TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 406.517 | Formula: C25H30N2O3
H donors: 0 H acceptors: 2 LogP: 5.26 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN(C(=O)c1ccccc1OCc1c(C)noc1C)Cc1ccc(cc1)C(C)(C)C
InChi: 1S/C25H30N2O3/c1-17-22(18(2)30-26-17)16-29-23-10-8-7-9-21(23)24(28)27(6)15-19-11-13-20(14-12-19)25(3,4)5/h7-14H,15-16H2,1-6H3
InChiKey: CXFPQUGESVRLIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	snurportin 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0804	0.0997	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.3735	0.5275	0.7537
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1561	0.2103	0.2924
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0804	0.0997	0.0915
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.2722	0.3797	0.374
Onchocerca volvulus		0.0183	0.0091	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0804	0.0997	0.0915
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0804	0.0997	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1561	0.2103	0.2113
Onchocerca volvulus		0.0183	0.0091	0.5
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0091	0.0091
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0804	0.0997	0.1318
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0372	0.0367	0.0278
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.6972	1	1
Echinococcus granulosus	snurportin 1	0.0372	0.0367	0.0278
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0804	0.0997	0.1318
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.2722	0.3797	0.374
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.6938	0.9951	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Echinococcus multilocularis	tumor protein p63	0.0408	0.042	0.0332
Loa Loa (eye worm)	hypothetical protein	0.6938	0.9951	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.4896	0.697	0.7005
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.4713	0.6703	0.9612
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.0367	0.0369
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0804	0.0997	0.0915
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1561	0.2103	0.5419
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.1561	0.2103	0.2924
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0804	0.0997	1
Mycobacterium leprae	conserved hypothetical protein	0.0183	0.0091	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1378	0.1836	0.2537
Echinococcus granulosus	tumor protein p63	0.0408	0.042	0.0332
Leishmania major	malonyl-coa decarboxylase-like protein	0.2726	0.3803	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.1378	0.1836	0.1845
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.1561	0.2103	0.2924
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0804	0.0997	0.1318
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.4896	0.697	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.2726	0.3803	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0183	0.0091	0.0091
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.4896	0.697	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1561	0.2103	0.2924
Entamoeba histolytica	hypothetical protein	0.4139	0.5865	0.8393
Brugia malayi	putative malonyl-CoA decarboxylase	0.6938	0.9951	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0804	0.0997	0.0915
Loa Loa (eye worm)	phosphatidylinositol 3	0.6214	0.8895	0.8939
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0035	0.0035
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2722	0.3797	0.3816
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.4896	0.697	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0804	0.0997	0.1318
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.4896	0.697	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0804	0.0997	0.0915
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0035	0.0035
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0804	0.0997	0.0915
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1561	0.2103	0.2924
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.2726	0.3803	0.5396
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.4896	0.697	1
Loa Loa (eye worm)	hypothetical protein	0.2174	0.2997	0.3012
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0804	0.0997	0.2442
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0804	0.0997	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.4139	0.5865	0.8393
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.1561	0.2103	0.203
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.4896	0.697	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0804	0.0997	0.1318
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0183	0.0091	0.5
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.094	0.1196	0.2709
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0804	0.0997	0.2442
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0804	0.0997	0.1318
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0804	0.0997	0.1002
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0804	0.0997	0.1002
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.2977	0.417	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1561	0.2103	0.2924
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.6972	1	1
Echinococcus multilocularis	snurportin 1	0.0372	0.0367	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0091	0.0091
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0804	0.0997	0.2442
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Brugia malayi	MH2 domain containing protein	0.0144	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0091	0.0091
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.2726	0.3803	0.5396
Loa Loa (eye worm)	phosphatidylinositol 3	0.0183	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.2722	0.3797	0.3816
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.2076	0.2854	0.2868
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.3735	0.5275	0.7537
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0183	0.0091	0.0091
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1965	0.2692	0.3781
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0804	0.0997	0.1318

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.5929 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	30.1313 uM	PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388]	ChEMBL.	No reference
Potency (functional)	190.1154 uM	PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in HTRF Activity in a Luteinizing Hormone Receptor Cell Line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1476008

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1359804