Detailed information for compound 1357268

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.28 | Formula: C15H13N3O7
  • H donors: 2 H acceptors: 5 LogP: 1.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)c1ccc(o1)C)NNC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C15H13N3O7/c1-9-2-7-12(25-9)15(21)24-8-13(19)16-17-14(20)10-3-5-11(6-4-10)18(22)23/h2-7H,8H2,1H3,(H,16,19)(H,17,20)
  • InChiKey: CLUTTYTYLVBVML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0558 0.0932
Trichomonas vaginalis mercuric reductase, putative 0.0062 0.1583 0.1588
Toxoplasma gondii NADPH-glutathione reductase 0.0062 0.1583 0.2217
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0062 0.1583 0.1588
Schistosoma mansoni chromobox protein 0.0073 0.1983 0.1983
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1983 0.1989
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0654 0.0656
Schistosoma mansoni lamin 0.0028 0.0298 0.0298
Plasmodium falciparum thioredoxin reductase 0.0179 0.5982 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.7412 0.7434
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Loa Loa (eye worm) hypothetical protein 0.0032 0.0451 0.0453
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0654 0.0656
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0663 0.0801
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.3888 0.4702
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0558 0.0559
Mycobacterium tuberculosis Conserved protein 0.0038 0.0663 0.0801
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0654 0.1094
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0298 0.0299
Brugia malayi Latrophilin receptor protein 2 0.005 0.1137 0.114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Brugia malayi jmjC domain containing protein 0.0094 0.2787 0.2795
Echinococcus multilocularis GPCR, family 2 0.005 0.1137 0.1901
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0964 0.0967
Schistosoma mansoni intermediate filament proteins 0.0028 0.0298 0.0298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0663 0.0801
Mycobacterium ulcerans lipase LipD 0.0038 0.0663 0.0665
Onchocerca volvulus 0.0032 0.0451 0.0186
Brugia malayi beta-lactamase 0.0038 0.0663 0.0665
Onchocerca volvulus 0.0097 0.2909 0.3169
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Echinococcus multilocularis peregrin 0.0029 0.033 0.0552
Schistosoma mansoni kinase 0.005 0.1115 0.1115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.1583 0.2647
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0898 0.0901
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0654 0.0656
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.827 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0654 0.0656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Trypanosoma brucei glucosidase, putative 0.0037 0.0654 0.1094
Schistosoma mansoni hypothetical protein 0.0164 0.5412 0.5412
Plasmodium falciparum thioredoxin reductase 0.0062 0.1583 0.2217
Schistosoma mansoni hypothetical protein 0.005 0.1137 0.1137
Onchocerca volvulus 0.0038 0.0663 0.0443
Brugia malayi jmjC domain containing protein 0.0035 0.0558 0.0559
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0062 0.1583 0.1588
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0062 0.1583 0.2217
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.2787 0.4659
Brugia malayi Cytochrome P450 family protein 0.0038 0.0693 0.0695
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.2918 0.4878
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.3326 0.3336
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0062 0.1583 0.2647
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0654 0.0573
Giardia lamblia Kinase, PLK 0.0097 0.2918 1
Leishmania major hypothetical protein, conserved 0.0038 0.0663 0.1108
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.033 0.0552
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0062 0.1583 0.1914
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.5576 0.9322
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0964 0.0967
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0062 0.1583 0.2647
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2918 0.4878
Echinococcus granulosus jumonji domain containing protein 0.004 0.0753 0.1259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.5212 0.5228
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0169 0.5602 1
Echinococcus granulosus lamin dm0 0.0028 0.0298 0.0498
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0782 0.0588
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.1583 0.2647
Brugia malayi beta-lactamase family protein 0.0038 0.0663 0.0665
Schistosoma mansoni alpha-glucosidase 0.0145 0.4695 0.4695
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0663 0.0665
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0062 0.1583 0.2647
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0421 0.0704
Brugia malayi glutaminase DH11.1 0.0285 0.997 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.2918 0.4878
Mycobacterium tuberculosis Probable oxidoreductase 0.0169 0.5602 0.6773
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0654 0.1094
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1066 0.1069
Toxoplasma gondii ABC1 family protein 0.0038 0.0663 0.0588
Giardia lamblia PHD finger protein 15 0.0029 0.033 0.1132
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.5576 0.9322
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0654 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0421 0.0421
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.3888 0.4702
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0062 0.1583 0.1583
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0179 0.5982 0.7232
Brugia malayi follicle stimulating hormone receptor 0.0239 0.8242 0.8267
Echinococcus granulosus thioredoxin glutathione reductase 0.0179 0.5982 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0868 0.0868
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.1583 0.2647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Trichomonas vaginalis esterase, putative 0.0038 0.0663 0.0665
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0558 0.0558
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0663 0.0665
Schistosoma mansoni lamin 0.0028 0.0298 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.5212 0.5228
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0062 0.1583 0.1588
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.1583 0.2647
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.033 0.033
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1983 0.1989
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0654 0.1094
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.1583 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0663 0.1108
Schistosoma mansoni glutaminase 0.0285 0.997 0.997
Brugia malayi glutathione reductase 0.0179 0.5982 0.6
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.8242 0.8267
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0663 0.0665
Loa Loa (eye worm) hypothetical protein 0.0041 0.0782 0.0785
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0654 0.0656
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0558 0.0932
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0663 0.0665
Brugia malayi chromobox protein homolog 3 0.0041 0.0782 0.0785
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0898 0.0901
Trypanosoma brucei polo-like protein kinase 0.0097 0.2918 0.4878
Mycobacterium tuberculosis Conserved protein 0.0038 0.0663 0.0801
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1983 0.1989
Plasmodium vivax thioredoxin reductase, putative 0.0179 0.5982 1
Echinococcus multilocularis chromobox protein 1 0.0073 0.1983 0.3315
Brugia malayi Heterochromatin protein 1 0.0073 0.1983 0.1989
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0693 0.0695
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.1137 0.1901
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.3888 0.6531
Loa Loa (eye worm) hypothetical protein 0.005 0.1137 0.114
Echinococcus granulosus geminin 0.0164 0.5412 0.9048
Loa Loa (eye worm) glutathione reductase 0.0179 0.5982 0.6
Onchocerca volvulus 0.0038 0.0663 0.0443
Schistosoma mansoni hypothetical protein 0.005 0.1137 0.1137
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0062 0.1583 0.2217
Mycobacterium ulcerans glutaminase 0.0285 0.997 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.3888 0.4702
Loa Loa (eye worm) glutaminase 2 0.0285 0.997 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0062 0.1583 0.2217
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.5576 0.5593
Brugia malayi intermediate filament protein 0.0028 0.0298 0.0299
Echinococcus granulosus GPCR family 2 0.005 0.1137 0.1901
Onchocerca volvulus Alhambra homolog 0.0029 0.033 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0558 0.0558
Echinococcus granulosus intermediate filament protein 0.0028 0.0298 0.0498
Brugia malayi Pre-SET motif family protein 0.0031 0.0421 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0898 0.0729
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.1137 0.1901
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0654 0.2242
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.5576 0.9322
Schistosoma mansoni hypothetical protein 0.0164 0.5412 0.5412
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Loa Loa (eye worm) glutaminase 0.0285 0.997 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0782 0.0785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0421 0.0423
Echinococcus granulosus peregrin 0.0029 0.033 0.0552
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.1583 0.5
Echinococcus multilocularis chromobox protein 1 0.0073 0.1983 0.3315
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0169 0.5602 0.6773
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0654 0.0656
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0654 0.0656
Brugia malayi Bromodomain containing protein 0.0029 0.033 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0663 0.1108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0663 0.1108
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0654 0.0656
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0421 0.0704
Echinococcus granulosus chromobox protein 1 0.0073 0.1983 0.3315
Trichomonas vaginalis set domain proteins, putative 0.0247 0.8539 0.8565
Echinococcus multilocularis thioredoxin glutathione reductase 0.0179 0.5982 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0654 0.2242
Plasmodium vivax SET domain protein, putative 0.0031 0.0421 0.0161
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1066 0.1069
Loa Loa (eye worm) hypothetical protein 0.0158 0.5212 0.5228
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0663 0.1108
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0663 0.0801
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0421 0.0421
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0378 0.0632
Loa Loa (eye worm) hypothetical protein 0.0027 0.0279 0.0279
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0062 0.1583 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.2918 0.2918
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0062 0.1583 0.1588
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0654 0.0656
Schistosoma mansoni hypothetical protein 0.005 0.1137 0.1137
Trichomonas vaginalis glutathione reductase, putative 0.0062 0.1583 0.1588
Loa Loa (eye worm) thioredoxin reductase 0.0179 0.5982 0.6
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.5576 0.5593
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.1137 0.114
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0663 0.0665
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.2787 0.4659
Loa Loa (eye worm) hypothetical protein 0.0108 0.3326 0.3336
Brugia malayi beta-lactamase family protein 0.0038 0.0663 0.0665
Brugia malayi Thioredoxin reductase 0.0179 0.5982 0.6
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.2918 0.3179
Schistosoma mansoni chromobox protein 0.0073 0.1983 0.1983
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0062 0.1583 0.2647
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Echinococcus multilocularis lamin dm0 0.0028 0.0298 0.0498
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0654 0.0656
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0663 0.0663
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.148 0.1485
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.033 0.0331
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Echinococcus granulosus chromobox protein 1 0.0073 0.1983 0.3315
Loa Loa (eye worm) hypothetical protein 0.0049 0.1102 0.1105
Trichomonas vaginalis glutaminase, putative 0.0285 0.997 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.2918 0.2927
Plasmodium falciparum glutathione reductase 0.0179 0.5982 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Mycobacterium tuberculosis Conserved protein 0.0038 0.0663 0.0801
Loa Loa (eye worm) beta-lactamase 0.0038 0.0663 0.0665
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.5212 0.5228
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0062 0.1583 0.2647
Schistosoma mansoni hypothetical protein 0.0108 0.3326 0.3326
Onchocerca volvulus 0.0038 0.0663 0.0443
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0298 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0663 0.0665
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0663 0.0665
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0663 0.0801
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0169 0.5602 0.6773
Schistosoma mansoni jumonji domain containing protein 0.0075 0.206 0.206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0421 0.0421
Treponema pallidum NADH oxidase 0.0062 0.1583 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2918 0.4878
Giardia lamblia NADH oxidase lateral transfer candidate 0.0062 0.1583 0.5426
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0663 0.0665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0663 0.0663
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.1137 0.114
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0782 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0335 0.0336
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0663 0.0588
Loa Loa (eye worm) hypothetical protein 0.0028 0.0298 0.0299
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0663 0.0665
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0335 0.0336
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.2918 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.033 0.0552
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.1583 0.2647
Mycobacterium ulcerans hypothetical protein 0.0038 0.0663 0.0665
Schistosoma mansoni alpha-glucosidase 0.0145 0.4695 0.4695
Leishmania major trypanothione reductase 0.0179 0.5982 1
Mycobacterium tuberculosis Probable reductase 0.0123 0.3888 0.4702
Echinococcus multilocularis geminin 0.0164 0.5412 0.9048
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.3888 0.4702
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0062 0.1583 0.2217
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0298 0.0299
Trypanosoma brucei trypanothione reductase 0.0179 0.5982 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0753 0.1259
Toxoplasma gondii thioredoxin reductase 0.0179 0.5982 1
Plasmodium vivax glutathione reductase, putative 0.0179 0.5982 1
Onchocerca volvulus 0.0247 0.8539 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Echinococcus granulosus lamin 0.0028 0.0298 0.0498
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.2918 0.4878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.1583 0.2647
Echinococcus multilocularis lamin 0.0028 0.0298 0.0498
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0062 0.1583 0.2647
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.1137 0.1901
Schistosoma mansoni hypothetical protein 0.005 0.1137 0.1137
Trypanosoma cruzi trypanothione reductase, putative 0.0179 0.5982 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.2918 0.2927
Echinococcus multilocularis musashi 0.0028 0.0298 0.0498
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0663 0.0665
Schistosoma mansoni hypothetical protein 0.0029 0.033 0.033
Onchocerca volvulus 0.0043 0.0868 0.0693
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.1137 0.1901
Mycobacterium ulcerans beta-lactamase 0.0038 0.0663 0.0665
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0654 0.1094
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0654 0.0656
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0663 0.0801
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0421 0.0161
Schistosoma mansoni alpha glucosidase 0.0037 0.0654 0.0654
Plasmodium falciparum glutathione reductase 0.0062 0.1583 0.2217
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0421 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2918 0.2927
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.3888 0.4702
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0663 0.1108
Brugia malayi PHD-finger family protein 0.0029 0.033 0.0331
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0663 0.0801
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0663 0.0801
Brugia malayi Pre-SET motif family protein 0.0217 0.7412 0.7434
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0062 0.1583 0.2217

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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