TDR Targets

Basic information

Technical information

TDR Targets ID: 1359118
Name: 4-(2-chlorophenoxy)-N-(2-morpholin-4-ylethyl) benzenesulfonamide
MW: 396.888 | Formula: C18H21ClN2O4S
H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1Oc1ccc(cc1)S(=O)(=O)NCCN1CCOCC1
InChi: 1S/C18H21ClN2O4S/c19-17-3-1-2-4-18(17)25-15-5-7-16(8-6-15)26(22,23)20-9-10-21-11-13-24-14-12-21/h1-8,20H,9-14H2
InChiKey: RHGRSYWNRCWBAO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(2-chlorophenoxy)-N-(2-morpholinoethyl)benzenesulfonamide
T0513-5548

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0634	0.0925
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.1152	0.1054
Schistosoma mansoni	cpg binding protein	0.0035	0.4393	0.4331
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.1152	0.1054
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.1152	0.2229
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.1152	0.2086
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.1152	0.2229
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.1152	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.1152	0.2086
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.1152	0.2086
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.1152	0.2086
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0006	0.0222	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0322	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.1152	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0939	0.1609
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.1152	0.2229
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0939	0.1719
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.1152	0.1054
Schistosoma mansoni	cpg binding protein	0.0037	0.4678	0.4619
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.1152	0.2229
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.1152	0.2086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.1152	0.2229
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.1152	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.1152	0.2086
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0222	0.0114
Brugia malayi	nuclear receptor NHR-88	0.0012	0.1152	0.2229
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.1152	0.1054
Brugia malayi	hypothetical protein	0.0006	0.0322	0.0239
Schistosoma mansoni	cpg binding protein	0.0037	0.4678	0.4619
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Brugia malayi	ecdysteroid receptor	0.0012	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.1152	0.2229
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.1152	0.2229
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.1152	0.2086
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0322	0.0223
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.1152	0.2086
Brugia malayi	nuclear hormone receptor	0.0012	0.1152	0.2229
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0634	0.0925
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.1152	0.2229
Brugia malayi	steroid hormone receptor	0.0012	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.1152	0.2229
Schistosoma mansoni	nuclear receptor	0.0006	0.0222	0.0114
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0222	0.0114
Schistosoma mansoni	coup transcription factor	0.0012	0.1152	0.1054
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0322	0.0223
Schistosoma mansoni	nuclear receptor nhr-48	0.0006	0.0222	0.0114
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.1152	0.2086
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.1152	0.2086
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.1152	0.1054
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.8867	0.5
Brugia malayi	hypothetical protein	0.0006	0.0322	0.0239
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Schistosoma mansoni	zinc finger protein	0.0006	0.0222	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.1152	0.1054
Echinococcus granulosus	cpg binding protein	0.0037	0.4678	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.1152	0.2086
Onchocerca volvulus		0.0035	0.4393	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.1152	0.2229
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.1152	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.1152	0.2229
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.1152	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0322	0.0215
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.1152	0.1054
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.1152	0.2086
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.1152	0.2086
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.1152	0.2229
Brugia malayi	CXXC zinc finger family protein	0.0035	0.4393	1
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.1152	0.2229
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.1152	0.2229
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.1152	0.2086
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.1152	0.2086
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.092	0.1672
Brugia malayi	nuclear receptor RXR	0.0006	0.0322	0.0239
Trichomonas vaginalis	helicase, putative	0.0008	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1152	0.2229
Echinococcus multilocularis	cpg binding protein	0.0037	0.4678	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0634	0.0531
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.1152	0.2229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0939	0.1609
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.1152	0.1054
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.1152	0.1054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.1152	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.1152	0.2229
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.4393	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0006	0.0222	0.0114
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.1152	0.2086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.1152	0.2229
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0634	0.0925
Schistosoma mansoni	nuclear receptor	0.0006	0.0222	0.0114
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.1152	0.1054
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0322	0.0239
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.1152	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.1152	0.2229
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0634	0.0925
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Onchocerca volvulus		0.0012	0.1152	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0322	0.0239
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.1152	0.2086
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.1152	0.2229

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1480397

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1359118