TDR Targets

Basic information

Technical information

TDR Targets ID: 1358296
Name: 2-phenylsulfonyl-5-(trifluoromethyl)pyridine
MW: 287.258 | Formula: C12H8F3NO2S
H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(c1ccccc1)c1ccc(cn1)C(F)(F)F
InChi: 1S/C12H8F3NO2S/c13-12(14,15)9-6-7-11(16-8-9)19(17,18)10-4-2-1-3-5-10/h1-8H
InChiKey: KSYGMGNKARZMJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

SMR000342597
T0518-0465
ZINC06048741
MLS000516490

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.545	0.8426
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.1372	0.1221
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.626	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.626	1
Brugia malayi	jmjC domain containing protein	0.0034	0.0588	0.0925
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.1046	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0068	0.2933	1
Brugia malayi	Endoplasmin precursor	0.0045	0.1305	0.2513
Trypanosoma brucei	trypanothione reductase	0.0046	0.1372	0.4162
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0038	0.0855	0.1515
Echinococcus granulosus	heat shock protein 90	0.0045	0.1305	0.2513
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Schistosoma mansoni	heat shock protein	0.0045	0.1305	0.138
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.4683	1
Brugia malayi	heat shock protein 90	0.0045	0.1305	0.2513
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0588	0.0508
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.045	0.1535
Echinococcus multilocularis	heat shock protein 90	0.0038	0.0855	0.1515
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0069	0.0235
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.1305	0.3912
Onchocerca volvulus		0.003	0.0271	0.1137
Echinococcus granulosus	heat shock protein 90	0.0038	0.0855	0.1515
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Toxoplasma gondii	Hsp90 domain-containing protein	0.0169	1	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.1372	0.0502
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.1305	0.3912
Echinococcus granulosus	heat shock protein	0.0045	0.1305	0.2513
Loa Loa (eye worm)	glutathione reductase	0.0046	0.1372	0.3093
Echinococcus multilocularis	endoplasmin	0.0042	0.1113	0.2088
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0069	0.0235
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.1372	0.4162
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0068	0.2933	1
Brugia malayi	Heterochromatin protein 1	0.0068	0.2927	0.6108
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0588	0.0925
Toxoplasma gondii	heat shock protein 75, putative	0.003	0.0259	0.0089
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Mycobacterium ulcerans	hypothetical protein	0.0068	0.2933	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.545	0.8426
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.2927	0.7101
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.1414	0.2755
Schistosoma mansoni	hypothetical protein	0.0084	0.4052	0.4726
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.626	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0042	0.1113	0.3196
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.003	0.0259	0.1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2927	0.9981
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0845	0.7695
Schistosoma mansoni	chromobox protein	0.0068	0.2927	0.3356
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0068	0.2933	0.3535
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0068	0.2933	1
Plasmodium falciparum	endoplasmin, putative	0.0032	0.045	0.045
Loa Loa (eye worm)	apoptosis regulator protein	0.0084	0.4052	1
Toxoplasma gondii	heat shock protein 90, putative	0.0045	0.1305	0.1153
Plasmodium vivax	heat shock protein 90, putative	0.003	0.0259	0.0089
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0588	0.1075
Mycobacterium tuberculosis	Probable reductase	0.0104	0.545	0.8426
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0084	0.4052	0.4726
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0845	0.288
Trichomonas vaginalis	heat shock protein, putative	0.0038	0.0855	0.2914
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Trypanosoma brucei	Heat shock protein 83, putative	0.0045	0.1305	0.3912
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0084	0.4052	0.8602
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0038	0.0855	0.6028
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2933	1
Mycobacterium ulcerans	lysophospholipase	0.0068	0.2933	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.545	0.8426
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.1305	0.3912
Schistosoma mansoni	hypothetical protein	0.0084	0.4052	0.4726
Plasmodium vivax	endoplasmin, putative	0.0045	0.1305	0.1153
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0068	0.2933	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2933	1
Brugia malayi	glutathione reductase	0.0046	0.1372	0.2661
Loa Loa (eye worm)	endoplasmin	0.0045	0.1305	0.2921
Plasmodium falciparum	esterase, putative	0.0068	0.2933	0.2933
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.545	0.8426
Giardia lamblia	Grp94/Hsp90	0.0042	0.1113	0.8311
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Trypanosoma cruzi	heat shock protein 85, putative	0.0038	0.0855	0.2228
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2927	0.6108
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Plasmodium vivax	heat shock protein, putative	0.0169	1	1
Plasmodium falciparum	glutathione reductase	0.0046	0.1372	0.1372
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.1372	0.3093
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0068	0.2933	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0068	0.2933	1
Trypanosoma cruzi	monoglyceride lipase, putative	0.0068	0.2933	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0038	0.0855	0.2228
Schistosoma mansoni	apoptosis regulator bax	0.0084	0.4052	0.4726
Echinococcus multilocularis	heat shock protein 90	0.0045	0.1305	0.2513
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Plasmodium vivax	PST-A protein	0.0068	0.2933	0.281
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0588	0.0925
Schistosoma mansoni	heat shock protein	0.003	0.0259	0.0107
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0588	0.0508
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0084	0.4052	0.8602
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0171	0.0171
Leishmania major	monoglyceride lipase, putative	0.0068	0.2933	1
Echinococcus granulosus	chromobox protein 1	0.0068	0.2927	0.6108
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0084	0.4052	0.8602
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.1305	0.3912
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1588	0.365
Schistosoma mansoni	heat shock protein	0.0045	0.1305	0.138
Plasmodium falciparum	thioredoxin reductase	0.0046	0.1372	0.1372
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Loa Loa (eye worm)	heat shock protein 75	0.003	0.0259	0.0225
Plasmodium falciparum	lysophospholipase, putative	0.0068	0.2933	0.2933
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0845	0.288
Trichomonas vaginalis	endoplasmin, putative	0.0032	0.045	0.1535
Plasmodium falciparum	lysophospholipase, putative	0.0068	0.2933	0.2933
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.545	0.8426
Brugia malayi	Thioredoxin reductase	0.0046	0.1372	0.2661
Loa Loa (eye worm)	heat shock protein 90	0.0045	0.1305	0.2921
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.1113	0.3796
Toxoplasma gondii	heat shock protein HSP90	0.0045	0.1305	0.1153
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.626	1
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Brugia malayi	jmjC domain containing protein	0.0093	0.4683	1
Plasmodium falciparum	lysophospholipase, putative	0.0068	0.2933	0.2933
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0948	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0845	0.1735
Schistosoma mansoni	endoplasmin	0.0045	0.1305	0.138
Schistosoma mansoni	endoplasmin	0.0045	0.1305	0.138
Loa Loa (eye worm)	hypothetical protein	0.003	0.0271	0.0256
Brugia malayi	Hsp90 protein	0.003	0.0259	0.0194
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0068	0.2933	1
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0084	0.4052	0.8602
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.1414	0.2755
Schistosoma mansoni	chromobox protein	0.0068	0.2927	0.3356
Toxoplasma gondii	thioredoxin reductase	0.0046	0.1372	0.1221
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0068	0.2933	1
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Brugia malayi	chromobox protein homolog 3	0.0038	0.0845	0.1493
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2927	0.9981
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.1113	0.3796
Trypanosoma brucei	monoglyceride lipase, putative	0.0068	0.2933	1
Plasmodium falciparum	heat shock protein 90	0.0045	0.1305	0.1305
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0948	0.1721
Trypanosoma cruzi	Heat shock protein 83, putative	0.0045	0.1305	0.3912
Echinococcus multilocularis	heat shock protein	0.0045	0.1305	0.2513
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Trypanosoma cruzi	heat shock protein 90, putative	0.0045	0.1305	0.3912
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.545	0.8426
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0042	0.1113	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1046	0.3568
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.003	0.0259	0.0194
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1046	0.3568
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.3348	0.3869
Leishmania major	heat shock protein 83-1	0.0045	0.1305	0.3912
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0045	0.1305	1
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.1305	0.3912
Schistosoma mansoni	hypothetical protein	0.0084	0.4052	0.4726
Trypanosoma brucei	heat shock protein, putative	0.0045	0.1305	0.3912
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.1305	0.3912
Leishmania major	trypanothione reductase	0.0046	0.1372	0.4162
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.1305	0.3912
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.1305	0.4449
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.003	0.0259	0.0194
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0084	0.4052	0.8602
Plasmodium vivax	glutathione reductase, putative	0.0046	0.1372	0.1221
Echinococcus granulosus	chromobox protein 1	0.0068	0.2927	0.6108
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.4683	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0068	0.2933	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.2283	0.544
Plasmodium vivax	heat shock protein 86, putative	0.0045	0.1305	0.1153
Echinococcus granulosus	endoplasmin	0.0042	0.1113	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0084	0.4052	1
Mycobacterium tuberculosis	Possible lysophospholipase	0.0068	0.2933	0.3535
Treponema pallidum	heat shock protein 90	0.0042	0.1113	0.5
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2927	0.6108

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1480316

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1358296