Detailed information for compound 1359162

Basic information

Technical information
  • TDR Targets ID: 1359162
  • Name: ethyl 1-[(2-ethyl-5-methyl-1H-imidazol-4-yl)m ethyl]-4-[(3-fluorophenyl)methyl]piperidine-4 -carboxylate
  • MW: 387.491 | Formula: C22H30FN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1(CCN(CC1)Cc1[nH]c(nc1C)CC)Cc1cccc(c1)F
  • InChi: 1S/C22H30FN3O2/c1-4-20-24-16(3)19(25-20)15-26-11-9-22(10-12-26,21(27)28-5-2)14-17-7-6-8-18(23)13-17/h6-8,13H,4-5,9-12,14-15H2,1-3H3,(H,24,25)
  • InChiKey: MOBXKUINRUYAJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methyl]-4-[(3-fluorophenyl)methyl]-4-piperidinecarboxylic acid ethyl ester
  • 1-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methyl]-4-(3-fluorobenzyl)isonipecotic acid ethyl ester
  • MLS000734706
  • SMR000317968
  • ethyl 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]-4-(3-fluorobenzyl)piperidine-4-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0102 0.0112 0.011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0004 0.0011
Echinococcus multilocularis glycyl tRNA synthetase 0.0019 0.0004 0.0011
Trichomonas vaginalis esterase, putative 0.0071 0.0072 0.018
Onchocerca volvulus 0.0028 0.0017 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0072 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0021 0.0053
Plasmodium falciparum calcium-dependent protein kinase 5 0.0104 0.0115 0.0114
Plasmodium vivax CDK-related protein kinase 6, putative 0.1442 0.1851 0.185
Schistosoma mansoni hypothetical protein 0.0047 0.004 0.0039
Toxoplasma gondii sugar transporter ST1 0.0048 0.0042 0.004
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) hypothetical protein 0.0079 0.0082 0.1107
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Echinococcus multilocularis CREB binding protein 0.0072 0.0073 0.0187
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0102 0.0112 0.0283
Loa Loa (eye worm) Notch2 0.0028 0.0017 0.0223
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0119 0.0134 0.0132
Echinococcus multilocularis slit 2 protein 0.0028 0.0017 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0104 0.0115 0.1551
Echinococcus granulosus tar DNA binding protein 0.0126 0.0143 0.0367
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0222 0.0267 0.0266
Echinococcus multilocularis neurogenic locus notch protein 4 0.0028 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0079 0.0082 0.1107
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0003 0.0038
Giardia lamblia Hexose transporter 0.0048 0.0042 0.2975
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0061 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Mycobacterium ulcerans hypothetical protein 0.0071 0.0072 0.007
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0124 0.0123
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0083 0.1118
Echinococcus granulosus GPCR family 2 0.0031 0.002 0.0052
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Toxoplasma gondii glycyl-tRNA synthetase 0.0019 0.0004 0.0003
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0019 0.0004 0.0003
Echinococcus multilocularis tumor protein p63 0.067 0.0849 0.2177
Onchocerca volvulus Serine\/threonine kinase homolog 0.0121 0.0136 0.1854
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.087 0.2232
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0143 0.1928
Echinococcus granulosus calcium dependent protein kinase 0.0098 0.0106 0.0273
Echinococcus multilocularis Mastin 0.0079 0.0082 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.0267 0.0266
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0019 0.0004 0.0011
Onchocerca volvulus 0.0079 0.0082 0.1104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Plasmodium falciparum protein kinase 6 0.1442 0.1851 0.185
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.0136 0.0135
Trypanosoma cruzi glucose transporter, putative 0.0048 0.0042 0.004
Brugia malayi MH2 domain containing protein 0.004 0.0032 0.0031
Brugia malayi serine/threonine-protein kinase plk-2 0.0121 0.0136 0.0136
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0104 0.0115 0.0115
Echinococcus granulosus Threonyl tRNA synthetase C 0.0019 0.0004 0.0011
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0105 0.0116 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0116 0.0295
Trypanosoma cruzi hexose transporter, putative 0.0058 0.0054 0.0053
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0003 0.0007
Schistosoma mansoni intermediate filament proteins 0.0033 0.0022 0.002
Echinococcus multilocularis CREB binding protein 0.0017 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0019
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Loa Loa (eye worm) hypothetical protein 0.0076 0.0078 0.1052
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0042 0.0561
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0002 0.0000067316
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0061 0.0153
Trypanosoma brucei glucose transporter 2A 0.0105 0.0116 0.0115
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0017 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0031 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0069 0.0067
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0017 0.0017
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0083 0.1118
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0002 0.0000067316
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0067 0.0067
Echinococcus granulosus protein jagged 2 0.0028 0.0017 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Leishmania major glucose transporter, lmgt2 0.0105 0.0116 0.0115
Mycobacterium ulcerans hypothetical protein 0.0079 0.0082 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Trypanosoma cruzi sugar transporter, putative 0.0048 0.0042 0.004
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0023 0.0021
Onchocerca volvulus 0.008 0.0083 0.1115
Schistosoma mansoni glucose transport protein 0.034 0.042 0.0419
Onchocerca volvulus 0.0028 0.0017 0.0192
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0036 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Echinococcus multilocularis GPCR, family 2 0.0031 0.002 0.0052
Echinococcus granulosus intermediate filament protein 0.0033 0.0022 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0042 0.0042
Leishmania major trypanothione reductase 0.0049 0.0043 0.0042
Onchocerca volvulus 0.0048 0.0042 0.054
Loa Loa (eye worm) CBP-B 0.0073 0.0074 0.0998
Onchocerca volvulus 0.0071 0.0072 0.0958
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0066 0.0066 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0038 0.0085
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0026 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.302 0.3898 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0104 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0059
Schistosoma mansoni protein kinase 0.0104 0.0115 0.0114
Plasmodium vivax SET domain protein, putative 0.0032 0.0021 0.0019
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Loa Loa (eye worm) RNA binding protein 0.0126 0.0143 0.1928
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0052 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Mycobacterium ulcerans sugar transporter 0.0048 0.0042 0.004
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0017 0.0017
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0064 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Echinococcus granulosus fibropellin Ia 0.0028 0.0017 0.0043
Trypanosoma cruzi hexose transporter, putative 0.0048 0.0042 0.004
Onchocerca volvulus 0.0028 0.0017 0.0192
Toxoplasma gondii microneme protein MIC17B 0.008 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0075 0.0077 0.1031
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.0053
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.302 0.3898 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0038 0.0096
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0048 0.0042 0.004
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Brugia malayi Sugar transporter family protein 0.034 0.042 0.042
Plasmodium falciparum glutathione reductase 0.0049 0.0043 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.302 0.3898 1
Loa Loa (eye worm) glutathione reductase 0.0049 0.0043 0.058
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0011 0.001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0002 0.0000067316
Echinococcus granulosus Tolloid protein 1 0.0075 0.0077 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni smad 0.0018 0.0003 0.0001
Brugia malayi Trypsin family protein 0.0079 0.0082 0.0082
Brugia malayi MH1 domain containing protein 0.0022 0.0008 0.0008
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0019 0.0004 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0124 0.0123
Echinococcus multilocularis fibrillin 1 0.0075 0.0077 0.0196
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0107 0.0105
Brugia malayi Cadherin domain containing protein 0.0028 0.0017 0.0017
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0017 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Echinococcus granulosus protein jagged 2 0.0028 0.0017 0.0043
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0026 0.0024
Echinococcus multilocularis Smad4 0.004 0.0032 0.0081
Schistosoma mansoni sugar transporter 0.0048 0.0042 0.004
Onchocerca volvulus 0.0048 0.0042 0.054
Brugia malayi MH2 domain containing protein 0.0018 0.0003 0.0003
Plasmodium vivax threonine--tRNA ligase, putative 0.0019 0.0004 0.0003
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0075 0.0077 0.1031
Schistosoma mansoni CREB-binding protein 2 0.0105 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Leishmania major glucose transporter, lmgt1 0.0105 0.0116 0.0115
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Echinococcus multilocularis lysyl tRNA synthetase 0.0076 0.0078 0.02
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0026 0.0062
Onchocerca volvulus 0.0493 0.0619 0.8573
Brugia malayi lysyl-tRNA synthetase 0.0076 0.0078 0.0078
Onchocerca volvulus 0.0048 0.0042 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Onchocerca volvulus 0.0048 0.0042 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Chlamydia trachomatis threonine--tRNA ligase 0.0019 0.0004 0.0369
Brugia malayi intermediate filament protein 0.0033 0.0022 0.0022
Echinococcus multilocularis lamin 0.0033 0.0022 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.002 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0098 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0072 0.0184
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0048 0.0042 0.004
Schistosoma mansoni hypothetical protein 0.034 0.042 0.0419
Mycobacterium tuberculosis Conserved protein 0.0071 0.0072 0.007
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0004 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.0053
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.7723 1 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0042 0.0042
Plasmodium vivax sugar transporter, putative 0.0048 0.0042 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0022 0.0022
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.7723 1 1
Mycobacterium ulcerans integral membrane transport protein 0.0048 0.0042 0.004
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0075 0.0077 0.1031
Echinococcus multilocularis laminin 0.0075 0.0077 0.0196
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.0272
Toxoplasma gondii protein kinase, putative 0.096 0.1226 0.1224
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Brugia malayi CXXC zinc finger family protein 0.0035 0.0025 0.0025
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0052 0.0132
Schistosoma mansoni Smad4 0.0018 0.0003 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0621 0.1592
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0026 0.0024
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0038 0.0036
Brugia malayi isocitrate dehydrogenase 0.0019 0.0004 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0116 0.0295
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0119 0.0134 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0103
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0021 0.0019
Schistosoma mansoni smad 0.004 0.0032 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0043 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0026 0.0062
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0075 0.0077 0.0075
Schistosoma mansoni cpg binding protein 0.0037 0.0027 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0116 0.0295
Onchocerca volvulus 0.008 0.0083 0.1115
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0017 0.0017
Brugia malayi Pre-SET motif family protein 0.0032 0.0021 0.0021
Brugia malayi glutathione reductase 0.0049 0.0043 0.0043
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0064 0.0063 0.0062
Leishmania major glucose transporter/membrane transporter D2, putative 0.0105 0.0116 0.0115
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0119 0.0134 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0098 0.0097
Loa Loa (eye worm) hypothetical protein 0.0572 0.0721 0.9723
Loa Loa (eye worm) hypothetical protein 0.0075 0.0077 0.1031
Echinococcus granulosus tumor protein p63 0.067 0.0849 0.2177
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0072 0.007
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0019 0.0004 0.0003
Echinococcus multilocularis enteropeptidase 0.0079 0.0082 0.0211
Brugia malayi RNA binding protein 0.0126 0.0143 0.0143
Schistosoma mansoni cpg binding protein 0.0037 0.0027 0.0026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0042 0.0561
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0028 0.0017 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0011 0.001
Plasmodium falciparum calcium-dependent protein kinase 1 0.0104 0.0115 0.0114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.3015 0.3892 0.9985
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0143 0.0141
Giardia lamblia Lysyl-tRNA synthetase 0.0076 0.0078 0.5683
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Mycobacterium tuberculosis Probable reductase 0.0112 0.0124 0.0123
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0032 0.0425
Entamoeba histolytica hypothetical protein 0.0076 0.0078 0.0189
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0004 0.0003
Echinococcus granulosus solute carrier family 22 0.0048 0.0042 0.0107
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Schistosoma mansoni protein kinase 0.0104 0.0115 0.0114
Loa Loa (eye worm) sugar transporter 0.034 0.042 0.5668
Schistosoma mansoni cpg binding protein 0.0035 0.0025 0.0023
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0079 0.0082 0.0081
Trichomonas vaginalis glucose transporter, putative 0.0105 0.0116 0.0295
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0052 0.0132
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0083 0.1118
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0038 0.0085
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0104 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0019 0.0004 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0104 0.0115 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.087 0.0869
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.7723 1 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0104 0.0115 0.0114
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0572 0.0721 0.072
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0038 0.0036
Leishmania major glucose transporter, lmgt3 0.0105 0.0116 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Echinococcus granulosus solute carrier family 22 0.0048 0.0042 0.0107
Schistosoma mansoni egf-like domain protein 0.0075 0.0077 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0014 0.0033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0019 0.0004 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus multilocularis synaptic vesicle 2 protein 0.0048 0.0042 0.0107
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0004 0.0002
Echinococcus granulosus notch 0.0028 0.0017 0.0043
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0121 0.0136 0.1834
Onchocerca volvulus 0.0048 0.0042 0.054
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.0053
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Toxoplasma gondii transporter, major facilitator family protein 0.0048 0.0042 0.004
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0022 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Plasmodium vivax hexose transporter 0.034 0.042 0.0419
Chlamydia trachomatis lysine--tRNA ligase 0.0076 0.0078 1
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Schistosoma mansoni Smad4 0.004 0.0032 0.003
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Onchocerca volvulus 0.0182 0.0216 0.2973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0108 0.0108
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0022 0.0295
Loa Loa (eye worm) Smad1 0.004 0.0032 0.0425
Onchocerca volvulus 0.0079 0.0082 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Brugia malayi hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0017 0.0015
Brugia malayi major facilitator superfamily protein 0.0048 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0079 0.0082 0.1107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0076 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0075 0.0077 0.1031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0108 0.0108
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0032 0.0081
Loa Loa (eye worm) nuclear factor I 0.0022 0.0008 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Mycobacterium ulcerans beta-lactamase 0.0071 0.0072 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Toxoplasma gondii sugar transporter ST3 0.0048 0.0042 0.004
Giardia lamblia Threonyl-tRNA synthetase 0.0019 0.0004 0.021
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Onchocerca volvulus 0.0048 0.0042 0.054
Trypanosoma brucei glucose transporter 1E 0.0105 0.0116 0.0115
Echinococcus granulosus lamin 0.0033 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.0295
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.002 0.0272
Schistosoma mansoni sugar transporter 0.0048 0.0042 0.004
Onchocerca volvulus 0.0048 0.0042 0.054
Toxoplasma gondii microneme protein MIC17A 0.008 0.0083 0.0081
Brugia malayi notch-like transmembrane receptor 0.0028 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0103
Plasmodium falciparum mitogen-activated protein kinase 2 0.0549 0.0692 0.0691
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0102 0.0112 0.0112
Onchocerca volvulus 0.0048 0.0042 0.054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0072 0.007
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0143 0.0141
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0019 0.0004 0.0003
Giardia lamblia Kinase, PLK 0.0121 0.0136 1
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0102 0.0112 0.0112
Brugia malayi Cadherin domain containing protein 0.0028 0.0017 0.0017
Onchocerca volvulus Slit protein homolog 0.0028 0.0017 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0043 0.0042
Plasmodium vivax lysine--tRNA ligase, putative 0.0076 0.0078 0.0076
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0102 0.0112 0.0276
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0019 0.0004 0.0003
Brugia malayi hypothetical protein 0.0048 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0071 0.0072 0.0958
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0104 0.0115 0.0114
Echinococcus multilocularis solute carrier family 22 0.0048 0.0042 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0025 0.0064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0119 0.0134 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0011 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Onchocerca volvulus Putative cubilin 0.0028 0.0017 0.0192
Loa Loa (eye worm) hypothetical protein 0.0098 0.0107 0.144
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0011 0.001
Echinococcus multilocularis fat cadherin tumor suppressor 0.0028 0.0017 0.0043
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0079 0.0082 0.0211
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0075 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0099 0.0108 0.1453
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.3015 0.3892 0.3891
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0048 0.0042 0.0107
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Onchocerca volvulus 0.008 0.0083 0.1115
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Loa Loa (eye worm) trypsin family protein 0.0079 0.0082 0.1107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Brugia malayi Muscle positioning protein 4 0.0028 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0064 0.0063 0.0062
Plasmodium vivax glutathione reductase, putative 0.0049 0.0043 0.0041
Brugia malayi hypothetical protein 0.0048 0.0042 0.0042
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0143 0.0143
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.7723 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Toxoplasma gondii ABC1 family protein 0.0071 0.0072 0.007
Echinococcus multilocularis smad 0.004 0.0032 0.0081
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0025 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0052 0.005
Brugia malayi MH2 domain containing protein 0.0587 0.0742 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0029 0.0071
Echinococcus granulosus enteropeptidase 0.0079 0.0082 0.0211
Leishmania major hypothetical protein, conserved 0.0024 0.0011 0.001
Onchocerca volvulus 0.0028 0.0017 0.0192
Onchocerca volvulus Putative transporter 0.0048 0.0042 0.054
Loa Loa (eye worm) hypothetical protein 0.008 0.0083 0.1118
Schistosoma mansoni hypothetical protein 0.0205 0.0245 0.0244
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0277 0.0709
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0102 0.0112 0.011
Onchocerca volvulus 0.0572 0.0721 1
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0076 0.0078 0.0076
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0004 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0098 0.1327
Giardia lamblia Prolyl-tRNA synthetase 0.0102 0.0112 0.8201
Plasmodium falciparum threonine--tRNA ligase 0.0019 0.0004 0.0003
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0014 0.0032
Toxoplasma gondii PAN/Apple domain-containing protein 0.008 0.0083 0.0081
Echinococcus granulosus Smad4 0.004 0.0032 0.0081
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0572 0.0721 0.9723
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Brugia malayi Pre-SET motif family protein 0.0216 0.026 0.026
Schistosoma mansoni smad1 5 8 and 0.004 0.0032 0.003
Leishmania major myo-inositol/proton symporter (MIT) 0.0048 0.0042 0.004
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.7723 1 1
Schistosoma mansoni hypothetical protein 0.0079 0.0082 0.0081
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0116 0.0115
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0124 0.0123
Brugia malayi hypothetical protein 0.0079 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0081
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Toxoplasma gondii thioredoxin reductase 0.0049 0.0043 0.0042
Brugia malayi Trypsin-like protease protein 5 0.0079 0.0082 0.0082
Trichomonas vaginalis glucose transporter, putative 0.0105 0.0116 0.0295
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0072 0.018
Echinococcus multilocularis protein jagged 1 0.0028 0.0017 0.0043
Echinococcus granulosus protein jagged 1 0.0028 0.0017 0.0043
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0119 0.0134 0.0132
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0004
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Echinococcus granulosus laminin 0.0075 0.0077 0.0196
Schistosoma mansoni slit 0.0028 0.0017 0.0015
Plasmodium vivax proline--tRNA ligase, putative 0.0119 0.0134 0.0132
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0038 0.0036
Brugia malayi GCC2 and GCC3 family protein 0.0028 0.0017 0.0017
Onchocerca volvulus 0.0079 0.0082 0.1104
Brugia malayi hypothetical protein 0.0182 0.0216 0.0216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0083 0.0087 0.1174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0072 0.007
Brugia malayi MH1 domain containing protein 0.0022 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0004 0.0011
Giardia lamblia Sugar-proton symporter 0.0048 0.0042 0.2975
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0076 0.0078 0.0196
Mycobacterium tuberculosis Conserved protein 0.0071 0.0072 0.007
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0025 0.0332
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0028 0.0017 0.0015
Trichomonas vaginalis glucose transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0043 0.058
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0000067316
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0000067316
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0004 0.0011
Brugia malayi beta-lactamase family protein 0.0071 0.0072 0.0072
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.3015 0.3892 0.9985
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0116 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0586
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0021 0.0053
Trypanosoma cruzi hexose transporter 0.0105 0.0116 0.0115
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0298 0.0762
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0004 0.0003
Echinococcus granulosus CREB binding protein 0.0065 0.0063 0.0163
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.7723 1 1
Onchocerca volvulus 0.0035 0.0025 0.0303
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0278
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.7723 1 1
Leishmania major protein kinase, putative 0.0104 0.0115 0.0114
Echinococcus multilocularis General substrate transporter 0.0292 0.0358 0.092
Echinococcus granulosus protein jagged 1 0.0028 0.0017 0.0043
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.7723 1 1
Echinococcus multilocularis neural cadherin 0.0028 0.0017 0.0043
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0104 0.0115 0.0114
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0621 0.1592
Schistosoma mansoni hypothetical protein 0.0205 0.0245 0.0244
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0017 0.0043
Echinococcus multilocularis notch 0.0028 0.0017 0.0043
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0038 0.0036
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0004 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0072 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0116 0.0115
Schistosoma mansoni hypothetical protein 0.0068 0.0067 0.0066
Brugia malayi MH1 domain containing protein 0.004 0.0032 0.0031
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0019
Loa Loa (eye worm) sugar transporter 0.0048 0.0042 0.0561
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0102 0.0112 0.0287
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0072 0.018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0152
Schistosoma mansoni sugar transporter 0.0048 0.0042 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Schistosoma mansoni Smad4 0.0018 0.0003 0.0001
Schistosoma mansoni lamin 0.0033 0.0022 0.002
Trypanosoma brucei polo-like protein kinase 0.0121 0.0136 0.0135
Echinococcus multilocularis tissue type plasminogen activator 0.0222 0.0267 0.0685
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Schistosoma mansoni glucose transport protein 0.034 0.042 0.0419
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0004 0.0003
Echinococcus granulosus tissue type plasminogen activator 0.0222 0.0267 0.0685
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0014 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0002 0.0000067316
Onchocerca volvulus 0.008 0.0083 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0116 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0072 0.018
Brugia malayi hypothetical protein 0.0048 0.0042 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0072 0.018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.026 0.3502
Onchocerca volvulus 0.0048 0.0042 0.054
Echinococcus granulosus neurogenic locus notch protein 4 0.0028 0.0017 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0079 0.0082 0.1107
Echinococcus multilocularis solute carrier family 22 0.0048 0.0042 0.0107
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.7723 1 1
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0116 0.0295
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0102 0.0112 0.011
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0019 0.0004 0.0059
Onchocerca volvulus 0.008 0.0083 0.1115
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0043 0.0041
Plasmodium falciparum thioredoxin reductase 0.0049 0.0043 0.0041
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Brugia malayi Zinc finger, C2H2 type family protein 0.3015 0.3892 0.3892
Loa Loa (eye worm) hypothetical protein 0.0075 0.0077 0.1031
Trichomonas vaginalis myo-inositol transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0143 0.0141
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0032 0.0081
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0052
Echinococcus granulosus microtubule associated protein 2 0.0686 0.087 0.2232
Trypanosoma brucei trypanothione reductase 0.0049 0.0043 0.0042
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0143 0.0141
Brugia malayi major facilitator superfamily protein 0.0048 0.0042 0.0042
Mycobacterium tuberculosis Conserved protein 0.0071 0.0072 0.007
Echinococcus granulosus smad 0.004 0.0032 0.0081
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.0136 0.0135
Toxoplasma gondii lysine-tRNA ligase 0.0076 0.0078 0.0076
Toxoplasma gondii calcium binding egf domain-containing protein 0.0075 0.0077 0.0075
Echinococcus granulosus General substrate transporter 0.0292 0.0358 0.092
Entamoeba histolytica serine/threonine protein kinase, putative 0.0121 0.0136 0.0338
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0038 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0143 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Plasmodium falciparum protein kinase 7 0.096 0.1226 0.1224
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0017 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0072 0.007
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0043 0.011
Onchocerca volvulus 0.008 0.0083 0.1115
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0038 0.0096
Echinococcus granulosus delta-like protein 1 0.0028 0.0017 0.0043
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0038 0.0036
Onchocerca volvulus 0.0098 0.0107 0.1448
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0002 0.0000067316
Schistosoma mansoni glycyl-tRNA synthetase 0.0019 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Echinococcus multilocularis transmembrane protease serine 3 0.0079 0.0082 0.0211
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0018 0.0047
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0104 0.0115 0.1551
Toxoplasma gondii subtilisin SUB12 0.008 0.0083 0.0081
Schistosoma mansoni lamin 0.0033 0.0022 0.002
Plasmodium falciparum proline--tRNA ligase 0.0119 0.0134 0.0132
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0083 0.1118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0098 0.0097
Echinococcus granulosus lamin dm0 0.0033 0.0022 0.0056
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0211
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0098 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni dihydroorotate dehydrogenase 0.7723 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.014 0.0139
Plasmodium falciparum calcium-dependent protein kinase 2 0.0104 0.0115 0.0114
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0072 0.007
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0048 0.0042 0.004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0098 0.0252
Onchocerca volvulus Neurogenic locus notch homolog 0.0028 0.0017 0.0192
Toxoplasma gondii microneme protein MIC4 0.008 0.0083 0.0081
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0038 0.0038
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.7723 1 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0072 0.0965
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0032 0.003
Schistosoma mansoni hypothetical protein 0.0494 0.0621 0.0619
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0124 0.0123
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0116 0.0115
Onchocerca volvulus 0.008 0.0083 0.1115
Trypanosoma brucei sugar transporter, putative 0.0048 0.0042 0.004
Toxoplasma gondii calcium binding egf domain-containing protein 0.0075 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0182 0.0216 0.2917
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.302 0.3898 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0038 0.0093
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0038 0.0506
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0121 0.0136 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Entamoeba histolytica protein kinase, putative 0.0104 0.0115 0.0284
Toxoplasma gondii kringle domain-containing protein 0.0222 0.0267 0.0266
Echinococcus granulosus glycyl tRNA synthetase 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Toxoplasma gondii microneme protein MIC17C 0.008 0.0083 0.0081
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0079 0.0082 0.1107
Echinococcus granulosus CREB binding protein 0.0017 0.0002 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0025 0.0064
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.3015 0.3892 0.9985
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0032 0.0081
Brugia malayi hypothetical protein 0.0035 0.0025 0.0025
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0004 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.003
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0019 0.0004 0.0004
Echinococcus granulosus solute carrier family 22 0.0048 0.0042 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0115 0.0114
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0083 0.1118
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0549 0.0692 0.0691
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Entamoeba histolytica protein kinase, putative 0.0104 0.0115 0.0284
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0052 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0014 0.0033
Schistosoma mansoni hypothetical protein 0.0222 0.0267 0.0266
Giardia lamblia GTOR 0.0045 0.0038 0.2676
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0079 0.0082 0.0211
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0002 0.0000067316
Onchocerca volvulus 0.0048 0.0042 0.054
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0116 0.0115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0004 0.0011
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Onchocerca volvulus 0.0048 0.0042 0.054
Brugia malayi Calcium binding EGF domain containing protein 0.0075 0.0077 0.0076
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0104 0.0115 0.1551
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Brugia malayi TAZ zinc finger family protein 0.0105 0.0116 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Onchocerca volvulus 0.0246 0.0298 0.4114
Toxoplasma gondii 1,3(4)-beta-glucanase 0.008 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0017 0.004
Plasmodium falciparum cysteine repeat modular protein 1 0.0222 0.0267 0.0266
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0004 0.0011
Echinococcus multilocularis geminin 0.0205 0.0245 0.0629
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0007 0.0005
Onchocerca volvulus 0.008 0.0083 0.1115
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0572 0.0721 0.072
Echinococcus granulosus slit 2 protein 0.0028 0.0017 0.0043
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0075 0.0077 0.1031
Toxoplasma gondii facilitative glucose transporter GT1 0.034 0.042 0.0419
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0072 0.0184
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0072 0.007
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0017 0.0043
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0003 0.0003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0108 0.1453
Schistosoma mansoni survival motor neuron protein 0.0047 0.004 0.0039
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0081
Loa Loa (eye worm) TK/ROR protein kinase 0.0222 0.0267 0.3602
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0079 0.0082 0.0082
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0076 0.0078 0.0076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0121 0.0136 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0038 0.0093
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0072 0.007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Echinococcus multilocularis solute carrier family 22 0.0048 0.0042 0.0107
Giardia lamblia High cysteine protein 0.0028 0.0017 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus multilocularis Tolloid protein 1 0.0075 0.0077 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.0229 0.0277 0.3728
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0019 0.0004 0.0007
Onchocerca volvulus 0.008 0.0083 0.1115
Echinococcus granulosus CREB binding protein 0.0017 0.0002 0.0005
Echinococcus multilocularis glycoprotein Antigen 5 0.0079 0.0082 0.0211
Schistosoma mansoni glucose transport protein 0.034 0.042 0.0419
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0004 0.0003
Echinococcus multilocularis CREB binding protein 0.0017 0.0002 0.0005
Leishmania major threonyl-tRNA synthetase, putative 0.0019 0.0004 0.0003
Onchocerca volvulus 0.0047 0.004 0.052
Echinococcus granulosus geminin 0.0205 0.0245 0.0629
Toxoplasma gondii hypothetical protein 0.008 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0103
Loa Loa (eye worm) hypothetical protein 0.0102 0.0112 0.1508
Leishmania major hypothetical protein, conserved 0.0071 0.0072 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0018 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0124 0.0123
Brugia malayi Kringle domain containing protein 0.0222 0.0267 0.0267
Plasmodium falciparum calcium-dependent protein kinase 4 0.0104 0.0115 0.0114
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0011 0.001
Echinococcus multilocularis calcium dependent protein kinase 0.0098 0.0106 0.0273
Brugia malayi Trypsin family protein 0.0079 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Chlamydia trachomatis proline--tRNA ligase 0.0036 0.0026 0.3237
Echinococcus multilocularis lamin dm0 0.0033 0.0022 0.0056
Echinococcus granulosus transmembrane protease serine 3 0.0079 0.0082 0.0211
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0079 0.0082 0.0081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0052
Mycobacterium leprae Probable lipase LipE 0.0071 0.0072 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0098 0.0097
Schistosoma mansoni smad1 5 8 and 0.004 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.0222 0.0267 0.3602
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0038 0.0093
Onchocerca volvulus 0.008 0.0083 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0004 0.0011
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Echinococcus granulosus Sugar transporter ERD6 protein 0.0048 0.0042 0.0107
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0048 0.0042 0.004
Schistosoma mansoni lysyl-tRNA synthetase 0.0076 0.0078 0.0076
Trichomonas vaginalis sugar transport protein, putative 0.0048 0.0042 0.0103
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.302 0.3898 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Leishmania major dihydroorotate dehydrogenase 0.7723 1 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0104 0.0115 0.0114
Echinococcus granulosus Mastin 0.0079 0.0082 0.0211
Mycobacterium ulcerans lipase LipD 0.0071 0.0072 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0284
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0002 0.0000067316
Loa Loa (eye worm) hypothetical protein 0.0068 0.0067 0.0906
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0032 0.0425
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0119 0.0134 0.0132
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0019 0.0004 0.0003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0048 0.0042 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0072 0.007
Brugia malayi Trypsin family protein 0.0572 0.0721 0.0721
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0042 0.0034 0.0457
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0003 0.0007
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.302 0.3898 1
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0019
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0032 0.0081
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0019 0.0004 0.0003
Brugia malayi TAR-binding protein 0.0126 0.0143 0.0143
Onchocerca volvulus 0.0048 0.0042 0.054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0072 0.007
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0116 0.0115
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0004 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0098 0.0252
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.004 0.004
Treponema pallidum threonyl-tRNA synthetase 0.0019 0.0004 0.114
Plasmodium falciparum hexose transporter 0.034 0.042 0.0419
Echinococcus granulosus glycoprotein Antigen 5 0.0079 0.0082 0.0211
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Brugia malayi Protein kinase domain containing protein 0.0222 0.0267 0.0267
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0048 0.0042 0.004
Toxoplasma gondii microneme protein, putative 0.008 0.0083 0.0081
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0047 0.0631
Schistosoma mansoni lysyl-tRNA synthetase 0.0076 0.0078 0.0076
Onchocerca volvulus 0.0033 0.0022 0.0265
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0003 0.0038
Echinococcus multilocularis solute carrier family 22 0.0048 0.0042 0.0107
Brugia malayi Cam kinase protein 1 0.0104 0.0115 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.014 0.0139
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0124 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0052
Onchocerca volvulus Arrow homolog 0.0075 0.0077 0.1026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0098 0.0252
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0052 0.005
Echinococcus multilocularis protein jagged 1 0.0028 0.0017 0.0043
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0004 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0291
Echinococcus granulosus synaptic vesicle 2 protein 0.0048 0.0042 0.0107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Echinococcus multilocularis cpg binding protein 0.0037 0.0027 0.007
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0048 0.0042 0.004
Trichomonas vaginalis conserved hypothetical protein 0.034 0.042 0.1075
Echinococcus multilocularis CREB binding protein 0.0017 0.0002 0.0005
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0102 0.0112 0.0287
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0019 0.0004 0.0004
Brugia malayi Sugar transporter family protein 0.0048 0.0042 0.0042
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0019 0.0004 0.0003
Trypanosoma brucei glucose transporter, putative 0.0105 0.0116 0.0115
Loa Loa (eye worm) MH2 domain-containing protein 0.0587 0.0742 1
Schistosoma mansoni cell polarity protein 0.0028 0.0017 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0079 0.0082 0.0081
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0043 0.011
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0048 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Schistosoma mansoni glucose transporter 0.0048 0.0042 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.014 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0024
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0002 0.0000067316
Onchocerca volvulus 0.0079 0.0082 0.1104
Loa Loa (eye worm) hypothetical protein 0.0075 0.0077 0.1031
Onchocerca volvulus 0.0028 0.0017 0.0192
Brugia malayi Trypsin family protein 0.0079 0.0082 0.0082
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0076 0.0078 0.0076
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0079 0.0082 0.0211
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0587 0.0742 1
Plasmodium falciparum lysine--tRNA ligase 0.0076 0.0078 0.0076
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0052 0.005
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0072 0.007
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Toxoplasma gondii sugar transporter ST2 0.0048 0.0042 0.004
Brugia malayi beta-lactamase 0.0071 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0021 0.0019
Plasmodium falciparum dihydroorotate dehydrogenase 0.7723 1 1
Leishmania major hypothetical protein, conserved 0.0222 0.0267 0.0266
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Brugia malayi Thioredoxin reductase 0.0049 0.0043 0.0043
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0004 0.0003
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0549 0.0692 0.0691
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Brugia malayi Sugar transporter family protein 0.0048 0.0042 0.0042
Brugia malayi Smad1 0.004 0.0032 0.0031
Loa Loa (eye worm) notch protein 0.0028 0.0017 0.0223
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0003 0.0007
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.302 0.3898 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0076 0.0078 0.0076
Brugia malayi MH2 domain containing protein 0.004 0.0032 0.0031
Schistosoma mansoni cercarial elastase (S01 family) 0.0079 0.0082 0.0081
Brugia malayi hypothetical protein 0.0229 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Echinococcus multilocularis protein jagged 2 0.0028 0.0017 0.0043
Echinococcus granulosus lysyl tRNA synthetase 0.0076 0.0078 0.02
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0021 0.0053
Echinococcus granulosus neural cadherin 0.0028 0.0017 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0072 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0011 0.001
Echinococcus granulosus solute carrier family 22 0.0048 0.0042 0.0107
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0017 0.0043
Brugia malayi beta-lactamase family protein 0.0071 0.0072 0.0072
Schistosoma mansoni septate junction protein 0.0028 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0102 0.0112 0.1508
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0054
Treponema pallidum prolyl-tRNA synthetase 0.0036 0.0026 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0072 0.0072
Onchocerca volvulus 0.0048 0.0042 0.054
Onchocerca volvulus 0.0079 0.0082 0.1104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0223
Echinococcus granulosus neurogenic locus protein delta 0.0028 0.0017 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0026 0.0062
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.3015 0.3892 0.9985
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0121 0.0136 0.0349
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Brugia malayi EGF-like domain containing protein 0.0028 0.0017 0.0017
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0104 0.0115 0.0114
Schistosoma mansoni notch 0.0028 0.0017 0.0015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.034 0.042 0.1079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Brugia malayi PAN domain containing protein 0.008 0.0083 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0072 0.0965
Onchocerca volvulus 0.0048 0.0042 0.054
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Toxoplasma gondii EGF family domain-containing protein 0.0028 0.0017 0.0015
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.034 0.042 0.1079
Leishmania major lysyl-tRNA synthetase, putative 0.0076 0.0078 0.0076
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0004 0.0003
Echinococcus multilocularis fibropellin Ia 0.0028 0.0017 0.0043
Brugia malayi Delta serrate ligand family protein 0.0028 0.0017 0.0017
Brugia malayi Fibulin-1 precursor 0.0075 0.0077 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0072 0.007
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0017 0.0043
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.7723 1 1
Leishmania major hypothetical protein, conserved 0.0048 0.0042 0.004
Brugia malayi MH1 domain containing protein 0.004 0.0032 0.0031
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0104 0.0115 0.0295
Schistosoma mansoni kinase 0.0064 0.0063 0.0062
Onchocerca volvulus 0.0033 0.0022 0.0265
Echinococcus granulosus cpg binding protein 0.0037 0.0027 0.007
Onchocerca volvulus 0.0071 0.0072 0.0958
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Plasmodium vivax glycine--tRNA ligase, putative 0.0019 0.0004 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0014 0.0033
Onchocerca volvulus 0.0032 0.0021 0.0248
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0104 0.0115 0.0114
Toxoplasma gondii hypothetical protein 0.008 0.0083 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0136 0.0134
Schistosoma mansoni sugar transporter 0.0048 0.0042 0.004
Schistosoma mansoni protein kinase 0.0104 0.0115 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0143 0.1928
Onchocerca volvulus 0.0048 0.0042 0.054
Onchocerca volvulus 0.0048 0.0042 0.054
Giardia lamblia Glycyl-tRNA synthetase 0.0019 0.0004 0.021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0104 0.0115 0.0295
Brugia malayi glycyl-tRNA synthetase 0.0019 0.0004 0.0004
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0143 0.0367
Echinococcus multilocularis musashi 0.0033 0.0022 0.0056
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0004 0.0059
Onchocerca volvulus 0.008 0.0083 0.1115
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0026 0.0062
Onchocerca volvulus 0.0222 0.0267 0.368
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0136 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0042 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0277 0.0709
Toxoplasma gondii PAN domain-containing protein 0.008 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0561
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0072 0.007
Schistosoma mansoni hypothetical protein 0.0028 0.0017 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0000067316
Schistosoma mansoni smad1 5 8 and 0.004 0.0032 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.0567 0.0566
Echinococcus granulosus CREB binding protein 0.0105 0.0116 0.0297

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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