Detailed information for compound 135811

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.181 | Formula: C12H9BrN2O2S
  • H donors: 1 H acceptors: 1 LogP: 2.98 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S1ON=C(N1)Cc1cc(Br)c2c(c1)cccc2
  • InChi: 1S/C12H9BrN2O2S/c13-11-6-8(7-12-14-17-18(16)15-12)5-9-3-1-2-4-10(9)11/h1-6H,7H2,(H,14,15)
  • InChiKey: YFUSQWARXQFIFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0099 0.1187 0.8207
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0165 0.0658
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0165 0.0658
Trypanosoma brucei unspecified product 0.0043 0.0469 0.2442
Echinococcus granulosus tar DNA binding protein 0.021 0.2622 0.2606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0718 0.444
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0077 0.0055
Brugia malayi beta-lactamase 0.0116 0.1411 0.1373
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0469 0.2442
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0447 0.5677 0.5886
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.0163 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0447 0.5677 0.5668
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0308 0.1731
Loa Loa (eye worm) hypothetical protein 0.003 0.0305 0.0263
Onchocerca volvulus 0.0116 0.1411 0.4707
Schistosoma mansoni hypothetical protein 0.0754 0.963 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0308 0.1148
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0121
Schistosoma mansoni ap endonuclease 0.0099 0.1187 0.1213
Entamoeba histolytica Flap nuclease, putative 0.003 0.0308 0.1412
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0066 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.0782 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0308 0.0287
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0059 0.0038
Onchocerca volvulus 0.0019 0.0163 0.0413
Onchocerca volvulus 0.0021 0.0186 0.0491
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0718 0.0724
Mycobacterium tuberculosis Conserved protein 0.0116 0.1411 0.1332
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0186 0.0171
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.1411 0.1332
Brugia malayi beta-lactamase family protein 0.0116 0.1411 0.1373
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0099 0.1187 0.8207
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0019 0.0163 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0718 0.444
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.002 0.0173 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1411 0.1445
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.002 0.0173 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0186 0.0143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0186 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0305 0.0284
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0186 0.0143
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Loa Loa (eye worm) RNA binding protein 0.021 0.2622 0.259
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0013 0.0077 0.0055
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.0057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0718 0.0724
Echinococcus granulosus flap endonuclease 1 0.003 0.0308 0.0286
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2581 0.2549
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0305 0.171
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0173 0.013
Trichomonas vaginalis Phospholipase C precursor, putative 0.002 0.0173 0.0585
Leishmania major DNA polymerase eta, putative 0.0062 0.0718 0.444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Schistosoma mansoni synaptojanin 0.002 0.0173 0.0157
Loa Loa (eye worm) hypothetical protein 0.0782 1 1
Echinococcus multilocularis dna polymerase eta 0.0062 0.0718 0.0697
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0251 0.0694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.013
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0165 0.0791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Brugia malayi CCR4 0.002 0.0173 0.013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0099 0.1187 0.8207
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0718 0.2435
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0077 0.0055
Schistosoma mansoni GTP-binding protein alpha subunit 0.0019 0.0163 0.0147
Brugia malayi TAR-binding protein 0.021 0.2622 0.259
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0173 0.0585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0186 0.0164
Leishmania major hypothetical protein, conserved 0.002 0.0173 0.0062
Echinococcus granulosus SWI:SNF matrix associated 0.0013 0.0077 0.0055
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0447 0.5677 0.5886
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0099 0.1187 0.1092
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0019 0.0163 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Leishmania major hypothetical protein, conserved 0.0026 0.0251 0.0694
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0019 0.0163 0.0142
Brugia malayi ecdysteroid receptor 0.0021 0.0186 0.0143
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1411 0.4785
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0019 0.0163 0.0142
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0186 0.0143
Schistosoma mansoni hypothetical protein 0.0754 0.963 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0019 0.0163 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0251 0.0694
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0718 0.444
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0173 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0469 0.2442
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.1411 0.1332
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.002 0.0173 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0173 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0186 0.0171
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0308 0.1399
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1411 0.1445
Leishmania major hypothetical protein, conserved 0.002 0.0173 0.0062
Echinococcus multilocularis tar DNA binding protein 0.021 0.2622 0.2606
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0186 0.0164
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0718 0.5416
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0186 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0251 0.1307
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.002 0.0173 0.0062
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Echinococcus granulosus dna polymerase eta 0.0062 0.0718 0.0697
Onchocerca volvulus 0.0019 0.0163 0.0413
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0043 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0186 0.0143
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0165 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1411 0.4785
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0186 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0186 0.0143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.1187 1
Mycobacterium leprae conserved hypothetical protein 0.0116 0.1411 0.5
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Loa Loa (eye worm) hypothetical protein 0.0145 0.1782 0.1746
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0163 0.0554
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0019 0.0163 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0186 0.0143
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.0173 0.013
Onchocerca volvulus 0.0116 0.1411 0.4707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0186 0.0164
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0099 0.1187 0.1168
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0059 0.0037
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.002 0.0173 0.0585
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0019 0.0163 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0045 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.1411 0.1332
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0283 0.0261
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Onchocerca volvulus 0.0116 0.1411 0.4707
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0186 0.0143
Loa Loa (eye worm) beta-lactamase 0.0116 0.1411 0.1373
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0015
Brugia malayi steroid hormone receptor 0.0021 0.0186 0.0143
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0186 0.0171
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.002 0.0173 0.0861
Schistosoma mansoni nuclear receptor 0.001 0.0043 0.0022
Echinococcus multilocularis synaptojanin 1 0.002 0.0173 0.0151
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0186 0.0164
Echinococcus granulosus synaptojanin 1 0.002 0.0173 0.0151
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.0173 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0186 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1411 0.4785
Brugia malayi G-protein alpha subunit 0.0019 0.0163 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0121
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1782 0.1764
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0305 0.0295
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0447 0.5677 0.5659
Schistosoma mansoni nuclear hormone receptor 0.001 0.0043 0.0022
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0019 0.0163 0.0147
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0099 0.1187 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0186 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Mycobacterium tuberculosis Conserved protein 0.0116 0.1411 0.1332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0447 0.5677 0.5886
Onchocerca volvulus 0.0235 0.2948 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0251 0.157
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.0163 0.0147
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0019 0.0163 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0718 0.444
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0043 0.0021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0287 0.0245
Loa Loa (eye worm) hypothetical protein 0.0062 0.0718 0.0678
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0718 0.0678
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0173 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.0163 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0251 0.157
Mycobacterium ulcerans lipase LipD 0.0116 0.1411 1
Leishmania major RNA-editing complex protein MP100, putative 0.002 0.0173 0.0062
Mycobacterium tuberculosis Conserved protein 0.0116 0.1411 0.1332
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0043 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.1411 0.1392
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0043 0.0022
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.0173 0.0157
Onchocerca volvulus Putative neutral sphingomyelinase 0.002 0.0173 0.0445
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0013 0.0077 0.0055
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0718 0.2435
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.002 0.0173 0.0585
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0173 0.0062
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Trypanosoma brucei RNA editing exonuclease 2 0.002 0.0173 0.0062
Brugia malayi nuclear receptor RXR 0.0011 0.0059 0.0015
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.002 0.0173 0.0062
Onchocerca volvulus 0.016 0.1973 0.6642
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0186 0.0164
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0308 0.1148
Echinococcus multilocularis muscleblind protein 0.0145 0.1782 0.1764
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0173 0.013
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0077 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0059 0.0015
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.002 0.0173 0.0062
Toxoplasma gondii ABC1 family protein 0.0116 0.1411 1
Mycobacterium ulcerans hypothetical protein 0.0116 0.1411 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0173 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0447 0.5677 0.5668
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.1411 0.1332
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0043 0.0021
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.002 0.0173 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0019 0.0163 0.0121
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0165 0.0658
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0019 0.0163 0.0554
Echinococcus multilocularis survival motor neuron protein 1 0.0782 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0077 0.0261
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0251 0.0694
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1411 1
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0718 0.0678
Schistosoma mansoni tar DNA-binding protein 0.021 0.2622 0.2706
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0043 0.0022
Schistosoma mansoni flap endonuclease-1 0.0027 0.027 0.0258
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.1411 0.1332
Schistosoma mansoni cript-related 0.002 0.0173 0.0157
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0019 0.0163 0.0121
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.002 0.0173 0.0062
Schistosoma mansoni nuclear receptor 0.001 0.0043 0.0022
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.0173 0.0151
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0186 0.0491
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0019 0.0163 0.0142
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.0163 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0209
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0019 0.0163 0.0121
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0019 0.0163 0.0147
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.0173 0.0151
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0308 0.1731
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0186 0.0143
Onchocerca volvulus 0.002 0.0173 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1411 1
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.002 0.0173 0.0062
Brugia malayi hypothetical protein 0.0019 0.0163 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0447 0.5677 0.5659
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0043 0.0021
Schistosoma mansoni DNA polymerase eta 0.0062 0.0718 0.0724
Schistosoma mansoni GTP-binding protein alpha subunit 0.0019 0.0163 0.0147
Plasmodium vivax exodeoxyribonuclease III, putative 0.002 0.0173 0.0716
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.1411 0.1392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0045 0.0023
Mycobacterium ulcerans beta-lactamase 0.0116 0.1411 1
Onchocerca volvulus 0.003 0.0305 0.0901
Trypanosoma brucei unspecified product 0.0062 0.0718 0.444
Toxoplasma gondii exonuclease III APE 0.0099 0.1187 0.8325
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0186 0.0164
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0186 0.0491
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0099 0.1187 0.1168
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0186 0.0171
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0163 0.0554
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.1411 0.1332
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.1411 1
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.1187 0.4027
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0019 0.0163 0.0121
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0019 0.0163 0.0142
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0186 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0163 0.0554
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0186 0.0491
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0019 0.0163 0.0142
Onchocerca volvulus 0.0029 0.0287 0.084
Schistosoma mansoni tar DNA-binding protein 0.021 0.2622 0.2706
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.002 0.0173 0.009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0173 0.013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0718 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0186 0.0143
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0251 0.1307
Brugia malayi Pre-SET motif family protein 0.003 0.0305 0.0263
Trypanosoma brucei unspecified product 0.0043 0.0469 0.2442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0305 0.0295
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0019 0.0163 0.0121
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.0163 0.0147
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.0173 0.0151
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1411 0.4785
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0298
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0718 0.0724
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Brugia malayi Pre-SET motif family protein 0.0207 0.2581 0.2549
Schistosoma mansoni hypothetical protein 0.016 0.1973 0.203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0186 0.0164
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0099 0.1187 1
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.1411 0.1332
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.002 0.0173 0.0062
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0186 0.0171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0186 0.0171
Trypanosoma cruzi pantothenate kinase subunit, putative 0.002 0.0173 0.0062
Schistosoma mansoni tar DNA-binding protein 0.021 0.2622 0.2706
Leishmania major pantothenate kinase subunit, putative 0.002 0.0173 0.0062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0718 0.0697
Giardia lamblia DINP protein human, muc B family 0.0062 0.0718 0.541
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0186 0.0143
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.0163 0.0147
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.0163 0.0142
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0173 0.0151
Echinococcus multilocularis flap endonuclease 1 0.003 0.0308 0.0286
Loa Loa (eye worm) histone methyltransferase 0.001 0.0045 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0043 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.1411 1
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.002 0.0173 0.0585
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0043 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0122
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0308 0.1148
Schistosoma mansoni ap endonuclease 0.0099 0.1187 0.1213
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0019 0.0163 0.0121
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0718 0.0587
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0059 0.0037
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0019 0.0163 0.0554
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0186 0.0164
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.0173 0.0157
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2948 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0718 0.444
Schistosoma mansoni hypothetical protein 0.002 0.0173 0.0157
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0019 0.0163 0.0147
Chlamydia trachomatis DNA topoisomerase I 0.0013 0.0077 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0121
Brugia malayi Flap endonuclease-1 0.003 0.0308 0.0266
Loa Loa (eye worm) TAR-binding protein 0.021 0.2622 0.259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0186 0.0143
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0718 0.444
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0173 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0186 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0305 0.0295
Plasmodium falciparum flap endonuclease 1 0.003 0.0308 0.208
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0043 0.0021
Schistosoma mansoni nuclear hormone receptor 0.001 0.0043 0.0022
Schistosoma mansoni brg-1 associated factor 0.0013 0.0077 0.0057
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Schistosoma mansoni hypothetical protein 0.0012 0.0066 0.0046
Brugia malayi SWIB/MDM2 domain containing protein 0.0013 0.0077 0.0034
Brugia malayi RNA binding protein 0.021 0.2622 0.259
Echinococcus granulosus endonuclease exonuclease phosphatase 0.002 0.0173 0.0151
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0186 0.0164
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0019 0.0163 0.0142
Brugia malayi hypothetical protein 0.0011 0.0059 0.0015
Mycobacterium leprae Probable lipase LipE 0.0116 0.1411 0.5
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0019 0.0163 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0447 0.5677 0.5668
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0308 0.1044
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0043 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0043 0.0021
Schistosoma mansoni neutral sphingomyelinase 0.002 0.0173 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0186 0.0171
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0173 0.0861
Schistosoma mansoni nocturnin 0.002 0.0173 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.021 0.2622 0.259
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0173 0.0585
Brugia malayi beta-lactamase family protein 0.0116 0.1411 0.1373
Loa Loa (eye worm) G protein alpha subunit 3 0.0019 0.0163 0.0121
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0043 0.0000033499
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0043 0.0021
Echinococcus granulosus geminin 0.0754 0.963 0.9629
Entamoeba histolytica sphingomyelinase C precursor, putative 0.002 0.0173 0.009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0186 0.0164
Brugia malayi Muscleblind-like protein 0.0145 0.1782 0.1746
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0718 0.444
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.016 0.1973 0.1938
Brugia malayi polk-prov protein 0.0019 0.0165 0.0122
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0099 0.1187 0.8325
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0059 0.0015
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0173 0.013
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0186 0.0171
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0165 0.0658
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0066 0.0044
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0298
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0718 0.444
Brugia malayi hypothetical protein 0.0011 0.0059 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0469 0.2442
Loa Loa (eye worm) brahma associated protein 0.0013 0.0077 0.0034
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.002 0.0173 0.0062
Brugia malayi nuclear receptor NHR-88 0.0021 0.0186 0.0143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0305 0.0284
Chlamydia trachomatis SWIB complex protein 0.0013 0.0077 0.5
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0019 0.0163 0.0121
Leishmania major endonuclease/exonuclease protein-like protein 0.002 0.0173 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0305 0.0295
Brugia malayi hypothetical protein 0.0017 0.0132 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0186 0.0143
Plasmodium vivax SET domain protein, putative 0.003 0.0305 0.171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0305 0.0284
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.021 0.2622 0.259
Echinococcus granulosus expressed protein 0.0019 0.0163 0.0142
Schistosoma mansoni tar DNA-binding protein 0.021 0.2622 0.2706
Brugia malayi CXXC zinc finger family protein 0.0029 0.0287 0.0245
Trichomonas vaginalis ap endonuclease, putative 0.0099 0.1187 0.4027
Plasmodium falciparum DNase I-like protein, putative 0.002 0.0173 0.0861
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0718 0.444
Plasmodium falciparum exodeoxyribonuclease III, putative 0.002 0.0173 0.0861
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1411 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0186 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0186 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0186 0.0143
Schistosoma mansoni synaptojanin 0.002 0.0173 0.0157
Trichomonas vaginalis esterase, putative 0.0116 0.1411 0.4785
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.0173 0.0585
Schistosoma mansoni cpg binding protein 0.0029 0.0287 0.0276
Loa Loa (eye worm) hypothetical protein 0.0145 0.1782 0.1746
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0634 0.4173
Echinococcus multilocularis geminin 0.0754 0.963 0.9629
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0043 0.0021
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0173 0.0716
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0186 0.0143
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.0173 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.1411 0.1373
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0186 0.0143
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0059 0.0015
Echinococcus granulosus dna polymerase kappa 0.0062 0.0718 0.0697
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0173 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0186 0.0164
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.002 0.0173 0.0062
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0173 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0019 0.0163 0.0142
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0718 0.444
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.013
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0186 0.0164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0099 0.1187 0.1149
Plasmodium vivax hypothetical protein, conserved 0.002 0.0173 0.0716
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0173 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1411 0.4785
Onchocerca volvulus 0.0019 0.0163 0.0413
Treponema pallidum exodeoxyribonuclease (exoA) 0.0099 0.1187 1
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0718 0.444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0186 0.0164
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0186 0.0143
Echinococcus multilocularis expressed protein 0.0019 0.0163 0.0142
Brugia malayi hypothetical protein 0.0026 0.0251 0.0209
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0015
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0718 0.0697
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0308 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0186 0.0164
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0173 0.0062
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0013 0.0077 0.0034
Echinococcus granulosus neutral sphingomyelinase 0.002 0.0173 0.0151
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.1411 0.1373
Schistosoma mansoni coup transcription factor 0.0021 0.0186 0.0171
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.002 0.0173 0.0585
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0077 0.0034
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0019 0.0163 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0099 0.1187 0.8207
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0019 0.0163 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0447 0.5677 0.5668
Schistosoma mansoni survival motor neuron protein 0.016 0.1973 0.203
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0077 0.0034
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.002 0.0173 0.0585
Giardia lamblia Inositol 5-phosphatase 4 0.002 0.0173 0.0076
Leishmania major hypothetical protein, conserved 0.002 0.0173 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0186 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0059 0.0038
Schistosoma mansoni tar DNA-binding protein 0.021 0.2622 0.2706
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0186 0.0143
Brugia malayi nuclear hormone receptor 0.0021 0.0186 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0718 0.444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0186 0.0164
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.0173 0.0151
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0741 0.9466 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0099 0.1187 0.8207
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0718 0.0678
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0718 0.0587
Schistosoma mansoni zinc finger protein 0.001 0.0043 0.0022
Onchocerca volvulus 0.0013 0.0077 0.0116
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0019 0.0163 0.0147
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0173 0.013
Echinococcus multilocularis cpg binding protein 0.003 0.0308 0.0287
Leishmania major DNA polymerase kappa, putative 0.0062 0.0718 0.444
Leishmania major hypothetical protein, conserved 0.0116 0.1411 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0099 0.1187 0.5
Onchocerca volvulus 0.002 0.0173 0.0445
Echinococcus granulosus muscleblind protein 0.0145 0.1782 0.1764
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0186 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0186 0.0143
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0186 0.0143
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0186 0.0171
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.1411 1
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0019 0.0163 0.0554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0043 0.0021
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.0057
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0019 0.0163 0.0554
Loa Loa (eye worm) hypothetical protein 0.0116 0.1411 0.1373
Giardia lamblia hypothetical protein 0.002 0.0173 0.0076
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0718 0.444
Brugia malayi exodeoxyribonuclease III family protein 0.0099 0.1187 0.1149
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0173 0.0716
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0019 0.0163 0.0554
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0143
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0173 0.0151

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -21 % Percentage change in plasma glucose after 4 days of treatment in db/db mouse at 5 mg/kg (po) in a postprandial assay ChEMBL. 8355249
Change (functional) = -21 % Percentage change in plasma glucose after 4 days of treatment in db/db mouse at 5 mg/kg (po) in a postprandial assay ChEMBL. 8355249
Change (functional) < -15 % Percentage change in plasma glucose after 4 days of treatment in db/db mouse at 1 mg/kg (po) in a postprandial assay ChEMBL. 8355249
Change (functional) < -15 % Percentage change in plasma glucose after 4 days of treatment in db/db mouse at 1 mg/kg (po) in a postprandial assay ChEMBL. 8355249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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