Detailed information for compound 1358042

Basic information

Technical information
  • TDR Targets ID: 1358042
  • Name: Maybridge3_001871
  • MW: 344.428 | Formula: C18H20N2O3S
  • H donors: 1 H acceptors: 3 LogP: 1.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1ccc(cc1)CN1CCS(=O)(=O)CC1
  • InChi: 1S/C18H20N2O3S/c21-18(16-4-2-1-3-5-16)19-17-8-6-15(7-9-17)14-20-10-12-24(22,23)13-11-20/h1-9H,10-14H2,(H,19,21)
  • InChiKey: NJHGBSAICIYFRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_185548
  • MLS000830764
  • N-{4-[(1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)methyl]phenyl}benzamide
  • SMR000458185
  • HTS 02309
  • IDI1_013258

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0036 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.5025 1 1
Echinococcus multilocularis histone acetyltransferase myst3 0.0056 0.0071 0.007
Entamoeba histolytica hypothetical protein 0.0037 0.0033 0.2225
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1916 0.1916
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi Liprin-alpha 2 0.0076 0.0112 0.0111
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0072 0.6898
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0121 0.0121
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0037 0.0033 0.2362
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0036 0.0035
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0056 0.0071 0.007
Brugia malayi nuclear hormone receptor 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.0796
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0036 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0613
Schistosoma mansoni hypothetical protein 0.0374 0.0707 0.0706
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0036 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Echinococcus granulosus histone acetyltransferase myst3 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0121 0.0121
Echinococcus granulosus polyhomeotic protein 2 0.0056 0.0071 0.007
Plasmodium falciparum cysteine repeat modular protein 1 0.0075 0.0109 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0017 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Brugia malayi Lethal protein 805 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Brugia malayi Importin beta-1 subunit 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0313 0.0586 0.0585
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0121 0.0121
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0021 0.1069
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0034 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0071 0.007
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Echinococcus granulosus cell adhesion molecule 0.0037 0.0034 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Mycobacterium leprae Probable lipase LipE 0.004 0.004 1
Mycobacterium ulcerans short chain dehydrogenase 0.0568 0.1095 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0021 0.178
Schistosoma mansoni nuclear receptor 0.0038 0.0036 0.0035
Echinococcus multilocularis cell adhesion molecule 0.0037 0.0034 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0034 0.0034
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0021 0.0021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus Sterile alpha motif type 0.0056 0.0071 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.001 0.1318
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Trypanosoma cruzi Kinesin-13 5, putative 0.0056 0.0071 0.6733
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0121 0.0121
Giardia lamblia Multidrug resistance-associated protein 1 0.0037 0.0033 0.2225
Plasmodium falciparum cysteine repeat modular protein 3 0.0075 0.0109 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0081 0.0121 0.0121
Toxoplasma gondii kringle domain-containing protein 0.0075 0.0109 1
Loa Loa (eye worm) projectin 0.0037 0.0034 0.0034
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0121 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0121 0.0121
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0036 0.0035
Brugia malayi Sphingomyelin synthase-related 1 0.0056 0.0071 0.007
Echinococcus granulosus sphingomyelin synthase protein 1 0.0056 0.0071 0.007
Schistosoma mansoni DNAj-like protein 0.0056 0.0071 0.007
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.3073
Schistosoma mansoni hypothetical protein 0.0075 0.0109 0.0108
Trypanosoma brucei p-glycoprotein 0.0037 0.0033 0.2362
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi bicaudal-C 0.0056 0.0071 0.007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.004 0.037
Brugia malayi Nuclear hormone receptor-like 1 0.0356 0.0671 0.0671
Brugia malayi RNA, U transporter 1 0.0099 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0121 0.0121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.004 0.004
Onchocerca volvulus 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus titin 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0036 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Mycobacterium ulcerans lipase LipD 0.004 0.004 0.0349
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0036 0.0035
Brugia malayi SPRY domain containing protein 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0121 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0056 0.0071 0.007
Brugia malayi Cytochrome P450 family protein 0.0027 0.0013 0.0012
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.3073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0121 0.0121
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0121 0.0121
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Schistosoma mansoni sodium-bile acid cotransporter related 0.5025 1 1
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0121 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0016 0.221
Schistosoma mansoni ephrin receptor 0.0047 0.0054 0.0053
Brugia malayi nuclear receptor NHR-67 0.0038 0.0036 0.0035
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0075 0.0109 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0121 0.0121
Toxoplasma gondii ABC1 family protein 0.004 0.004 0.3698
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0102 0.0102
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0021 0.1069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0372 0.0702 0.0702
Echinococcus multilocularis Netrin receptor DCC 0.0037 0.0034 0.0034
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0071 0.007
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0054 0.4848
Brugia malayi conserved hypotetical protein 0.0038 0.0036 0.0035
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0037 0.0034 0.0034
Loa Loa (eye worm) UNCoordinated family member 0.0037 0.0034 0.0034
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0036 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0121 0.0121
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.025 0.025
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0309 0.0309
Schistosoma mansoni nuclear receptor 0.0038 0.0036 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0121 0.0121
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.001 0.0009
Echinococcus granulosus liprin alpha 2 0.0076 0.0112 0.0111
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Echinococcus multilocularis titin 0.0037 0.0034 0.0034
Echinococcus multilocularis snurportin 1 0.0372 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0056 0.0071 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.004 0.5703
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.002 0.002
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.001 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Trypanosoma brucei multidrug resistance protein E 0.0037 0.0033 0.2362
Schistosoma mansoni polyhomeotic 0.0056 0.0071 0.007
Echinococcus granulosus G1Y162 protein 0.0037 0.0034 0.0034
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0037 0.0033 0.2964
Onchocerca volvulus 0.0037 0.0034 0.0034
Trichomonas vaginalis esterase, putative 0.004 0.004 0.5703
Brugia malayi hypothetical protein 0.0056 0.0071 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0121 0.0121
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0017 0.0132
Echinococcus granulosus Netrin receptor DCC 0.0037 0.0034 0.0034
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0076 0.0112 0.0111
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0021 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0056 0.0071 0.6493
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Echinococcus multilocularis neuroglian 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0021 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0062 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0411 0.0411
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0075 0.0109 1
Brugia malayi nuclear receptor RXR 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0037 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0309 0.0309
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0076 0.0112 0.0111
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0038 0.0036 0.0035
Brugia malayi protein unc-22 0.0037 0.0034 0.0034
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Schistosoma mansoni neuroglian 0.0037 0.0034 0.0034
Echinococcus multilocularis Sterile alpha motif type 0.0056 0.0071 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0121 0.0121
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0034 0.0034
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.001 0.1318
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0021 0.1234
Loa Loa (eye worm) hypothetical protein 0.0964 0.1885 0.1885
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0121 0.0121
Leishmania major pentamidine resistance protein 1 0.0037 0.0033 0.2447
Echinococcus granulosus single minded 2 0.0071 0.0102 0.0102
Brugia malayi nuclear hormone receptor 0.0081 0.0121 0.0121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0071 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0613
Plasmodium falciparum cysteine repeat modular protein 4 0.0075 0.0109 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0121 0.0121
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.001 0.3921
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0121 0.0121
Schistosoma mansoni myosin-binding protein-related 0.0037 0.0034 0.0034
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0045 0.0044
Brugia malayi myotactin form A 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Probable hydrolase 0.004 0.004 0.037
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus multidrug resistance associated protein 7 0.0037 0.0033 0.0032
Echinococcus granulosus pdz domain containing protein 0.0056 0.0071 0.007
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0062 0.8832
Brugia malayi coiled-coil like protein 1 0.0076 0.0112 0.0111
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0037 0.0033 0.2447
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0121 0.0121
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0029 0.265
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.004 0.037
Mycobacterium ulcerans beta-lactamase 0.004 0.004 0.0349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0017 0.0153
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Schistosoma mansoni Protein aveugle 0.0056 0.0071 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0075 0.0109 0.0108
Echinococcus multilocularis multidrug resistance associated protein 4 0.0022 0.0004 0.0004
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Entamoeba histolytica ABC transporter, putative 0.0037 0.0033 0.2225
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0045 0.0044
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.001 0.1318
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.004 0.0349
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.001 0.0009
Brugia malayi Lethal protein 805 0.0037 0.0034 0.0034
Plasmodium falciparum conserved protein, unknown function 0.0075 0.0109 1
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0109 1
Trichomonas vaginalis taga, putative 0.0031 0.0021 0.2959
Onchocerca volvulus 0.0025 0.001 0.0009
Plasmodium vivax protein kinase, putative 0.0065 0.009 0.8248
Echinococcus granulosus endonuclease reverse transcriptase 0.0075 0.0109 0.0108
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni nephrin 0.0037 0.0034 0.0034
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.001 0.1318
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0121 0.0121
Brugia malayi AIDA-1b 0.0056 0.0071 0.007
Loa Loa (eye worm) acetyltransferase 0.0175 0.0309 0.0309
Schistosoma mansoni ran 0.0026 0.0011 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0062 0.8832
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0037 0.0033 0.0032
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0062 0.5727
Onchocerca volvulus 0.0075 0.0109 0.0108
Brugia malayi hypothetical protein 0.0056 0.0071 0.007
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.003 0.002 0.002
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0017 0.0132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0121 0.0121
Loa Loa (eye worm) tnks protein 0.0056 0.0071 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0228 0.0227
Giardia lamblia CEGP1 protein 0.0075 0.0109 1
Onchocerca volvulus 0.5025 1 1
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Giardia lamblia Multidrug resistance-associated protein 1 0.0036 0.0032 0.2123
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0021 0.0194
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0121 0.0121
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0226 0.0411 0.0411
Echinococcus granulosus usherin 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0075 0.0109 1
Brugia malayi nuclear receptor RXR 0.0038 0.0036 0.0035
Schistosoma mansoni zinc finger protein 0.0038 0.0036 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Brugia malayi steroid hormone receptor 0.0081 0.0121 0.0121
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0037 0.0033 0.2362
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Echinococcus granulosus neuroglian 0.0037 0.0034 0.0034
Echinococcus multilocularis titin 0.0037 0.0034 0.0034
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Brugia malayi hypothetical protein 0.0038 0.0036 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0121 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.004 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0121 0.0121
Echinococcus multilocularis usherin 0.0037 0.0034 0.0034
Mycobacterium ulcerans hypothetical protein 0.004 0.004 0.0349
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0021 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Onchocerca volvulus 0.0056 0.0071 0.007
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0017 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0121 0.0121
Plasmodium falciparum cysteine repeat modular protein 2 0.0075 0.0109 1
Onchocerca volvulus 0.0056 0.0071 0.007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.004 0.0349
Leishmania major p-glycoprotein e 0.0037 0.0033 0.2447
Onchocerca volvulus 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Schistosoma mansoni sodium-bile acid cotransporter related 0.2038 0.4031 0.4031
Brugia malayi ecdysteroid receptor 0.0081 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0075 0.0109 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0121 0.0121
Giardia lamblia Hypothetical protein 0.0075 0.0109 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.002 0.1652
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.001 0.0009
Onchocerca volvulus 0.0118 0.0196 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0121 0.0121
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Schistosoma mansoni sodium-bile acid cotransporter 0.2988 0.5929 0.5928
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0506 0.0971 0.0971
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0021 0.2959
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0021 0.178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0036 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0121 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0476 0.435
Schistosoma mansoni tripartite motif protein trim9 0.0037 0.0034 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Echinococcus granulosus Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Brugia malayi multidrug resistance related protein 1 0.0037 0.0033 0.0032
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0021 0.1919
Schistosoma mansoni spingomyelin synthetase-related 0.0056 0.0071 0.007
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0021 0.1069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Brugia malayi ecdysone receptor 0.0038 0.0036 0.0035
Onchocerca volvulus 0.0056 0.0071 0.007
Trypanosoma brucei hypothetical protein, conserved 0.004 0.004 0.3223
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Loa Loa (eye worm) AIDA-1b 0.0056 0.0071 0.007
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0043 0.0045 0.0044
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0121 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0013 0.0012
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0037 0.0033 0.2884
Onchocerca volvulus 0.004 0.004 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.1993
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Brugia malayi PAS domain containing protein 0.0097 0.0153 0.0152
Schistosoma mansoni Protein aveugle 0.0056 0.0071 0.007
Onchocerca volvulus 0.0037 0.0034 0.0034
Onchocerca volvulus 0.004 0.004 0.004
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0011 0.0796
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Schistosoma mansoni phd finger protein 0.0056 0.0071 0.007
Onchocerca volvulus 0.0964 0.1885 0.1885
Leishmania major GTP-binding protein, putative 0.0026 0.0011 0.0112
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Trypanosoma cruzi Kinesin-13 5, putative 0.0056 0.0071 0.6733
Onchocerca volvulus 0.0037 0.0034 0.0034
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0054 0.4402
Echinococcus granulosus snurportin 1 0.0372 0.0702 0.0702
Plasmodium vivax hypothetical protein, conserved 0.004 0.004 0.359
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0121 0.0121
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0021 0.1069
Echinococcus granulosus multidrug resistance associated protein 4 0.0022 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0374 0.0707 0.0706
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Brugia malayi beta-lactamase 0.004 0.004 0.004
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0056 0.0071 0.6115
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Onchocerca volvulus Tankyrase homolog 0.0056 0.0071 0.007
Echinococcus multilocularis multidrug resistance associated protein 1 0.0037 0.0033 0.0032
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0056 0.0071 0.6493
Schistosoma mansoni coup transcription factor 0.0081 0.0121 0.0121
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0021 0.1069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0037 0.0034 0.0034
Echinococcus granulosus titin 0.0037 0.0034 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0037 0.0033 0.2447
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.004 0.037
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Echinococcus granulosus fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) TK/EPH protein kinase 0.1183 0.2322 0.2322
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0037 0.0034 0.0034
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0056 0.0071 0.007
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0021 0.1919
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0036 0.0035
Loa Loa (eye worm) DR-78 0.0038 0.0036 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.004 0.004
Echinococcus multilocularis multidrug resistance associated protein 7 0.0037 0.0033 0.0032
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0011 0.0951
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Trichomonas vaginalis ran, putative 0.0026 0.0011 0.1467
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0121 0.0121
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Onchocerca volvulus 0.0029 0.0017 0.0016
Brugia malayi hypothetical protein 0.0043 0.0045 0.0044
Schistosoma mansoni hemicentin 0.0037 0.0034 0.0034
Toxoplasma gondii hypothetical protein 0.0075 0.0109 1
Loa Loa (eye worm) hypothetical protein 0.0324 0.0607 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0036 0.0035
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0037 0.0033 0.2447
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0121 0.0121
Brugia malayi ephrin receptor 1 precursor 0.0479 0.0916 0.0916
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus multilocularis ephrin type A receptor 4 A 0.1048 0.2054 0.2053
Loa Loa (eye worm) myotactin form A 0.0037 0.0034 0.0034
Echinococcus granulosus Netrin receptor DCC 0.0037 0.0034 0.0034
Brugia malayi beta-lactamase family protein 0.004 0.004 0.004
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.004 0.037
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0017 0.0132
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0037 0.0033 0.2447
Loa Loa (eye worm) hypoxia-induced factor 1 0.0299 0.0557 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Echinococcus granulosus ephrin type A receptor 4 A 0.1048 0.2054 0.2053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Echinococcus multilocularis pdz domain containing protein 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni smdr2 0.0031 0.0021 0.0021
Mycobacterium leprae conserved hypothetical protein 0.004 0.004 1
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0075 0.0109 1
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0036 0.0035
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Leishmania major importin beta-1 subunit, putative 0.0028 0.0016 0.0671
Echinococcus granulosus multidrug resistance associated protein 1 0.0037 0.0033 0.0032
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0036 0.0035
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0034 0.0034
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0121 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0034 0.0034
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.004 0.004
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.002 0.1652
Giardia lamblia MRP-like ABC transporter 0.0037 0.0033 0.2225
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Echinococcus granulosus importin subunit beta 1 0.0035 0.0029 0.0029
Echinococcus granulosus nephrin 0.0037 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.3686
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0702 0.0702
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.1993
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0121 0.0121
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0036 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0036 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus multilocularis Netrin receptor DCC 0.0037 0.0034 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0016 0.221
Leishmania major p-glycoprotein 0.0031 0.0021 0.1234
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0102 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Trypanosoma cruzi multidrug resistance protein E, putative 0.0037 0.0033 0.2884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.001 0.0578
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0034 0.0034
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Plasmodium falciparum importin beta, putative 0.0035 0.0029 0.2524
Onchocerca volvulus 0.0071 0.0102 0.0102
Echinococcus multilocularis polyhomeotic protein 2 0.0056 0.0071 0.007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0062 0.5654
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0032
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.001 0.0009
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Brugia malayi ABC transporter transmembrane region family protein 0.0037 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0036 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0568 0.1095 1
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0121 0.0121
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Brugia malayi MH2 domain containing protein 0.0134 0.0228 0.0227
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0121 0.0121
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0036 0.0035
Onchocerca volvulus 0.0038 0.0036 0.0035
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0036 0.0035
Plasmodium falciparum protein kinase, putative 0.003 0.002 0.1652
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0121 0.0121
Entamoeba histolytica hypothetical protein, conserved 0.0075 0.0109 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0054 0.4402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0016 0.221
Echinococcus granulosus geminin 0.0374 0.0707 0.0706
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0036 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.004 0.004
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Echinococcus multilocularis endonuclease reverse transcriptase 0.0075 0.0109 0.0108
Brugia malayi Shank2E 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Brugia malayi tailless protein 0.0038 0.0036 0.0035
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0103 1
Brugia malayi myotactin form B 0.0037 0.0034 0.0034
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0029 0.0029
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0071 1
Entamoeba histolytica hypothetical protein 0.0028 0.0016 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0121 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0109 1
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.004 0.037
Echinococcus granulosus Sterile alpha motif SAM 0.0076 0.0112 0.0111
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0037 0.0033 0.2884
Leishmania major hypothetical protein, conserved 0.0037 0.0034 0.2648
Onchocerca volvulus 0.0038 0.0036 0.0035
Echinococcus granulosus liprin alpha 2 0.0056 0.0071 0.007
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0021 0.2959
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.2291
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0153 0.0152
Brugia malayi nuclear receptor NHR-88 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Entamoeba histolytica cysteine-rich surface protein, putative 0.0075 0.0109 1
Onchocerca volvulus 0.0056 0.0071 0.007
Onchocerca volvulus 0.0037 0.0034 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0036 0.0035
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Echinococcus multilocularis geminin 0.0374 0.0707 0.0706
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.3686
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0121 0.0121
Schistosoma mansoni lip-related protein (liprin) alpha 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Brugia malayi ABC transporter family protein 0.0031 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0021 0.1069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0017 0.0132
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0075 0.0109 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Echinococcus granulosus contactin 0.0037 0.0034 0.0034
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.001 0.0578
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0054 0.0053
Schistosoma mansoni nephrin 0.0037 0.0034 0.0034
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0011 0.001
Echinococcus multilocularis liprin alpha 2 0.0076 0.0112 0.0111
Schistosoma mansoni hypothetical protein 0.0145 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0228 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.004 0.5703
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0411 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0121 0.0121
Giardia lamblia Kinesin-13 0.0056 0.0071 0.6115
Loa Loa (eye worm) multidrug resistance-associated protein 0.0023 0.0005 0.0005
Onchocerca volvulus 0.004 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Trypanosoma cruzi hypothetical protein 0.0056 0.0071 0.6733
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.2291
Schistosoma mansoni ephrin receptor 0.0974 0.1905 0.1904
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.004 0.037
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.3073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0011 0.0684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0121 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.009 0.8742
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni ran 0.0026 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Brugia malayi nuclear receptor NHR-88 0.0081 0.0121 0.0121
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0324 0.0607 0.0607
Schistosoma mansoni single-minded 0.0097 0.0153 0.0152
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0056 0.0071 0.007
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Giardia lamblia Multidrug resistance-associated protein 1 0.0037 0.0033 0.2225
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis cgi-62, putative 0.0056 0.0071 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.004 0.004 0.3299
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0032
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Echinococcus multilocularis liprin alpha 2 0.0056 0.0071 0.007
Echinococcus multilocularis Fibronectin, type III 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0011 0.0684
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0036 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0016 0.121
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.001 0.1318
Brugia malayi Nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) lethal protein 805 0.0037 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0121 0.0121
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Brugia malayi multidrug resistance protein 3 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Leishmania major ABC-thiol transporter 0.0037 0.0033 0.2447
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0056 0.0071 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0036 0.0035
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0021 0.0021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0036 0.0035
Echinococcus multilocularis Sterile alpha motif SAM 0.0056 0.0071 0.007
Brugia malayi hypoxia-induced factor 1 0.0299 0.0557 0.0556
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0002 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0102 0.0102
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0021 0.1069
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Entamoeba histolytica multidrug resistance protein, putative 0.0037 0.0033 0.2225
Echinococcus granulosus Fibronectin type III 0.0037 0.0034 0.0034
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0062 0.5727
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0034 0.0034
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.001
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) CAMK protein kinase 0.0037 0.0034 0.0034
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0054 0.0053
Echinococcus multilocularis transfer RNA-Phe 0.0037 0.0034 0.0034
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.2565
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0071 0.007
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi beta-lactamase family protein 0.004 0.004 0.004
Entamoeba histolytica protein kinase, putative 0.0075 0.0109 1
Schistosoma mansoni importin beta-1 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Brugia malayi cask-interacting protein 2 0.0056 0.0071 0.007
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0056 0.0071 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0037 0.0034 0.0034
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Plasmodium vivax importin-beta 2, putative 0.0035 0.0029 0.2524
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0017 0.0613
Echinococcus granulosus EG95 0.0037 0.0034 0.0034
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Loa Loa (eye worm) beta-lactamase 0.004 0.004 0.004
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0076 0.0112 0.0111
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Giardia lamblia ABC transporter, putative 0.0037 0.0033 0.2225
Onchocerca volvulus 0.0031 0.0021 0.0021

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0041 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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