserved protein	0.0017	0.0084	0.0081
Schistosoma mansoni	importin-beta 2	0.0007	0.0008	0.0025
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0167	0.0472
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0055	0.0364	0.063
Schistosoma mansoni	importin beta-1	0.0035	0.0215	0.065
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.001	0.003
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0073	0.0219
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2684	0.8106
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.001	0.0005
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0073	0.0126
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.013	0.0363
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0031	0.0536
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0017	0.0084	0.0244
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0087	0.025
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0235	0.0407
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0033	0.009
Plasmodium falciparum	transportin	0.0007	0.0008	0.0016
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0095	0.0274
Brugia malayi	CCG1-interacting factor B	0.0017	0.0084	0.0244
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0027	0.0161	0.0454
Echinococcus granulosus	ETS transcription factor Elf 1	0.0013	0.0053	0.016
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0005
Entamoeba histolytica	protein kinase, putative	0.0033	0.0205	0.0585
Echinococcus granulosus	Phospholipase carboxylesterase	0.0027	0.0161	0.0486
Schistosoma mansoni	hypothetical protein	0.004	0.0252	0.0762
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0055	0.0364	0.6802
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0073	0.0186
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0227	0.0685
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0031	0.0067
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0027	0.0161	0.047
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0215	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0255
Loa Loa (eye worm)	fli-1 protein	0.0265	0.1905	0.5753
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0095	0.0253
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.013	0.0345
Brugia malayi	MGC79044 protein	0.0027	0.0161	0.0478
Mycobacterium tuberculosis	Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase)	0.0017	0.0084	0.0081
Echinococcus multilocularis	Ankyrin	0.0014	0.0064	0.0111
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0033	0.0098
Onchocerca volvulus	Alpha\/beta hydrolase2 homolog	0.0017	0.0084	0.2665
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	1
Loa Loa (eye worm)	D-ets-2 protein	0.0013	0.0053	0.0152
Leishmania major	hypothetical protein, conserved	0.0017	0.0084	0.0224
Echinococcus multilocularis	protein phosphatase methylesterase 1	0.0017	0.0084	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0033	0.009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0033	0.009
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0969	0.1678
Plasmodium vivax	PST-A protein	0.0027	0.0161	0.047
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0084	0.0074
Toxoplasma gondii	protein c14orf29, putative	0.0027	0.0161	0.3051
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.0265	0.0459
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.013	0.0363
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0013	0.0053	0.016
Plasmodium falciparum	lysophospholipase, putative	0.0027	0.0161	0.047
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0031	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0033	0.009
Mycobacterium ulcerans	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD	0.137	1	1
Toxoplasma gondii	hypothetical protein	0.0017	0.0084	0.1559
Giardia lamblia	Protein phosphatase methylesterase-1	0.0017	0.0084	0.4068
Plasmodium falciparum	BEM46-like protein, putative	0.0027	0.0161	0.047
Mycobacterium ulcerans	lipase LipV	0.0017	0.0084	0.0074
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0215	0.065
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0219
Echinococcus multilocularis	abhydrolase domain containing 3	0.0027	0.0161	0.0279
Brugia malayi	DNA-binding protein D-ETS-3	0.0013	0.0053	0.0152
Brugia malayi	kap beta 3 protein	0.0007	0.0008	0.0016
Echinococcus granulosus	Ankyrin	0.0014	0.0064	0.0194
Leishmania major	hypothetical protein, conserved	0.0017	0.0084	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0087	0.0255
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.013	0.0345
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0153	0.2501
Schistosoma mansoni	hypothetical protein	0.0047	0.0306	0.0924
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0073	0.0219
Echinococcus granulosus	nibrin	0.001	0.0031	0.0093
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0013	0.0053	0.0092
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.002	0.0053
Loa Loa (eye worm)	amidase	0.0055	0.0364	0.1092
Onchocerca volvulus		0.001	0.0033	0.0979
Toxoplasma gondii	hypothetical protein	0.0027	0.0161	0.3051
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0031	0.0062
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0033	0.0056
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0033	0.0098
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.001	0.0007
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0161	0.047
Brugia malayi	jmjC domain containing protein	0.0015	0.0073	0.0211
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0073	0.0191
Mycobacterium ulcerans	hydrolase	0.0027	0.0161	0.0151
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0027	0.0161	0.0279
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0055	0.0364	0.1017
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0033	0.009
Brugia malayi	topoisomerase	0.001	0.0031	0.0084
Echinococcus granulosus	ETS transcription factor Elf 2	0.0013	0.0053	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0033	0.009
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0033	0.0098
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0465	0.3368	1
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0027	0.0161	0.3051
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0038	0.0235	0.0407
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0033	0.0098
Mycobacterium tuberculosis	Unknown protein	0.0017	0.0084	0.0081
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0033	0.0098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0033	0.009
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0521	0.1574
Brugia malayi	Fli-1 protein	0.0265	0.1905	0.5753
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0031	0.0083
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0521	0.1574
Plasmodium falciparum	lysophospholipase, putative	0.0465	0.3368	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0009	0.0029	0.005
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0033	0.0056
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0007	0.0008	0.0016
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0666	0.2006
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0227	0.0393
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.0601	0.104
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.013	0.0363
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0027	0.0161	0.0486
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0017	0.0084	0.1559
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0015	0.0073	0.0126
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0153	0.0412
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0033	0.0056
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.008	0.0077
Plasmodium vivax	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Toxoplasma gondii	phospholipase/carboxylesterase	0.0027	0.0161	0.3051
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0033	0.0098
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0031	0.0021
Onchocerca volvulus		0.0007	0.001	0.0234
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0382	0.1146
Schistosoma mansoni	peptidase	0.0027	0.0161	0.0486
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0031	0.0536
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0084	0.0081
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0027	0.0161	0.0486
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0148	0.0256
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0073	0.0186
Plasmodium falciparum	lysophospholipase, putative	0.0027	0.0161	0.047
Treponema pallidum	carboxylesterase (est)	0.0017	0.0084	0.1081
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.0601	0.1808
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.013	0.012
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0031	0.0093
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0027	0.0161	0.047
Schistosoma mansoni	tyrosine kinase	0.0042	0.0265	0.0801
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0027	0.0161	0.0454
Trypanosoma cruzi	serine peptidase, putative	0.0027	0.0161	0.045
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.013	0.012
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0457	0.331	0.5731
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0021
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0521	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0033	0.0098
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.3368	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.008	0.0077
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0087	0.0084
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0015	0.0073	0.0207
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0021
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0031	0.0067
Plasmodium vivax	PST-A protein	0.0027	0.0161	0.047
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0465	0.3368	1
Mycobacterium ulcerans	lysophospholipase	0.0017	0.0084	0.0074
Plasmodium vivax	lysophospholipase, putative	0.0027	0.0161	0.047
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0027	0.0161	0.3051
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.001	0.0021
Schistosoma mansoni	protein phosphatase methylesterase 1 (S33 family)	0.0017	0.0084	0.0253
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0031	0.0062
Trypanosoma cruzi	amidase, putative	0.0055	0.0364	0.1055
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.001	0.0021
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0465	0.3368	1
Plasmodium vivax	lysophospholipase, putative	0.0027	0.0161	0.047
Schistosoma mansoni	hypothetical protein	0.0013	0.0053	0.016
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0095	0.1311
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0031	0.0067
Onchocerca volvulus	Putative protein phosphatase methylesterase 1	0.0017	0.0084	0.2665
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0033	0.009
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0084	0.0074
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0033	0.0098
Onchocerca volvulus		0.0023	0.013	0.4197
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0095	0.0253
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0031	0.0062
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0148	0.0447
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0073	0.0126
Brugia malayi	Amidase family protein	0.0055	0.0364	0.1092
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0055	0.0364	0.1074
Toxoplasma gondii	hypothetical protein	0.0017	0.0084	0.1559
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0063	0.1989
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.013	0.012
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0063	0.0191
Schistosoma mansoni	growth factor receptor-bound protein	0.0008	0.002	0.0061
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0073	0.0211
Echinococcus granulosus	maspardin	0.0017	0.0084	0.0253
Schistosoma mansoni	ets-related	0.0265	0.1905	0.5757
Toxoplasma gondii	HEAT repeat-containing protein	0.0007	0.0008	0.0105
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0017	0.0084	0.0224
Echinococcus granulosus	abhydrolase domain containing protein 8	0.0017	0.0084	0.0253
Trichomonas vaginalis	ran, putative	0.0026	0.0148	0.0415
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0073	0.0126
Brugia malayi	hypothetical protein	0.001	0.0031	0.0084
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.013	0.0363
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0382	0.0661
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0465	0.3368	1
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0013	0.0053	0.0092
Plasmodium falciparum	esterase, putative	0.0465	0.3368	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0033	0.009
Toxoplasma gondii	peptidase S15, putative	0.0027	0.0161	0.3051
Echinococcus granulosus	growth factor receptor bound protein 2	0.0008	0.002	0.0061
Schistosoma mansoni	amidase	0.0457	0.331	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.013	0.0385
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.0265	0.0459
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0087	0.025
Trypanosoma brucei	monoglyceride lipase, putative	0.0465	0.3368	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0009	0.0029	0.0087
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0148	0.0438
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0073	0.1345
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0027	0.0161	0.0454
Echinococcus granulosus	protein C ets 2	0.0013	0.0053	0.016
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0033	0.009
Schistosoma mansoni	hypothetical protein	0.004	0.0252	0.0762
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0033	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0385
Mycobacterium tuberculosis	Unknown protein	0.0017	0.0084	0.0081
Loa Loa (eye worm)	hypothetical protein	0.001	0.0031	0.0084
Toxoplasma gondii	exonuclease III APE	0.0018	0.0095	0.1777
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0033	0.009
Brugia malayi	Uncoordinated protein 44	0.0014	0.0063	0.0182
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0033	0.009
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0521	0.1566
Echinococcus multilocularis	c src tyrosine kinase	0.0009	0.0029	0.005
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0027	0.0161	0.0454
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0033	0.0098
Trichomonas vaginalis	conserved hypothetical protein	0.0465	0.3368	1
Mycobacterium tuberculosis	Conserved hypothetical alanine rich protein	0.0017	0.0084	0.0081
Mycobacterium leprae	conserved hypothetical protein	0.0017	0.0084	0.0212
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.0265	0.0459
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0087	0.0077
Leishmania major	GTP-binding protein, putative	0.0026	0.0148	0.0415
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0063	0.0109
Schistosoma mansoni	ap endonuclease	0.0018	0.0095	0.0287
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0007
Schistosoma mansoni	ets-related	0.0013	0.0053	0.016
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.001	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0033	0.009
Plasmodium falciparum	lysophospholipase, putative	0.0465	0.3368	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0087	0.1151
Echinococcus granulosus	tyrosine protein kinase HCK	0.0033	0.0205	0.0619
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0328	0.099
Echinococcus granulosus	protein phosphatase methylesterase 1	0.0017	0.0084	0.0253
Mycobacterium ulcerans	amidase	0.0055	0.0364	0.0355
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0263	0.0455
Trypanosoma brucei	monoglyceride lipase, putative	0.0465	0.3368	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0033	0.009
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.001	0.0005
Mycobacterium tuberculosis	Possible hydrolase	0.0017	0.0084	0.0081
Echinococcus multilocularis	nibrin	0.001	0.0031	0.0053
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0167	0.0472
Brugia malayi	MGC83647 protein	0.0027	0.0161	0.0478
Plasmodium vivax	unspecified product	0.0027	0.0161	0.047
Echinococcus granulosus	ETS transcription factor Elf 5	0.0013	0.0053	0.016
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0055	0.0364	0.1017
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0167	0.0467
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.001	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0265	0.0459
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0027	0.0161	0.047
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.001	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0063	0.0182
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0017	0.0084	0.0212
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0033	0.009
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.013	0.0363
Echinococcus multilocularis	NCK adaptor protein	0.0008	0.002	0.0035
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0216	0.1545	0.4666
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0033	0.009
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0457	0.331	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Onchocerca volvulus		0.0017	0.0084	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0073	0.0211
Mycobacterium tuberculosis	Probable hydrolase	0.0017	0.0084	0.0081
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0382	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0508	0.1527
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0263	0.0795
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0161	0.0454
Brugia malayi	jmjC domain containing protein	0.0015	0.0073	0.0211
Schistosoma mansoni	nck2/grb4	0.0008	0.002	0.0061
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.001	0.0137
Mycobacterium ulcerans	hypothetical protein	0.0465	0.3368	0.3361
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0073	0.0126
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0666	0.1153
Brugia malayi	Ets-domain containing protein	0.0087	0.0601	0.1808
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.013	0.012
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0095	0.0258
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.009
Loa Loa (eye worm)	hypothetical protein	0.0023	0.013	0.0385
Echinococcus granulosus	c src tyrosine kinase	0.0009	0.0029	0.0087
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0084	0.0081
Trypanosoma cruzi	monoglyceride lipase, putative	0.0465	0.3368	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0033	0.0056
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0031	0.0067
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0031	0.0062
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0009	0.0029	0.0087
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0235	0.0703
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.008	0.0077
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0055	0.0364	0.11
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.001	0.0005
Leishmania major	monoglyceride lipase, putative	0.0465	0.3368	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.008	0.0077
Schistosoma mansoni	topbp1	0.001	0.0031	0.0093
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0063	0.0182
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0033	0.009
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.001	0.003

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0329 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.7308 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1480693

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1357223