Detailed information for compound 1359549

Basic information

Technical information
  • TDR Targets ID: 1359549
  • Name: N-(2-methylpropyl)-2-(4,8,8-trimethyl-2-oxo-6 ,7-dihydropyrano[5,6-g]chromen-3-yl)acetamide
  • MW: 357.443 | Formula: C21H27NO4
  • H donors: 1 H acceptors: 2 LogP: 3.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CNC(=O)Cc1c(=O)oc2c(c1C)cc1c(c2)OC(CC1)(C)C)C
  • InChi: 1S/C21H27NO4/c1-12(2)11-22-19(23)9-16-13(3)15-8-14-6-7-21(4,5)26-17(14)10-18(15)25-20(16)24/h8,10,12H,6-7,9,11H2,1-5H3,(H,22,23)
  • InChiKey: DMEWGXIOKDOUPD-UHFFFAOYSA-N  

Network

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Synonyms

  • N-isobutyl-2-(4,8,8-trimethyl-2-oxo-6,7-dihydropyrano[5,6-g]chromen-3-yl)acetamide
  • N-isobutyl-2-(2-keto-4,8,8-trimethyl-6,7-dihydropyrano[5,6-g]chromen-3-yl)acetamide
  • N-(2-methylpropyl)-2-(4,8,8-trimethyl-2-oxo-6,7-dihydropyrano[5,6-g]chromen-3-yl)ethanamide
  • STOCK1N-64436
  • ZINC04089587

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0895 0.1646
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0687
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0042 0.1832
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0001 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.006 0.04 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0687
Schistosoma mansoni hypothetical protein 0.0049 0.0315 0.0578
Schistosoma mansoni endoplasmin 0.0032 0.0176 0.0323
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0135 0.1228
Brugia malayi Fibulin-1 precursor 0.0015 0.0039 0.0355
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0871 0.7919
Leishmania major DNA polymerase kappa, putative 0.0019 0.007 0.3117
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0167 0.0212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0355
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Brugia malayi hypothetical protein 0.0146 0.11 1
Trichomonas vaginalis endoplasmin, putative 0.002 0.0075 0.2251
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0079 0.4072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0076 0.0139
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0176 0.0633
Toxoplasma gondii EGF family domain-containing protein 0.0015 0.0034 0.0118
Echinococcus granulosus microtubule associated protein 2 0.0681 0.5442 1
Echinococcus multilocularis nibrin 0.0012 0.0012 0.0015
Schistosoma mansoni heat shock protein 0.0032 0.0176 0.0323
Toxoplasma gondii calcium binding egf domain-containing protein 0.0015 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0355
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Brugia malayi hypothetical protein 0.0027 0.0135 0.1228
Schistosoma mansoni hypothetical protein 0.002 0.0079 0.0144
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0022 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0077
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0001 0.001
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Brugia malayi nuclear receptor NHR-88 0.002 0.0076 0.0687
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0176 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0881 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0022 0.019
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0015 0.0034 0.0062
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0001 0.001
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0176 0.1885
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0012 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0076 0.0096
Schistosoma mansoni brg-1 associated factor 0.0011 0.0001 0.0002
Schistosoma mansoni topbp1 0.0012 0.0012 0.0022
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0176 1
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0123 0.6763
Echinococcus multilocularis fat cadherin tumor suppressor 0.0015 0.0034 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0012 0.0329
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0012 0.0329
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0709 0.6446
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis geminin 0.0496 0.3943 0.5013
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Onchocerca volvulus 0.0146 0.11 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Onchocerca volvulus 0.0027 0.0135 0.122
Echinococcus granulosus heat shock protein 90 0.0032 0.0176 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0162 0.9195
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0015 0.0034 0.0305
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0176 0.1885
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.3544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Echinococcus granulosus protein jagged 2 0.0015 0.0034 0.0062
Echinococcus granulosus neurogenic locus notch protein 0.0015 0.0034 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0076 0.0687
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0355
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0892 0.7157 1
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0069 0.3488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0287 0.0365
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0287 0.2607
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0687
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0039 0.0355
Plasmodium falciparum heat shock protein 90 0.0032 0.0176 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0012 0.0619
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0135 0.1228
Echinococcus multilocularis neural cadherin 0.0015 0.0034 0.0043
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.007 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0062 0.0423 0.3842
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0026 0.0033
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0135 0.1228
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0076 0.0687
Echinococcus multilocularis heat shock protein 0.0032 0.0176 0.0223
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Echinococcus granulosus cpg binding protein 0.0037 0.0213 0.0391
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0079 0.4439
Loa Loa (eye worm) endoplasmin 0.0032 0.0176 0.1596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Loa Loa (eye worm) hypothetical protein 0.0067 0.0458 0.4163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0687
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0123 0.0114
Leishmania major hypothetical protein, conserved 0.003 0.0162 0.9142
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0167 0.0306
Echinococcus granulosus X box binding protein 1 0.0284 0.2223 0.4084
Brugia malayi Muscle positioning protein 4 0.0015 0.0034 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0287 0.0527
Echinococcus granulosus heat shock protein 90 0.0026 0.0123 0.0225
Brugia malayi MH2 domain containing protein 0.0118 0.0871 0.7919
Brugia malayi topoisomerase 0.0012 0.0012 0.0108
Schistosoma mansoni cpg binding protein 0.0037 0.0213 0.0391
Echinococcus granulosus protein jagged 1 0.0015 0.0034 0.0062
Treponema pallidum heat shock protein 90 0.0026 0.0123 0.0111
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0012 0.0329
Loa Loa (eye worm) Notch2 0.0015 0.0034 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0135 0.1228
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0135 0.1228
Chlamydia trachomatis DNA ligase 0.0012 0.0012 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0076 0.0139
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0076 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1242 1 1
Echinococcus multilocularis fibropellin Ia 0.0015 0.0034 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0042 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0687
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0123 0.0111
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0015 0.0039 0.0355
Onchocerca volvulus 0.002 0.0079 0.0705
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0076 0.0139
Giardia lamblia Grp94/Hsp90 0.0026 0.0123 0.6763
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Schistosoma mansoni heat shock protein 0.0032 0.0176 0.0323
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0123 0.655
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Schistosoma mansoni patched 1 0.0051 0.033 0.0606
Schistosoma mansoni hypothetical protein 0.0014 0.0026 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1295 0.2379
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0135 0.1228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Onchocerca volvulus 0.006 0.04 0.3631
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.3544
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0042 0.2338
Brugia malayi steroid hormone receptor 0.002 0.0076 0.0687
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0076 0.0678
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0012 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Schistosoma mansoni hypothetical protein 0.0049 0.0315 0.0578
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0176 1
Plasmodium vivax heat shock protein, putative 0.0013 0.0022 0.1199
Echinococcus multilocularis neurogenic locus notch protein 4 0.0015 0.0034 0.0043
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0892 0.7157 1
Echinococcus granulosus slit 2 protein 0.0015 0.0034 0.0062
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0881 0.112
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0039 0.0355
Loa Loa (eye worm) hypothetical protein 0.006 0.04 0.3637
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0135 0.1228
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.007 0.3117
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0015 0.0034 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0687
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.033 1
Schistosoma mansoni endoplasmin 0.0032 0.0176 0.0323
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0176 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Onchocerca volvulus Neurogenic locus notch homolog 0.0015 0.0034 0.0296
Schistosoma mansoni hypothetical protein 0.0494 0.3925 0.7213
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0076 0.0687
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0012 0.0039
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0034 0.0305
Schistosoma mansoni DNA polymerase eta 0.0019 0.007 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0287 0.0527
Echinococcus multilocularis neurogenic locus protein delta 0.0015 0.0034 0.0043
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1242 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Onchocerca volvulus 0.0015 0.0034 0.0296
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Onchocerca volvulus 0.0015 0.0034 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0012 0.0329
Schistosoma mansoni hypothetical protein 0.0049 0.0315 0.0578
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.3544
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0076 0.0096
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0076 0.0096
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.035 0.2758 0.2758
Schistosoma mansoni cpg binding protein 0.0037 0.0213 0.0391
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0079 0.0714
Onchocerca volvulus Peroxidase homolog 0.0027 0.0135 0.122
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0176 0.1596
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0076 0.0096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0513 0.0942
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.1832
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0026 0.0048
Brugia malayi nuclear hormone receptor 0.002 0.0076 0.0687
Echinococcus multilocularis heat shock protein 90 0.0032 0.0176 0.0223
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Brugia malayi Cadherin domain containing protein 0.0015 0.0034 0.0305
Echinococcus multilocularis notch 0.0015 0.0034 0.0043
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.007 0.0635
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0162 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0687
Echinococcus granulosus GPCR family 2 0.0031 0.0167 0.0306
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0123 0.6763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0687
Echinococcus granulosus Tolloid protein 1 0.0015 0.0039 0.0072
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0001 0.001
Onchocerca volvulus Huntingtin homolog 0.0121 0.0897 0.8145
Echinococcus granulosus endoplasmin 0.0026 0.0123 0.0225
Onchocerca volvulus 0.0035 0.0197 0.1781
Brugia malayi hypothetical protein 0.0012 0.0012 0.0108
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0123 0.0225
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.3544
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.0306
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0162 0.9195
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0079 0.0144
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0135 0.1228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.007 0.2096
Echinococcus granulosus protein jagged 1 0.0015 0.0034 0.0062
Trichomonas vaginalis heat shock protein, putative 0.002 0.0075 0.2251
Onchocerca volvulus 0.0027 0.0135 0.122
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.007 0.2096
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.007 0.0058
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0176 1
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0176 0.0633
Echinococcus multilocularis tumor protein p63 0.0408 0.3228 0.4104
Schistosoma mansoni hypothetical protein 0.0496 0.3943 0.7246
Plasmodium falciparum endoplasmin, putative 0.002 0.0075 0.4236
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0076 0.0139
Onchocerca volvulus Putative cubilin 0.0015 0.0034 0.0296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.007 0.0128
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0881 0.8002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0076 0.0139
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.033 0.0419
Giardia lamblia DINP protein human, muc B family 0.0019 0.007 0.3543
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0176 1
Schistosoma mansoni DNA ligase IV 0.0012 0.0012 0.0022
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0001 0.001
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0012 0.0108
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0001 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0042 0.0077
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.3701
Onchocerca volvulus Arrow homolog 0.0015 0.0039 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0012 0.0329
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0615
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Brugia malayi hypothetical protein 0.002 0.0075 0.0681
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.3701
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0076 0.0139
Brugia malayi Kringle domain containing protein 0.002 0.0079 0.0714
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0076 0.0687
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0135 0.1228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0287 0.0527
Echinococcus multilocularis protein jagged 1 0.0015 0.0034 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0162 0.9245
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Schistosoma mansoni laminin gamma-3 chain 0.0015 0.0034 0.0062
Echinococcus granulosus Protein patched homolog 1 0.0051 0.033 0.0606
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0123 0.6763
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7865 1
Echinococcus granulosus peroxidasin 0.0027 0.0135 0.0248
Echinococcus granulosus dna polymerase kappa 0.0019 0.007 0.0128
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0076 0.0678
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Brugia malayi hypothetical protein 0.0012 0.0012 0.0108
Onchocerca volvulus 0.0015 0.0034 0.0296
Schistosoma mansoni hypothetical protein 0.0496 0.3943 0.7246
Loa Loa (eye worm) hypothetical protein 0.0051 0.033 0.2995
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.0306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0709 0.6446
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0042 0.0381
Onchocerca volvulus 0.0015 0.0034 0.0296
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.007 0.0128
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0015 0.0039 0.0355
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0167 0.1514
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.033 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0146 0.11 1
Echinococcus multilocularis slit 2 protein 0.0015 0.0034 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0012 0.0329
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0167 0.1514
Leishmania major DNA polymerase eta, putative 0.0019 0.007 0.3117
Echinococcus granulosus neurogenic locus notch protein 4 0.0015 0.0034 0.0062
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0287 0.0365
Trypanosoma brucei unspecified product 0.0013 0.0022 0.0615
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0176 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.007 0.0089
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.007 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0287 0.0527
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.007 0.0039
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0176 0.5315
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0615
Brugia malayi hypothetical protein 0.003 0.0162 0.1476
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.007 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0076 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0135 0.1228
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Brugia malayi Peroxidasin 0.0027 0.0135 0.1228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Onchocerca volvulus Huntingtin homolog 0.0121 0.0897 0.8145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0012 0.0329
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0135 0.122
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0022 0.1199
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0167 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0076 0.0139
Schistosoma mansoni hypothetical protein 0.0049 0.0315 0.0578
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0076 0.0687
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0034 0.0305
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.5442 0.6919
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0012 0.0619
Brugia malayi Blistered cuticle protein 3 0.0027 0.0135 0.1228
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0167 0.0212
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0022 0.0619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0687
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0042 0.2338
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0167 0.0306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.033 0.2995
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0001 0.0012
Onchocerca volvulus 0.0012 0.0012 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0714
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0001 0.0002
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.035 0.2758 0.275
Schistosoma mansoni egf-like domain protein 0.0015 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Onchocerca volvulus Peroxidase homolog 0.0027 0.0135 0.122
Echinococcus granulosus nibrin 0.0012 0.0012 0.0022
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0022 0.1199
Echinococcus multilocularis protein jagged 2 0.0015 0.0034 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0167 0.1514
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0076 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0687
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0687
Echinococcus multilocularis fibrillin 1 0.0015 0.0039 0.005
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3925 0.4991
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0388 0.0493
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0079 0.4439
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0162 0.9195
Echinococcus multilocularis cpg binding protein 0.0037 0.0213 0.0271
Loa Loa (eye worm) brahma associated protein 0.0011 0.0001 0.001
Schistosoma mansoni heat shock protein 0.0013 0.0022 0.004
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3925 0.7213
Schistosoma mansoni peroxidasin 0.0027 0.0135 0.0248
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.035 0.2758 0.3844
Schistosoma mansoni septate junction protein 0.0015 0.0034 0.0062
Echinococcus granulosus neurogenic locus protein delta 0.0015 0.0034 0.0062
Brugia malayi Protein kinase domain containing protein 0.002 0.0079 0.0714
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0076 0.0096
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.1293
Schistosoma mansoni notch 0.0015 0.0034 0.0062
Brugia malayi Delta serrate ligand family protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0121 0.0897 0.8146
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0034 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Brugia malayi heat shock protein 90 0.0032 0.0176 0.1596
Loa Loa (eye worm) hypothetical protein 0.0119 0.0881 0.8002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0287 0.0527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Schistosoma mansoni hypothetical protein 0.0067 0.0458 0.0842
Echinococcus granulosus geminin 0.0496 0.3943 0.7246
Schistosoma mansoni coup transcription factor 0.002 0.0076 0.0139
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Echinococcus multilocularis heat shock protein 90 0.0026 0.0123 0.0156
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Echinococcus multilocularis neurogenic locus protein delta 0.0015 0.0034 0.0043
Trypanosoma brucei unspecified product 0.0013 0.0022 0.0615
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0012 0.0329
Schistosoma mansoni hypothetical protein 0.0284 0.2223 0.4084
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0042 0.1832
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0148
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Echinococcus granulosus expressed conserved protein 0.0112 0.0822 0.1511
Echinococcus multilocularis endoplasmin 0.0026 0.0123 0.0156
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0458 0.4163
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0176 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0687
Echinococcus granulosus delta-like protein 1 0.0015 0.0034 0.0062
Echinococcus multilocularis expressed conserved protein 0.0112 0.0822 0.1045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0076 0.0096
Onchocerca volvulus 0.002 0.0076 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0687
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.007 0.3544
Onchocerca volvulus 0.0027 0.0135 0.122
Echinococcus multilocularis neurogenic locus notch protein 0.0015 0.0034 0.0043
Echinococcus granulosus laminin 0.0015 0.0039 0.0072
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.0306
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0022 0.0117
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.007 0.0058
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0039 0.0355
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0015 0.0039 0.0072
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0162 0.9245
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.5442 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.3544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0687
Brugia malayi Endoplasmin precursor 0.0032 0.0176 0.1596
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0162 0.1476
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0162 0.9245
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.007 0.0668
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Schistosoma mansoni nuclear hormone receptor 0.002 0.0076 0.0139
Echinococcus granulosus tumor protein p63 0.0408 0.3228 0.5932
Schistosoma mansoni cpg binding protein 0.0035 0.0197 0.0362
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.035 0.2758 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0001 0.0001
Brugia malayi CHE-14 protein 0.0051 0.033 0.2995
Schistosoma mansoni thyroid hormone receptor 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0135 0.122
Echinococcus granulosus heat shock protein 0.0032 0.0176 0.0323
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0022 0.0076
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0449 0.1624
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0002
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0176 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0197 0.1789
Echinococcus granulosus notch 0.0015 0.0034 0.0062
Echinococcus multilocularis protein jagged 1 0.0015 0.0034 0.0043
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.1832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0287 0.2607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0709 0.6446
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0076 0.0139
Schistosoma mansoni slit 0.0015 0.0034 0.0062
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Schistosoma mansoni peroxidasin 0.0027 0.0135 0.0248
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0176 1
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0123 0.0111
Loa Loa (eye worm) hypothetical protein 0.0121 0.0897 0.8146
Giardia lamblia High cysteine protein 0.0015 0.0034 0.1325
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.3544
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0076 0.0096
Echinococcus granulosus fibropellin Ia 0.0015 0.0034 0.0062
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1242 1 1
Echinococcus multilocularis laminin 0.0015 0.0039 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0076 0.0687
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0076 0.0139
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0881 0.1618
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0022 0.0637
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0022 0.0619
Plasmodium vivax endoplasmin, putative 0.0032 0.0176 1
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0076 0.0139
Echinococcus granulosus protein jagged 2 0.0015 0.0034 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0355
Echinococcus granulosus dna polymerase eta 0.0019 0.007 0.0128
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0123 0.0155
Leishmania major hypothetical protein, conserved 0.002 0.0079 0.3681
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0022 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0687
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0042 0.0381
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0022 0.1199
Toxoplasma gondii calcium binding egf domain-containing protein 0.0015 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0687
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0079 0.01
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.3701
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.1514
Echinococcus multilocularis dna polymerase kappa 0.0019 0.007 0.0089
Brugia malayi hypothetical protein 0.0121 0.0897 0.8146
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Brugia malayi notch-like transmembrane receptor 0.0015 0.0034 0.0305
Brugia malayi Cadherin domain containing protein 0.0015 0.0034 0.0305
Echinococcus multilocularis Tolloid protein 1 0.0015 0.0039 0.005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0053
Schistosoma mansoni cell polarity protein 0.0015 0.0034 0.0062
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0135 0.122
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0012 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.3544
Echinococcus multilocularis peroxidasin 0.0027 0.0135 0.0172
Onchocerca volvulus Slit protein homolog 0.0015 0.0034 0.0296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Loa Loa (eye worm) notch protein 0.0015 0.0034 0.0305
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Schistosoma mansoni topbp1 0.0012 0.0012 0.0022
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0003
Schistosoma mansoni thyroid hormone receptor 0.002 0.0076 0.0139
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0871 0.7919
Brugia malayi ecdysteroid receptor 0.002 0.0076 0.0687
Echinococcus multilocularis neurogenic locus notch protein 0.0015 0.0034 0.0043
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Echinococcus granulosus neural cadherin 0.0015 0.0034 0.0062
Echinococcus granulosus FTZ F1 alpha 0.002 0.0076 0.0139
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0108
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1295 0.1646
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.007 0.3544
Echinococcus multilocularis X box binding protein 1 0.0284 0.2223 0.2826
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0635
Leishmania major heat shock protein 83-1 0.0032 0.0176 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0076 0.0096
Onchocerca volvulus 0.0015 0.0034 0.0296
Brugia malayi CXXC zinc finger family protein 0.0035 0.0197 0.1789
Toxoplasma gondii kringle domain-containing protein 0.002 0.0079 0.0281
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0135 0.122
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Trypanosoma brucei heat shock protein, putative 0.0032 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.3544
Echinococcus granulosus neurogenic locus notch protein 0.0015 0.0034 0.0062
Brugia malayi isocitrate dehydrogenase 0.0016 0.0042 0.0381
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0022 0.0076
Brugia malayi Hsp90 protein 0.0013 0.0022 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.007 0.0635
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0098 0.0709 0.6446
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1228
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0076 0.0139
Echinococcus multilocularis protein patched 0.0051 0.033 0.0419
Brugia malayi DKFZp564C0469 protein 0.0012 0.0012 0.0108
Trypanosoma brucei unspecified product 0.0019 0.007 0.3544
Brugia malayi EGF-like domain containing protein 0.0015 0.0034 0.0305
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0012 0.0000031374
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0012 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0415 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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