Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2934 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2934 | 0.2934 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2035 | 0.6936 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2035 | 0.6936 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2934 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2035 | 0.6936 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2934 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0984 | 0.3355 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1761 | 0.1761 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1761 | 0.1761 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2934 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0984 | 0.0984 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1761 | 0.1761 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0984 | 0.3355 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1761 | 0.1761 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2934 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1761 | 0.1761 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1761 | 0.6003 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2035 | 0.6936 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1761 | 0.6003 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1761 | 0.1761 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2934 | 0.2934 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1761 | 0.1761 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.