TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 560.588 | Formula: C23H26F2N2O8S2
H donors: 2 H acceptors: 5 LogP: 3.19 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)CCc1cc(F)c(cc1F)[S+](=O)(N1CCN(CC1)[S+](=O)(c1ccc2c(c1)OCCO2)[O-])[O-]
InChi: 1S/C23H26F2N2O8S2/c1-2-33-23(28)6-3-16-13-19(25)22(15-18(16)24)37(31,32)27-9-7-26(8-10-27)36(29,30)17-4-5-20-21(14-17)35-12-11-34-20/h4-5,13-15H,2-3,6-12H2,1H3
InChiKey: CFAMPLHRWUCMER-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pyruvate kinase, muscle	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, M2 isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium leprae	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Chlamydia trachomatis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Babesia bovis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium parvum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	ko:K00873 pyruvate kinase [EC2.7.1.40], putative	Get druggable targets OG5_126685	All targets in OG5_126685
Toxoplasma gondii	pyruvate kinase PyK1	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium berghei	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	Pyruvate kinase isozyme R, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium yoelii	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Giardia lamblia	Pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium vivax	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium ulcerans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium knowlesi	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Theileria parva	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania donovani	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma congolense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Entamoeba histolytica	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase-PB	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, muscle isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium falciparum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium hominis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Neospora caninum	Pyruvate kinase (EC 2.7.1.40), related	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, muscle	605 aa	521 aa	34.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Mycobacterium leprae	Probable pyruvate kinase PykA	0.004	0.0844	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0067	0.2716	0.4534
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.2716	0.2045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Plasmodium vivax	vivapain-2	0.0115	0.5991	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.2716	0.3638
Plasmodium vivax	vivapain-3	0.0067	0.2716	0.3638
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0115	0.5991	0.5622
Loa Loa (eye worm)	hypothetical protein	0.004	0.0844	0.0844
Loa Loa (eye worm)	cysteine protease	0.0115	0.5991	0.5991
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Brugia malayi	Cathepsin L-like precursor	0.0074	0.32	0.2573
Echinococcus granulosus	cathepsin l1	0.0115	0.5991	0.5622
Entamoeba histolytica	cysteine protease, putative	0.0115	0.5991	1
Onchocerca volvulus		0.0115	0.5991	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0067	0.2716	0.2045
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0844	0.0844
Onchocerca volvulus		0.0074	0.32	0.4578
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Echinococcus granulosus	cathepsin L	0.0067	0.2716	0.2045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.004	0.0847	0.0003
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.32	0.2573
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0067	0.2716	0.3638
Entamoeba histolytica	cysteine proteinase, putative	0.0067	0.2716	0.4534
Entamoeba histolytica	cysteine proteinase, putative	0.0067	0.2716	0.4534
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0115	0.5991	0.5991
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Echinococcus multilocularis	cysteine protease	0.0115	0.5991	0.5886
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Echinococcus multilocularis	cathepsin b	0.0173	1	1
Loa Loa (eye worm)	cathepsin B	0.0072	0.3041	0.3041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Giardia lamblia	Cathepsin B precursor	0.0072	0.3041	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0847	0.0847
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.5991	0.5622
Toxoplasma gondii	cathepsin B	0.0072	0.3041	0.4269
Mycobacterium ulcerans	pyruvate kinase	0.004	0.0844	0.5
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.5991	1
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.2716	0.2045
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.5991	0.5991
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.004	0.0847	0.0847
Trypanosoma cruzi	cysteine protease, putative	0.0067	0.2716	0.2045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.3041	0.24
Onchocerca volvulus	Cathepsin L homolog	0.0115	0.5991	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0074	0.32	0.2573
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0115	0.5991	1
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Echinococcus granulosus	cathepsin l1	0.0074	0.32	0.2573
Plasmodium vivax	unspecified product	0.004	0.0847	0.0006
Echinococcus granulosus	cathepsin b	0.0173	1	1
Schistosoma mansoni	cathepsin s	0.004	0.0847	0.0003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Echinococcus multilocularis	pyruvate kinase	0.004	0.0844	0.0603
Leishmania major	cysteine peptidase A (CPA)	0.0115	0.5991	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0173	1	1
Giardia lamblia	Cathepsin B precursor	0.0072	0.3041	1
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0844	0.0844
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Onchocerca volvulus		0.0115	0.5991	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.32	0.32
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0115	0.5991	0.5622
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.32	0.5341
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.32	0.4578
Trypanosoma cruzi	cysteine peptidase, putative	0.0115	0.5991	0.5622
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0067	0.2716	0.2045
Entamoeba histolytica	cysteine proteinase, putative	0.0067	0.2716	0.4534
Trypanosoma cruzi	cysteine peptidase, putative	0.0115	0.5991	0.5622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma cruzi	cruzipain precursor, putative	0.004	0.0847	0.0003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Loa Loa (eye worm)	fibroinase	0.0115	0.5991	0.5991
Brugia malayi	cathepsin L-like precursor	0.0074	0.32	0.2573
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0115	0.5991	0.5622
Loa Loa (eye worm)	ctsf protein	0.0115	0.5991	0.5991
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0115	0.5991	0.5886
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0115	0.5991	1
Echinococcus granulosus	cathepsin b	0.0173	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.2716	0.2045
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0072	0.3041	0.4269
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.2716	0.3638
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0115	0.5991	0.5622
Onchocerca volvulus		0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0067	0.2716	0.3638
Echinococcus multilocularis	cathepsin L	0.0067	0.2716	0.2525
Brugia malayi	Cathepsin L-like precursor	0.0074	0.32	0.2573
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.004	0.0847	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0115	0.5991	0.5622
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.2716	0.2045
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Trypanosoma cruzi	cysteine peptidase, putative	0.004	0.0847	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Toxoplasma gondii	cathepsin CPL	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Echinococcus multilocularis	cysteine protease	0.0115	0.5991	0.5886
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0072	0.3041	0.4269
Onchocerca volvulus		0.0115	0.5991	1
Echinococcus multilocularis	pyruvate kinase	0.004	0.0844	0.0603
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0074	0.32	0.2573
Entamoeba histolytica	cysteine proteinase 2	0.0067	0.2716	0.4534
Loa Loa (eye worm)	hypothetical protein	0.0074	0.32	0.32
Onchocerca volvulus		0.0115	0.5991	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0115	0.5991	1
Plasmodium vivax	unspecified product	0.0067	0.2716	0.3638
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0115	0.5991	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0067	0.2716	0.4534
Echinococcus granulosus	cysteine protease	0.0067	0.2716	0.2045
Echinococcus multilocularis	cathepsin b	0.0173	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Plasmodium vivax	vivapain-1	0.0067	0.2716	0.3638
Echinococcus granulosus	cathepsin L cysteine protease	0.0067	0.2716	0.2045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.32	0.32
Echinococcus multilocularis	cathepsin L cysteine protease	0.0115	0.5991	0.5886
Loa Loa (eye worm)	hypothetical protein	0.0115	0.5991	0.5991
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.0844	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Brugia malayi	Cathepsin L-like precursor	0.004	0.0847	0.0003
Schistosoma mansoni	cathepsin F (C01 family)	0.0115	0.5991	0.5622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.3041	0.4269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.32	0.4578
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Plasmodium vivax	vivapain-2	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Onchocerca volvulus	Cathepsin L homolog	0.0115	0.5991	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0115	0.5991	0.5886
Brugia malayi	Cathepsin L-like precursor	0.0115	0.5991	0.5622
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0072	0.3041	0.24
Onchocerca volvulus		0.0115	0.5991	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0067	0.2716	0.2045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.5991	1
Onchocerca volvulus		0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Onchocerca volvulus	Cathepsin F homolog	0.0115	0.5991	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.2716	0.2045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.2716	0.2045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Trypanosoma cruzi	cruzipain precursor, putative	0.0115	0.5991	0.5622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0067	0.2716	0.3638
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.5991	1
Giardia lamblia	Cathepsin B precursor	0.0072	0.3041	1
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0847	0.0847
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0847	0.0847
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0115	0.5991	0.5886
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Chlamydia trachomatis	pyruvate kinase	0.004	0.0844	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0844	0.0844
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Leishmania major	cathepsin L-like protease	0.0115	0.5991	1
Entamoeba histolytica	cysteine protease, putative	0.0067	0.2716	0.4534
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M2 isoform. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1475598

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1359207