Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1004 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3293 | 0.3293 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.3047 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2097 | 0.4775 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.3293 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.3047 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.3293 | 0.3293 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1004 | 0.3047 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1004 | 0.3047 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.3293 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.2097 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1004 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2097 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1004 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.3293 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1004 | 0.3047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.