Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.0074 | 0.0074 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.0421 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.1394 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0421 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0074 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.0074 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0421 | 0.0421 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0421 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0421 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.0074 | 0.1749 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1394 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0421 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0074 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.1394 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1000 uM | Compound was tested for inhibition of MAdCAM-1/alpha4 beta7 mediated cell adhesion to T-cell lymphoma, HUT78 cells | ChEMBL. | No reference |
Inhibition (functional) | > 1000 % | Inhibition of MAdCAM-1/alpha4 beta7-mediated cell adhesion to T-cell lymphoma, HUT78 cells at 500 microM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.