Detailed information for compound 1360155

Basic information

Technical information
  • TDR Targets ID: 1360155
  • Name: N-[2-[2-(4-methylphenoxy)ethylsulfanyl]-1,3-b enzothiazol-6-yl]furan-2-carboxamide
  • MW: 410.509 | Formula: C21H18N2O3S2
  • H donors: 1 H acceptors: 2 LogP: 5.49 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCCSc1nc2c(s1)cc(cc2)NC(=O)c1ccco1
  • InChi: 1S/C21H18N2O3S2/c1-14-4-7-16(8-5-14)25-11-12-27-21-23-17-9-6-15(13-19(17)28-21)22-20(24)18-3-2-10-26-18/h2-10,13H,11-12H2,1H3,(H,22,24)
  • InChiKey: ACWREBPQADGTKE-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[2-(4-methylphenoxy)ethylthio]-1,3-benzothiazol-6-yl]-2-furancarboxamide
  • N-[2-[2-(4-methylphenoxy)ethylthio]-1,3-benzothiazol-6-yl]-2-furamide
  • D336-3628
  • NCGC00118832-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0142 0.0785
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Brugia malayi RNA binding protein 0.0066 0.0265 0.2268
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0142 0.0351
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0111 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0432
Echinococcus multilocularis tensin 0.0014 0.0009 0.0023
Brugia malayi TAR-binding protein 0.0066 0.0265 0.2268
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.000000000020712 0.000000000051138
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0017 0.0028 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.007 0.0252
Brugia malayi hypothetical protein 0.0017 0.0028 0.0239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.3252
Entamoeba histolytica hypothetical protein 0.0074 0.0308 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0014 0.0009 0.0023
Echinococcus multilocularis chromobox protein 1 0.0072 0.0295 0.0729
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.1176 0.151
Loa Loa (eye worm) SRC-1 0.0017 0.0028 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Echinococcus granulosus SH2 domain containing adapter protein F 0.0014 0.0009 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0274 0.2345
Schistosoma mansoni hypothetical protein 0.0035 0.0116 0.0287
Echinococcus multilocularis GPCR, family 2 0.0016 0.0023 0.0056
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0004 0.0016
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0012 0.0003 0.0007
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0273
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Onchocerca volvulus 0.0028 0.0082 0.5256
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1465 0.7165 1
Schistosoma mansoni suppressor of cytokine signaling 0.0014 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus granulosus chromobox protein 1 0.0072 0.0295 0.0729
Echinococcus granulosus tar DNA binding protein 0.0066 0.0265 0.0655
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0308 0.0761
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.000000000020712 0.00000000017697
Echinococcus multilocularis SH2 domain containing protein 7 0.0014 0.0009 0.0023
Echinococcus granulosus tumor protein p63 0.0194 0.0899 0.222
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0014 0.0009 0.0023
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0028 0.0069
Leishmania major DNA polymerase eta, putative 0.0067 0.0274 0.6365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0157 0.0386
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.000000000020712 0.000000000074568
Entamoeba histolytica hypothetical protein 0.0074 0.0308 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0273
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0056
Mycobacterium tuberculosis Conserved protein 0.0043 0.0157 0.0065
Echinococcus granulosus tyrosine protein kinase Srms 0.0017 0.0028 0.0069
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.0277 0.8975
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.204 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0014 0.0009 0.0023
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0009 0.0079
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0111 0.3888
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0056
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0575 0.2778 0.374
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000067216
Onchocerca volvulus 0.0014 0.0009 0.0588
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus multilocularis 0.0014 0.0009 0.0023
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0009 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.007 0.1632
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0155 0.5254
Trichomonas vaginalis C-MYB, putative 0.0068 0.0277 0.9363
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0082 0.2789
Trypanosoma brucei trypanothione reductase 0.0099 0.0429 0.2415
Schistosoma mansoni hypothetical protein 0.0369 0.1762 0.435
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.0277 0.8975
Echinococcus granulosus Chromo domain 0.0012 0.000000000020712 0.000000000051138
Echinococcus granulosus bloom syndrome protein 0.0025 0.0064 0.0158
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0295 1
Brugia malayi Protein kinase domain containing protein 0.0017 0.0028 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0432
Echinococcus granulosus suppressor of cytokine signaling 7 0.0014 0.0009 0.0023
Echinococcus multilocularis SH2 motif 0.0014 0.0009 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0157 0.0065
Echinococcus granulosus signal transduction protein lnk realted 0.0014 0.0009 0.0023
Brugia malayi CHD4 protein 0.0012 0.000000000020712 0.00000000017697
Brugia malayi hypothetical protein 0.0026 0.007 0.0598
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0064
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0064
Echinococcus granulosus SH2 motif 0.0014 0.0009 0.0023
Schistosoma mansoni brg-1 associated factor 0.0012 0.0003 0.0007
Mycobacterium tuberculosis Conserved protein 0.0043 0.0157 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Plasmodium falciparum glutathione reductase 0.0034 0.0111 0.2584
Mycobacterium tuberculosis Conserved protein 0.0043 0.0157 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0111 0.0106
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0017 0.0028 0.0069
Brugia malayi SH2 domain containing protein 0.0017 0.0028 0.0239
Brugia malayi beta-lactamase family protein 0.0043 0.0157 0.1337
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0157 0.0065
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0007
Mycobacterium tuberculosis Probable reductase 0.0225 0.1052 0.1334
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0116 0.0992
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0278 0.9417
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0142 0.0045
Schistosoma mansoni tensin 0.0014 0.0009 0.0023
Loa Loa (eye worm) SH2 domain-containing protein 0.0014 0.0009 0.0079
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0017 0.0028 0.179
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0012 0.0003 0.0007
Loa Loa (eye worm) TK/ABL protein kinase 0.0017 0.0028 0.0239
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0142 0.4619
Echinococcus granulosus tyrosine protein kinase shark 0.0592 0.2863 0.7068
Echinococcus multilocularis tyrosine protein kinase Blk 0.0017 0.0028 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0265 0.0655
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0265 0.0655
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0003 0.0007
Echinococcus granulosus geminin 0.0528 0.2544 0.6282
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Brugia malayi beta-lactamase family protein 0.0043 0.0157 0.1337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0082 0.2789
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0028 0.0069
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0429 0.0451
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0049 0.1146
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0066 0.0564
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0016
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0012 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Echinococcus granulosus tyrosine protein kinase Src42A 0.0017 0.0028 0.0069
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0295 0.2524
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Brugia malayi Heterochromatin protein 1 0.0072 0.0295 0.2524
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0003 0.0066
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0111 0.0108
Brugia malayi Protein kinase domain containing protein 0.0017 0.0028 0.0239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0012 0.0003 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Entamoeba histolytica hypothetical protein 0.0074 0.0308 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0225 0.1052 0.1278
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0028 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.117 1
Schistosoma mansoni tyrosine kinase 0.0017 0.0028 0.0069
Plasmodium vivax glutathione reductase, putative 0.0099 0.0429 1
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0157 0.3652
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0056
Echinococcus granulosus microtubule associated protein 2 0.0833 0.405 1
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0003 0.0024
Schistosoma mansoni GTPase activating protein 0.0014 0.0009 0.0023
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0017 0.0028 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.007 0.1632
Echinococcus multilocularis dna polymerase eta 0.0067 0.0274 0.0677
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0014 0.0009 0.0023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0111 0.0946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.3252
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0009 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0606
Echinococcus granulosus SH2 motif 0.0014 0.0009 0.0023
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.000000000020712 0.000000000051138
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.0009 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0111 0.2509
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0124 0.0555 0.474
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0142 0.1216
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0111 0.2584
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0157 0.53
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0157 0.0866
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000067216
Loa Loa (eye worm) SH2 domain-containing protein 0.0014 0.0009 0.0079
Brugia malayi SH2 domain containing protein 0.0017 0.0028 0.0239
Echinococcus granulosus NCK adaptor protein 0.0014 0.0009 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0157 0.53
Plasmodium vivax hypothetical protein, conserved 0.0012 0.000000000020712 0.00000000048321
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000067216
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0004 0.0101
Onchocerca volvulus 0.0031 0.0097 0.6222
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0014 0.0009 0.0299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0014 0.0009 0.0023
Loa Loa (eye worm) RNA binding protein 0.0066 0.0265 0.2268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0003 0.0066
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0429 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0014 0.0009 0.0588
Entamoeba histolytica hypothetical protein 0.0012 0.000000000020712 0.00000000067216
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.014 0.8954
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0157 0.1337
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0268 0.0964
Brugia malayi cytokine inducible SH2-containing protein 5 0.0014 0.0009 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.3252
Schistosoma mansoni tyrosine kinase 0.0017 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Schistosoma mansoni Smad4 0.0017 0.0026 0.0064
Echinococcus multilocularis tyrosine protein kinase shark 0.0592 0.2863 0.7068
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.117 1
Brugia malayi MH1 domain containing protein 0.0017 0.0026 0.0221
Echinococcus granulosus tyrosine kinase 0.0017 0.0028 0.0069
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.405 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Echinococcus multilocularis NCK adaptor protein 0.0014 0.0009 0.0023
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0014 0.0009 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0111 0.2584
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0268 0.0661
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0157 0.0386
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0265 0.0655
Entamoeba histolytica SH2 domain containing protein 0.0014 0.0009 0.0299
Loa Loa (eye worm) STAT protein 0.0014 0.0009 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0017 0.0028 0.0069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0142 0.4819
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0111 0.2509
Echinococcus granulosus SHC transforming protein 3 0.0014 0.0009 0.0023
Brugia malayi Smad1 0.0017 0.0026 0.0221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0157 0.0065
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0037
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.0277 0.8975
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0026 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.007 0.1632
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Trichomonas vaginalis C-MYB, putative 0.0068 0.0277 0.9363
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0106
Trichomonas vaginalis pc-MYB2, putative 0.0068 0.0277 0.9363
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0028 0.0069
Mycobacterium ulcerans beta-lactamase 0.0043 0.0157 0.0152
Echinococcus granulosus GPCR family 2 0.0016 0.0023 0.0056
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0007
Echinococcus granulosus N chimaerin 0.0014 0.0009 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0308 0.0761
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0142 0.0785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Trypanosoma brucei unspecified product 0.0041 0.0142 0.0785
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0268 0.0264
Onchocerca volvulus 0.0014 0.0009 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0028 0.0069
Loa Loa (eye worm) beta-lactamase 0.0043 0.0157 0.1337
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0014 0.0009 0.0079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.1176 0.1454
Brugia malayi beta-lactamase 0.0043 0.0157 0.1337
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0136 0.0491
Echinococcus granulosus tyrosine protein kinase Blk 0.0017 0.0028 0.0069
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Echinococcus granulosus SWI:SNF matrix associated 0.0012 0.0003 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Leishmania major DNA polymerase kappa, putative 0.0041 0.0142 0.3252
Toxoplasma gondii thioredoxin reductase 0.0099 0.0429 0.1543
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0142 0.0351
Schistosoma mansoni hypothetical protein 0.0012 0.000000000020712 0.000000000051138
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0023
Brugia malayi protein-tyrosine kinase 0.0017 0.0028 0.0239
Echinococcus granulosus tensin 0.0014 0.0009 0.0023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0142 0.0351
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.0277 0.8975
Onchocerca volvulus 0.0012 0.0003 0.0181
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0429 0.1058
Echinococcus multilocularis Chromo domain 0.0012 0.000000000020712 0.000000000051138
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0009 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0142 0.1216
Onchocerca volvulus 0.0043 0.0157 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0017 0.0028 0.0909
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.204 1 1
Brugia malayi MH1 domain containing protein 0.0017 0.0026 0.0221
Trypanosoma brucei unspecified product 0.0028 0.008 0.0432
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0009 0.0023
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0142 0.4819
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0111 0.375
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0197 0.168
Plasmodium falciparum thioredoxin reductase 0.0034 0.0111 0.2584
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0014 0.0009 0.0079
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0429 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0197 0.168
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.1198
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0429 0.3662
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Brugia malayi STAT protein, DNA binding domain containing protein 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0014 0.0009 0.0588
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0157 0.53
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0111 0.0399
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0064 0.2163
Trypanosoma brucei unspecified product 0.0028 0.008 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0265 0.0655
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0157 0.0065
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.405 1
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0116 0.0992
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0268 0.6212
Mycobacterium ulcerans lipase LipD 0.0043 0.0157 0.0152
Echinococcus multilocularis tyrosine protein kinase Srms 0.0017 0.0028 0.0069
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.000000000020712 0.000000000051138
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0056
Echinococcus multilocularis SH2 motif 0.0014 0.0009 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0056
Onchocerca volvulus 0.0017 0.0028 0.179
Loa Loa (eye worm) brahma associated protein 0.0012 0.0003 0.0024
Echinococcus granulosus expressed conserved protein 0.0014 0.0009 0.0023
Schistosoma mansoni hypothetical protein 0.0528 0.2544 0.6282
Trichomonas vaginalis pc-MYB2, putative 0.0068 0.0277 0.9363
Trypanosoma brucei RNA helicase, putative 0.0369 0.1762 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0012 0.0003 0.0024
Schistosoma mansoni hypothetical protein 0.0074 0.0308 0.0761
Echinococcus granulosus smad 0.0017 0.0026 0.0064
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0004 0.0101
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0028 0.0069
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0157 0.0386
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Trichomonas vaginalis MYB72, putative 0.0068 0.0277 0.9363
Plasmodium falciparum thioredoxin reductase 0.0099 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.000000000020712 0.00000000017697
Trichomonas vaginalis MYB3r3, putative 0.0068 0.0277 0.9363
Onchocerca volvulus 0.0043 0.0157 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0265 0.2268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0026 0.0221
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0194
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0268 0.0264
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0017 0.0028 0.0069
Schistosoma mansoni SH2A 0.0014 0.0009 0.0023
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0014 0.0009 0.0023
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0068 0.0278 0.1001
Brugia malayi glutathione reductase 0.0099 0.0429 0.3662
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0009 0.0079
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0017 0.0028 0.0069
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0111 0.0106
Brugia malayi tRNA modification GTPase TrmE family protein 0.0014 0.0009 0.0079
Schistosoma mansoni nck2/grb4 0.0014 0.0009 0.0023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0142 0.0045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.1052 0.1334
Giardia lamblia DINP protein human, muc B family 0.0041 0.0142 0.5041
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0268 0.0661
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0017 0.0028 0.0069
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0014 0.0009 0.0023
Loa Loa (eye worm) TK protein kinase 0.0017 0.0028 0.0239
Leishmania major DNA polymerase eta, putative 0.0039 0.0136 0.3113
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0111 0.0399
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.0009 0.0023
Onchocerca volvulus 0.0017 0.0028 0.179
Leishmania major hypothetical protein, conserved 0.0026 0.007 0.1547
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.1052 0.1334
Echinococcus granulosus SH2 domain containing protein 7 0.0014 0.0009 0.0023
Schistosoma mansoni DNA polymerase eta 0.0067 0.0274 0.0677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Echinococcus multilocularis tensin 0.0014 0.0009 0.0023
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.204 1 1
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Brugia malayi RhoGAP domain containing protein 0.0014 0.0009 0.0079
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.007 0.1547
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0009 0.0023
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0009 0.0023
Brugia malayi Protein kinase domain containing protein 0.0017 0.0028 0.0239
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0273
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.0009 0.0079
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0026 0.0064
Echinococcus multilocularis smad 0.0017 0.0026 0.0064
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.1052 0.1334
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.4746
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0157 0.0386
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0155 0.9915
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.000000000020712 0.00000000048321
Loa Loa (eye worm) SH2 domain-containing protein 0.0014 0.0009 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Brugia malayi hypothetical protein 0.0017 0.0025 0.0211
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0014 0.0009 0.0023
Brugia malayi Sex muscle abnormal protein 5 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0014 0.0009 0.0588
Brugia malayi SWIB/MDM2 domain containing protein 0.0012 0.0003 0.0024
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0429 0.1058
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0142 0.0138
Entamoeba histolytica protein kinase, putative 0.0014 0.0009 0.0299
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0265 0.2268
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0157 0.3587
Echinococcus granulosus tyrosine kinase 0.0017 0.0028 0.0069
Schistosoma mansoni tensin 0.0014 0.0009 0.0023
Brugia malayi hypothetical protein 0.0014 0.0009 0.0079
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.1176 0.151
Loa Loa (eye worm) Smad1 0.0017 0.0026 0.0221
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0017 0.0028 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.1176 0.151
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.000000000020712 0.00000000017697
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0014 0.0009 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0265 0.0655
Onchocerca volvulus 0.0017 0.0028 0.179
Echinococcus granulosus tyrosine protein kinase Src64B 0.0017 0.0028 0.0069
Schistosoma mansoni tensin 0.0014 0.0009 0.0023
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0064 0.2163
Brugia malayi Tensin 0.0014 0.0009 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0157 0.3587
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0111 0.0606
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0432
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0265 0.2268
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Brugia malayi MH2 domain containing protein 0.0017 0.0026 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus multilocularis SHC transforming protein 3 0.0014 0.0009 0.0023
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0028 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0157 0.53
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0017 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Echinococcus multilocularis SH2 motif 0.0014 0.0009 0.0023
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0014 0.0009 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0026 0.0221
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0068
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0244
Schistosoma mansoni chromobox protein 0.0072 0.0295 0.0729
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0014 0.0009 0.0023
Leishmania major trypanothione reductase 0.0099 0.0429 1
Onchocerca volvulus 0.0017 0.0028 0.179
Schistosoma mansoni adapter molecule crk 0.0014 0.0009 0.0023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0111 0.375
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0014 0.0009 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.0194
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0068
Brugia malayi chromobox protein homolog 3 0.004 0.014 0.1198
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.000000000020712 0.000000000051138
Schistosoma mansoni tyrosine kinase 0.0017 0.0028 0.0069
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0012 0.0003 0.0066
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0277 0.9363
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0111 0.2584
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0111 0.2584
Echinococcus granulosus dna polymerase kappa 0.0041 0.0142 0.0351
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0274 0.1537
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0142 0.0138
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0066 0.0564
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0009 0.0079
Mycobacterium ulcerans hypothetical protein 0.0043 0.0157 0.0152
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.007 0.0374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0268 0.0264
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0024 0.0571
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0703
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0136 0.3113
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1465 0.7165 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0026 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.3252
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0056
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Echinococcus multilocularis chromobox protein 1 0.0072 0.0295 0.0729
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0024 0.0085
Leishmania major hypothetical protein, conserved 0.0043 0.0157 0.3587
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0004 0.0016
Brugia malayi MH2 domain containing protein 0.0017 0.0026 0.0221
Entamoeba histolytica hypothetical protein 0.0074 0.0308 1
Brugia malayi MH2 domain containing protein 0.0249 0.117 1
Echinococcus multilocularis N chimaerin 0.0014 0.0009 0.0023
Brugia malayi Protein kinase domain containing protein 0.0017 0.0028 0.0239
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Brugia malayi Thioredoxin reductase 0.0099 0.0429 0.3662
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0026 0.0064
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0043 0.0157 1
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0014 0.0009 0.0588
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0575 0.2778 0.2776
Schistosoma mansoni chromobox protein 0.0072 0.0295 0.0729
Trichomonas vaginalis MYB, putative 0.0068 0.0278 0.9417
Brugia malayi Protein kinase domain containing protein 0.0017 0.0028 0.0239
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0064 0.0158
Schistosoma mansoni tensin-related 0.0014 0.0009 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0082 0.0203
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0157 0.0065
Echinococcus multilocularis tyrosine kinase 0.0017 0.0028 0.0069
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0017 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0052 0.0197 0.168
Echinococcus granulosus chromobox protein 1 0.0072 0.0295 0.0729
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.0277 0.8975
Echinococcus granulosus suppressor of cytokine signaling 6 0.0014 0.0009 0.0023
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0028 0.0239
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0014 0.0009 0.0023
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0014 0.0009 0.0588
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0064
Echinococcus granulosus tyrosine protein kinase ABL1 0.0017 0.0028 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0157 0.0152
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0064 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0157 0.0065
Toxoplasma gondii ABC1 family protein 0.0043 0.0157 0.0564
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0265 0.0655
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0295 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0111 0.0606
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0155 0.5254
Brugia malayi polk-prov protein 0.0013 0.0004 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Loa Loa (eye worm) hypothetical protein 0.0067 0.0274 0.2345
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.1052 0.1334
Echinococcus granulosus Smad4 0.0017 0.0026 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0111 0.2509
Schistosoma mansoni tyrosine kinase 0.0017 0.0028 0.0069
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0157 0.1337
Onchocerca volvulus 0.0017 0.0028 0.179
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0157 0.0152
Schistosoma mansoni tensin-related 0.0014 0.0009 0.0023
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.000000000020712 0.00000000017697
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0004 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0142 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0003 0.0066
Schistosoma mansoni shc transforming protein 0.0014 0.0009 0.0023
Schistosoma mansoni tyrosine kinase 0.0592 0.2863 0.7068
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0274 0.6365
Echinococcus multilocularis geminin 0.0528 0.2544 0.6282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Trichomonas vaginalis esterase, putative 0.0043 0.0157 0.53
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.000000000020712 0.000000000051138
Brugia malayi hypothetical protein 0.0074 0.0308 0.2633
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0003 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0142 0.3252
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0157 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000020712 0.00000000070125
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0023
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0009 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0308 0.0761
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0111 0.2509
Loa Loa (eye worm) hypothetical protein 0.0043 0.0157 0.1337
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0575 0.2778 1
Echinococcus granulosus dna polymerase eta 0.0067 0.0274 0.0677
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0111 0.2509
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0111 0.2509
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0017 0.0028 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0157 0.53
Schistosoma mansoni hypothetical protein 0.0528 0.2544 0.6282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0079
Echinococcus granulosus hypothetical protein 0.0014 0.0009 0.0023
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0575 0.2778 0.2775
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.0278 0.9417
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0007
Schistosoma mansoni signal transduction protein lnk-related 0.0014 0.0009 0.0023
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0003 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.1052 0.1334
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0014 0.0009 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0197 0.168
Schistosoma mansoni smad 0.0017 0.0026 0.0064
Brugia malayi SH2 domain containing protein 0.0014 0.0009 0.0079
Onchocerca volvulus 0.0014 0.0009 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0785
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.007 0.1547
Loa Loa (eye worm) RecQ helicase 0.0025 0.0064 0.0546
Schistosoma mansoni tyrosine kinase 0.0017 0.0028 0.0069
Echinococcus multilocularis tumor protein p63 0.0194 0.0899 0.222
Giardia lamblia Myb 1-like protein 0.0068 0.0278 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0003 0.0096
Plasmodium falciparum glutathione reductase 0.0099 0.0429 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0142 0.0785
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0268 0.0661
Echinococcus multilocularis Smad4 0.0017 0.0026 0.0064
Schistosoma mansoni vav2 0.0014 0.0009 0.0023
Echinococcus granulosus tyrosine protein kinase Fyn 0.0017 0.0028 0.0069
Echinococcus multilocularis signal transduction protein lnk realted 0.0014 0.0009 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0268 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.004 0.014 0.4746
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0268 0.0223
Schistosoma mansoni tyrosine kinase 0.0579 0.2796 0.6903
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.0095
Loa Loa (eye worm) glutathione reductase 0.0099 0.0429 0.3662
Echinococcus granulosus tyrosine protein kinase Src42A 0.0014 0.0009 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1312 0.1702
Brugia malayi SRC-1 0.0017 0.0028 0.0239
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0028 0.0239
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.000000000020712 0.000000000051138

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.5623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.