Detailed information for compound 1360175

Basic information

Technical information
  • TDR Targets ID: 1360175
  • Name: 4-(4-methylpiperidin-1-yl)sulfonyl-N-(3-methy lpyridin-2-yl)benzamide
  • MW: 373.469 | Formula: C19H23N3O3S
  • H donors: 1 H acceptors: 4 LogP: 2.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)S(=O)(=O)c1ccc(cc1)C(=O)Nc1ncccc1C
  • InChi: 1S/C19H23N3O3S/c1-14-9-12-22(13-10-14)26(24,25)17-7-5-16(6-8-17)19(23)21-18-15(2)4-3-11-20-18/h3-8,11,14H,9-10,12-13H2,1-2H3,(H,20,21,23)
  • InChiKey: XWOOCURYYXHETC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(4-methyl-1-piperidyl)sulfonyl]-N-(3-methyl-2-pyridyl)benzamide
  • 4-[(4-methyl-1-piperidinyl)sulfonyl]-N-(3-methyl-2-pyridyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1265 1
Brugia malayi PHD-finger family protein 0.0028 0.0336 0.0721
Schistosoma mansoni tar DNA-binding protein 0.0139 0.4655 0.6488
Trypanosoma cruzi cardiolipin synthetase, putative 0.0035 0.0618 0.3029
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0951 0.2043
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0951 0.6616
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0679 0.0946
Entamoeba histolytica phospholipase D, putative 0.01 0.3132 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0835 0.5364
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0717 0.0587
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0951 1
Schistosoma mansoni zinc finger protein 0.0022 0.0108 0.015
Leishmania major hypothetical protein, conserved 0.0043 0.0951 0.1399
Mycobacterium tuberculosis Conserved protein 0.0043 0.0951 0.0409
Brugia malayi Bromodomain containing protein 0.0042 0.0908 0.195
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1265 0.1763
Loa Loa (eye worm) hypothetical protein 0.006 0.1597 0.343
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1265 0.1861
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.001
Trypanosoma cruzi cardiolipin synthetase, putative 0.0035 0.0618 0.3029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2818 0.3927
Loa Loa (eye worm) hypothetical protein 0.004 0.0835 0.1793
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Loa Loa (eye worm) hypothetical protein 0.0124 0.4064 0.8731
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0951 0.4275
Brugia malayi beta-lactamase family protein 0.0043 0.0951 0.2043
Brugia malayi TAR-binding protein 0.0139 0.4655 1
Schistosoma mansoni hypothetical protein 0.0023 0.0153 0.0213
Mycobacterium tuberculosis Conserved protein 0.0043 0.0951 0.0409
Brugia malayi beta-lactamase 0.0043 0.0951 0.2043
Leishmania major hypothetical protein, conserved 0.0028 0.0337 0.0496
Echinococcus multilocularis phospholipase D 0.0088 0.2682 0.3738
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0951 0.4275
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0951 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.0861 0.185
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0007 0.001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0951 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0951 0.6616
Echinococcus multilocularis geminin 0.0205 0.7175 1
Schistosoma mansoni phospholipase D 0.01 0.3132 0.4366
Brugia malayi RNA binding protein 0.0139 0.4655 1
Echinococcus granulosus zinc finger protein 0.0022 0.0108 0.015
Schistosoma mansoni tar DNA-binding protein 0.0139 0.4655 0.6488
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0806 0.1124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.4655 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.6796 0.9472
Onchocerca volvulus Huntingtin homolog 0.0124 0.4064 1
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0153 0.0329
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1265 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0951 0.4275
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0717 0.4089
Brugia malayi hypothetical protein 0.0028 0.0337 0.0724
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0835 0.1163
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.6796 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0078 0.2292 0.4925
Loa Loa (eye worm) hypothetical protein 0.0084 0.2514 0.5402
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0835 0.1163
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0235 0.0327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.6796 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1265 0.1763
Loa Loa (eye worm) hypothetical protein 0.0045 0.1012 0.2173
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0951 0.0409
Mycobacterium ulcerans lipase LipD 0.0043 0.0951 0.0386
Onchocerca volvulus 0.0043 0.0951 0.234
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0717 0.0153
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0235 0.0327
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0235 0.0327
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0835 0.5364
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0717 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.4064 0.8731
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Toxoplasma gondii ABC1 family protein 0.0043 0.0951 0.095
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0835 0.1163
Brugia malayi Phospholipase d protein 1 0.01 0.3132 0.6729
Echinococcus multilocularis zinc finger protein 0.0022 0.0108 0.015
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.6796 0.6604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2818 0.3927
Echinococcus granulosus phospholipase D1 0.01 0.3132 0.4366
Loa Loa (eye worm) TAR-binding protein 0.0139 0.4655 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.6796 0.9472
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1265 0.2717
Brugia malayi MAP kinase sur-1 0.0052 0.1265 0.2717
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1597 0.343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1265 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1786 0.3837
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0951 0.0409
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0951 0.6616
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0951 0.2043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0835 0.1163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0951 0.0409
Onchocerca volvulus Huntingtin homolog 0.0124 0.4064 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2818 0.3927
Loa Loa (eye worm) hypothetical protein 0.0028 0.0337 0.0724
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0679 0.0946
Loa Loa (eye worm) inositol-1 0.0037 0.0717 0.1539
Schistosoma mansoni tar DNA-binding protein 0.0139 0.4655 0.6488
Schistosoma mansoni inositol monophosphatase 0.0037 0.0717 0.0999
Trypanosoma brucei cardiolipin synthetase 0.0035 0.0618 0.3029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.1822 0.2539
Onchocerca volvulus 0.0043 0.0951 0.234
Mycobacterium ulcerans hypothetical protein 0.0043 0.0951 0.0386
Schistosoma mansoni hypothetical protein 0.0205 0.7175 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0951 0.0409
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0717 0.1054
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1265 0.1763
Brugia malayi Inositol-1 0.0037 0.0717 0.1539
Brugia malayi hypothetical protein 0.0036 0.0679 0.1459
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1265 0.1861
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0835 0.1163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2818 0.3927
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1265 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1265 0.1763
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1265 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0951 0.2043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1265 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2818 0.3927
Onchocerca volvulus 0.0043 0.0951 0.234
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0951 0.0386
Schistosoma mansoni hypothetical protein 0.0205 0.7175 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2818 0.3927
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.6796 1
Brugia malayi hypothetical protein 0.0124 0.4064 0.8731
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0835 0.0635
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0835 0.2156
Mycobacterium leprae Probable lipase LipE 0.0043 0.0951 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.6796 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0951 0.0386
Loa Loa (eye worm) hypothetical protein 0.0084 0.2514 0.5402
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.001
Trypanosoma brucei cardiolipin synthetase, putative 0.0035 0.0618 0.3029
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0337 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0835 0.5364
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0951 0.4275
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0007 0.0016
Brugia malayi beta-lactamase family protein 0.0043 0.0951 0.2043
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0679 0.0946
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1265 1
Schistosoma mansoni hypothetical protein 0.0041 0.0861 0.12
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0835 0.1228
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0951 0.0409
Schistosoma mansoni inositol monophosphatase 0.0037 0.0717 0.0999
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0717 0.4089
Mycobacterium ulcerans beta-lactamase 0.0043 0.0951 0.0386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1597 0.343
Trypanosoma brucei protein kinase, putative 0.0052 0.1265 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0835 0.2156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.2818 0.6054
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0951 0.1325
Entamoeba histolytica phospholipase D, putative 0.01 0.3132 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0951 0.2043
Trichomonas vaginalis esterase, putative 0.0043 0.0951 0.4275
Loa Loa (eye worm) hypothetical protein 0.0047 0.1093 0.2349
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0835 0.2156
Schistosoma mansoni hypothetical protein 0.0036 0.0679 0.0946
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.1822 0.2539
Brugia malayi Bromodomain containing protein 0.0083 0.2475 0.5317
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0026 0.0056
Schistosoma mansoni bromodomain containing protein 0.007 0.1975 0.2752
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.6796 1
Schistosoma mansoni tar DNA-binding protein 0.0139 0.4655 0.6488
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.001
Echinococcus granulosus geminin 0.0205 0.7175 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1786 0.3837
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0717 0.0999
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0806 0.1124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0007 0.001
Echinococcus granulosus phospholipase D 0.0088 0.2682 0.3738
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0951 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0007 0.001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0835 0.1793
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0337 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1265 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0835 0.1163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2818 0.3927
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0861 0.185
Loa Loa (eye worm) RNA binding protein 0.0139 0.4655 1
Brugia malayi Phospholipase D. Active site motif family protein 0.0035 0.0618 0.1328
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0951 0.1325
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0717 0.4089
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.4655 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1265 0.1436
Mycobacterium tuberculosis Conserved protein 0.0043 0.0951 0.0409
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0717 0.0999
Echinococcus multilocularis tar DNA binding protein 0.0139 0.4655 0.6488
Echinococcus granulosus tar DNA binding protein 0.0139 0.4655 0.6488
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0084 0.2514 0.748
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0835 0.1163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.2818 0.6054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0951 0.1325
Echinococcus multilocularis GPCR, family 2 0.0019 0.0007 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0951 0.4275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0951 0.1325
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1265 0.1763
Schistosoma mansoni tar DNA-binding protein 0.0139 0.4655 0.6488
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0835 0.1163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0911 0.1956
Echinococcus granulosus GPCR family 2 0.0019 0.0007 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.6796 0.9472
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0007 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1265 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1597 0.343
Echinococcus multilocularis phospholipase D1 0.01 0.3132 0.4366
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.6796 0.9472
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1265 1
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0035 0.0618 0.0435

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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