Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0126 | 0.0126 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.466 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1193 | 0.1193 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1025 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.466 | 1 |
Onchocerca volvulus | 0.0033 | 0.1193 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0033 | 0.1193 | 0.2353 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1193 | 0.1193 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3374 | 0.3374 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0126 | 0.0126 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1025 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.466 | 0.466 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1025 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3374 | 0.3374 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1025 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1193 | 0.2353 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0126 | 0.0126 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1193 | 0.1193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.466 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1193 | 0.2353 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1193 | 0.2353 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0174 | 0.0174 |
Onchocerca volvulus | 0.0033 | 0.1193 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1025 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.466 | 0.466 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0126 | 0.0126 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1193 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1193 | 0.1193 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.466 | 0.466 |
Schistosoma mansoni | lamin | 0.0033 | 0.1193 | 0.2353 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1193 | 0.2353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.466 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.466 | 0.466 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3374 | 0.3374 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.466 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.1025 | 0.1025 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1146 | 0.1146 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.466 | 0.466 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3374 | 0.3374 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1025 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1871 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.466 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1025 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.1193 | 0.2353 |
Schistosoma mansoni | lamin | 0.0033 | 0.1193 | 0.2353 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1193 | 0.1193 |
Brugia malayi | RNA binding protein | 0.0076 | 0.466 | 0.466 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.466 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1025 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0008 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1122.0185 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.