Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.4504 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.4504 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.4504 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.4504 | 0.4504 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1026 | 0.1026 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9646 | 0.9646 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0251 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.