Detailed information for compound 1359201

Basic information

Technical information
  • TDR Targets ID: 1359201
  • Name: N-(2-chloro-4-methylphenyl)-3-pyridin-4-yl-1, 2,4-oxadiazole-5-carboxamide
  • MW: 314.726 | Formula: C15H11ClN4O2
  • H donors: 1 H acceptors: 4 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Cl)NC(=O)c1onc(n1)c1ccncc1
  • InChi: 1S/C15H11ClN4O2/c1-9-2-3-12(11(16)8-9)18-14(21)15-19-13(20-22-15)10-4-6-17-7-5-10/h2-8H,1H3,(H,18,21)
  • InChiKey: GMYUKSIIIOYHJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chloro-4-methyl-phenyl)-3-(4-pyridyl)-1,2,4-oxadiazole-5-carboxamide
  • N-(2-chloro-4-methylphenyl)-3-(4-pyridyl)-1,2,4-oxadiazole-5-carboxamide
  • N-(2-chloro-4-methyl-phenyl)-3-pyridin-4-yl-1,2,4-oxadiazole-5-carboxamide
  • E213-1703
  • NCGC00121323-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0281 0.6711 1
Entamoeba histolytica hypothetical protein 0.0064 0.1069 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.1069 0.1172
Echinococcus granulosus cathepsin l1 0.0281 0.6711 0.6599
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0064 0.1069 0.1369
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0535 0.0552
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0064 0.1069 0.0884
Loa Loa (eye worm) hypothetical protein 0.0098 0.1954 0.2194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0162 0.3608 0.5377
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.3434 0.4986
Giardia lamblia Cysteine protease 0.0064 0.1069 0.0942
Brugia malayi fibroinase precursor 0.0064 0.1069 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0535 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0281 0.6711 1
Brugia malayi MH2 domain containing protein 0.0117 0.2443 0.2758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0535 0.0552
Echinococcus granulosus cathepsin L 0.0162 0.3608 0.3392
Plasmodium vivax vivapain-2 0.0281 0.6711 1
Giardia lamblia Encystation-specific protease 0.0064 0.1069 0.0942
Onchocerca volvulus 0.0281 0.6711 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0823 0.1155
Brugia malayi cathepsin Z-like cysteine proteinase 0.0064 0.1069 0.1172
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.1069 0.1172
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Leishmania major cysteine peptidase A (CPA) 0.0281 0.6711 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0064 0.1069 0.1172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0281 0.6711 0.6599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1069 0.1369
Echinococcus granulosus cathepsin b 0.0358 0.8715 0.8671
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.1069 0.0884
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.6711 0.7686
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0823 0.0887
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0064 0.1069 0.1162
Trypanosoma cruzi cysteine proteinase, putative 0.0162 0.3608 0.4103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Plasmodium falciparum serine repeat antigen 7 0.0064 0.1069 0.1524
Trypanosoma cruzi cruzipain precursor, putative 0.0098 0.1954 0.2194
Trypanosoma cruzi cruzipain precursor, putative 0.0281 0.6711 0.7686
Echinococcus multilocularis cathepsin b 0.0358 0.8715 0.8671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0329 0.0237
Trypanosoma brucei cysteine peptidase C (CPC) 0.0155 0.3434 0.5117
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0064 0.1069 0.1524
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0081 0.0121
Onchocerca volvulus Cathepsin L homolog 0.0064 0.1069 0.0182
Onchocerca volvulus Cathepsin L homolog 0.0281 0.6711 1
Brugia malayi cathepsin L precursor 0.0064 0.1069 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0256 0.0126
Echinococcus granulosus cathepsin l1 0.0183 0.4172 0.3974
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0281 0.6711 0.6599
Plasmodium falciparum serine repeat antigen 4 0.0064 0.1069 0.1524
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.3608 0.3911
Toxoplasma gondii preprocathepsin c precursor, putative 0.0064 0.1069 0.1524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1954 0.2194
Plasmodium falciparum cysteine proteinase falcipain 3 0.0281 0.6711 1
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0155 0.3434 0.3902
Plasmodium falciparum serine repeat antigen 6 0.0064 0.1069 0.1524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0064 0.1069 0.1524
Plasmodium vivax serine-repeat antigen (SERA) 0.0064 0.1069 0.1524
Onchocerca volvulus 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Echinococcus multilocularis cathepsin b 0.0358 0.8715 0.8671
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Onchocerca volvulus 0.0064 0.1069 0.0182
Onchocerca volvulus 0.0281 0.6711 1
Plasmodium vivax vivapain-1 0.0162 0.3608 0.5339
Toxoplasma gondii cathepsin B 0.0155 0.3434 0.5077
Giardia lamblia Cysteine protease 0.0064 0.1069 0.0942
Loa Loa (eye worm) hypothetical protein 0.0183 0.4172 0.4754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0823 0.0993
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.1069 0.1369
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Giardia lamblia Cathepsin B precursor 0.0064 0.1069 0.0942
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0535 0.0552
Echinococcus granulosus cathepsin L 0.0064 0.1069 0.0767
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Brugia malayi Cathepsin L-like precursor 0.0183 0.4172 0.4754
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0064 0.1069 0.1524
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0064 0.1069 0.1162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0823 0.0887
Brugia malayi Cathepsin L-like cysteine proteinase 0.0183 0.4172 0.4754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4172 0.6116
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Plasmodium vivax vivapain-2 0.0281 0.6711 1
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0064 0.1069 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.1069 0.1369
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.036 0.0283
Brugia malayi Cathepsin L-like precursor 0.0183 0.4172 0.4754
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0064 0.1069 0.0884
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0155 0.3434 0.5077
Giardia lamblia Hypothetical protein 0.0064 0.1069 0.0942
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0162 0.3608 0.4103
Giardia lamblia Cathepsin L-like protease 0.0064 0.1069 0.0942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Loa Loa (eye worm) hypothetical protein 0.0281 0.6711 0.7686
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0823 0.0887
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.1069 0.1172
Plasmodium vivax unspecified product 0.0098 0.1954 0.2854
Toxoplasma gondii cathepsin CPC1 0.0064 0.1069 0.1524
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Loa Loa (eye worm) hypothetical protein 0.0098 0.1954 0.2194
Brugia malayi cathepsin L-like precursor 0.0183 0.4172 0.4754
Schistosoma mansoni cathepsin F (C01 family) 0.0281 0.6711 0.7611
Trypanosoma cruzi cysteine peptidase, putative 0.0098 0.1954 0.2194
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.1069 0.1172
Giardia lamblia Cathepsin B precursor 0.0155 0.3434 1
Brugia malayi Cathepsin L-like precursor 0.0098 0.1954 0.2194
Giardia lamblia Cathepsin B precursor 0.0064 0.1069 0.0942
Brugia malayi cathepsin F-like cysteine proteinase 0.0098 0.1954 0.2194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0098 0.1954 0.2194
Loa Loa (eye worm) cathepsin B 0.0155 0.3434 0.3902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0535 0.0552
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2443 0.2758
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0358 0.8715 1
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Echinococcus granulosus cathepsin l cysteine peptidase 0.0281 0.6711 0.6599
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Schistosoma mansoni cathepsin F (C01 family) 0.0281 0.6711 0.7611
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.4172 0.6022
Schistosoma mansoni cathepsin C 0.0064 0.1069 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0064 0.1069 0.1524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0256 0.0126
Echinococcus granulosus cathepsin L cysteine protease 0.0162 0.3608 0.3392
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0064 0.1069 0.1524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0064 0.1069 0.1524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.0113
Giardia lamblia Cathepsin L-like protease 0.0064 0.1069 0.0942
Toxoplasma gondii cathepsin CPL 0.0281 0.6711 1
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trypanosoma cruzi cysteine protease, putative 0.0162 0.3608 0.4103
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.6711 0.7686
Schistosoma mansoni cathepsin F (C01 family) 0.0183 0.4172 0.4583
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0823 0.1226
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.1069 0.0942
Giardia lamblia Cathepsin B precursor 0.0155 0.3434 1
Echinococcus multilocularis cathepsin L 0.0162 0.3608 0.3392
Brugia malayi cathepsin Z-like cysteine proteinase 0.0064 0.1069 0.1172
Plasmodium falciparum cysteine proteinase falcipain 1 0.0162 0.3608 0.5339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.3608 0.3911
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1069 0.1369
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0358 0.8715 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0823 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0823 0.0776
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0358 0.8715 1
Onchocerca volvulus Cathepsin F homolog 0.0281 0.6711 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0064 0.1069 0.1172
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.1069 0.1369
Onchocerca volvulus 0.0281 0.6711 1
Echinococcus multilocularis cathepsin L 0.0064 0.1069 0.0767
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.3608 0.5139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Giardia lamblia Cathepsin B precursor 0.0064 0.1069 0.0942
Onchocerca volvulus 0.0281 0.6711 1
Loa Loa (eye worm) fibroinase 0.0281 0.6711 0.7686
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2443 0.2758
Echinococcus granulosus cysteine protease 0.0162 0.3608 0.3392
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.6711 0.7686
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0617 0.0678
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0064 0.1069 0.1369
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0183 0.4172 0.4754
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.6711 0.7686
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Loa Loa (eye worm) hypothetical protein 0.0358 0.8715 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.0113
Trypanosoma cruzi cysteine proteinase, putative 0.0162 0.3608 0.4103
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.3608 0.5139
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0536 0.0556
Plasmodium falciparum serine repeat antigen 9 0.0064 0.1069 0.1524
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0823 0.0776
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0823 0.0591
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0098 0.1954 0.2194
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Giardia lamblia Cysteine protease 0.0064 0.1069 0.0942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0281 0.6711 1
Brugia malayi Cathepsin L-like precursor 0.0281 0.6711 0.7686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Echinococcus multilocularis cysteine protease 0.0281 0.6711 0.6599
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.1069 0.1172
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Plasmodium vivax unspecified product 0.0064 0.1069 0.1524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.1069 0.0884
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0064 0.1069 0.1524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0358 0.8715 1
Echinococcus multilocularis cysteine protease 0.0281 0.6711 0.6599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.1069 0.0942
Trypanosoma cruzi cysteine peptidase, putative 0.0162 0.3608 0.4103
Onchocerca volvulus 0.0183 0.4172 0.5581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.1069 0.1172
Entamoeba histolytica cysteine proteinase, putative 0.0162 0.3608 0.5139
Entamoeba histolytica cysteine protease, putative 0.0281 0.6711 1
Loa Loa (eye worm) cysteine protease 0.0281 0.6711 0.7686
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0536 0.0799
Plasmodium falciparum serine repeat antigen 8 0.0064 0.1069 0.1524
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0064 0.1069 0.1524
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0462 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0175 0.0002
Schistosoma mansoni cathepsin B (C01 family) 0.0064 0.1069 0.0884
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.6711 1
Toxoplasma gondii cathepsin CPC2 0.0064 0.1069 0.1524
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0064 0.1069 0.1524
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Giardia lamblia Hypothetical protein 0.0064 0.1069 0.0942
Loa Loa (eye worm) hypothetical protein 0.0064 0.1069 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0823 0.0993
Echinococcus multilocularis cathepsin L cysteine protease 0.0281 0.6711 0.6599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.1069 0.1369
Plasmodium falciparum serine repeat antigen 1 0.0064 0.1069 0.1524
Entamoeba histolytica cysteine proteinase 2 0.0162 0.3608 0.5139
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0064 0.1069 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0965 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0175 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.6711 0.7686
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0358 0.8715 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0064 0.1069 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Plasmodium falciparum serine repeat antigen 3 0.0064 0.1069 0.1524
Onchocerca volvulus 0.0281 0.6711 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.1069 0.0884
Loa Loa (eye worm) hypothetical protein 0.0183 0.4172 0.4754
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Loa Loa (eye worm) hypothetical protein 0.0183 0.4172 0.4754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0162 0.3608 0.5377
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0823 0.0512
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0064 0.1069 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0175 0.0002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0281 0.6711 0.6599
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0064 0.1069 0.1524
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0823 0.1155
Brugia malayi Papain family cysteine protease containing protein 0.0162 0.3608 0.4103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Schistosoma mansoni cathepsin s 0.0098 0.1954 0.194
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0064 0.1069 0.1524
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0823 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0823 0.0993
Schistosoma mansoni cathepsin S (C01 family) 0.0064 0.1069 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0064 0.1069 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4172 0.6116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0162 0.3608 0.3911
Entamoeba histolytica cysteine proteinase 1, putative 0.0162 0.3608 0.5139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.3608 0.5253
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.1069 0.0942
Plasmodium falciparum serine repeat antigen 5 0.0064 0.1069 0.1524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0281 0.6711 0.7686
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0823 0.1226
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0281 0.6711 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.1069 0.0884
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0064 0.1069 0.0942
Giardia lamblia Cathepsin B precursor 0.0064 0.1069 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0462 0.0441
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0054 0.0081
Onchocerca volvulus 0.0281 0.6711 1
Giardia lamblia Cathepsin B precursor 0.0064 0.1069 0.0942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Giardia lamblia Cathepsin B precursor 0.0155 0.3434 1
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.1069 0.1172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Loa Loa (eye worm) ctsf protein 0.0281 0.6711 0.7686
Plasmodium vivax unspecified product 0.0162 0.3608 0.5339
Giardia lamblia Cysteine protease 0.0064 0.1069 0.0942
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0281 0.6711 0.7686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Echinococcus granulosus cathepsin b 0.0358 0.8715 0.8671
Brugia malayi cathepsin B-like cysteine proteinase 0.0358 0.8715 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Plasmodium vivax vivapain-3 0.0162 0.3608 0.5339
Echinococcus multilocularis cathepsin L cysteine protease 0.0281 0.6711 0.6599
Plasmodium falciparum serine repeat antigen 2 0.0064 0.1069 0.1524
Giardia lamblia Cathepsin L precursor 0.0064 0.1069 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0256 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.1069 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.6711 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0064 0.1069 0.1524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0162 0.3608 0.5253
Entamoeba histolytica cysteine protease, putative 0.0162 0.3608 0.5139
Brugia malayi hypothetical protein 0.0035 0.0328 0.0315
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0064 0.1069 0.1524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.3434 0.3703
Brugia malayi cathepsin L-like cysteine proteinase 0.0064 0.1069 0.1172
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0064 0.1069 0.1524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.1069 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.1069 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.6711 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.1069 0.0884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.6711 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0536 0.0724
Brugia malayi Papain family cysteine protease containing protein 0.0162 0.3608 0.4103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0175 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0965 0.0759
Entamoeba histolytica cysteine protease, putative 0.0064 0.1069 0.1162
Leishmania major cathepsin L-like protease 0.0281 0.6711 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.1069 0.1369
Onchocerca volvulus Cathepsin L homolog 0.0281 0.6711 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.104 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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