Detailed information for compound 1359600

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.645 | Formula: C27H34F2N4O4S
  • H donors: 1 H acceptors: 3 LogP: 4.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN1CCN(CC1)c1ccc(cc1NC(=O)/C=C/c1ccc(cc1)OC(F)F)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C27H34F2N4O4S/c1-2-31-16-18-32(19-17-31)25-12-11-23(38(35,36)33-14-4-3-5-15-33)20-24(25)30-26(34)13-8-21-6-9-22(10-7-21)37-27(28)29/h6-13,20,27H,2-5,14-19H2,1H3,(H,30,34)/b13-8+
  • InChiKey: LBBMXZNBFBXUDL-MDWZMJQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens APOBEC3A and APOBEC3B deletion hybrid Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.082 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.0021
Brugia malayi CHE-14 protein 0.1034 0.3061 0.4086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0041 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0053 0.0071
Entamoeba histolytica hypothetical protein 0.0074 0.0183 1
Schistosoma mansoni cpg binding protein 0.0029 0.0049 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0091 0.0121
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.012 0.0116
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0027 0.0041 0.2243
Loa Loa (eye worm) hypothetical protein 0.006 0.014 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0018 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0018 0.0013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0142 0.0183
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.007 0.132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0053 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0295 0.0844 0.1127
Brugia malayi conserved hypotetical protein 0.0015 0.0004 0.0006
Brugia malayi steroid hormone receptor 0.0031 0.0053 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0053 0.0071
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0004 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0091 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0287 0.082 0.2348
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0019 0.0025
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.251 0.7491 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0019 0.0306
Trypanosoma brucei unspecified product 0.0014 0.0001 0.0002
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.251 0.7491 0.749
Brugia malayi isocitrate dehydrogenase 0.0019 0.0018 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0044 0.0059
Echinococcus granulosus intermediate filament protein 0.0027 0.0042 0.0051
Schistosoma mansoni hypothetical protein 0.1033 0.3059 0.4081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0067 0.0191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0019 0.0025
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0295 0.0844 0.1127
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0053 0.012 0.0161
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus granulosus lamin dm0 0.0027 0.0042 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0142 0.0184
Brugia malayi beta-lactamase family protein 0.0043 0.0091 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0019 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0142 0.0164
Echinococcus granulosus tumor protein p63 0.0408 0.1184 0.1576
Mycobacterium ulcerans lipase LipD 0.0043 0.0091 0.0095
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.02 0.0196
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0053 0.0066
Echinococcus multilocularis neuropeptide s receptor 0.0973 0.2879 0.2876
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0053 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0411 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0019 0.0025
Mycobacterium ulcerans beta-lactamase 0.0043 0.0091 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0091 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0054
Echinococcus multilocularis GPCR, family 2 0.0048 0.0103 0.0099
Schistosoma mansoni hypothetical protein 0.1033 0.3059 0.4081
Brugia malayi nuclear receptor NHR-67 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0053 0.0049
Brugia malayi intermediate filament protein 0.0027 0.0042 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0053 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0091 0.079
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.5
Schistosoma mansoni hypothetical protein 0.0048 0.0103 0.0133
Brugia malayi Muscleblind-like protein 0.0179 0.0497 0.0663
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0269 0.0359
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0053 0.0071
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0019 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0067 0.0191
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0183 0.0239
Brugia malayi beta-lactamase 0.0043 0.0091 0.0121
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0623 0.1828 0.2441
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0223 0.0298
Echinococcus granulosus neuropeptide receptor A26 0.0973 0.2879 0.384
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.028 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0091 0.026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0053 0.0067
Plasmodium vivax ataxin-2 like protein, putative 0.0183 0.0509 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.007 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0053 0.0067
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0067 0.0083
Brugia malayi nuclear hormone receptor 0.0031 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Echinococcus granulosus geminin 0.1033 0.3059 0.408
Schistosoma mansoni hypothetical protein 0.0082 0.0207 0.0271
Toxoplasma gondii hypothetical protein 0.01 0.0262 0.5103
Schistosoma mansoni nuclear receptor 0.0015 0.0004 0.0001
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0117 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0142 0.0184
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.012 0.0161
Leishmania major DNA polymerase kappa, putative 0.002 0.002 0.0026
Echinococcus multilocularis dna polymerase kappa 0.002 0.002 0.0015
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.012 0.0155
Brugia malayi glutaminase DH11.1 0.0276 0.0789 0.1053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0053 0.0067
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.02 0.3885
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0019 0.0025
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0117 0.1078
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0019 0.0025
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0018 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0142 0.0164
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0053 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.001 0.0008
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0067 0.0063
Schistosoma mansoni hypothetical protein 0.0285 0.0814 0.1082
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.001 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.0021
Onchocerca volvulus 0.0015 0.0004 0.0041
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.003 0.004
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0041 0.0037
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0019 0.0026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.002 0.0056
Schistosoma mansoni nuclear receptor 0.0015 0.0004 0.0001
Echinococcus multilocularis protein dispatched 1 0.1034 0.3061 0.3058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0103 0.0099
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0101 0.0129
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0067 0.0191
Schistosoma mansoni alpha-glucosidase 0.0138 0.0373 0.0494
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0019 0.0025
Brugia malayi Probable ClpP-like protease 0.008 0.02 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.002 0.0026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0091 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Schistosoma mansoni cpg binding protein 0.0029 0.0049 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.1034 0.3061 0.3058
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0019 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0053 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.082 0.109
Mycobacterium tuberculosis Conserved protein 0.0043 0.0091 0.079
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0004 0.0006
Onchocerca volvulus 0.0027 0.0042 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0117 0.0151
Loa Loa (eye worm) hypothetical protein 0.008 0.02 0.0267
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0101 0.0129
Echinococcus granulosus dna polymerase kappa 0.002 0.002 0.002
Onchocerca volvulus 0.0043 0.0091 0.086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0053 0.0071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0053 0.0066
Brugia malayi CXXC zinc finger family protein 0.0028 0.0044 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0091 0.079
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1034 0.3061 0.4086
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0183 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0053 0.0071
Brugia malayi mbt repeat family protein 0.0047 0.0101 0.0135
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0019 0.0021
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0019 0.0025
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0067 0.0191
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0004 0.0041
Schistosoma mansoni alpha-glucosidase 0.0138 0.0373 0.0494
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1178 0.3493 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.02 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0623 0.1828 0.2441
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0019 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0053 0.0049
Brugia malayi ecdysone receptor 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.044 0.0436
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.0514 0.0681
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.1152 0.1148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0091 0.079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0091 0.026
Brugia malayi Pre-SET motif family protein 0.0037 0.007 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.007 0.0089
Loa Loa (eye worm) hypothetical protein 0.0365 0.1055 0.1408
Echinococcus granulosus muscleblind protein 0.0179 0.0497 0.0658
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0053 0.0067
Loa Loa (eye worm) hypothetical protein 0.251 0.7491 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0183 0.0239
Brugia malayi hypothetical protein 0.0074 0.0183 0.0244
Brugia malayi nuclear receptor NHR-88 0.0031 0.0053 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0053 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0053 0.0049
Loa Loa (eye worm) MBCTL1 0.0053 0.012 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.0242
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0004 0.0041
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0043 0.0516
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0053 0.0507
Loa Loa (eye worm) hypothetical protein 0.015 0.0411 0.0549
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0053 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0019 0.0025
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.001 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.002 0.1067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.082 0.109
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0019 0.0025
Echinococcus multilocularis sterol regulatory element binding protein 0.1034 0.3061 0.3058
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0103 0.0132
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0019 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0393 0.0524
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0053 0.0071
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0074 0.0183 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0053 0.0067
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.001 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0091 0.0121
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0004 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.082 0.0816
Schistosoma mansoni coup transcription factor 0.0031 0.0053 0.0067
Onchocerca volvulus 0.006 0.014 0.1322
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0103 0.0138
Echinococcus granulosus GPCR family 2 0.0048 0.0103 0.0132
Echinococcus granulosus neuropeptide s receptor 0.0973 0.2879 0.384
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.251 0.7491 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0164 0.0219
Schistosoma mansoni hypothetical protein 0.0048 0.0103 0.0133
Echinococcus granulosus dnaJ subfamily B 0.0397 0.1152 0.1533
Echinococcus granulosus dna polymerase eta 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0004 0.0006
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0041 0.074
Trichomonas vaginalis esterase, putative 0.0043 0.0091 0.026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.082 0.1094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.007 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Loa Loa (eye worm) DR-78 0.0015 0.0004 0.0006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0082 0.0207 0.027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0004 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.001 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0067 0.3653
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0004 0.0006
Schistosoma mansoni alpha glucosidase 0.0035 0.0067 0.0084
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.082 0.1094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0053 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0067 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0053 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0411 0.0549
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0091 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0067 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0053 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0053 0.0049
Brugia malayi nuclear receptor NHR-88 0.0015 0.0004 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0053 0.0066
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0043 0.0516
Leishmania major hypothetical protein, conserved 0.0043 0.0091 0.0121
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.02 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.02 0.3885
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0019 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0053 0.0071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0164 0.0214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.007 0.0088
Brugia malayi hypothetical protein 0.0016 0.001 0.0013
Mycobacterium ulcerans hypothetical protein 0.0328 0.0944 0.1238
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0091 0.079
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0026
Schistosoma mansoni hypothetical protein 0.0103 0.0269 0.0354
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0223 0.0298
Mycobacterium tuberculosis Conserved protein 0.0043 0.0091 0.079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.007 0.0089
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.251 0.7491 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0101 0.0097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0328 0.0944 1
Entamoeba histolytica hypothetical protein 0.0074 0.0183 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.014 0.0182
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0067 0.125
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.002 0.0056
Echinococcus granulosus cpg binding protein 0.0029 0.0049 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0411 0.0549
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0026
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1034 0.3061 0.4083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.02 0.3711
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0101 0.0955
Echinococcus multilocularis muscleblind protein 1 0.0179 0.0497 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0026
Plasmodium vivax SET domain protein, putative 0.0037 0.007 0.1073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0053 0.0066
Loa Loa (eye worm) hypothetical protein 0.1034 0.3061 0.4086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0091 0.079
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0004 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0091 0.0116
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0266 0.0349
Onchocerca volvulus 0.0365 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0183 0.0509 0.068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0053 0.0067
Brugia malayi tailless protein 0.0015 0.0004 0.0006
Brugia malayi Melibiase family protein 0.0068 0.0164 0.0219
Brugia malayi nuclear hormone receptor 0.0015 0.0004 0.0006
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0041 0.0055
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0101 0.0135
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0117 0.1078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.001 0.0008
Brugia malayi follicle stimulating hormone receptor 0.0247 0.0701 0.0935
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0018 0.0023
Mycobacterium leprae Probable lipase LipE 0.0043 0.0091 0.3045
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.0509 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.044 0.0436
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0091 0.0121
Echinococcus multilocularis cpg binding protein 0.0029 0.0049 0.0045
Schistosoma mansoni hypothetical protein 0.0397 0.1152 0.1534
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0794 0.8375
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0026
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0101 0.013
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0091 0.026
Echinococcus multilocularis muscleblind protein 0.0179 0.0497 0.0493
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0053 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0223 0.0298
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0042 0.0056
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0053 0.0507
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0018 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0091 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0013
Onchocerca volvulus 0.0028 0.0044 0.0417
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.0514 0.051
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0067 0.0191
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0053 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.082 0.1089
Giardia lamblia DINP protein human, muc B family 0.002 0.002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0067 0.0089
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.044 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Onchocerca volvulus 0.0043 0.0091 0.086
Schistosoma mansoni hypothetical protein 0.0074 0.0183 0.0239
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.0509 0.068
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0103 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0164 0.047
Trichomonas vaginalis conserved hypothetical protein 0.1034 0.3061 0.8762
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0026
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0142 0.2731
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.0701 0.0935
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.3493 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0026
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.3493 1
Schistosoma mansoni hypothetical protein 0.0048 0.0103 0.0133
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.251 0.7491 1
Brugia malayi Pre-SET motif family protein 0.0252 0.0716 0.0956
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0103 0.0099
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0295 0.0844 0.1127
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.044 0.0582
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0019 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0142 0.0185
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0019 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0004 0.0006
Onchocerca volvulus 0.0043 0.0091 0.086
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0021
Trypanosoma brucei unspecified product 0.0014 0.0001 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0082 0.0207 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.082 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.007 0.0089
Toxoplasma gondii LsmAD domain-containing protein 0.0183 0.0509 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.0509 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.012 0.0156
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0067 0.0089
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0018 0.0277
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0042 0.0056
Schistosoma mansoni intermediate filament proteins 0.0027 0.0042 0.0052
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.044 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0142 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0053 0.0071
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0019 0.1043
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.251 0.7491 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0142 0.0189
Mycobacterium ulcerans hypothetical protein 0.0043 0.0091 0.0095
Onchocerca volvulus 0.0037 0.007 0.0666
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.012 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus granulosus sterol regulatory element binding protein 0.1034 0.3061 0.4082
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0091 0.3045
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0041 0.005
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0266 0.0262
Brugia malayi hypothetical protein 0.0016 0.001 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0973 0.2879 0.2876
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0123 0.2359
Loa Loa (eye worm) hypothetical protein 0.0103 0.0269 0.0359
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0004 0.0006
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0019 0.0015
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.02 0.3711
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0053 0.0066
Echinococcus multilocularis lamin 0.0027 0.0042 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0716 0.0956
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0266 0.035
Brugia malayi hypothetical protein 0.0118 0.0315 0.042
Echinococcus multilocularis geminin 0.1033 0.3059 0.3056
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0067 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0091 0.026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0117 0.4744
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0067 0.0191
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.02 0.0261
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0067 0.0191
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0053 0.0507
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0091 0.026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0266 0.035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0103 0.0132
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.251 0.7491 1
Onchocerca volvulus 0.0027 0.0042 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0091 0.1489
Onchocerca volvulus 0.0031 0.0053 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0053 0.0071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.002 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0018 0.0277
Schistosoma mansoni lamin 0.0027 0.0042 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0018 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0019 0.0025
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.251 0.7491 1
Brugia malayi mbt repeat family protein 0.0047 0.0101 0.0135
Loa Loa (eye worm) hypothetical protein 0.0179 0.0497 0.0663
Trypanosoma brucei unspecified product 0.002 0.002 0.0026
Brugia malayi hypothetical protein 0.0365 0.1055 0.1408
Loa Loa (eye worm) glutaminase 2 0.0276 0.0789 0.1053
Schistosoma mansoni cpg binding protein 0.0028 0.0044 0.0054
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0004 0.0006
Schistosoma mansoni patched 1 0.1034 0.3061 0.4083
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0053 0.0067
Brugia malayi ecdysteroid receptor 0.0031 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.0183 0.0509 0.068
Brugia malayi hypothetical protein 0.0015 0.0004 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0053 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0018 0.0013
Echinococcus multilocularis musashi 0.0027 0.0042 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0091 0.079
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0018 0.0023
Schistosoma mansoni lamin 0.0027 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Echinococcus multilocularis protein patched 0.1034 0.3061 0.3058
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0266 0.0262
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0018 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0103 0.0138
Mycobacterium ulcerans glutaminase 0.0276 0.0789 0.1029
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.002 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0067 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Loa Loa (eye worm) glutaminase 0.0276 0.0789 0.1053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0053 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0042 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0041 0.0055
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.251 0.7491 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.001 0.0013
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0101 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0026
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0019 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0067 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0103 0.0138
Trypanosoma brucei glucosidase, putative 0.0035 0.0067 0.0089
Onchocerca volvulus 0.0092 0.0238 0.2254
Onchocerca volvulus 0.0047 0.0101 0.0955
Brugia malayi hypothetical protein 0.0015 0.0004 0.0006
Brugia malayi MH2 domain containing protein 0.0144 0.0393 0.0524
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0004 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0091 0.0121
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0266 0.5186
Leishmania major DNA polymerase eta, putative 0.002 0.002 0.0026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0067 0.3653
Leishmania major hypothetical protein, conserved 0.0183 0.0509 0.068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0018 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0223 0.0298
Brugia malayi hypothetical protein 0.0183 0.0509 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0065 0.008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0019 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.082 0.109
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0142 0.0137
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0053 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0053 0.0071
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0041 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.0509 0.068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Loa Loa (eye worm) beta-lactamase 0.0043 0.0091 0.0121
Brugia malayi beta-lactamase family protein 0.0043 0.0091 0.0121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0006
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0053 0.0067
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0013
Echinococcus granulosus Niemann Pick C1 protein 0.1034 0.3061 0.4082
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.3493 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0101 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0053 0.0071
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0019 0.0025
Echinococcus multilocularis dna polymerase eta 0.002 0.002 0.0015
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.02 0.0262
Onchocerca volvulus 0.0015 0.0004 0.0041
Echinococcus granulosus lamin 0.0027 0.0042 0.0051
Echinococcus multilocularis tumor protein p63 0.0408 0.1184 0.1181
Echinococcus granulosus Protein patched homolog 1 0.1034 0.3061 0.4082
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0142 0.1339
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0019 0.1043
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0393 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0164 0.0214
Toxoplasma gondii ABC1 family protein 0.0043 0.0091 0.1724
Trichomonas vaginalis glutaminase, putative 0.0276 0.0789 0.2258
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0053 0.0066
Schistosoma mansoni glutaminase 0.0276 0.0789 0.1049
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0179 0.0497 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0053 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0053 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0018 0.0019
Schistosoma mansoni hypothetical protein 0.0048 0.0103 0.0133
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0266 0.035
Entamoeba histolytica hypothetical protein 0.0074 0.0183 1
Toxoplasma gondii hypothetical protein 0.0028 0.0043 0.0778
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0121
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.002 0.0026
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0101 0.013
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0004 0.0001
Brugia malayi nuclear receptor RXR 0.0016 0.001 0.0013
Onchocerca volvulus 0.0287 0.082 0.7774
Mycobacterium tuberculosis Conserved protein 0.0043 0.0091 0.079
Brugia malayi nuclear receptor RXR 0.0015 0.0004 0.0006
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.012 0.0155
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0623 0.1828 0.2441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0053 0.0071
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0019 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0004 0.0001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0266 0.035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0053 0.0071
Echinococcus multilocularis lamin dm0 0.0027 0.0042 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0053 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0053 0.0071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0053 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0019 0.0055
Leishmania major mitochondrial DNA polymerase beta 0.0623 0.1828 0.2441

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.28 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) = 7.32 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.