Detailed information for compound 1359739

Basic information

Technical information
  • TDR Targets ID: 1359739
  • Name: [2-oxo-2-(2-phenylethylamino)ethyl] 3-(4-chlo rophenyl)sulfonylpropanoate
  • MW: 409.884 | Formula: C19H20ClNO5S
  • H donors: 1 H acceptors: 4 LogP: 2.91 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)CCS(=O)(=O)c1ccc(cc1)Cl)NCCc1ccccc1
  • InChi: 1S/C19H20ClNO5S/c20-16-6-8-17(9-7-16)27(24,25)13-11-19(23)26-14-18(22)21-12-10-15-4-2-1-3-5-15/h1-9H,10-14H2,(H,21,22)
  • InChiKey: FMGFHCCXNIHBRH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-chlorophenyl)sulfonylpropanoic acid [2-oxo-2-(2-phenylethylamino)ethyl] ester
  • 3-(4-chlorophenyl)sulfonylpropionic acid [2-keto-2-(2-phenylethylamino)ethyl] ester
  • T0515-0479
  • MLS000392194
  • SMR000261127

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclin dependent kinase 0.0304 0.3038 0.3038
Onchocerca volvulus 0.0023 0.0141 0.0984
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0071 0.0499
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0141 0.0075
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0141 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0141 0.0087
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.0656 0.0656
Echinococcus granulosus tyrosine protein kinase HCK 0.0059 0.0508 0.1671
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.0656 0.0656
Entamoeba histolytica protein kinase, putative 0.0059 0.0508 0.1671
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0064 0.0562 0.0562
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0301 0.3005 0.989
Echinococcus granulosus cyclin dependent kinase 5 0.0304 0.3038 1
Plasmodium vivax protein kinase Crk2 0.0304 0.3038 1
Schistosoma mansoni nck2/grb4 0.0014 0.0052 0.0172
Entamoeba histolytica cell division protein kinase 2, putative 0.0304 0.3038 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.165 0.543
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0141 0.0234
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0029
Trypanosoma cruzi cdc2-related kinase 3 0.0304 0.3038 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0463
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0029 0.0097
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0011 0.0012 0.0041
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0656 0.216
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0052 0.0172
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0029 0.0029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0656 0.216
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.3038 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0081 0.0266
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0029 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.0952
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0354 0.1164
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0656 0.0656
Echinococcus granulosus NCK adaptor protein 0.0014 0.0052 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0029 0.0097
Echinococcus granulosus cyclin dependent kinase 1 0.0304 0.3038 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0029 0.0206
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1932 0.636
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0354 0.1164
Echinococcus granulosus tyrosine kinase 0.0066 0.0583 0.1919
Trichomonas vaginalis CMGC family protein kinase 0.0304 0.3038 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0029
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0073 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Schistosoma mansoni tyrosine kinase 0.0073 0.0656 0.216
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0656 0.216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0172
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0304 0.3038 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0029 0.0097
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0141 0.0075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0097
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0052 0.0172
Echinococcus multilocularis tyrosine protein kinase Srms 0.0066 0.0583 0.0583
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0029 0.0097
Plasmodium falciparum protein kinase 5 0.0304 0.3038 1
Giardia lamblia Kinase, CMGC CDK 0.0304 0.3038 0.5
Echinococcus multilocularis cyclin dependent kinase 1 0.0304 0.3038 0.3038
Schistosoma mansoni adapter molecule crk 0.0014 0.0052 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0029 0.0097
Trypanosoma brucei cdc2-related kinase 1 0.0304 0.3038 1
Trypanosoma cruzi cdc2-related kinase 1 0.0304 0.3038 1
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0052 0.0172
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0073 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0029 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0029 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0029 0.0029
Trypanosoma brucei glucosidase, putative 0.0044 0.0354 0.0952
Mycobacterium ulcerans hypothetical protein 0.0023 0.0141 0.0075
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0354 0.0952
Onchocerca volvulus 0.001 0.001 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0097
Entamoeba histolytica cell division protein kinase 2, putative 0.0304 0.3038 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0029 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0141 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0141 0.0463
Trypanosoma cruzi cdc2-related kinase 1 0.0304 0.3038 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.0052 0.0172
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0081 0.5
Onchocerca volvulus 0.0012 0.0029 0.0206
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1932 0.1932
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0097
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0304 0.3038 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1932 0.636
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0141 0.0075
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0793 0.8076 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0141 0.0463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0029 0.0097
Schistosoma mansoni tyrosine kinase 0.0016 0.0073 0.0242
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0141 0.0463
Brugia malayi hypothetical protein 0.0148 0.1429 0.4704
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0029 0.0206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0081 0.0266
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0141 0.0463
Echinococcus multilocularis cyclin dependent kinase 1 0.0304 0.3038 0.3038
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0029 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0141 0.0234
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0354 0.0952
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0029 0.0097
Brugia malayi ecdysteroid receptor 0.0012 0.0029 0.0097
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0304 0.3038 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Blk 0.0066 0.0583 0.1919
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0097
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0354 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0097
Schistosoma mansoni tyrosine kinase 0.0073 0.0656 0.216
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0656 0.0656
Echinococcus multilocularis tyrosine protein kinase Blk 0.0066 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0017 0.0081 0.0266
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0081 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0081 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0029 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0141 0.0087
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0073 0.0242
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0141 0.0463
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0148 0.1429 0.4704
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0141 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.0052 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0029 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0097
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0656 0.0656
Echinococcus multilocularis cyclin dependent kinase 5 0.0304 0.3038 0.3038
Brugia malayi nuclear receptor NHR-88 0.0012 0.0029 0.0097
Trypanosoma brucei cdc2-related kinase 3 0.0304 0.3038 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0029 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0066 0.0583 0.1919
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0304 0.3038 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1932 0.1932
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.0656 0.0656
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.0656 0.216
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Brugia malayi Protein kinase domain containing protein 0.0304 0.3038 1
Schistosoma mansoni coup transcription factor 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0081 0.0266
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0052 0.0172
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0304 0.3038 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0141 0.0075
Loa Loa (eye worm) TK protein kinase 0.0059 0.0508 0.1671
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0463
Onchocerca volvulus 0.0114 0.1077 0.7536
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0354 0.1164
Schistosoma mansoni tyrosine kinase 0.0016 0.0073 0.0242
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.0052 0.0172
Mycobacterium ulcerans haloalkane dehalogenase 0.0793 0.8076 1
Loa Loa (eye worm) SRC-1 0.0073 0.0656 0.216
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0029 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0097
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0304 0.3038 1
Trichomonas vaginalis CMGC family protein kinase 0.0304 0.3038 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0656 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0354 0.0952
Echinococcus granulosus tyrosine protein kinase Src42A 0.0064 0.0562 0.1849
Entamoeba histolytica protein kinase, putative 0.0011 0.0012 0.0041
Echinococcus granulosus cyclin dependent kinase 0.0304 0.3038 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0029 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0029 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.3038 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0354 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0029 0.0097
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.0073 0.0073
Onchocerca volvulus Huntingtin homolog 0.0148 0.1429 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0656 0.216
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0071 0.0235
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0029 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0073 0.0073
Brugia malayi SRC-1 0.0073 0.0656 0.216
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.0952
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0029 0.0097
Brugia malayi Sex muscle abnormal protein 5 0.0014 0.0052 0.0172
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0141 0.0234
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0071 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0235
Brugia malayi protein-tyrosine kinase 0.0066 0.0583 0.1919
Brugia malayi nuclear hormone receptor 0.0012 0.0029 0.0097
Schistosoma mansoni alpha glucosidase 0.0044 0.0354 0.1164
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0141 0.0075
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0029 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0029 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.0952
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.0656 0.0656
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.0656 0.0656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0029 0.0097
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.0052 0.0172
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0354 0.1164
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.0952
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0354 0.0952
Trypanosoma cruzi cdc2-related kinase 3 0.0304 0.3038 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0029 0.0097
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.0073 0.0242
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0141 0.0075
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1932 0.636
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.0583 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0029 0.0097
Brugia malayi cell division control protein 2 homolog 0.0304 0.3038 1
Giardia lamblia Kinase, CMGC CDK 0.0304 0.3038 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.1429 0.4704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0097
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0354 0.0952
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0354 0.0952
Schistosoma mansoni alpha-glucosidase 0.0169 0.165 0.543
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.0656 0.216
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0354 0.0952
Echinococcus multilocularis tyrosine protein kinase HCK 0.0059 0.0508 0.0508
Loa Loa (eye worm) TK protein kinase 0.0066 0.0583 0.1919
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.0656 0.216
Onchocerca volvulus Huntingtin homolog 0.0148 0.1429 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0073 0.0242
Brugia malayi steroid hormone receptor 0.0012 0.0029 0.0097
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0029 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0029 0.0097
Echinococcus granulosus tyrosine protein kinase Lyn 0.0076 0.069 0.2271
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0354 0.0952
Trichomonas vaginalis CMGC family protein kinase 0.0304 0.3038 1
Echinococcus multilocularis NCK adaptor protein 0.0014 0.0052 0.0052
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0052 0.0172
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0141 0.0075
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0304 0.3038 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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