Detailed information for compound 1359582

Basic information

Technical information
  • TDR Targets ID: 1359582
  • Name: N-(4-methoxy-2-nitrophenyl)-2-(3-methylpiperi din-1-yl)acetamide
  • MW: 307.345 | Formula: C15H21N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)[N+](=O)[O-])NC(=O)CN1CCCC(C1)C
  • InChi: 1S/C15H21N3O4/c1-11-4-3-7-17(9-11)10-15(19)16-13-6-5-12(22-2)8-14(13)18(20)21/h5-6,8,11H,3-4,7,9-10H2,1-2H3,(H,16,19)
  • InChiKey: QHHJZFSEIQVRSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxy-2-nitro-phenyl)-2-(3-methyl-1-piperidyl)acetamide
  • N-(4-methoxy-2-nitrophenyl)-2-(3-methyl-1-piperidinyl)acetamide
  • N-(4-methoxy-2-nitro-phenyl)-2-(3-methylpiperidin-1-yl)ethanamide
  • SMR000176727
  • BAS 01248743
  • N-(4-Methoxy-2-nitro-phenyl)-2-(3-methyl-piperidin-1-yl)-acetamide
  • MLS000555371

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0959 1 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0576 0.5959 0.5906
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0525 0.0524
Brugia malayi Muscleblind-like protein 0.018 0.1792 0.1792
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0211 0.014
Onchocerca volvulus 0.0959 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0497 0.063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0026
Echinococcus granulosus lamin dm0 0.0028 0.0184 0.0307
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0576 0.5959 0.5959
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0277 0.041
Loa Loa (eye worm) hypothetical protein 0.018 0.1792 0.1791
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0211 0.014
Schistosoma mansoni cpg binding protein 0.003 0.0203 0.0285
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0576 0.5959 0.5959
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0576 0.5959 0.5906
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0576 0.5959 1
Brugia malayi Pre-SET motif family protein 0.0252 0.2547 0.2547
Echinococcus multilocularis GPCR, family 2 0.0019 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.018 0.1792 0.1791
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0026
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0959 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0184 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0091 0.009
Brugia malayi CXXC zinc finger family protein 0.003 0.0203 0.0203
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0576 0.5959 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0959 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0256 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0277 0.041
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0324 0.0324
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0277 0.0463
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2913 0.282
Schistosoma mansoni lamin 0.0028 0.0184 0.0253
Onchocerca volvulus 0.0287 0.2913 0.278
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0277 0.0463
Echinococcus granulosus cpg binding protein 0.0031 0.0221 0.0369
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0211 0.014
Echinococcus granulosus intermediate filament protein 0.0028 0.0184 0.0307
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0211 0.014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2547 0.2546
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0959 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0959 1 1
Echinococcus granulosus muscleblind protein 0.018 0.1792 0.3006
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0576 0.5959 1
Schistosoma mansoni hypothetical protein 0.0019 0.0091 0.0096
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0959 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0184 0.0184
Echinococcus multilocularis lamin dm0 0.0028 0.0184 0.0307
Echinococcus multilocularis cpg binding protein 0.0031 0.0221 0.0369
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0031
Echinococcus multilocularis musashi 0.0028 0.0184 0.0307
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0091 0.0151
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0211 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0277 0.0463
Schistosoma mansoni ap endonuclease 0.0023 0.013 0.0161
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Loa Loa (eye worm) hypothetical protein 0.0028 0.0184 0.0183
Schistosoma mansoni cpg binding protein 0.0031 0.0221 0.0315
Schistosoma mansoni hypothetical protein 0.0019 0.0091 0.0096
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.4348 0.7295
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0525 0.0525
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0568 0.0901
Schistosoma mansoni lamin 0.0028 0.0184 0.0253
Brugia malayi hypothetical protein 0.003 0.0211 0.0211
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0959 1 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0576 0.5959 1
Schistosoma mansoni cpg binding protein 0.0031 0.0221 0.0315
Schistosoma mansoni intermediate filament proteins 0.0028 0.0184 0.0253
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0576 0.5959 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0576 0.5959 0.5906
Loa Loa (eye worm) hypothetical protein 0.006 0.0525 0.0524
Echinococcus multilocularis muscleblind protein 0.018 0.1792 0.3006
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0211 0.014
Brugia malayi Pre-SET motif family protein 0.0037 0.0277 0.0277
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0959 1 1
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0576 0.5959 0.5959
Onchocerca volvulus 0.003 0.0203 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.013 0.0216
Echinococcus granulosus lamin 0.0028 0.0184 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0563 0.5829 0.9777
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0211 0.014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.013 0.0216
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0959 1 1
Mycobacterium tuberculosis Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) 0.0318 0.3247 0.3159
Schistosoma mansoni hypothetical protein 0.0019 0.0091 0.0096
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0576 0.5959 0.5959
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0959 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0091 0.0151
Echinococcus granulosus GPCR family 2 0.0019 0.0091 0.0151
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0091 0.0091
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0576 0.5959 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.003 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0276
Schistosoma mansoni hypothetical protein 0.0041 0.0324 0.0489
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0091 0.0091
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0576 0.5959 1
Echinococcus granulosus dnaJ subfamily B 0.0423 0.4348 0.7295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.009
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0959 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0277 0.041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0277 0.041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0525 0.0525
Brugia malayi intermediate filament protein 0.0028 0.0184 0.0184
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0184 0.0183
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0576 0.5959 1
Echinococcus multilocularis lamin 0.0028 0.0184 0.0307
Leishmania major hypothetical protein, conserved 0.003 0.0211 0.014
Plasmodium vivax SET domain protein, putative 0.0037 0.0277 0.0253
Trypanosoma brucei hypothetical protein, conserved 0.0563 0.5829 0.9777
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.013 0.0129
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.013 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.013 0.0161
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0277 0.0253
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0323
Onchocerca volvulus 0.0037 0.0277 0.0095
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0034 0.0056
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0034 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0032 0.0052
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0576 0.5959 1
Schistosoma mansoni hypothetical protein 0.0423 0.4348 0.728
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0048 0.0047
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.013 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0091 0.0151
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.013 0.013
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0032 0.0052
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0019 0.0091 0.0096
Echinococcus multilocularis muscleblind protein 1 0.018 0.1792 0.3006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.0178
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0563 0.5829 0.9777
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0576 0.5959 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0091 0.0151
Brugia malayi hypothetical protein 0.002 0.0098 0.0098
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0959 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0028 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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